Brain Waves - nootropics-flow state

How to Hack Your Flow State with Nootropics

David Tomen
David Tomen
13 minute read
Flow is the ultimate state of consciousness where you feel and perform your best. And nootropics can assist in getting to, maintaining, and coming out of an amazing flow experience

Flow is an optimal state of consciousness. The flow state is also known as being “in the zone”. It’s where you perform your best. And you feel your best.

We’ve all experienced flow at some time in our life. Recall a time where you were totally absorbed in something. It had your total attention. You were so focused that everything else disappeared.

Your sense of self vanished. Self-consciousness didn’t exit. Time dilated. A 5-hour experience felt like 5 minutes. But the opposite is also true. Time can slow down. So it feels like things are happening in slow motion.

But however you experienced this flow state, your physical and mental performance were off the charts.

A McKinsey & Co. report studied 5,000 executives during workshops. And concluded that senior executives in flow are 5-times better and more productive than those that aren’t.[i]

With a little knowledge and some practice, you’ll recognize a flow state coming on. And with your brain chemistry and brain waves optimized with the right nootropics, you’ll experience flow like never before.

This article is all about hacking your flow state. What recent research shows is happening to you during flow. And the variables you can influence to go into the zone more often.

Definition of the Flow State

The term we now call “Flow” was originally penned by professor and researcher Mihály Csíkszentmihályi in his book “Flow: The Psychology of Optimal Experience”.[ii]

Csíkszentmihályi hypothesized that people are happiest when they are in a state of flow. A state in which you are so involved in an activity that nothing else matters.

In an interview Csíkszentmihályi did with Wired magazine in 1996, he described flow as:

“being completely involved in an activity for its own sake. The ego falls away. Time flies. Every action, movement, and thought follows inevitably from the previous one, like playing jazz. Your whole being is involved, and you’re using your skills to the utmost.”[iii]

This state we now call “flow” has fascinated across cultures. And throughout written history.

Buddhism and Taoism refer to flow as the “action of inaction”, or “doing without doing”. Ancient Advaita texts including the Bhagavad-Gita also refer to a state which we now call “flow”.

Steven Kotler, author of The Rise of Superman[iv] and cofounder of the Flow Genome Project writes that athletes in action and adventure sports consistently enter the flow state. Because their activity frequently puts them in life or death situations. It’s “flow or die”.


The Neurobiology of the Flow State

When you enter a flow state, three changes in your neurobiology have been identified:

  1. Neuroanatomy – Your prefrontal cortex shuts down. This is known as “Transient Hypofrontality”. Your prefrontal cortex is the part of your brain that hosts your higher cognitive functions, sense of morality, sense of will, and your sense of self. Going into flow is like someone hitting the ‘Pause’ button on this section of your brain.

David Eagleman, director of Baylor College of Medicine’s Laboratory for Perception and Action, found that when your prefrontal cortex goes on hiatus, perception of time changes.[v]

Aaron Dietrich of the American University of Beirut found that Transient Hypofrontality is associated with every altered state of consciousness. Dietrich conducted a lot of research on flow state during exercise-induced states of consciousness.[vi]

It’s why you feel a “runner’s high”. Your inner critic is turned to ‘off’. You have no sense of being ‘self-conscious’.

Charles Limb of John Hopkins conducted a study with 11 jazz musicians aged 25 – 56 using a fMRI machine. And found that during jazz improvisation, their prefrontal cortex shut down.[vii]

  1. Neurotransmitters – Once you experience a flow state, the feeling and memory are so profound, it stays with you. And you want more of what you just had. The flow state experience is profound largely because of the neurotransmitters involved.

Flow begins with suffering and anxiety. And your inner critic is in high gear. The early stage of flow starts with a spike in the neurotransmitter norepinephrine, and the hormone cortisol.

Either you become exhausted, or if you’re wise enough to notice this state – you surrender and relax. Nitric oxide increases, and flushes the stress chemicals out of your blood stream.

Once you enter the flow state, dopamine kicks in. It feels like you want more of this. And you should keep on doing it. Endorphins increase and you feel no pain.

The neurotransmitter anandamide increases which primarily affects cannabinoid receptors. Anandamide (from the Sanskrit word for ‘bliss’) affects your feelings of motivation and pleasure.[viii]

And finally you enter the memory consolidation stage with raises in the neurotransmitter serotonin.

