N-Acetyl L-Cysteine (NAC or N-acetylcysteine) is the N-acetyl derivative of the naturally occurring amino acid L-cysteine. And works primarily by helping restore the body’s natural antioxidant glutathione (γ-glutamylcysteinylglycine; GSH).
As the most abundant antioxidant in your body, GSH is responsible for maintaining oxidative balance in each of your cells.
Taking glutathione as a nootropic supplement does not adequately restore GSH levels in your brain because it can’t cross the blood-brain barrier. This vastly underrated nootropic, NAC easily penetrates the blood-brain barrier and raises glutathione levels in your brain.[i]
NAC has been used to treat acetaminophen poisoning for decades.[ii] Every year there are 56,000 ER visits from Tylenol overdose, resulting in at least 100 deaths. [iii] NAC provides the glutathione your liver needs to fight off the metabolite NAPQI in Tylenol that does severe liver damage.
As a nootropic, NAC helps prevent glutamate toxicity, boosts dopamine, and reduces inflammation, oxidative and free radical damage.
N-Acetyl L-Cysteine helps:
- Neuroprotection. NAC as a precursor of glutathione, is a potent antioxidant, anti-inflammatory and free radical scavenger.[iv] Your brain is especially vulnerable to inflammation, free radical and oxidative damage. Affecting cognition, long-term potentiation, memory and mood.
- Neurotransmitters. NAC modulates glutamate levels and dopamine release in the brain. Excess glutamate in your brain is toxic to brain cells affecting neuron health, cognition, memory and mood. And NAC protects dopamine receptors. Influencing dopamine levels and function in your brain. Even protecting dopaminergic nerve terminals from chronic methamphetamine use.[v]
- Anxiety and depression. NAC reduces irritability, anxiety and depression. NAC increases your body’s antioxidant capacity, and balances excitatory and inhibitory neurotransmitters in your brain. Resulting in less anxiety and depression.
Table of Contents
Overview
N-Acetyl L-Cysteine (NAC) is the N-acetyl form of the naturally occurring amino acid L-Cysteine.
L-Cysteine is naturally produced in your body using the amino acid methionine. You can also get L-Cysteine from eating ricotta and cottage cheese, yogurt, pork, chicken, turkey, duck, wheat germ, granola and oat flakes.
But acute stress, illness, or a poor diet can deplete L-Cysteine levels in your body and brain. The quickest and most efficient way to boost levels of L-Cysteine is to supplement with N-Acetyl L-Cysteine (NAC).
NAC regulates the amount of glutamate in your brain. Glutamate is a neurotransmitter that is responsible for sending signals between neurons in the brain. This plays an important role in learning and forming memories.
But too much glutamate can be toxic to brain cells. NAC regulates the amount of glutamate and keeps it at safe, healthy levels.
NAC influences the amount of dopamine available in your brain. It works to keep dopamine receptors healthy and able to transmit and receive dopamine. These neurotransmitters are crucial for cognitive energy and drive, motor control, feelings of pleasure, and focus.
NAC is a precursor to the powerful anti-oxidant glutathione (GSH). GSH is a potent anti-inflammatory, anti-oxidant and free radical scavenger.
Your brain is especially vulnerable to inflammation, free radical and oxidative damage. If left unchecked, inflammation, oxidation and free radicals can negatively affect cognition, long-term potentiation, memory and mood.
As a nootropic, NAC can boost glutathione and dopamine levels in your brain. NAC is also used by medical professionals to treat serious cognitive disorders like schizophrenia, bipolar disorder, severe depression and anxiety.
How does N-Acetyl L-Cysteine work in the Brain?
N-Acetyl L-Cysteine boosts brain health and function in several ways. But two in particular stand out.
- N-Acetyl L-Cysteine reduces oxidative stress. Oxidative stress results in free radical damage in brain cells. Leading to neurodegeneration and ultimately Alzheimer’s, Parkinson’s and other age-related neuronal disorders. Proteins and DNA are injured, inflammation, tissue damage and cellular apoptosis (cell death) are the result.
And neurohackers are not immune to oxidative stress no matter what your age. Keep this in mind the next time you reach for a Diet Coke. Consumption of the artificial sweetener aspartame induces cortical inflammation and oxidative stress.
Researchers did a study with 30 adult male Wistar rats randomly divided into 3 groups. The control group received distilled water. The second group was given aspartame. And the third group was given aspartame and NAC. Oral administration was done in the morning daily for 90 days.
The study found that NAC affected Brain-Derived Neurotrophic Factor (BDNF) levels, blocked the COX-2 and PGE2 inflammatory enzymes, and reduced the expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) inflammatory cytokines in the rat cerebral cortex. They also found that NAC replenished glutathione levels.
