December 11, 2016 at 11:23 pm #2720
Hello. Been searching all over the web for correct info but haven’t gotten consistent info. I’m a vyvanse user who has experienced 2 things. Lessening of efficacy which has led me to dose twice per day for add symptoms , but also a general anxiety while using the medication. When I remove the med I am unfocused etc. I’ve tried other stims but found vyvanse provides the best focus and also the worst anxiety. My goal is to do this 1) find a stack that can keep the effects of the med coming and possibly even lessen or discontinue one or both doses. And 2) lessen the anxiety I have on the medication. I have no issues with sleep it is more of a general nervousness throughout the day that is greatly affecting my life! Help! I do not want to use a lot of supplements. Just very simple but effective if that’s at all possible. I’ve been looking at l theanine and magnesium specifically but am confused as to if this is correct as well as dosages and type to get. Thank you so much !!! JenniferDecember 12, 2016 at 3:03 pm #2722
Jennifer, this is a little complicated so stick with me. From your description of symptoms, it sounds like you don’t have enough neurotransmitters to support Vyvanse. Which is likely the reason you had to up your dosage.
Vyvanse (Lisdexamfetamine) is a ‘prodrug’ of dextroamphetamine which means it is inactive until your red blood cells break it down into dextroamphetamine and l-lysine.
Dextroamphetamine then helps the associated transporters release more dopamine, norepinephrine, and serotonin from their storage sites in your neurons. If you don’t have enough of these neurotransmitters available then you won’t experience the intended effects of Vyvanse as much. And you can experience anxiety and irritability due to not enough serotonin and/or dopamine. (Or too much dopamine which is unlikely in your case).
L-lysine is important too because it helps produce Acetyl-CoA which is necessary to produce acetylcholine. Which helps everything in your brain communicate among other things.
The only really accurate way to find out your levels of neurotransmitters is to get tested. And then you have a better idea of what you need to fix. Otherwise, it’s a guessing game and lots of experimenting.
First, I suggest you take a good B-Complex vitamin which includes B9 folate (not folic acid) and B12 methylcobalamin (not cobalamin). With Magnesium-L-threonate. All necessary to make neurotransmitters.
Next I’d try Rhodiola Rosea to help boost serotonin. But we also encounter another problem with using stimulants long-term. They seem to be hard on neurons and wear them out. To counter this issue you can use Lion’s Mane Mushroom to help repair and grow new neurons (neurogenesis).
I know this sounds like a lot but please believe me that it’s worth it in the long-run. It took me years to figure out how to make this all work. I still use Ritalin and have not had to increase my dose because I give my brain what it needs to make good use of Ritalin.
To save money you might want to try Mind Lab Pro which is my favorite pre-made nootropic stack which includes most of the above. Although I still supplement with a good B-Complex vitamin and magnesium. And I use double the recommended dose of Mind Lab Pro because I’m severely Adult ADD. One dose in the morning and one at noon.
Please report back with how this works for you. And what you finally settle on that works best. Everyone’s body is different and what works for me may not work as well for you.
And one final note: I am not medical doctor and don’t even play one on TV. These are all suggestions from a guy with ADD who has done his homework. 🙂 Good luck!
December 12, 2016 at 10:38 pm #2724
- This reply was modified 1 month ago by David Tomen.
Wow thank you so much for that info. I will take your advice. I an still wondering though , with all of the mentioned supplements , will the anxiety also be addressed ? I believe this is the most troublesome for me as its caused me to stop Vyvanse many times because it’s such a terrible feeling. Then , I restart again when I begin to struggle with focus.
Will this stack address this ? Also just to be clear , the premade supplement you mentioned AS WELL as a additional B-Complex and magnesium. Correct? I will look into this tonight.
I can’t thank you enough. I’ve been extremely worried about this! You are clearly quite knowledgeable Jennifer
December 13, 2016 at 12:04 am #2726
- This reply was modified 1 month ago by David Tomen.
Jennifer, I suggest you do a search on NootropicsExpert.com (use the search feature at the top right) for “anxiety” and see what turns up. There are several nootropics that I did not mention that also address anxiety. And it would have been overwhelming for anyone if I had talked about them.
As I mentioned, you have no way of knowing for sure what’s going on with your neurotransmitters. If serotonin is low you’ll feel anxiety. If dopamine is too high or too low you’ll feel anxiety. If norepinephrine or epinephrine is out of whack you’ll feel anxiety. If GABA is low you’ll feel anxiety.
This is why we experiment with nootropic supplements until we find something that works. But they may not work forever. I’m adding to and subtracting from my stack the more I learn. And as my body changes. It’s also why we say “start low” when starting something new. To find out how your body reacts.
To answer your question about Mind Lab Pro + a high-quality B-Complex, my answer is yes. There are a couple of RDA-level B-Vitamins in that stack. But for me, not nearly enough. And I have a suspicion would not be enough for you either considering your issues.
Nootropics are as much an art as they are a science. We have decades of clinical research to draw from. But only about 20 years of practical real-world experience. And only about 5 – 10 years of people really sharing their experience with nootropics. Again, it’s why we experiment.