Acetyl-L-Carnitine (ALCAR)

David Tomen
Author:
David Tomen
Jill Corleone, RD
Fact Checked:
Jill Corleone, RD
10 minute read
Acetyl-L-Carnitine may reverse age-related cognitive decline, boost energy, and improve memory.

Key Takeaways

  1. Acetyl-L-Carnitine (ALCAR) is a synthesized version of L-Carnitine that enhances energy production, supports fat burning, and improves cognitive function.
  2. ALCAR facilitates fatty acid transport to mitochondria, boosts acetylcholine formation, and exhibits antioxidant properties.
  3. ALCAR benefits brain health by supporting mitochondrial function, protecting brain cells, and improving cerebral blood circulation.
  4. It has potential therapeutic effects on conditions such as Alzheimer’s, dementia, Parkinson’s, depression, and mild cognitive impairment.
  5. ALCAR supplementation dosage recommendation is 500 – 1,500 mg per day depending on the desired goal.

 

Acetyl-L-Carnitine (ALCAR, ALC or LAC) is a synthesized version of L-Carnitine. Which is a derivative of the amino acids lysine and methionine.

ALCAR is more bioavailable than L-Carnitine. It easily crosses the blood-brain barrier. And delivers L-Carnitine across cell membranes and into your brain (which L-Carnitine would not be able to cross on its own).

L-Carnitine is naturally made in your liver and kidneys. And then transported to other tissues including your brain and heart.

ALCAR helps:

Acetyl-L-Carnitine (ALCAR) Overview

L-Carnitine is an amino acid that’s synthesized in your body. You also get it from red meat and dairy.

High quality Acetyl L-Carnitine is found naturally in grass-fed beef and mutton.L-Carnitine is considered a “conditionally essential” nutrient because when your body uses it faster than it can produce it, you need supplemental L-Carnitine either from food or a supplement.

L-Carnitine is used throughout your body. Here we’re talking about the Acetyl-L-Carnitine form of L-Carnitine because of its affects on brain health and chemistry.

L-Carnitine vs. Acetyl-L-Carnitine: What’s the Difference?

L-Carnitine and Acetyl-L-Carnitine are often referred to as Carnitine. But each are structurally different, and each has its advantages.

L-Carnitine: Helps produce energy within the mitochondria of your cells, but is not capable of crossing the blood-brain barrier. Supplemental L-Carnitine is difficult for your body to absorb; only 18% of it reaches your bloodstream.

L Carnitine supplements are favored by athletes and dieters who want Carnitine’s fat-metabolizing benefits. But are not seeking any brain benefits.

L-Carnitine chemical structure
L-Carnitine

Acetyl-L-Carnitine: Is easier to absorb and used by your body than L-Carnitine. In one animal study, who were given 2 grams of ALCAR daily for 50 days, ALCAR boosted blood levels of ALCAR by 43%.[i]

Acetyl-L-Carnitine chemical structure
Acetyl-L-Carnitine

 

ALCAR does everything that L-Carnitine does, but by adding an acetyl group, it but can also cross the blood-brain barrier. In another animal study, researchers found that ALCAR supports mitochondrial function which then protects brain cells from oxidative stress, while L-Carnitine does not.[ii]

How does Acetyl-L-Carnitine Work in the Brain?

Acetyl-L-Carnitine boosts brain health and function in several ways. But two in particular stand out.

  1. ALCAR boosts acetylcholine, a neurotransmitter tied to memory and overall brain function. Acetyl-L-Carnitine is a precursor to acetylcholine in the presence of Coenzyme-A. Test tube studies shows that ALCAR donates a “methyl group” to help make acetylcholine.[iii]

Alzheimer’s-diseased brains show a 25% to 40% reduction in carnitine acetyltransferase, an enzyme that works with L-Carnitine & Acetyl-L-Carnitine.

This enzyme decline led researchers to link low ALCAR with low acetylcholine, and Alzheimer’s onset. They went on to suggest that the therapeutic properties of ALCAR supplementation is a viable therapy for brain regeneration.[iv]

  1. ALCAR promotes brain energy metabolism by supporting your brain cell’s mitochondria in creating ATP which is your main source of cellular energy.[v]

ALCAR works as a shuttle transport for fatty acids through cell membranes into mitochondria to assist with adenosine triphosphate (ATP) synthesis.[vi]

ALCAR is essential for fatty acid oxidation:

  • ALCAR shuttles fatty acids into mitochondria, for the creation of ATP.
  • ALCAR then shuttles fatty acids out of mitochondria, and flushes out tox ic byproducts.