The researchers concluded that NAC prevented neurotoxicity and improved neurological function, suppressed brain inflammation, and oxidative stress response.[vi]
- N-Acetyl L-Cysteine relieves depression. Major depressive disorder is one of the most common psychiatric disorders. It’s a burden on the individual, family and the community. And the pharmaceutical companies are making literally billions on selling various anti-depressants. Not treating the cause, producing a host of side effects, and in most cases just ‘dumbing down’ the symptoms.
But the pipeline for new anti-depressant drug discovery is at a near stand-still for treating problems like schizophrenia, bipolar disorder, depression and common forms of autism.
The good news is that neuroscience continues to work on the problem. And have shown that many of these disorders share inflammation and oxidative stress as part of their disease physiology.
Neuroscientists also discovered that associated pathways causing these diseases include a reduction in proteins that stimulate neuron growth (neurotrophins), increased apoptosis (cell death), and reduced energy generation in mitochondria.
It turns out that NAC seems to have multiple effects on all these pathways. NAC reduces the core symptoms of schizophrenia, reduces depression, and reduces cravings for a number of addictions including cocaine, cannabis and tobacco.[vii]
How things go bad
As we get older or suffer from chronic illness, our brain and body chemistry and energy metabolism changes.
↑ Oxidative stress in brain cells increase
↓ Free radicals damage neurons
↓ Dopamine receptors stop working
↑ Glutamate toxicity causes cell damage and apoptosis
↓ Brain-Derived Neurotrophic Factor (BDNF) declines
↓ Mitochondria energy declines
All of these changes are often attributed to chronic illness, lifestyle choices, and aging.
Unchecked, they could lead to neurodegenerative diseases like Parkinson’s, Alzheimer’s, major depression, schizophrenia, OCD, addictions, autism, and a drop in quality of life.
N-Acetyl L-Cysteine to the rescue
N-Acetyl L-Cysteine (NAC) is a slightly modified version of the sulfur-containing amino acid L-Cysteine. When taken as a supplement, NAC replenishes intracellular levels of the natural antioxidant glutathione (GSH). Restoring your cells’ ability to fight damage from reactive oxygen species (ROS).
Conventional medicine has used NAC for decades as an inhaled mucous thinner to treat symptoms of cystic fibrosis. NAC is given intravenously (IV) or orally as a treatment for acute acetaminophen poisoning. NAC quickly restores glutathione levels, averting permanent disability or death.
The nootropics community has recently discovered NAC as a way to suppress inflammation in the brain. NAC prevents oxidative stress on brain cells, eliminates free radicals, restores Brain-Derived Neurotrophic Factor (BDNF), rejuvenates dopamine receptors, and improves overall cognitive function.
NAC can help boost cognition, Long-Term Potentiation for long-term memory formation, short-term and working memory, improve your mood and quell anxiety.
How does N-Acetyl L-Cysteine feel?
Neurohackers report that supplementing with NAC could be the best nootropic they’ve ever used for their brain and overall health. Comments include:
- Thinking is clearer (less brain fog)
- Memory improves
- Concentration and attention improves
- Less anxiety
- Less depression
- Less irritable
- Mood improves (like a ‘clean high’)
- Symptoms caused by ADHD meds disappear
- Obsessive Compulsive behavior decreases
- Sleep quality improves
- Energy levels increase
- Weight maintenance is easier
- Less flu and colds
- Skin looks better
- Feel younger
- Hangovers are less severe
The Research
N-Acetyl L-Cysteine increases dopamine
Treatments for Parkinson’s Disease are limited to replacing dopamine in the brain. As well as some medications designed to slow down the disease.
In 2016, researchers at Thomas Jefferson University showed that oxidative stress in the brain could play a critical role in the progression of Parkinson’s. And this stress lowers levels of glutathione, a compound produced in the brain to counteract oxidative stress.
Studies show that N-Acetyl L-Cysteine (NAC) helps reduce oxidative damage to neurons by helping restore the levels of the antioxidant glutathione.
In this study, Parkinson’s patients were placed into two groups. The first group received 50 mg/kg NAC intravenously (IV) once per week. And 600 mg of NAC as a supplement twice a day on non-IV days.
The second (control) group received only their standard Parkinson’s treatment. Patients were evaluated at the beginning of the study and again 3 months later.
The evaluation consisted of the Unified Parkinson’s Disease Rating Scale (UPDRS), and a SPECT brain scan which measures the amount of dopamine transporter in the brain.
Compared to controls, the patients receiving NAC had significant improvements in their scores. One of the study authors said, “We have not previously seen an intervention for Parkinson’s disease have this kind of effect on the brain”. This study demonstrated for the first time the direct effect of NAC on the brain’s dopamine system. NAC has the unique ability to enable dopamine neurons to recover their function.[viii]
N-Acetyl L-Cysteine repairs Traumatic Brain Injury
Traumatic brain injury (TBI) is a major public health issue affecting 1.7 million Americans each year.[ix] TBI can be caused by sports injuries, work accidents, car and motorcycle accidents, falls, and your wife hitting you over the head with a frying pan.
