Rhodiola Rosea L. (Golden Root, Roseroot, Arctic Root) is an adaptogenic herb and nootropic that has been used in traditional medicine in Russia and Scandinavian countries for hundreds of years.
In Russia, Rhodiola Rosea is widely used as a remedy for fatigue, poor concentration, and decreased memory. It’s also believed to make workers more productive.
The Journal of the American Botanical Council reported on 180 studies done on Rhodiola Rosea since 1960. The bulk of the research shows how this herb works in treating physical endurance, fatigue, depression, impotence, infections, fertility, cold and flu, tuberculosis, cancer, and anxiety.[i]
German researchers describe the benefits of Rhodiola Rosea for pain, headache, scurvy, hemorrhoids, as a stimulant, and as an anti-inflammatory.[ii]
This ancient remedy has remarkable stress-relieving and anti-anxiety properties. And stands shoulder to shoulder with some of the most potent drugs used to treat depression and anxiety.
Here we’re going to explore how Rhodiola Rosea benefits your brain.
Rhodiola Rosea helps:
- Reduce Stress and Fatigue: Rhodiola Rosea helps reduce stress and fatigue, increase energy, alertness and stamina, while boosting mental performance under periods of chronic stress. Research shows Rhodiola Rosea can increase attention to detail-oriented tasks by improving concentration over a prolonged period. The ideal study nootropic.
- Improve Mood. Rhodiola Rosea boosts mood by influencing serotonin and norepinephrine levels in your brain, and the feel-good opioids like beta-endorphins.
- Neuronal Regeneration: Rhodiola Rosea helps in neurogenesis by repairing and growing new neurons. It also activates the synthesis and re-synthesis of ATP, your body and brain cell’s main energy source. Rhodiola Rosea helps reduce the inflammatory C-reactive protein. And salidroside, one of many components of this incredible herb, protects neurons from oxidative stress-induced cell death.
Table of Contents
Overview
Rhodiola Rosea L. (Golden Root, Roseroot, Arctic Root) has been used for several thousand years in traditional medicine. It grows in primarily dry sandy ground at high altitudes in the arctic areas of Europe and Asia.
The plant is 12 – 30 inches high and produces yellow blossoms. The Greek physician, Dioscorides, first recorded the medicinal applications of ‘rodia riza’ in 77 C.E. in De Materia Medica.[iii]
This ancient herbal adaptogen has remarkable anti-depressant and anti-anxiety qualities. And has been shown to be as good as many prescription pharmaceuticals in treating depression and anxiety.
In total, Rhodiola Rosea contains 140 compounds in the roots and rhizome. The critical components include rosavin, rosarian, and rosin, collectively known as rosavins.
Certain chemicals must be present for Rhodiola Rosea to work. And these include rosavin, rosarin, rosin, salidroside, and tyrosol. The first 3 of these compounds are found only in Rhodiola Rosea. It takes a synergistic combination of these chemicals for this herb to be effective.
To ensure the supplement you choose works and contains pure Rhodiola Rosea, it needs to be standardized to contain at least 3% rosavins and 1% salidroside. This is the ratio found in the natural root. (See more about selecting the right Rhodiola Rosea supplement in “Available Forms” later in this article).
Studies on organs, tissues, cells and enzymes show that Rhodiola Rosea extracts exhibit adaptogenic effects that are neuroprotective, cardio protective, anti-fatigue, anti-depressive, anxiolytic, nootropic, and has life-extension qualities.[iv]
Rhodiola Rosea is known as an adaptogen. Which means it helps your body adapt to stress, both mental and physical.
How does Rhodiola Rosea work in the Brain?
Rhodiola Rosea boosts brain health and function in several ways. But two in particular stand out.
- Rhodiola Rosea enhances mood. Reports from the nootropics community, and data from clinical trials show that Rhodiola Rosea encourages a balanced mood.
One double-blind, placebo-controlled trial worked with male and female subjects aged 18 – 70 years. All were diagnosed with mild to moderate depression.
One group received two 340 mg tablets of Rhodiola Rosea extract (SHR-5) daily. A second group received double the dose of the first group per day. And the third group received a placebo daily.
The efficacy of SHR-5 extract for depression complaints was assessed on the first day. And again on day 42 of the trial. The research team reported that Groups A and B saw significant improvements in depression, insomnia, emotions and overall quality of life.
The team concluded that Rhodiola Rosea extract has potent anti-depressant qualities in those with mild to moderate depression. When administered in doses of either 340 or 680 mg per day over 6-weeks.[v]
- Rhodiola Rosea improves mental performance under stress. Mental fatigue can cause brain fog, and make it hard to focus. It can affect your performance at school, and on the job.
Rhodiola Rosea stimulates your nervous system to fight fatigue that stifles mental clarity. And studies show it even saves injured neurons. And encourages the growth and development of brain cells.
One animal study in China explored the effects of Rhodiola Rosea on the number of neurons in the hippocampus of rats with depression induced by chronic stress.
This study has a direct correlation on how Rhodiola Rosea works in the human brain. And its value as a nootropic. In this study, 50 rats were divided into 5 groups: normal control, untreated, negative control, positive control and Rhodiola Rosea-treated groups.