ALCAR helps maintain mitochondrial function in nearly every cell of your body and brain.
ALCAR helps maintain mitochondrial function in nearly every cell of your body. Your brain consumes at least 20% of your body’s energy. And generates a lot of toxic byproducts as well as different chronic intermittent stressors. . So ALCAR supplementation is particularly important for a healthy brain.

How things go bad

As we get older, our brain chemistry and energy metabolism changes.[vii]

↓ Nerve growth factor in the brain declines

↓ Acetyl-L-Carnitine levels decline

↓ Acetylcholine levels decline

↓ Mitochondria loses efficiency

All of these age-related changes are contributing factors to cognitive impairment and the neurodegenerative diseases of aging, including Alzheimer’s and dementia.

ALCAR Nootropic benefits

Animal research conducted at the Linus Pauling Institute at Oregon State University shows that Acetyl-L-Carnitine will:[viii]

  • Restore efficient mitochondrial energy production
  • Replenish age-related changes to mitochondrial structure
  • Replenish ALCAR and acetylcholine levels in the brain and body

One of the most potent Acetyl-L-Carnitine benefits is that it has the ability to boost acetylcholine and rejuvenate brain cells (including mitochondria). This has been proven to benefit those with age-related brain diseases like Alzheimer’s and major depressive symptoms.[ix]

And one animal study conducted in New Delhi showed that Acetyl L-Carnitine reduces lipofuscin in the cerebral cortex, hippocampus, striatum and thalamus.

How does Acetyl-L-Carnitine feel?

You may not feel ALCAR… unless you’re elderly, have low energy levels, or have Erectile Dysfunction. Within those specific groups, users of Acetyl-L-Carnitine report it helps with memory, mental fatigue, mood, mental performance and the ability to get and maintain an erection.

How does ALCAR make you feel?ALCAR’s brain support and its ability to support the mitochondria in your brain cells should boost cognition in all age and gender groups.

As a nootropic, ALCAR user reviews report a boost in energy and quicker thinking.

ALCAR Clinical Research

In one study, researchers showed that ALCAR may have beneficial effects for depression and dementia in the aging brain.[x]

Another study out of Italy; researchers showed that Acetyl-L-Carnitine stimulated the growth of new neurites. More of these minute projections from nerve cell bodies meant increased signaling between cells throughout the central nervous system (brain and spinal cord).[xi]

And a study conducted at the Mount Sinai School of Medicine in New York found that ALCAR has potential in treating the symptoms of Parkinson’s Disease. By directly affecting mitochondrial respiration and assisting dopamine receptors and the use of dopamine in the brain.

ALCAR helps with Mild Cognitive Impairment (MCI)

A gold-standard double-blind, randomized controlled trial on 1,204 people showed significant effect on attention, mental performance, memory and higher mental functions.[xii]

In this study ALCAR seemed to ward off further brain deterioration. And could be considered as therapy for brain degeneration.

Acetyl-L-Carnitine slows rate of cognitive decline

130 Alzheimer’s patients were given ALCAR or a placebo daily for a year. They were tested across 14 points of cognitive performance.

This research showed a slower decline in cognitive performance with the ALCAR group compared to the placebo group.[xiii]

ALCAR effective for Chronic Fatigue Syndrome

acetyl-l-carnitine helps reduce chronic fatigueAcetyl-L-Carnitine has been shown to improve fatigue in patients with chronic fatigue syndrome.

In a randomized, double-blind, crossover study; 36 people were treated for 3 months with either amantadine (used to treat Chronic Fatigue), or 1 gram of ALCAR twice daily.

The results of the study showed that ALCAR was better tolerated and more effective for brain function than the pharmaceutical for fatigue.[xiv]

Acetyl-L-Carnitine protects from oxidative damage of Ecstasy (MDMA)

Research has shown ALCAR to be effective in protecting your mitochondria from oxidative stress. But these guys took it a step further.