Many survivors end up with long-term or even permanent neurocognitive dysfunction. Affecting cognition, motor function (movement) and personality. These disabilities are estimated to cost $9.2 billion in lifetime medical costs and $51.2 billion in productivity losses.[x]
A major cause of TBI comes from blast exposure on the battlefield. Symptoms are similar to other causes of TBI; dizziness, hearing loss, headache, memory loss, sleep issues, and neurocognitive dysfunction.
In a brain subjected to TBI there is glutamate toxicity, free-radical injury to brain cells, electrolyte imbalances, mitochondrial dysfunction, inflammation, apoptosis (cell death) and stroke.[xi][xii]
This double blind, placebo-controlled study was conducted with 81 active duty service members at a forward deployed field hospital in Iraq. All service members in this study were exposed to significant ordinance blast and met the criteria for TBI.
Service members were randomly assigned to receive either a placebo or N-Acetyl L-Cysteine (NAC) for 7 days. The resolution after 7 days of all the TBI symptoms listed above was the main outcome measure of this study.
The researchers concluded that NAC was a safe pharmaceutical countermeasure of blast-induced TBI. And that further work on long term outcomes and the potential use of NAC in civilian TBI is warranted.[xiii]
N-Acetyl L-Cysteine helps alleviate depression
Both depression and bipolar disorder are complicated by glutathione depletion. The researchers in this double-blind, multicenter, placebo-controlled study worked with 75 subjects with bipolar disorder.
Subjects received 1 gram of NAC twice daily for 24 weeks. NAC treatment caused a significant improvement with depression with those using NAC.
The researchers concluded, “NAC appears a safe and effective augmentation strategy for depressive symptoms”. In this case with people suffering from bipolar disorder.[xiv]
Dosage Notes
N-Acetyl L-Cysteine (NAC) suggested dosage for cognitive benefit is 600 mg 3-times per day.
Clinical studies have found that doses up to 2,000 mg per day are safe and effective.
And one German study showed the safety of 2,800 mg per day for 3 months in patients with cystic fibrosis.[xv]
NAC has also proven effective against seasonal influenza and flu-like illnesses. One large study of older adults in Italy took 600 mg of NAC twice daily for 6 months. Only 25% of those adults who used NAC experienced flu-like episodes compared to 79% in the placebo group.[xvi]
Side Effects
N-Acetyl L-Cysteine (NAC) is the N-acetyl form of the naturally occurring amino acid L-Cysteine. NAC is considered non-toxic and very safe.
NAC is a slightly modified version of the sulfur-containing amino acid L-Cysteine. So NAC in powder form can have an unpleasant smell.
Very rarely can NAC cause nausea, vomiting, diarrhea or constipation. Even more rare are rashes, fever, headache, drowsiness, low blood pressure and liver problems.
Side effects can be a result of very high doses of NAC. And if you have a genetic condition called Cystinuria do not use NAC. This rare condition causes stones to form in the kidneys, ureter and bladder from cysteine. NAC is the N-Acetyl form of Cysteine.
One study has also found that long-term use of high-dose NAC can deplete your body’s stores of zinc. So if you are using NAC everyday you should also supplement with zinc and low dose copper.
Available Forms
N-Acetyl L-Cysteine is available in powder, tablet and capsule form. NAC capsules and tablets are usually 600 mg.
Some supplement makers add other compounds to their formula. So ensure you read labels carefully. And stick with manufacturers who follow Good Manufacturing Practices (GMP). And are GMP-Certified.
Nootropics Expert Recommendation
N-Acetyl L-Cysteine (NAC) 600 mg, 3-times per day
We highly recommend using N-Acetyl L-Cysteine (NAC) as a nootropic supplement.
Your body does synthesize some L-Cysteine from methionine. And you can get L-Cysteine from foods such as dairy, poultry, pork, and some grains and nuts.
But most of us don’t get enough N-Acetyl L-Cysteine from our diet. So supplementation will help. And N-Acetyl L-Cysteine is a highly bioavailable form of L-Cysteine. So you should feel its effects faster.
NAC is helpful for most neurohackers to improve mood, memory, cognition, and concentration. And NAC helps alleviate brain fog, anxiety, and irritability.
NAC is especially helpful to those dealing with Obsessive Compulsive Disorder. And stacked with ADHD meds, NAC helps alleviate some of the negative side effects associated with stimulants.
You can safely use up to 1,800 mg of NAC per day. The usual dose for cognitive improvement is 600 mg. dosed 3 times throughout your day.