  1. Brain Waves – Research using EEG and fMRI in the last 5 years have identified the brain waves involved in the flow state.

When you approach a flow state, the spike in norepinephrine and cortisol is accompanied by busy, hyperactive Beta brain waves. When you get too tired or frustrated. Or if you’re wise enough and simply relax. Nitric oxide kicks in along with relaxed but alert Alpha brain waves.

Once you enter the flow state, along with dopamine, endorphins and anandamide, you experience Theta brain waves. Theta brain waves are the states experienced by long-time meditators. This is the state of optimum feeling and heightened performance. We rarely go into Theta during a regular waking state of consciousness.

As you leave the flow state, you go into deep Delta brain waves. This is the stage of memory consolidation along with a boost in serotonin. You get the afterglow of immense satisfaction. And the good feelings of serotonin.

Flow State is not an Ability or Skill

Now that we understand what happens leading up to, during, and after a flow state. It’s tempting to think we can use this as a ‘prescription’ to achieve flow. But flow isn’t as easy as learning a simple recipe.flow-state-triggers

Being a long-time meditator, I’m going to take some liberties here. And go a little deep on you.

Flow is the underlying state at which you naturally exist. Ask any long-term student of meditation. While you normally can’t achieve the flow state at will. You can re-create flow through practice. Especially the practice of letting go.[ix]

You see this all the time with athletes participating in extreme sports. You see it in musicians during an extended and inspired jam session.

As a copywriter, I experience flow almost every day. Writing a piece like this requires intense research. And flooding my brain and system to overwhelm. Until the flood gates burst. And I start to write. This is flow.

So practice and repetition may help you develop the ability to experience flow on demand. Visualization can be part of the ‘repetition’ process.

How to Recognize a Flow State

When you are under extreme pressure. And you lose focus. You simply don’t know what to do. Panic can begin to set in. And it feels like you really don’t want to go there …

This is often the beginning stage of the flow state. It can be hellish. Or if you recognize it for what it is. You can catch the wave. And ride it through.

Earlier, we discussed nearly all the major neurotransmitters involved in various stages of flow. And the brain waves involved in each.

Well, it turns out you can have a much deeper, more pleasant, memorable flow experience when neurotransmitters and brain waves are optimized. My life and work is an example of how flow can be hacked.

But nootropics alone can’t produce a flow state. It’s a full body experience. Nootropics however can help achieve and provide a better, fuller, richer flow experience.

Next, we’ll look at some nootropics that can help in each stage of a flow state. Both optimizing neurotransmitters and brain waves.


Best Nootropics for Hacking a Flow State

While nootropics will not induce a flow state. The right supplements can certainly provide a more pleasant, powerful experience.

The neurotransmitters involved in flow include norepinephrine, dopamine, endorphins, anandamide, and serotonin. Nitric oxide is needed to help flush out the stress chemicals that allow you to go into flow. And brain waves involved in flow include Beta, Alpha, Theta and Delta waves.

Each of these neurotransmitters and brain wave patterns can be influenced by the right nootropic. And we have a lot of nootropics to choose from. So this next section are suggestions for assisting each stage of flow.

There are many more options for optimizing neurotransmitters and brain waves than what I include below. This is not a definitive list. But my intention is to get you started.

Experiment and see what works best for you.

Dopamine & Norepinephrine

The production of dopamine in your body follows this metabolic pathway:

Phenylalanine → Tyrosine → L-DOPA → Dopamine → Norepinephrine

Dopamine is converted to norepinephrine by the enzyme dopamine β-monooxygenase, with O2 and ascorbic acid (Vitamin C) as cofactors.

If dopamine levels are low, norepinephrine levels will be low as well. And you won’t go into flow.