Male rats were given Acetyl-L-Carnitine before a dose of Ecstasy (MDMA). ALCAR pretreatment “exerts effective neuroprotection against MDMA-induced neurotoxicity at the mitochondrial level”, said the researchers.[xv]

Keep that in mind before your next party.

ALCAR for Erectile Dysfunction?

Carnitine versus androgen administration. In this study, 120 patients were split into 3 groups. Group 1 was given 160 mg of testosterone per day. The 2nd group was given 2 grams of Propionyl-L-Carnitine plus 2 grams of Acetyl L Carnitine hcl per day. And the 3rd group a placebo.

Did you know that there’s an International Index of Erectile Function?

Turns out the Propionyl-L-Carnitine/Acetyl-L-Carnitine stack was better than testosterone for sexual dysfunction. Without the side effects of an enlarged prostate, better orgasms, more sexual desire and improved mood.[xvi]

Propionyl-L-Carnitine chemical structure
Propionyl-L-Carnitine

 

ALCAR Recommended Dosage

  • Acetyl-L-Carnitine suggested dosage for cognitive benefits is 1 – 4 grams per day.
  • For improved mood and elimination of chronic fatigue, 1 – 3 grams of ALCAR per day.
  • For age-related memory concerns, 1 – 2 grams of ALCAR per day.

ALCAR is water-soluble and can be taken on an empty stomach with water. A few supplement manufacturers recommend taking their Acetyl-L-Carnitine with a meal. Which may imply that it’s fat-soluble although I’ve found no evidence in the scientific literature.

ALCAR Side Effects

Acetyl-L-Carnitine is produced naturally in your body. So is considered well-tolerated and safe.

Side effects are rare but can include nausea, vomiting, increased agitation, weight loss, and restlessness.

You can also see an increase in seizure frequency if you have any kind of seizure disorder.

ALCAR and thyroid hormones. L-carnitine inhibits both triiodothyronine (T3) and thyroxine (T4) entry into the cell. Which means ALCAR supplementation may make thyroid hormone replacement therapy less effective. But could also help someone suffering from hyperthyroidism.

Types of ALCAR to buy

  • Acetyl-L-Carnitine: L-Carnitine with an extra acetyl group. This version of l carnitine is more bioavailable and easily crosses the blood-brain barrier.
  • L-Carnitine: This is the standard form of l carnitine found in food.
  • Lipo-Carn®: A proprietary blend of Alpha-Lipoic Acid and Acetyl-L-Carnitine. Studies show this combination is a powerful anti-aging duo.
    Performance Lab Energy contains an effective dose of ALCAR
    Performance Lab Energy contains an effective dose of ALCAR

    Together, these two help combat diabetes, glucose metabolism, boost energy production, lower high blood pressure, fat metabolism, maintain proper cognitive function, protects the body from radiation and chemical toxins and helps immunity.[xvii]

  • Propionyl-L-Carnitine: L-Carnitine combined with propionic acid. This form is noted for its antioxidant activity, reducing oxidative stress biomarkers, and is used for heart health applications. Also useful for erectile dysfunction.
  • Biosint™ is pharmaceutical grade Acetyl-L-Carnitine that is manufactured in Italy by Sigma Tau HealthSciences

You can also get 500 mg Acetyl L-Carnitine, 100 mg BioEnhanced R-Lipoic Acid, 100 mg CoQ10, 10 mg BioPQQ®, and 2.5 mg BioPerine® in one dose of my favorite energy supplement Performance Lab® Energy.

Nootropics Expert Recommendation

Acetyl-L-Carnitine 500 – 1,500 mg per day

Nootropics Expert Tested and Approved I recommend using Acetyl-L-Carnitine as a nootropic supplement.

Your body does synthesize some ALCAR on its own. And from the food you eat. But most L-Carnitine comes from red meat. And unless you eat a lot of great quality grass-fed beef or mutton you can not produce sufficient amounts, and likely have an Acetyl-L-Carnitine deficiency.

ALCAR is especially helpful for those suffering from age-related cognitive decline. Studies show it helps stop or reverse brain degeneration with Alzheimer’s Disease, and geriatric depression. Particularly in the early stages of the disease.

I suggest starting with a dose of 500 mg ALCAR daily. ALCAR is a great compliment to a stack including any of the racetams. Take enough Alpha GPC or CDP-Choline to eliminate a racetam-induced headache. Then add 500 mg of ALCAR.