[i] Neuwelt E.A., Pagel M.A., Hasler B.P., Deloughery T.G., Muldoon L.L. “Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.” Cancer Research. 2001 Nov 1;61(21):7868-74 (source)
[ii] Scalley R.D., Conner C.S. “Acetaminophen poisoning: a case report of the use of acetylcysteine.” American Journal of Hospital Pharmacy. 1978 Aug;35(8):964-7. (source)
[iii] Neergaard L. “Most Popular painkiller is lead cause of acute liver failure” National AIDS Treatment Advocacy Project natap.org Dec. 25, 2005 retrieved June 17, 2016 (source)
[iv] Eakin K., et. Al. “Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury” PLoS One. 2014; 9(4): e90617. (source)
[v] Hashimoto K., Tsukada H., Nishiyama S., Fukumoto D., Kakiuchi T., Shimizu E., Iyo M. “Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine.” Annals of the New York Academy of Sciences. 2004 Oct;1025:231-5. (source)
[vi] Saleh A.A.S. “Anti-neuroinflammatory and antioxidant effects of N-acetyl cysteine in long-term consumption of artificial sweetener aspartame in the rat cerebral cortex” The Journal of Basic & Applied Zoology Volume 72, October 2015, Pages 73–80 (source)
[vii] European College of Neuropsychopharmacology (ECNP). “Amino acid offers potential therapeutic alternative in psychiatric disorders.” Science Newsline Medicine sciencenewsline.com October 7, 2013 Retrieved June 18, 2016 (source)
[viii] Monti D.A., Zabrecky G., Kremens D., Lian T.W., Wintering N.A., Cai J., Wei X., Bazzan A.J., Zhong L., Bowen B., Intenzo C.M., Iacovitti L., Newberg A.B. “N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson’s Disease: Preliminary Clinical and Cell Line Data.” PLOS ONE, 2016; 11 (6): e0157602 (source)
[ix] Faul M, Xu L, Wald MM, Coronado VG (2010) “Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002–2006”. Atlanta (GA): Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. (source)
[x] Rutland-Brown W., Langlois J.A., Thomas K.E., Xi Y.L. “Incidence of traumatic brain injury in the United States, 2003.” Journal of Head Trauma Rehabilitation. 2006 Nov- Dec;21(6):544-8. (source)
[xi] Yi J.H., Hazell A.S. “Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury.”Neurochemistry International. 2006 Apr;48(5):394-403 (source)
[xii] Farkas O., Povlishock J.T. “Cellular and subcellular change evoked by diffuse traumatic brain injury: a complex web of change extending far beyond focal damage.” Progress in Brain Research. 2007;161:43-59. (source)
[xiii] Hoffer M.E., Balaban C., Slade M.D., Tsao J.W., Hoffer B. “Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study.”PLoS One. 2013;8(1):e54163. (source)
[xiv] Berk M., Copolov D.L., Dean O., Lu K., Jeavons S, Schapkaitz I., Anderson-Hunt M., Bush A.I. “N-acetyl cysteine for depressive symptoms in bipolar disorder–a double-blind randomized placebo-controlled trial.” Biological Psychiatry. 2008 Sep 15;64(6):468-75 (source)
[xv] Dauletbaev N., Fischer P., Aulbach B., Gross J., Kusche W., Thyroff-Friesinger U., Wagner T.O., Bargon J. “A phase II study on safety and efficacy of high-dose N-acetylcysteine in patients with cystic fibrosis.” European Journal of Medical Research. 2009 Aug 12;14(8):352-8. (source)
[xvi] De Flora S., Grassi C., Carati L. “Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetyl cysteine treatment”. The European Respiratory Journal. 1997 Jul;10(7):1535-41. (source)
Dear David,
Thank you for the wonderful work that you do and I have spent many an hour reading all of the invaluable information you put out here for us all to access.
I suffer from Gilbert’s syndrome but the doctors in the UK don’t really have any understanding of it and believe it to not cause any symptoms.
Just from my own research, I believe that the excess bilirubin causes excess glutamate and inflammation in the brain. High levels of serotonin and maybe dopamine and low levels of GAMMA. Information is so hard to find on it though.
I have always been a happy and positive person but recently I am constantly fatigued, have brain fog, anxious, have pure O tendencies and recently have had depression because of the ongoing symptoms. I am hoping that the above detective work may help me in finding a nootropic that could help. I was given an SSRI antidepressant (citralopram) which literally sent me over the edge with suicidal thoughts etc so stopped that straight away!
Anyway, enough babbling; Basically would NAC be a good one to start with? and would it be a good idea to mix it with Saffron extract or Lemon balm.
I am using the Pro lab multivitamin tablets, milk thistle, taurine, turmeric and L methionine at the moment. But I am lost to be honest as lots of nootropics seem to focus on raising serotine and dopamine.
Any help at all would be very much appreciated.
I am in the UK so some nootropics are hard to get.
Thank you so much and really even a slight nudge in the right direction would be super.
Kind regard
Clare
Clare, I know nothing of Gilbert’s Syndrome except what I read on Wikipedia. So defer to your knowledge and what you have learned.
If it’s true that it causes excess glutamate then I suggest tracking down the nootropics that keep glutamate under control. And help prevent glutamate toxicity. Use the search function here on Nootropics Expert. And search for the keyword “glutamate”.
You’ll get several false positives. So it’ll take some reading. But you are looking for nootropics that prevent glutamate toxicity.