The research team found that the number of neurons in the hippocampus in the Rhodiola Rosea-treated group were increased and recovered to normal level.
The study concluded that Rhodiola Rosea promotes the proliferation and differentiation of neural stem cells in the hippocampus. And may play a role in saving injured neurons of the hippocampus.[vi]
How things go bad:
Chronic stress and cortisol can damage your brain. Neuroscientists at the University of California, Berkeley, found that chronic stress triggers long-term changes in brain structure and function.[vii]
Chronic stress changes neural networks. Cortisol creates a domino effect that hard-wires pathways between the hippocampus and amygdala. (The amygdala (lizard brain) is the area responsible for your fight-or-flight response).
This hard-wiring caused by stress is not the way the brain was designed. But chronic, ongoing stress tricks the brain into rebuilding circuits and hunkering down for the long haul.
This re-wiring appears to be permanent. Unless you intervene with something like Rhodiola Rosea.
Chronic stress seems to ‘flip a switch’ in stem cells in the brain. And turns them into a type of cell that prevents connections to the prefrontal cortex. Preventing improved learning and memory.
And laying down the scaffolding linked to anxiety, depression and PTSD (Post Traumatic Stress Disorder).
↓ Chronic stress reduces levels of serotonin and norepinephrine
↓ Chronic stress reduces the number of neurons
↑ Anxiety and depression increases
↓ Chronic stress induces brain fog and memory loss
Under conditions of chronic stress and excess cortisol you experience mental and physical fatigue.
Rhodiola Rosea to the rescue
Rhodiola Rosea undoes damage to your brain caused by chronic stress. It helps keep it healthy. And even improves your body and brain’s response to stress.
Rhodiola Rosea relieves stress by balancing your body’s stress-response system. And helps your body return to a relaxed state by influencing key brain chemicals like serotonin, norepinephrine and beta-endorphins (opioid neuropeptides).[viii]
Rhodiola Rosea can also help prevent and repair damage caused by C-reactive protein and free radicals.
Rhodiola Rosea even provides protection and regeneration of neurons during periods of stress. It helps in the synthesis and re-synthesis of ATP. The main fuel source for the mitochondria in your cells.
Any kind of fatigue you experience – regardless of source – Rhodiola Rosea is like your “magic bullet”. Mood, energy, stamina and concentration can all increase with a dose of this herb.
Many neurohackers even report improved libido and sexual performance when using Rhodiola Rosea.
If you get an effective dose of real standardized Rhodiola Rosea extract, you should experience an effect.
How does Rhodiola Rosea feel?
The time required to begin feeling the effects of Rhodiola Rosea depends on your genetics, mental and physical condition, environment, behavior and lifestyle.
Some neurohackers report feeling its effects in just a few days. While others require as much as 3 weeks. Clinical studies show that most people experience the full benefits of Rhodiola Rosea in 30 – 40 days.
If you don’t notice a change within 40 days, Rhodiola Rosea may not be effective for you.
Many report that Rhodiola Rosea provides a pronounced anti-anxiety effect. Depression lifts and overall quality of life improves.
Rhodiola Rosea should give you an energy lift. It could improve your mood, focus, level of concentration and alertness.
The Research
Rhodiola Rosea has a reputation in the nootropic community for its energizing and anti-fatigue qualities.
One double-blind, placebo-controlled trial was carried out with 161 cadets aged from 19 – 21 years. The intent was to measure the effect of a single dose of Rhodiola Rosea extract (SHR-5) on capacity for mental work against a background of fatigue and stress.
An additional objective was to try two different doses of the extract. The other dose being 50% higher. So the cadets were given either 2 or 3 capsules of Rhodiola Rosea extract.
The study showed a “pronounced anti-fatigue effect” in the cadets. With no significant differences between the two dosage groups. But there was a “possible trend in favor of the lower dose” in the cognitive tests.[ix]
Rhodiola Rosea as a nootropic
The aim of this study was to investigate the effect of repeated low-dose treatment of Rhodiola Rosea extract (SHR-5) on mental performance with fatigued physicians.
The researchers recruited a group of 56 healthy, young physicians working night duty at the Armenian State Medical University. Tests involved overall level of mental fatigue, associative thinking, short-term memory, calculation, ability of concentration, and speed of audio-visual perception.
Tests were done before and after night duty during 3 periods of 2 weeks each. The young doctors received Rhodiola Rosea extract tablets or a placebo for the first 2 weeks. Followed by a 2 week ‘washout’ period. And finishing with another 2 weeks of Rhodiola Rosea extract tablets or a placebo.
The research team found a statistically significant improvement in cognitive tests during the first 2 weeks. No side effects were reported. And the young doctors had a reduction in general fatigue under stressful conditions.[x]
Rhodiola Rosea as an anti-depressant
One study published in Phytomedicine was run as a “proof of concept” trial to evaluate the efficacy of using Rhodiola Rosea compared to the anti-depressant ‘sertraline’ for major depressive disorder.
Sertraline (Zoloft©) is a pharmaceutical SSRI used to treat depression, anxiety, panic attacks, and obsessive-compulsive disorder (OCD). And it comes with a host of side effects including fatigue, diarrhea, anorexia, convulsions, confusion, decreased libido, and ejaculation failure.