Some have found ALCAR stacked with Coenzyme Q-10 has a profound effect on everything from mood to bipolar disorder. Especially combined with Alpha-Lipoic Acid.|

You can also get 500 mg Acetyl L-Carnitine, 100 mg BioEnhanced R-Lipoic Acid, 100 mg CoQ10, 10 mg BioPQQ®, and 2.5 mg BioPerine® in one dose of my favorite energy supplement Performance Lab® Energy.

Age-related cognitive disorders like Alzheimer’s may want to up the dose to 1,500 mg per day.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Rebouche C.J. “Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism.” Annals of the New York Academy of Sciences 2004 Nov;1033:30-41. (source)

[ii] Liu J., Head E., Kuratsune H., Cotman C.W., Ames B.N. “Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats.” Annals of the New York Academy of Sciences2004 Nov;1033:117-31. (source)

[iii] White H.L., Scates P.W. “Acetyl-L-carnitine as a precursor of acetylcholine.” Neurochemical Research 1990 Jun;15(6):597-601. (source)

[iv] Kalaria R.N., Harik S.I. “Carnitine acetyltransferase activity in the human brain and its microvessels is decreased in Alzheimer’s disease.”Annals of Neurology 1992 Oct;32(4):583-6. (source)

[v] Berg J.M., Tymoczko J.L., Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. (source)

[vi] Berg J.M., Tymoczko J.L., Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. (source)

[vii] Costell M., O’Connor J.E., Grisolía S. “Age-dependent decrease of carnitine content in muscle of mice and humans.” Biochemical and Biophysical Research Communications 1989 Jun 30;161(3):1135-43. (source)

[viii] Gomez L.A., Heath S.D., Hagen T.M. “Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart” Mechanics of Aging Development 2012 Feb-Mar; 133(0): 99–106. (source)

[ix] Pettegrew J.W., Levine J., McClure R.J. “Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer’s disease and geriatric depression.” Molecular Psychiatry 2000 Nov;5(6):616-32. (source)

[x] Ferrari F., Gorini A., Villa R.F. “Functional proteomics of synaptic plasma membrane ATP-ases of rat hippocampus: effect of l-acetylcarnitine and relationships with Dementia and Depression pathophysiology.” European Journal of Pharmacology 2015 Jun 5;756:67-74. (source)

[xi] Taglialatela G., Navarra D., Olivi A., Ramacci M.T., Werrbach-Perez K., Perez-Polo J.R., Angelucci L. “Neurite outgrowth in PC12 cells stimulated by acetyl-L-carnitine arginine amide.” Neurochemical Research 1995 Jan;20(1):1-9. (source)

[xii] Montgomery S.A., Thal L.J., Amrein R. “Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease” International Clinical Psychopharmacology 2003 Mar;18(2):61-71. (source)

[xiii] Spagnoli A. et. Al. “Long-term acetyl-L-carnitine treatment in Alzheimer’s disease.” Neurology. 1991 Nov;41(11):1726-32. (source)

[xiv] Tomassini V., Pozzilli C., Onesti E., Pasqualetti P., Marinelli F., Pisani A., Fieschi C. “Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomized, double-blind, crossover trial.” Journal of Neurological Science 2004 Mar 15;218(1-2):103-8. (source)

[xv] Alves E. et. Al “Acetyl-l-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain” Cellular Neuroscience Volume 158, Issue 2, 23 January 2009, Pages 514–523 (source)

[xvi] Cavallini G., Caracciolo S., Vitali G., Modenini F., Biagiotti G. “Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging.”Urology 2004 Apr;63(4):641-6. (source)

[xvii] Liu J., Head E., Gharib A.M., Yuan W., Ingersoll R.T., Hagen T.M., Cotman C.W., Ames B.N. “Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.” Proceeding of the National Academy of Sciences of the United States of America 2002 Feb 19;99(4):2356-61. (source)

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Join The Discussion - 348 comments

Jason
July 11, 2020

Be careful with ALCAR, I took 500mg x 2 daily for 6 months and I starts to develop psychosis, it’s not fun at all.

    David Tomen
    July 12, 2020

    Jason, thanks for sharing your experience.