It’s much more difficult to try and reduce both serotonin and dopamine at the same time. Because usually you’ll raise one which depresses the other. Not reduce both at the same time.
NAC may not be a good idea because it supports dopamine. Instead, after you finished researching glutamate toxicity I suggest you do another search for inflammation. And find the nootropics that can help tame inflammation. But be careful, because some that tame inflammation also boost dopamine and/or serotonin.
For example, Saffron extracts (crocin & safranal) inhibit the uptake of dopamine and norepinephrine in the brain. So while to helps with inflammation it also boosts something you don’t want boosted.
Dear David,
A friend of mine is struggling with a cocaine addiction and he is trying not to use it anymore but the cravings are sometimes so strong that he does use it again.
What nootropics do you think will help to get off of cocaine? I know that NAC can help because NAC regulates the amount of glutamate in the brain and also influences the amount of dopamine that is available in our brain.
Are there any other nootropics that could be added to NAC that will help him to quit using cocaine?
Many thanks,
Adrian
Adrian, I like your thinking. And your approach to this. It’s a tough one but the only other thing I can think of to try is L-Glutamine: https://nootropicsexpert.com/l-glutamine/.
Other option is do a search of Nootropics Expert for the keyword “cravings”. And see what turns up. You’ll get references to reduction of cravings for things like sugar. Not sure if that will help because I haven’t thought it completely through. But worth exploring I think.
If you had to give someone your top 3 suggestions for healing dopamine receptors after Adderall and Vyvanse abuse , what would be your top 3 picks that you know for certain would help ? Please answer , it would be very much appreciated
Malik, I’ve had great success with NAC, Mind Lab Pro and Aniracetam. I’d use Ashwagandha as well if I could by my body doesn’t like it.
Any ideas on whether its safe to take glutathione supplements at the same time as NAC?
Jaf, I don’t think it’s contraindicated. But too much of anything is not a good idea.
Hi David,
I started using NAC about four months ago for withdrawal from antidepressant Nortriptyline (Allegron). You recommended NAC to treat the withdrawal as Traumatic Brain Injury (TBI). I went down from 100mg of allegron to 75mg. I don’t want to decrease the dosage any more, I like the way I feel at the moment. But I would like to add the final two nootropics to my stack – Pine Bark Extract that you recommended at the consultation we had and Vitamin D because my Vitamin D level is a bit low. My stack at the moment is very big and I don’t want to take something that I don’t need. So I was thinking, because I don’t withdraw from antidepressant any more to stop taking NAC. But on the other hand I don’t want to feel worse by stopping it. As I mentioned my stack is very big, and I’m not sure how to see if NAC gives me any benefit at the moment. Even if it helps a little bit and I’ll stop it I don’t think I will be able to tell, because of the other nootropics that I take.
David what do you think the best thing for me to do in this situation?
Any help is greatly appreciated.
Mick, you know I’m a big fan of NAC and would continue to use it. Because it’s a precursor to the synthesis of glutathione which is a potent antioxidant, anti-inflammatory and free radical scavenger. And NAC modulates glutamate levels and dopamine release in your brain. Those are all pretty convincing reasons to use it every day. Don’t you think?
I think it’s a peace of mind continuing with NAC, even if it makes me feel a little bit better in my situation at the moment. By stopping it I’m risking feeling a bit worse than I do now, so I think it’s worth it.
Thanks David.
Hi David,
If my whey protein isolate powder (NOW Sports, so reputable) contains 728mg L Cysteine per serving, and I consume 2 servings per day, is it ok to take NAC separately, 600mg 3 times a day as recommended?
I didn’t notice the whey protein contained L Cysteine until after I bought the NAC. I also take 30mg zinc with 2mg copper as recommended.
I’m wondering if NAC on top of L Cysteine basically means I am then taking too much ‘Cysteine’ in general, as 2 servings of the whey protein is approx 1,500mg, and the 1,800mg NAC means a total of 3,300mg per day…
Thank you!
Chris
Chris, one German study showed the safety of 2,800 mg of NAC per day for 3 months in patients with cystic fibrosis. But I’d check the “side effects” section above in this review to keep an eye out for symptoms. Because side effects from L-Cysteine are usually associated with high doses. If you don’t experience any of those side effects (including getting your liver checked) then you should be OK.
HI DAVID ,,would like to know if I take supplement with NAC will give the same results of l cysteine ..I need to know as there is amino acid supplements contain L cysteine wonder if it gives the same effect ,,and if I take it for long term it will have any side effects,,
Mr. Sam, my understanding is an acetyl group was added to cysteine to help make it more bioavailable and so it could cross the blood-brain barrier. I do not think you’ll get the same nootropic benefit that’s provided by NAC if you just use L-Cysteine.
Hello David,
After reading most of your post, i have a confusion i.e. I feel Ala, NAC and Taurine are interconnected to each other either because on glutathione or cysteine.