This trial recruited 57 people diagnosed with depression. They were given standardized Rhodiola Rosea extract, sertraline, or a placebo for 12 weeks. 3 different depression scoring tests were used during the trial.
The researchers concluded that Rhodiola Rosea produced less antidepressant effect than sertraline, but it also resulted in “significantly fewer adverse events and was better tolerated.”
The research team concluded that even though Rhodiola offered slightly less anti-depressant benefits, it possessed “a more favorable risk to benefit ratio for those with mild to moderate depression”.[xi]
Dosage Notes
Recommended dose of Rhodiola Rosea is 150 – 200 mg per day.
Look for an extract that is standardized to contain rosavins and salidrosides in a 3:1 ratio. This mimics the ratio of these compounds that naturally occur in Rhodiola Rosea root.
No additional benefit seems to come from taking more than 1,000 mg per day.
Side Effects
Rhodiola Rosea is a natural adaptogen and herb that has been used successfully for thousands of years. It’s considered non-toxic and safe. And very few side effects have been reported.
Considerably higher than recommended doses could result in dry mouth, nausea, upset stomach, headache, insomnia and weight loss.
Since Rhodiola Rosea acts as a Monoamine Oxidase Inhibitor (MAOI), you should not use it if you’re taking MAOI meds. MAOI’s are a type of anti-depressant drug used to treat bipolar disorder, panic disorder, social anxiety disorder and PTSD.
MAOI meds influence serotonin levels in the brain. So taking MAOI’s in combination with Rhodiola Rosea has the potential to cause serotonin syndrome.
Available Forms
Rhodiola Rosea is available as a powder, capsules, tablets and tea.
Active ingredients of Rhodiola Rosea include rosavins and salidrosides. Make sure you look for the percentage of active ingredients listed on the bottle or package.
Ideally you’re looking for a 3:1 ratio of rosavins and salidrosides. This mimics the ratio of these compounds naturally occurring in the Rhodiola Rosea root.
Rhodiola Rosea can sometimes be found in some of higher quality pre-formulated nootropic stacks. For example, Mind Lab Pro® contains 11 brain enhancing nootropic compounds including Rhodiola Rosea (standardized to 3% rosavins, and 1% salidrosides).
I recommend Mind Lab Pro because it addresses all aspects of anxiety resistance, memory and cognitive enhancement, stabilizes mood, brain repair, and maintenance.
This premium nootropic stack is designed to affect neurotransmitters, cognitive energy, brain waves, neuroprotection, and regeneration. See my Mind Lab Pro review for a detailed report.
Now this is where it gets tricky if you choose to buy individual Rhodiola supplements. And probably the reason why some forum threads and user reviews report no effect from using Rhodiola Rosea.
In the late 1980’s, demand for Rhodiola Rosea-based phytomedicines dramatically increased. The wild-grown, raw material was over-harvested, resulting in a steady decline in the quality and effectiveness of Rhodiola Rosea.
Studies revealed that other species of genus Rhodiola were being substituted for Rhodiola Rosea. While some of these mixed batches were highly variable in quality, others had no pharmacological or nootropic effect.[xii]
The American Botanical Council has more on Rhodiola Rosea and problems with adulterants in this extensive report.
So do your best to find out where the supplement maker gets their raw Rhodiola Rosea. Hostile environments like Siberia seem to produce higher quality Rhodiola Rosea.
The active ingredients for most nootropic benefit include; Rosavin, Rosaridin, Rosarin, Rosin, Salidroside, and Tyrosol. The first 3 are collectively referred to as “rosavins”. And the other big one is “salidroside” which has several iterations.
Avoid supplements that list “other ingredients” on the label. And look for Certified Organic to ensure the root used to make your Rhodiola Rosea supplement is free of heavy metals, pesticides and herbicides.
Nootropics Expert Recommendation
Rhodiola Rosea Extract 150 – 200 mg per day
We recommend using Rhodiola Rosea as a nootropic supplement.
Your body does not make Rhodiola Rosea on its own. So to get its benefits you must take it as a supplement.
Rhodiola Rosea is especially helpful for those suffering from anxiety and stress. Studies show it helps stop and reverse the devastating effects of stress in your brain, and body. This nootropic helps repair the damage to neurons caused by chronic stress.
Rhodiola Rosea is a powerful adaptogen. Which means it helps increase the effect of certain hormones when activity is low. And will block excess stimulation when activity is too high.
Rhodiola Rosea as an adaptogen helps balance norepinephrine in the body caused by chronic stress. It also boosts serotonin and the feel-good opioid chemical beta-endorphins.
Using Rhodiola Rosea can help eliminate brain fog, increase concentration during brutal periods like exams or business presentations, boost energy by increasing the ATP fueling your mitochondria, and protect your brain cells from free radical damage.
Rhodiola Rosea helps alleviate mental and physical fatigue, improves stress response, and provides better quality of sleep. It can even help out your sex life.
Rhodiola Rosea is especially helpful for those suffering from anxiety and panic disorders. Studies have shown the calming effect of this herb was equal to some popular antidepressant and anti-anxiety drugs. Without the side effects.