    I do include a warning about “increased seizure frequency if you have a seizure disorder”. The problem is when someone has an ‘underlying condition’ that they’re not aware of. And then have a bad reaction to a nootropic supplement unexpectedly. Unfortunately, there is no way to offer a warning in that type of situation.

Nike
June 3, 2020

Hello again David,

I would like to ask you if it’s acceptable to take ALCAR with SAMe? Does they have same mechanism of action or can interact with each other? I take also Escitalopram for general anxiety and Cialis 5 mg for enlarged prostate.

    David Tomen
    June 3, 2020

    Nike, SAM-e (https://nootropicsexpert.com/sam-e/) has a completely different mechanism of action than ALCAR. The only real ‘crossover’ is ALCAR is a cofactor in the synthesis of acetylcholine. And SAM-e increases the number of muscarinic receptors which acetylcholine binds to. So they support each other.

      Nike
      June 5, 2020

      Thanks a lot David for your reply. I thought SAMe was increasing serotonin. So does it mean in increases Serotonin, Dopamine and Noradrenaline? or it just helps these neurotransmitters to work better? I am a bit confused now.

        David Tomen
        June 5, 2020

        Nike, SAM-e is a methyl donor needed for the production and recycling of hormones, cytokines, and the neurotransmitters acetylcholine, dopamine, norepinephrine, and serotonin. If SAM-e wasn’t present they would not get made.

        Nike
        June 7, 2020

        Dear David,

        Thanks for your reply. So if I got it well it does not increases directly neurotransmitters but it’s essential for their production.

        Also, I would like to ask you if it’s possible to measure SAMe in your blood? And if so, which test I need to ask my doctor to order for laboratory.

        Thanks for your help.

        David Tomen
        June 7, 2020

        Nike, I’m not aware of any lab test for measuring SAM-e levels. It would likely be an ineffective test anyway because of the way SAM-e is used in your brain and body.

        Nino
        June 11, 2020

        Hello David,

        I would like to ask you one question about amino acids in general and specifically about ALCAR. Can you take it with other amino acids before breakfast? For example I take L-citruline and is it possible to mix with it?

        Thanks.

        David Tomen
        June 12, 2020

        Nino, you can take them together. The key to using amino acids is to take them on an empty stomach and an hour before eating anything. Otherwise, they’ll end up competing for the same amino acid transporters as the aminos in your meal. And you will not experience the full benefit of the amino acid supplements.

Mjd
May 11, 2020

I get bad depression when taking alpha GPC or UMP and Tryptophan, am taking alcar lately and am afraid it might be causing depression as well, but am into resistance training and interested with its ergogenic benefits. Any ideas? Thank you for everything.

    David Tomen
    May 11, 2020

    Mjd, Google “ergonomic benefits” and see what turns up. Clearly your throwing something off with these supplements which affect acetylcholine and serotonin. ALCAR is a cofactor in acetylcholine synthesis too. And your system needs something else. Only you can find out what that is. Find a good list and go through them one by one. Maybe you need to boost some hormones or something like dopamine instead.

DAKA
March 24, 2020

I notice recentlly that ALCAR decreases my blood sugar when taken alone , without food. Even taken with breakfast sometimes i feel weak after that. Do you recomend me to split ALCAR into 2 doses ,ie 1g twice, or to remove it. I also noticed a difference of the timing in those glucose disposal agents(300mg ALA,1,5-2g ALCAR, 1,5gFENUGREEK) when taken prior-during-after the breakfast. If i take them prior-breakfast i would get a nasty Hypoglucemia.
Is Alcar absorbtion decreased by food?
Best regrads
Y

    David Tomen
    March 24, 2020

    Daka, ALCAR does not affect blood sugar so something else must be going on. The side effects of this supplement are rare but do include “nausea, vomiting, increased agitation, weight loss, and restlessness.” You may be one of those people.

    Taking ALCAR with food is not a problem. You can try it with a meal and see if that solves your problem. And reduce the dosage. If you still have problems I suggest not using it.

Jina Yoo
March 15, 2020

Hi David,
Thank you very much for the opportunity to ask you, an expert ahead of our time.
Would it be a good thing to take ACETY L-CARNITINE w/my ADHD stimulant, together (w/little gap between)and coq10, magnesium glycinate (120mg), Raw D3 w/probiotics/3,6,9 from chia seed oil? Thank you so much for your time/expertise.