Nootropics to boost dopamine

  • Ginkgo Biloba and Flow StateGinkgo Biloba – Ginkgo acts as a monoamine oxidase inhibitor (MAOI) which reduces levels of monoamine oxidase (MAO) in the brain. MAO breaks down dopamine.[x] Particularly as you get older. And Ginkgo is very effective in boosting cerebral circulation. Providing your brain the nutrients and neurotransmitters it needs during flow.
  • L-Tyrosine is the precursor to producing dopamine in your brain. Tyrosine enhances working memory, executive function, creative flow states, reduces stress, improves mood and is anti-anxiety. Suggested dosage of L-Tyrosine is 350- 500 mg twice per day.
  • Mucuna Pruriens (L-Dopa) – Mucuna works as an antioxidant and heavy metal chelator, improves memory and cognition, reduces depression and boosts libido. L-Dopa is also the precursor to dopamine. Suggested dosage of Mucuna Pruriens is 250 – 500 mg per day.
  • N-Acetyl L-Cysteine (NAC) – NAC is an amino acid that regulates the amount of glutamate and dopamine in your brain. And NAC protects your dopamine receptors. Influencing dopamine levels and function in your brain.
  • NADH – NADH is the active coenzyme form of Vitamin B3 (niacin) present in every cell in your body. NADH helps stimulate the production of dopamine, norepinephrine and serotonin.[xi] All neurotransmitters involved in flow.
  • Vitamin B6 and B12 – Both vitamins B6 and B12 are a prerequisite to achieve a flow state. This is NOT optional. Both are required for the synthesis of neurotransmitters dopamine, norepinephrine and serotonin. B12 even helps increase serotonin and dopamine levels in your brain. And even mild deficiency in B6 results in down-regulation of GABA and serotonin. Without it you will not experience the afterglow of an amazing flow state.

Nitric Oxide

Nitric oxide is required to flush the high levels of norepinephrine and cortisol produced to ensure a smooth transition into the flow state.Hacking flow state

  • Oat Straw – Oat Straw is an MAO-B inhibitor which increases dopamine levels in your brain. Oat Straw can improve attention, focus, cognition and concentration. And it helps boost nitric oxide and inhibits the enzyme PDE4 which helps dilate blood vessels.[xii] Flushing out your system to prepare you for a full flow experience.
  • NADH – NADH does double duty during the flow state. Not only does it boost dopamine, norepinephrine and serotonin. It also helps boost the production of nitric oxide to help flush out the stress chemicals so you can go into flow.
  • Pramiracetam – This nootropic from the racetam-family has a profound effect on the synthesis of acetylcholine in your brain. Helping all the other neurotransmitters function better. But Pramiracetam also increases nitric oxide activity in your brain.[xiii]
  • Vitamin B3 (niacin) – Niacin does double-duty by helping to stimulate the production of dopamine, norepinephrine and serotonin. Critical neurotransmitters involved in the flow state. And niacin boosts the production of nitric oxide. Helping to flush out the stress chemicals necessary to ensure you enter flow.


  • Phenibut – This nootropic is an analogue of GABA which stimulates your pituitary gland to secrete Human Growth Hormone. And helps produce endorphins that make you feel good during and after a flow state.
  • Picamilon – Is used to boost GABA in your brain and produce alpha brain waves. Picamilon also helps produce the endorphins that make you feel good during and after a flow state.
  • Rhodiola Rosea – Rhodiola is nearly mandatory for a mind-blowing flow state. This adaptogen not only boosts serotonin and norepinephrine levels contributing to good mood. But it also increases the feel-good opioids like beta-endorphins.


  • Ginseng – Ginseng does double-duty during the flow state. This adaptogen provides neuro-protection on the dopaminergic-pathway. And is also a potent serotonin reuptake inhibitor (SSRI).[xiv] Working as an antidepressant and contributing to a great conclusion to flow.
  • L-Theanine – Commonly found in green tea, L-Theanine helps boost GABA, serotonin and dopamine in your brain.
  • Rhodiola Rosea – Rhodiola helps improve alertness, energy, memory and mood, is anti-anxiety and anti-depressant, reduces fatigue and boosts cognition and concentration. Rhodiola influences serotonin and norepinephrine levels in your brain. Suggested dosage of Rhodiola extract is 150 – 200 mg per day.
  • Vitamins B6, B8 and B9 are all needed to help the synthesis of serotonin in your brain.