You can safely take up to 600 mg of Rhodiola Rosea extract daily if needed. Most get all the benefit they need with 150 – 200 mg. Half of the dose in the morning, and another early afternoon.
And make sure your getting genuine Rhodiola Rosea extract with a 3:1 ratio of rosavins and salidrosides. Read the user reviews and labels.
You can buy individual Rhodiola Rosea supplements. Or you could try my favorite pre-formulated nootropic stack Mind Lab Pro® which includes Rhodiola Rosea (standardized to 3% rosavins, and 1% salidrosides).
Mind Lab Pro contains a synergistic blend of 11 brain enhancing nootropics covering all aspects of cognition and brain health. See my full Mind Lab Pro review for more.
[i] Brown R.P., Gerbarg P.L., Ramazanov Z. “Rhodiola rosea: A Phytomedicinal Overview” The Journal of the American Botanical Council Issue: 56 Page: 40-52 herbalgram.org (source)
[ii] Panossian A., Wikman, Wagner H. “Plant adaptogens III.* Earlier and more recent aspects and concepts on their mode of action”Phytomedicine, Vol. 6(4), pp. 287–300 (source)
[iii] Brown R.P., Gerbarg P.L., Ramazanov Z. “Rhodiola rosea: A Phytomedicinal Overview” The Journal of the American Botanical Council Issue: 56 Page: 40-52 herbalgram.org (source)
[iv] Panossian A., Wikman G., Sarris J. “Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.” Phytomedicine. 2010 Jun;17(7):481-93. (source)
[v] Darbinyan V., Aslanyan G., Amroyan E., Gabrielyan E., Malmström C., Panossian A. “Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression.” Nordic Journal of Psychiatry. 2007;61(5):343-8. (source)
[vi] Qin Y.J., Zeng Y.S., Zhou C.C., Li Y., Zhong Z.Q. “[Effects of Rhodiola rosea on level of 5-hydroxytryptamine, cell proliferation and differentiation, and number of neuron in cerebral hippocampus of rats with depression induced by chronic mild stress].” in Chinese Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2842-6. (source)
[vii] “New evidence that chronic stress predisposes brain to mental illness” University of California, Berkeley Feb. 11, 2014, Retrieved Mar. 24, 2016 (source)
[viii] Lishmanov Iu.B., Trifonova Zh.V., Tsibin A.N., Maslova L.V., Dement’eva L.A. “[Plasma beta-endorphin and stress hormones in stress and adaptation].” – in Russian Biull Eksp Biol Med. 1987 Apr;103(4):422-4. (source)
[ix] Shevtsov V.A., Zholus B.I., Shervarly V.I., Vol’skij V.B., Korovin Y.P., Khristich M.P., Roslyakova N.A., Wikman G. “A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.” Phytomedicine. 2003 Mar;10(2-3):95-105. (source)
[x] Darbinyan V., Kteyan A., Panossian A., Gabrielian E., Wikman G., Wagner H. “Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.” Phytomedicine. 2000 Oct;7(5):365-71. (source)
[xi] Mao J.J., Xie S.X., Zee J., Soeller I., Li QS., Rockwell K., Amsterdam J.D. “Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.” Phytomedicine. 2015 Mar 15;22(3):394-9. (source)
[xii] Booker A., Jalil B., Frommenwiler D., Reich E., Zhai L., Kulic Z., Heinrich M. “The authenticity and quality of Rhodiola rosea products.”Phytomedicine. 2016 Jun 15;23(7):754-62 (source)
I am taking 800mg standard Rohdiol 3% 1%
And in top taking 500mg Saliderside 3% from another top supplier
Which makes it 1300mg un total
Can I take modafinil with this or Anaracetm?
Benyamin, good question and the answer is I’m not sure. Because Rhodiola Rosea acts like an MAOI and Aniracetam seems to activate dopamine d2 and d3 receptors.
Neither nootropic is a direct precursor to the synthesis of dopamine in your brain. Nor is Modafinil which acts as a partial dopamine reuptake inhibitor.
Aniracetam shouldn’t be a problem. It’s Modafinil which is the wild card here. Only way to find out is to try it. Side effects, if any, may be unpleasant. But certainly not life-threatening for the average person.
Hi David, are the changes caused by taking this permanent? Ie you talk about how chronic stress changes neural networks and the changes this nootropic can make. Are these changes present only with continued use or is there a recommended time frame to get optimum results (ie taking it for 12 weeks, 24 weeks etc). Thank you
Georgie, some report feeling its effects in just a few days. While others require as much as 3 weeks. Clinical studies show that most people experience the full benefits of Rhodiola Rosea in 30 – 40 days.
Preventing and repairing damage caused by C-reactive protein and free radicals is an ongoing process. And Rhodiola Rosea helps your body return to a relaxed state by influencing key brain chemicals like serotonin, norepinephrine and beta-endorphins (opioid neuropeptides). But this too is an ongoing process.
So once you begin experiences the benefits of Rhodiola you’ll need to keep on using it to continue experiencing those benefits. If you feel nothing after using the recommended dosage for 40 days in a row then Rhodiola Rosea is not for you.