Does it mean if i use ala then taking nac is unnecessaryn or vice-versa.
Secondly, I need recommendation from you which nootropics i use to increase mental energy. My blood pressure is generally normal but on lower side. My feets are also cold in summer time.
I have used many nootropics for energy as recommended in your post but still nothing helped me out. I am lacking basic mental energy and motivation. I tried up till now mct oil, alcar, ala, pine bark extract for energy.
To fight this mental fatigue only krill oil, nalt help a bit. I don’t know what’s the problem.
Do you have any suggestions?
Regards
Shivansh Batra
Shivansh, Alpha Lipoic Acid, NAC and Taurine are all very different nootropic supplements. For example, cysteine provided by NAC helps in the synthesis of Taurine. But it has other nootropic functions as well.
You’ve already hinted at a clue on what may be contributing to your mental fatigue. With krill oil it means you’re low in DHA. And with NALT it means you’re low in dopamine and norepinephrine. Both have an effect on energy levels. Please see dosage recommendations including timing during the day for both DHA and NALT here on Nootropics Expert.
A basic energy stack (https://nootropicsexpert.com/best-energy-supplements-to-buy/) includes ALCAR, Alpha Lipoic Acid, CoQ10 and PQQ. That stack ensures your mitochondria can make adequate ATP which is your most basic and fundamental source of energy.
Motivation is associated with the dopamine pathway. But you need more than to simply boost dopamine if you want to activate that pathway. You also need a nootropic to activate AMPA receptors. Which is explained in this post: https://nootropicsexpert.com/hacking-motivation-with-nootropics/
The key to making this all work is using adequate dosages and the right timing during your day. You’ll find that info in each of the relevant reviews. Let me know if you require further clarification.
My daughter takes 2400 mg NAC daily (split into two doses) with extra vitamin C to treat a lung problem. She recently started an antidepressant, Lexapro, and seems to be worse. Her symptoms mimic a mild serotonin syndrome. I’ve had serotonin syndrome five separate times from all different meds. I am extremely prone to it. I have yet to find a doctor who has any knowledge on this to help me with this problem as I also have four rear immune and neurodegenerative conditions that need treating but because of this I can’t take the meds I need. I’m hoping you can help me with two things: do you know any specialist that might be able to help me with the too prone to serotonin syndrome issue or have knowledge on it and/or do you know if the combo of an antidepressant and high dose NAC could cause serotonin syndrome? I have read that it affects glutathione and dopamine and serotonin but couldn’t find the direct effect on serotonin. I have found in research that it increases the minimal effective dose of Lexapro so definitely interacts. I appreciate any help you can give in this matter. Thank you.
Amy, I am not aware of any direct contraindication for NAC with Lexapro. But be aware of two things: 1. Lexapro inhibits the liver enzyme CYP2D6 which will increase the effectiveness of anything that is normally metabolized by that enzyme. So I suspect that the already high dose of NAC is even higher when using Lexapro.
2. The other thing is high dosages of NAC suppress zinc levels. Zinc is needed as a cofactor in the synthesis of serotonin.
It sounds like such a high dose of NAC with Lexapro is throwing some major neurotransmitters out of balance. Which will cause side effects and some could mimic Serotonin Syndrome.
I suggest you cut back on your NAC dose and see how that works. The maximum recommended dose for NAC is 1,800 mg and that’s usually split into 3 doses per day. And add a zinc supplement along with a low dose copper supplement. More on zinc here: https://nootropicsexpert.com/zinc/
Hi David ,
I did a Genova methylation panel to check on my current levels, and cysteine came back very low and taurine very high. I supplement with 3000mgs of oral NAC daily divided 3 times thorough out the day to try and boost Glutathione levels. I also supplement Taurine 1000mgs 2 x a day. My physician seems to think the cysteine is converting to taurine somehow. Have you heard of this? He wants me to stop the oral NAC and start transdermal 3 x a day. Just wondering what your thoughts are on the NAC taurine interaction. Thanks.
Paul, Taurine is naturally derived from cysteine in your pancreas. Using both NAC and taurine will influence taurine levels in your system.
David, can I continue taking my multivitamins and other supplements like L-Glutamine with NAC 1000mg?
Delia, yes you can and it’s a great addition to your stack. Esp. if you want to support your immune system.
Greetings
I am curious, David, if you find it possible that n-acetylcysteine could exacerbate or even induce, a cobalamin deficiency. The reason I ask is that shortly after consuming NAC over a period of two days (in total, 1700mg) I began to present with symptoms of b9/b12 deficiency. I did some cursory research in the sequence of glutathione production and found that vitamins b6,9,12 are all involved in the production of glutathione (https://www.researchgate.net/figure…or-biosynthesis-of-Glutathione_fig1_321662012).
Now, being that NAC is a glutathione precursor, do you think that this could have caused a cobalamin deficiency or exacerbated a deficiency I had already had (but was without symptoms)?
Nathan, it was likely a deficiency you were already experiencing and did not know it was happening.