    David Tomen
    March 15, 2020

    Jina, it is absolutely a good thing. See my entire ADHD nootropic stack here: https://nootropicsexpert.com/best-nootropics-for-adhd-add/

      Jina Yoo
      March 15, 2020

      Thank you, you’re too cool and 12 steps ahead of so many experts. It’s exactly what I’ve wanted/been looking for, a desert. So, happy for the knowledge, that has been your experience, also, it’s a gem/your site as a unit. T.Y.! There’s hope. ✨✅

Jean
March 14, 2020

Hi David,

Is it okay to take Alcar as a young man? Do I have to worry about oxidative stress? I was looking for some information about this and I’m a little worried. I read these posts on longecity and I’m in doubt: https://www.longecity.org/forum/topic/50494-accidentally-took-alcar-is-this-stuff-safe/ http://www.longecity.org/forum/topic/26055-alcar-age-adjusted-dose-ranging/
I intend to take Alcar to have more energy to study.

    David Tomen
    March 14, 2020

    Jean, ALCAR used at recommended age-appropriate dosages will not cause “oxidative stress”. In fact, it is restorative and energizing especially when used with R-Lipoic Acid, CoQ10 and PQQ. That stack supports ATP production in mitochondria which is fundamentally where your energy comes from.

    Here’s two ideas for you for energy for studying:

    https://nootropicsexpert.com/best-energy-supplements-to-buy-in-2020/ which describes two stacks you can try. Get the nootropics individually or the stacks described in that post.

    And here’s a post I did specifically for studying: https://nootropicsexpert.com/best-nootropics-for-studying/

      Jean
      March 15, 2020

      I am 17 years old. Would it be okay to take 1-3 grams of Alcar? I was thinking about first testing Alcar and then trying a stack that helps mitochondria, depending on the results.

      I already use some nootropics from the recommended stack for studying like citicoline, bacopa monnieri, caffeine (I will try the others sometime).

      I would use Alcar to avoid caffeine daily, i need energy all day. Any lack of energy worsens my motivation.

        David Tomen
        March 16, 2020

        Jean, I wouldn’t go as a high as 3 grams at 17. Because it’s highly unlikely your brain needs it.

        I suggest coming at your energy levels from other angles too like supplementing with R-Lipoic Acid, CoQ10 and PQQ. And if you are using caffeine make sure you are supporting what it’s depleting including the B-Vitamins, L-Tyrosine and lowering cortisol.

        Search for “energy” top right and 1 of 2 of the 2020 posts explains how that works. Because I detail how Performance Lab Stim works and why.

Jason
March 5, 2020

Isnt it bad that mind lab pro hasnt this one in its stack?

    David Tomen
    March 6, 2020

    Jason, I don’t think so because higher dosages of ALCAR are required to be effective. And the daily MLP dose would end up being 3 – 4 capsules minimum if it included this nootropic.

    This is not an expensive nootropic supplement which means most can afford to buy it. The alternative is getting Performance Lab Energy which contains ALCAR and which I include in one of my daily nootropic stacks.

Mike Kaminski
March 1, 2020

Hello David thank you for an amazing article, taking 2g of Alcar daily really eased my anxiety… However should it be taking with ALA? My worries with ALA is that it surpresses the Thyroid Hormones, I am also a bodybuilder could this benefit me?

    David Tomen
    March 1, 2020

    Mike, you do not need to use ALCAR with Alpha Lipoic Acid. ALA can lower thyroid hormone but this is usually only a concern with someone who has thyroid problems. If you have a healthy thyroid you shouldn’t have a problem.

      Mike Kaminski
      March 4, 2020

      Thank you! I also started taking SSRI’s…. Couldn’t find data online if Alcar and SSRI interact…. Thanks

        David Tomen
        March 4, 2020

        Mike, it shouldn’t because ALCAR affects the synthesis of acetylcholine. And SSRI’s work primarily on serotonin and its receptors and transporters.

        Going forward, the quickest way to figure this kind of thing out is learn the mechanism of action of the drug you are using. The look at the mechanism of action for each nootropic. If there is a direct or close match then you’ve got trouble. But if they are completely unrelated then ‘most’ of the time you shouldn’t have a problem.

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