Hello,
Can rhodiola be taken while taking some psylocybin at the same time?
If not, how long should be the brake after stopping rhodiola(800mg daily)?
Best,
M
M, the half-life of salidroside is 1.32 hours (https://www.hindawi.com/journals/jsm/2014/563043/). But because of its mechanism of action I don’t suggest you use them concurrently. Or you may end up dealing with some very unwanted side effects.
I’d give it a day between the two just to be safe.
Hello David – thank you so much for the information. Question for you:
I have always sufferred from ADD and mild depression so distractedness, procrastination, mood swings, end of day blues have been part of my days forever. Adderal and Adrafinil worked to some extent but both had side effects. I am starting a business so recently turned to NeuroPeak and Calm Now from Zhou. I supplement with LTyrosine, LTheanine, D3, omega 3s, and a mushroom formula.
I like the state this puts me in during the day: I am more effective, workout more, drink less. However:
One major drawback… I have pretty bad headaches around bedtime (despite drinking plenty of water), my brain is ON and I don’t really “feel” tired. Only getting 4-5 hours of sleep per night isn’t the way to go.
I suspect it may be the Rhodiola Rosa giving me headaches but I am not 100% sure (I also worry about 500mcg of B12 every day). How do I figure out my “hack”? I imagine some of this is trial and error but if you have any advice on getting it right without buying every supplement on the market that would be very much appreciated. Thank you!
Alex, Rhodiola Rosea acts as a Monoamine Oxidase Inhibitor (MAOI). So it’ll boost the effectiveness of anything in your stack that increases dopamine. And possibly serotonin.
I suggest eliminating the Calm Now supplement for a day or two and see if that makes a difference. It could be the Rhodiola. Or you’re having a bad reaction to Ashwagandha.
Hi David,
I use 10 mg Escilopratam and 100-200 mg modafinil daily. I got rhodiola rosea and red korean ginseng powders.
I need energy, motivation and focus to start a new business. I am so tired in these days, so thats why i bought these two.
So using all of them are safe?
I think dopamine is the key factor for motivation. What would your best nootropic for increasing dopamine?
Thanks
Hakan, Rhodiola Rosea acts as a Monoamine Oxidase Inhibitor (MAOI) so taking it with an SSRI like Escilopratam is NOT a good idea. Because you put yourself in danger of Serotonin Syndrome. And it will amplify the effects of Modafinil as well.
Most think that dopamine is the key to motivation. Turns out that the missing link is activating AMPA receptors which in turn goes on to activate the dopamine/reward pathway in the brain. I explain this pathway here: https://nootropicsexpert.com/hacking-motivation-with-nootropics/
Rhodiola Rosea happens to be one of the ways to activate this pathway. But you shouldn’t be using it. You do have other options however that are listed in that motivation post I linked to.
Hi David,
My question is about how you mentioned that Rhodiola acts as a MAOI. It acts as a MAOI but you said it is safe and non-toxic? Is its acting as a MAOI something that should make someone avoid eating or using anything that contraindicates MAOIs in general (chocolate, coffee, etc)?
I take Wellbutrin (DNRI) and Concerta (stimulant) in the morning. I also take clomipramine (tricyclic antidepressant) and Bacopa Monnieri at night.
I am looking into Rhodiola because after taking concerta for 2 years, I have developed a tolerance for Concerta and I am still tired and drowsy even after taking it. Is it a really bad idea to try Rhodiola with this cocktail of stuff?
Thank you
Rifat, to avoid tolerance with Concerta and avoid the crash after it wears off, you need this: https://nootropicsexpert.com/best-nootropics-for-adhd-add/. That stack described in that post was designed to support the use of prescription stimulants while avoiding the crash.
Thank you so much David, I will check it out!
Hi David,
I am wondering if Rhodiola Rosea is safe to take with L-Tryptophan?
When I drink coffee on Rhodiola, I find I tend to overfocus on things & cannot shift my attention easily which I believe is due to an imbalance of dopamine (too much) & serotonin (not enough) This does not happen when I drink caffeine.
As some days I really do require a coffee (i.e. if I did not get a lot of sleep & have a lot to do) – on these days can I take L-tryptophan to help balance serotonin & dopamine?
Thanks for your amazing website!
Hope you’re keeping well.
George, you can use L-Tryptophan to boost serotonin to keep it in balance with dopamine. But take it in the evening before bed. It’ll still do the job including going on to produce melatonin for the night. Taking it early in the day is not such a good idea.
Caffeine influences acetylcholine, epinephrine (adrenaline), serotonin and boosts the use of dopamine. Which is the effect your feeling when using it. https://nootropicsexpert.com/caffeine/
There’s a delicate balancing act going on here that is tough to nail down.
Thanks David. Very helpful.
Finally, if I were to mix St John’s Worts or 5HTP with Rhodiola Rosea, would that be okay as well?
George, you can’t use St. John’s wort with most other nootropics. Because it affects GABAA, GABAB and glutamine receptors, as well as the inhibition of monoamine Oxidase-A and -B activity. And synaptic uptake of serotonin, dopamine and norepinephrine.
If you use it with 5-HTP you’ll most certainly experience Serotonin Syndrome. Which can be deadly.