I tell almost every single person I consult with to add a B-Complex supplement to their stack. Because most of us are deficient in 2 or more of the B-Vitamins, magnesium, lithium, iodine, and other critical vitamins and minerals. Being low in just one of them affects a ton of stuff going on in your body and brain.
Hi I see your recommendation of 3x per day. Does that mean morning, afternoon, and bed? I know there are some musings about its short life. I was planning 7 am, 2-3 pm, and before bed around 10-11. Thanks!
Frank, 3-times per day for NAC means morning, noon and before bed.
Hello David, great article I wanted to ask if I can add it to my stack as something makes me very anxious: Bacopa, Ashwaganda, Alpha Gpc, phosphatidylserine, ALCAR, DHA and sometimes rhodiola…. Can I add NAC for focus and anxiety relief?
Mike, you can try NAC but not sure it will work as you’d like. A better idea I think is find out what in your stack is causing you to feel anxiety. Try eliminating one nootropic at a time and see if that helps you figure this out. Before adding something else.
It’s actually triggered by college studies… Also I reduced the Alpha Gpc to 300mg and Phosphatidylserine to 100mg daily (instead of 200mg)
My mom has chronic renal disease: nephrologist said she will be starting renal dialysis soon. Her primary care doctor said to hold off on dialysis and to try NAC first. Your thoughts on this.
Victoria, her doctor is onto something because NAC has been used in clinical settings for acetaminophen poisoning for decades. Using NAC may not be enough in your Mom’s case so keep an eye on things. Because sometimes modern medicine can be a life saver.
What is a good combination of amino acids for boosting mental performance? I am using ALA, Carnitine, Tyrosine, and Theanine. Considering Taurine and NAC.
Michael, take a look at the table near the top of this page: https://nootropicsexpert.com/best-nootropics/.
You are looking for the first section I think for; “Processing speed, Decision-Making, Focus, Flow, & Thinking”. The nootropics listed there will help and it looks like you’re nearly there with what you are using now. Just make sure you are getting dosage and timing during the day right.
Hi, I’m looking for an explanation for a problem I have with NAC, maybe you can help me?
I’ve been trying all sorts of supplements and nootropics for a year for a range of debilitating issues (chronic fatigue, anhedonia, GAD) after a few years on methylphenidate (I had to stop because it made me very anxious in the end with little benefits left).
NAC is by far the only one that works very well on me, I basically feel like my normal self when I take it and I don’t even need a high dose (400mg daily is enough), it seemed perfect!
The problem is if I take it more than a week it makes me very depressed (almost suicidal if I don’t stop quickly) with massive brainfog.
I don’t see it listed anywhere as a side effect and I’ve not encountered anyone else with the same problem.
I don’t believe it’s an excess of GABA since I don’t take a high dose and I’m used to take a lot of GABA precursors everyday for my anxiety (and I don’t take them when I take NAC).
Do you know if NAC is an acetylcholine booster by any chance? It’s the only explanation that would make sense to me since all choline boosters give me depression and brainfog (Alpha GPC, ALCAR, Coluracetam, even fish oil), but I haven’t find this information.
Or maybe you’ll have a better explanation, if I could counterbalance this side effect I really think I could have something close to a normal life again…
Thank you!
Jammy, it’s definitely not an acetylcholine booster. It’s a precursor to glutathione. But it is a slightly modified version of the sulfur-containing amino acid L-Cysteine. Some people have problems with sulfur.
And Side Effects though rare, can cause rashes, fever, headache, drowsiness, low blood pressure and liver problems.
The only other thing I can think of is it’s become clear to me over the years that expecting “one pill” to solve your problems is not a reasonable expectation. And inevitably throws something out of balance. In this case we know that NAC can deplete your body’s stores of zinc. So if you are using NAC everyday you should also supplement with zinc and low dose copper.
Hello David.
I really like your videos. You put a lot of effort into research with shows with the details that you provide.
One comment regarding sound quality! May I suggest that you find a method for increasing the volume for your mic? Many times I have to increase my speaker volume for your videos.
Keep up the good work.
Vincent, thanks for your feedback and I am aware of the sound levels. It’s a struggle because if I increase the volume too much the background noise is so bad you’d not want to watch any of my videos. I even changed microphones. From a $600 Sennheiser to a $100 Audio-Technica. So I’ll keep on working on it. And thank you for watching my videos! Means a lot to me because they’re a lot of work to make and produce.
I recently met a gentleman that YOU assisted in healing from the destruction and chaos Crystal Meth did to his Brain chemistry. I stopped injecting meth 7 months ago, I am living a hell of my perception of reality.
I have sense that I lost My Self, I have Panic attacks that feel I am going to die from them. My every day psychosis is has bound my home, my perception of reality is completely unfamiliar and I Go to sleep with fear, and wake up with fear.
My Psychiatrist has been trying his best but I see that he is out of ideas.