Brain WavesBrain Waves - nootropics-flow state

  • L-Theanine – L-Theanine boosts alpha brain waves (8-12Hz) promoting alert relaxation.[xv] And theta brain waves associated with creativity and relief from trauma.
  • Phenibut – This analogue of the inhibitory neurotransmitter GABA easily crosses the blood-brain barrier. Phenibut helps relieve anxiety, stress and boosts the production of alpha brain waves.[xvi]
  • Picamilon – Picamilon is a combination of the neurotransmitter GABA and Vitamin B3 (niacin). GABA on its own cannot cross the blood-brain barrier. But Picamilon does cross into the brain with the help of niacin. Picamilon has been shown in clinical studies to boost the production of alpha brain waves.[xvii]
  • Noopept – This potent nootropic modulates AMPA and NDMA receptors in your brain. Modulates levels of glutamate within neurons and protecting brain cells. Influences Long-Term Potentiation needed to develop long-term memory. And boosts Alpha and Beta brain wave activity.
  • Phenylpiracetam – This nootropic has been banned by the World Anti-Doping Agency preventing athletes from using it in competition because of its stimulatory effects. But Phenylpiracetam has also been shown in clinical studies to affect Alpha and Beta brain waves.[xviii]

Flow is the Ultimate State of Consciousness

Flow is the ultimate state of consciousness where you feel and perform your best. And nootropics can certainly assist in getting to, maintaining, and coming out of an amazing flow experience.

One final note on all the nootropic supplements suggested above. You may have noticed that the B-Vitamins are involved in synthesizing and producing all major neurotransmitters.

Every nootropic stack should include a high quality B-Complex formula that includes highly bioavailable  Vitamin B9 (folate not folic acid) and B12 (methylcobalamin not cobalamin).

For dosage recommendations, side effects and drug interactions, click on the link to each nootropic to see the full article on that supplement.

When you’re in flow, your productivity and creativity go through the roof. Steven Kotler, author of The Rise of Superman found that being in flow (or the Zone), can increase productivity by 500 – 700%.

Think about that for a minute. One day in flow can produce as much as what would normally take you a full week to do. And nootropics can help.

If you’ve experienced the flow state and have any suggestions that could help the rest of us neurohackers. I’d appreciate your comments below.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Cranston S., Keller S. “Increasing the ‘meaning quotient’ of work” McKinsey Quarterly January 2013 (source)

[ii] Csikszentmihalyi, M. (1990). “Flow: The Psychology of Optimal Experience”. New York: Harper and Row. ISBN 0-06-092043-2

[iii] Geirland J. “Go With The Flow”. Wired September 1, 1996. (source)

[iv] Kotler S. “Rise of Superman” New Harvest. March 1, 2014 ISBN 1477800832

[v] Eagleman B.M., “Brain Time” June 23, 2009 (source)

[vi] Dietrich A. “Transient hypofrontality as a mechanism for the psychological effects of exercise.” Psychiatry Research. 2006 Nov 29;145(1):79-83. (source)

[vii] “The Musical Brain: Novel Study of Jazz Players Shows Common Brain Circuitry Processes Both Music and Language” John Hopkins Medicine February 19, 2014 (source)

[viii] Mahler S.V., Smith K.S., Berridge K.C. “Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances ‘liking’ of a sweet reward.” Neuropsychopharmacology. 2007 Nov;32(11):2267-78 (source)

[ix] Csikszentmihalyi M. “Finding Flow” Psychology Today July 1, 1997 (source)

[x] Wu W.R., Zhu X.Z. “Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice.”Life Sciences. 1999;65(2):157-64. (source)

[xi] Swerdlow R.H. “Is NADH effective in the treatment of Parkinson’s disease?” Drugs Aging. 1998 Oct;13(4):263-8. (source)

[xii] Nie L., Wise M.L., Peterson D.M., Meydani M. “Avenanthramide, a polyphenol from oats, inhibits vascular smooth muscle cell proliferation and enhances nitric oxide production.” Atherosclerosis. 2006 Jun;186(2):260-6 (source)

[xiii] Corasaniti M.T., Paoletti A.M., Palma E., Granato T., Navarra M., Nisticò G. “Systemic administration of pramiracetam increases nitric oxide synthase activity in the cerebral cortex of the rat.” Functional Neurology. 1995 May-Jun;10(3):151-5. (source)

[xiv] Niederhofer H. “Panax ginseng may improve some symptoms of attention-deficit hyperactivity disorder.” Journal of Dietary Supplements. 2009;6(1):22-7. (source)

[xv] Mason R. “200 mg of Zen” Alternative and Complementary Therapies. July 2004, 7(2): 91-95. (source)

[xvi] Nemeroff C.B. “The role of GABA in the pathophysiology and treatment of anxiety disorders.” Psychopharmacology Bulletin. 2003;37(4):133-46. (source)

[xvii] Nemeroff C.B. “The role of GABA in the pathophysiology and treatment of anxiety disorders.” Psychopharmacology Bulletin. 2003;37(4):133-46. (source)

[xviii] Gower A.J., Noyer M., Verloes R., Gobert J., Wülfert E. “ucb L059, a novel anti-convulsant drug: pharmacological profile in animals.”European Journal of Pharmacology. 1992 Nov 10;222(2-3):193-203. (source)

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Join The Discussion - 17 comments

Nikolitsa Agoudimou
May 3, 2023


Pavlos Stephanides
March 27, 2023

In the nitric oxide section, can citrulline considered as an alternative in order to flush out the high levels of norepinephrine?