And Rhodiola Rosea acts like an MAOI just like St. Johns’ wort. Which will cause serious trouble too.
Hi David,
I have a question:
1.). Do you need to cycle Rhodiola Rosea to avoid building up a tolerance? It has really helped me with focus / concentration & I do not want it to go away!
2.) I am on a low dose of Zoloft – is it safe to mix? I have been doing so for two weeks & have been absolutely fine
Thank you for all your amazing information!
George, you won’t develop a tolerance to Rhodiola Rosea. But it does influence serotonin and dopamine because it acts as an MAOI. And Zoloft is an SSRI which affects serotonin. Be careful because this combo can raise your serotonin levels too much. Which can cause Serotonin Syndrome which can be deadly.
Thank you, David.
One last point – if I am coming/tapering off Zoloft then; can Rhodiola Rosea be used to alleviate some of the withdrawal side effects?
George, it’s highly unlikely. Because detoxing from things like SSRIs is not just a matter of replacing what the drug was doing. Recent research has found that drugs like SSRIs do much more that influence neurotransmitters like serotonin and its receptors and transporters. It seems they also influence things like gene expression, mess up the balance of neurotransmitters, sometimes desensitize or damage synapses, and more.
While some nootropics can often accomplish what you were trying to do with meds, they are not a direct replacement.
Is it fine to take RR with hemp tea 3% CBD and curcumin extract and black pepper extract?
Paul, not aware of any contraindication.
Since rhodiola acts as a MAOI could I take it safely with my ADHD medication Ritalin?
Eamonn, good question and it depends on how much Rhodiola Rosea you’re using. Using both will force even more dopamine into the extra-cellular space which could cause problems.
Only way to find out is trial and error. While not toxic if you misjudge, the worst that can happen are the side effects you get from excess dopamine or norepinephrine.
Is it safe to take Gotu Kola, Ashwagandha and Rhodiola Rosea together? Do these compliment each other as a stack? Thanks in advance.
Kristian, you can use them in the same stack. Just keep the dosage of each to the lower end of “recommended” dosages.
Hi David,
I’m shooting for 2nd question, thankful period. I don’t know or…if it’s OK to take 4 potent adaptogens. Ashwagandha (250mg), Rhodiola (150mg), Shatavari (450mg) roots, and Amla berry (150mg) to be able to take along w/my ADHD medicine/stimulant? 2 caps every am, I tried it 1X but felt irritated so I’ve stopped till green/red light. Thank you, cup overflowing. Cheers again.
Jina, the key to making this work is to study the “mechanism of action” for your stimulant medication. And the “mechanism of action” or “pharmacology” for each of the adaptogens you are using. Wikipedia is a good source for learning how the stimulant works in your brain. And use Nootropics Expert for most of the adaptogens you mentioned.
Your stimulant likely affects dopamine and norepinephrine in your brain. As an example, Rhodiola Rosea is a monoamine oxidase inhibitor (MAOI). Which means it boosts dopamine as well. When you combine that with your stimulant you could end up with too much dopamine or norepinephrine. Which causes irritation.
Hi David,
If I understood well there are two different RR with min. 3% Salidroside or 3% Rosavins and 1% of Salidroside, right? But What is different?
Today it arrived package with RR 3% Salidroside 500mg.
I feel little depression and I have anxiety sometimes weak, sometimes stronger, from day to day it is different.
I think it was better to take with Rosavins than Salidroside.
What is a good combination with this? In stack, I have L-tyrosine, Alpha gpc, L – theanine (which helps me to have smaller anxiety, I take 1 cap of 200mg per day in the morning), phenibut, noopept,…
Dean, ideally you’re looking for a 3:1 ratio of rosavins and salidrosides. Not the other way around.
But Rhodiola Rosea is a Monoamine Oxidase Inhibitor (MAOI) which boosts dopamine and serotonin levels in your brain. Not a good idea if you’re using Phenibut.
Ok, the next one I will purchase 3:1 ratio of rosavins and salidrosides.
Could you please explain me in a few sentences why isn’t good to take RR with Phenibut? I take Phenibut 1-2 times per week.
p.s. I didn’t get e-mail when you answered. I checked “Notify me when new comments are added.”
Dean, I mentioned being careful with Phenibut when using an MAOI because the MAOI forces neurotransmitters back into your system. And it may cause Phenibut’s benefits to be amplified to dangerous levels. Just like if you were to take Phenibut while using a prescription antidepressant. I can’t promise this will happen. Just that the potential may be there and you could be treading on dangerous ground.
My apologies about email notifications. We’ve tried various methods to make that happen. But each time we try something new it messes something else up. This is an important feature and I’ll have my IT guru continue working on it. But until then you’ll need to check back each time manually.
Hi David,
Is it safe to take Rhodiola + oat straw extract + matcha green tea + coffee in the morning on a daily basis ?
Thanks,
J
J, not sure about Matcha because I haven’t done the research. The rest of your stack looks OK. But all of these nootropics influence dopamine. Which must be in balance with serotonin.
So if you start this stack and begin to feel irritable or otherwise weird it means too much dopamine and/or norepinephrine.
You can counter this by using 500 mg L-Tryptophan to restore serotonin. But if it makes you feel tired after you take it then do it 60 mins. before bed. You’ll sleep better and restore the balance too.
Thanks David for recommendation.
However for example if i feel good and without weirdness or irritableness, should i still take L-Tryptophan to balance chemicals out in my system ?
I just have made some re-search about L-Tryptophan and i have been scared off due to negative side effects it is cousin for lot of people.
I would appreciate your thoughts on this.
Thanks.
J
J, if you are not experiencing the effects of excess dopamine then ignore L-Tryptophan for now.
Hello David.
I am taking Rhodiola 280mg(2pills) up to 560mg(4pills) per day combined in one suplement pill with siberian ginseng 170mg up to 340mg per day. This gives me evident energy boost to the point I started to have mild problem with smooth sleeping at night.
Since today I’ve added Bacopa Monnieri 440mg (20%bacosides) per day and L-theanine 150mg up to 300mg per day.
Is this ok combo of 3 or 4 nootropics for antianxiety, antidepressive and antiobssesive thoughts effect in your opinion? I wonder if there is no contradictory effect when combined.
Thank you.
Maciej, I don’t see any problems with this stack and how these nootropics work together. But whether it would help you relieve your symptoms depends on how your brain and body respond to them. Because they work as ‘adaptogens’ and help bring systems back in balance. Try them and see if you feel better.
Note that Rhodiola and Ginseng have stimulant qualities so it’s best to use them much earlier in the day.
Hey David, is daily Rhodiola Rosea use safe with a once-off dose of MDMA? What about with occasional small doses of Adderall? Cheers.
Since Rhodiola Rosea acts as a Monoamine Oxidase Inhibitor (MAOI) I wouldn’t take the chance with MDMA. And even with Adderall it would be risky for some people
Hi David Tomen, how big is the difference between an extract of Salidroside 5%, 4% and 3% when i take an daily amount of 600 mg Rhodiola Rosea, would i really feel any difference between 3% and 4% Salidroside?.
Andrea, probably not. I think a much more important factor to consider is the quality and purity of your Rhodiola Rosea extract.
With or without food for better results?
Daka, the rosavins and salidrosides in Rhodiola Rosea are water soluble as far as I know. So do not need fat to enter cell walls. But some of the other compounds in this adaptogen including some of the vitamins are fat-soluble. So to get their benefit as well you need to take it with food containing healthy fats. Or a tablespoon of unrefined coconut oil or MCT Oil.
Hi Davids,
Is Rodiola safe with clonazepam?
Thanks in advance.
Miguel, it could be a problem. But I’d double-check using this: https://www.drugs.com/drug_interactions.html. Type in Clonazepam and go to drug interactions listed under “R” and look for Rhodiola Rosea.
Hello. I find good brand but its 60x 500mg Capsules (Equivalent to 10000mg), 5% Rosavins (25mg), 3% Salidrosides (15mg). Is this ok ratio? Thank you
Filip, this review is based on Rhodiola Rosea to be standardized to contain at least 3% rosavins and 1% salidroside. This is the ratio found in the natural root.
The ratio of the supplement you have is fine but will likely provide more anti-anxiety properties than energy as described above.
Hi David,
I’m interested in Rhodiola Rosea (RR) for mental fog as well as mental/physicall fatigue. I noticed in your video, you didn’t mention interactions with SSRIs, only MOAIs.
1. Have you seen any information on the safety of taking RR with Luvox?
2. Also, are there other nootropics I can research for fog and fatigue that might not affect serotonin.
Thank you!
Shorty
Shorty, I’d be careful about using Rhodiola Rosea with Luvox for two reasons. First is it acts like a MAOI which also affects serotonin. And second, Luvox inhibits several cytochrome P450 enzymes which means that any other drug or nootropic you take, Luvox will amplify its effectiveness. At times this can be dangerous depending on the drug or supplement.
Please see this post for boosting energy and battling fatigue: https://nootropicsexpert.com/best-energy-supplements-to-buy-in-2019/
Does Rhodiola have any interactions with oral birth control pill ( Yasmin – drospirenone and ethinyl estradiol) ?
Hana, Rhodiola Rosea does seem to have some effect on estrogen. But according to this study (http://cancerres.aacrjournals.org/content/64/7_Supplement/663.3), the researchers concluded that “when taken orally, [Rhodiola Rosea] is unlikely to present an estrogenic risk to women who may seek to avoid such agents.”
Thank you very much for reply.And thank you for providing such incredible amount of precious information on your site.
My wife has been long term on Prozac..in decades not years. She abruptly took herself off Prozac 40 mg about 4 months ago and is experiencing difficult withdrawal symptoms..quick to cry for no real reason, high levels of anxiety, extreme levels of fatigue and bouts of insomnia. She has gotten some temporary relief from Kava and chewable Pharma GABA tabs. Right now , she is considering going back on Prozac 20 mg for 6-8 months and then tapering off over a year vs. taking Rhodiola Rosea after hearing claims it can work in 3 days. There is a major undertaking that is about to unfold that will demand her improved energetic mood and calm focus. I have read many of your articles and have observed that you are not just selling products but providing valuable and actionable education. We would value your insights highly!