    David Tomen
    March 31, 2023

    Pavlos, nitric oxide inhibits the release of norepinephrine and dopamine and specific regions of your brain.

    John D.
    May 1, 2023

    Anecdotal but I have found citruline to work for this purpose. However, after about a week of daily use my blood pressure drops too low and I become unmotivated and have less creative thinking. I am looking for a replacement. Oat straw does not work for me either. I do not response well to MAO-B inhibitors.

Andy R
January 14, 2023

I landed on this article after searching for “anandamide.” What a great read! I am wondering if you have heard of the product Anandatol, which is produced by Immunocorp. They claim it increases anandamide, probably through the same mechanisms as CBD since it is primarily a hemp extract with various extra potentiating ingredients. It sounds promising though I’m not clear on its intended use (for clinical anxiety/depression? or just a mild lift). I am very curious as to what you think of it.

    David Tomen
    January 18, 2023

    Andy, Cannabidiol ( inhibits the degradation of the endocannabinoid anandamide ( Their “hemp extract” is basically CBD Oil. And the company that makes that supplement added a few other ingredients that helps anandamide work better.

      Andy R
      January 19, 2023

      Thanks for the confirmation and links! It did sound like a CBD product to me.

Danny Mulvihill
September 23, 2021

Wow, excellent article David! I was attempting to pull together info on the neurophysiology for a podcast on flow and your article massively accelerated that effort.

I’m really looking forward to checking out more of your site!

    David Tomen
    September 24, 2021

    Thanks Danny. Happy it was helpful to you. Good luck with your podcast!

May 23, 2021

Would be great to have a stack for CREATIVITY!

    David Tomen
    May 24, 2021

    Rev, great idea and I’ll put it on my list of article to write this year. Thank you!

December 16, 2019

Your simplification of the roll of nitric oxide (presumably eNOS?) Was breathtaking

Mike Benz
February 17, 2018

David, thank you so much for this fantastic article and website. I’m excited to start using MindLabPro’s formula as you’ve suggested. I noticed that they list their Vitamin B9 component as “synthetic folic acid.” In this article, however, you noted that the preferred form of B9 is folate. I’ve also seen this recommendation elsewhere – with folate or folinic acid suggested as superior forms, while folic acid itself suggested as having potentially adverse effects. Are you comfortable with MindLabPro’s formulation? Would you recommend adding folate separately? Thanks!

    Mike Benz
    February 17, 2018

    David, further reading on MindLabPro’s website reveals that their B9 form is indeed folate. Perhaps “synthetic” in the description on the other page was meant to indicate that it is folate, and not folic acid, in their formulation.

    Thanks again for the insights!

      David Tomen
      February 17, 2018

      Mike, folate is the preferred from of Vitamin B9 because it is ready to use by your body. No conversion necessary. Mind Lab Pro is using folate and not folic acid (which is synthetic). I believe it is a mistake in the copy on their website.

      The company that makes Mind Lab Pro is Opti Nutra. And they use their own proprietary “BioGenesis” method of producing vitamins and minerals. It’s a fairly complicated process using a yeast culture. But the result is the same type of vitamin or mineral you would get from food. And that your body recognizes as the type it can use.

      I am completely comfortable with Mind Lab Pro’s formula and ingredients or I would not have used it daily for over 2 years. I’ve tried other stacks and MLP works best for me.

February 11, 2018

Thanks for your article David. I am working towards brain optimization & flow states with changes in habits and various nootropics. I appreciate your list and agree with your explanations! My biggest issue is being decisive about what I want going on in my life–this has to happen first before I can delve into flow. Time to let some things go!

    David Tomen
    February 12, 2018

    Christine, there is much wisdom in … “Time to let some things go!”. And in my humble opinion it may help to let this go too “being decisive about what I want going on in my life–this has to happen first before I can delve into flow”.

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