Withdrawal from antidepressant meds is brutal and has been documented in clinical trials. I’m not a doctor so please take my advice such as it is with that in mind.
I have found the Dr. Kelly Brogan has likely the best advice for folks wanting to get off of antidepressants. I don’t have a professional relationship with her (yet) but highly recommend looking up her website and programs for SSRI detox and withdrawal.
Your wife has the right idea that for now it’s best to resume the meds while you research ways of getting off of them.
I am convinced from personal experience and feedback from the nootropics community that this can be managed with nootropic supplements. But it takes time, patience, and lots of experimenting until you find what works. Quitting antidepressants ‘cold-turkey’ is not a good idea.
I’m on Lexapro, is Rodiola safe with this ssri?
Otto, you should be cautious about using Rhodiola Rosea with Lexapro because it is a potent Monoamine Oxidase Inhibitor (MAOI). Which affects primarily dopamine and norepinephrine but does affect serotonin to a certain extent. It could cause Serotonin Syndrome which is very dangerous.
Considering the MAOI-effect, I assume that it’s not advisable to take it with 5-htp? Can I take Rhodiola for lunch and 5-htp in the evening?
You could try it. But longterm use of Rhodiola stays in your system. I think I’d be more concerned with dopamine precursors than serotonin precursors. Just keep your 5-HTP dose at the low end.
Hello David,
Does Rhodiola induces the release of dopamine?
Other sources mention that, but not here, so i am curious.
Thanks
Aleksandar, Rhodiola may influence some dopamine release because it acts as a monoamine oxidase inhibitor (MAOI). But it has more of an influence on other key neurotransmitters like serotonin, norepinephrine and beta-endorphins.
Rhodiola would not a be first choice if you were looking to boost dopamine.
Thanks, David!
I hear it is an MAOI. Are there dietary restrictions then, on things like cheese etc?
Good question but I have not seen any evidence of Rhodiola’s MAOI action associated with the ‘cheese effect’ anywhere.
Hi David,
Thanks for the huge amount of information.
Two questions regarding the dose: let’s assume a daily dose of 200mg.
Do I take it all at once (e.g. in the morning) or rather twice a day (e.g. 100mg in the morning, 100mg at noon)?
Do I take it before (empty stomache) or with a meal?
I’m mainly looking to reduce fatigue and boost cognition/concentration. The anti depressant/anxiety properties aren’t my main goal.
Thanks,
Patrick
Patrick, if you have 100 mg capsules, I’d suggest taking one in the morning and the other at noon. Too late in the day may affect sleep.
I haven’t seen anything regarding solubility so follow the label directions. And keep in mind that most studies and experience shows that it takes awhile for Rhodiola Rosea to ‘build up’ in your system before you experience all of its benefits.
Great, thanks for the reply 🙂
Hi there,
I’m researching for the best rhodiola, but not funding how it is sourced. I don’t want to waste my time and money.
Is there any companies or brands that are legit?
Thank you
Christina, Gaia Herbs, Swanson and NOW Foods come to mind. Each company should disclose their source of Rhodiola. And I know each of these companies tests and re=tests their products before sale.
I am using Rhodolia since one week. 2 decades of cronic pain and stress are reduced by 90 procent. I tried about everything to improve my health and nothing really helped. In just one week this herb has given me my life back. I hope it continues to work.
Is it safe to combine rhodiola rosea, ashwaganda and bacopa monnieri? Are there any risks?
Leo, all are considered adaptogens so considered non-toxic and safe at recommended doses. I suggest looking at this from a different angle and study the side effects and potential drug interactions for each instead.
I’ve used all three at the same time without any problem. But each of us is wired differently and that may not work for everyone.
Can my son 14 yrs take Rhodiola?
Mattana, I haven’t done the research for someone as young as 14. But Rhodiola is considered an adaptogen and is non-toxic. So at the lowest recommended dose and as long as he’s not taking a MAOI there shouldn’t be a problem.
I suggest you do a little more research to verify this just to be safe. If you find anything to the contrary please let us know.
Do you have a supplement reccomendation for Rhodiola? Thanks!
Nell, Gaia Herbs is the only supplement maker that I’m aware of that state their Rhodiola Rosea is wild harvested and sourced from Siberia. I’d still suggest digging as deep as you can and make sure that claim is accurate.
Can I take Rhodiola and NAC together?
Larry, you should be able to safely use Rhodiola and NAC together. I do and have not had any issues. The mechanism of action of each nootropic is different.
What about polygala tenuifolia?
Bryan, most of the studies for Polygala tenuifolia (in English anyway) are with rats and mice. I imagine there are plenty more with human subjects in some Chinese medical database of which I do not have access. So it goes on my list (for which I thank you) to be reviewed somewhere down the line.
Thanks so much for the prompt response. I stopped taking the zhou supplements and the L-Tyrosine and will layer them back in seperately to try to identify better. It seems L-tyrosine can also cause headaches.
What do you mean by Ashwaganda? I don’t think there is any in what I’m taking.
Best –
Alex
Alex, I looked up one of the supplements from Zhou you said you were using and Ashwagandha was on the list of ingredients.
Just realized this thank you.