I been taking lorazepam and droperidol and switch to haloperidol every now and then). Nothing helps, I need to recover my heart, and more importantly My Mind. I am 30 years old, and injected Meth for 4 years straight.
The Friend YOU saved from death, got me a bottle of L-Dopa Macuna 20%, GABA 750mg and 5-htp 200mg a pill, and in 3 days I could not believe that I was actually recuperating my familiar perception of reality. That is Why I am here, because I experienced a glimpse of my old healthy self. would you be kind and lead me to the nootropics that will give me back my hope for existence?.
Thank You kindly. YOU are changing the world.
Tomasz, the relief you got from using L-DOPA, GABA and 5-HTP was temporary because it was mimicking in part the action of crystal meth. There is no harm in doing this as long as you are aware of possible contraindications with some the the prescription drugs you are using.
For example, you need to be extra careful with something like GABA when using Lorazepam. Because Lorazepam increases the effects of the neurotransmitter GABA at the GABAa receptor. Combining it with supplemental GABA could put you into a coma. Same goes with any drug that increases serotonin and using it with 5-HTP.
For long-term relief you need to start repairing your brain. Including growing new neurons, dendrites, synapses, and increasing myelin synthesis which protects axons. You also need to tame inflammation including over-active glial cells. (I encourage you to search each of the keywords mentioned in this sentence and see which nootropic helps each of these).
You can start with boosting BDNF: https://nootropicsexpert.com/13-nootropics-to-boost-bdnf/
This post on traumatic brain injury explains things that can go bad and ways to reverse or fix that damage: https://nootropicsexpert.com/best-nootropics-for-traumatic-brain-injury/
Hello David
Could you please tell me if there is any interaction with antibiotics?Also can Nac help in treating prostatitis?Last question, can Nac considered as a biofilm disruptor?Please answer me thoroughly…
Thank you very much
Konstantinos, please re-read this section again for what NAC is and how it works: https://nootropicsexpert.com/n-acetyl-l-cysteine/#overview
If prostatitis is caused by problems with glutathione, glutamate, dopamine or inflammation then NAC may help.
You’d need to check interactions with each specific antibiotic to see if there is any problem.
And what is a biofilm disruptor?
Biofilm is a surface which microbes hide there…as a result antibiotics cannot penetrate into…so you ve got to find biofilm disruptors in order to break that surface…NAC is supposed to be one of them…
Yes, NAC has been proven to be a biofilm disruptor: https://www.sciencedirect.com/science/article/pii/S095461111630141X. Thank you Konstantinos.
Can I start using NAC and resume it for lifelong?
will it show any adverse side effect of I stop taking it?
Ashif, NAC is simply L-Cysteine with an acetyl group added to boost bioavailability. L-Cysteine is naturally present in your body and all you are doing with this nootropic supplement is using additional L-Cysteine which you are not getting from food.
So yes, you can take this daily for life and there will be no side effects when or if you stop taking it.
Hi David,
Trying to understand if this is a good idea – I was taking piracetam and alpha-gpc for some time.
Now, I want to stop taking it and move to something different to ensure I target multiple paths to a healthier brain, so I am thinking of stopping alpha gpc and piracetam and using the following:
1. NALT
2. PS
3. Lion’s Mane
4. NAC
Goal – motivation (and if I may say, fearlessness? I want to get rid of some imposter syndrome), memory, and long-term ngf.
What’s your opinion on it?
NAC – I am not sure if I need it or not. The only reason it’s in the list is because of its ability to prevent alcohol damage. Can it create dopamine imbalance if I take both nalt and nac?
Sparsh, NALT and NAC work fine together. I use both 3-times per day. NAC supports the dopamine created by NALT.
I’d keep on using Alpha GPC if I were you because it boosts acetylcholine which you need. And works in concert with PS to keep brain cells healthy. And course, Lion’s Mane for neurogenesis and neuron health.
Hi David,
I am on OMAD and Keto diet. I mean I eat only one meal (low carb and high fat) a day! Is it safe and effective to take 1800 mg with my meal?
Thanks in advance!
Mehra, I don’t think NAC is going to mess with your Keto diet. But if you are going to do 1,800 mg it should be divided into 3 doses of 600 mg each. One in the morning, one at noon and one in the evening.
Hello David
I have tinnitus…Can NAC helping in reducing or even eliminating of tinnitus?
Do you know other supplemnets or even a combination that can help in that condition?Thanks in advance….
Konstantinos, not the I’m aware of. But I did send out an email in June about tinnitus that you can see here: https://mailchi.mp/38c358b3560e/try-these-nootropics-for-tinnitus
Thanks for all the great work. I find NAC helps me significantly. My only concern with “non-nutrient” compounds (i.e. anything other than vitamins and minerals), is there always seems to be someone suggesting an eventual negative effect on the brain, and for some reason my concern is always regarding the possibility of seizures. Is there any risk of seizures with longterm use of NAC given the effect on glutamate, or conversely any risk of seizures if it’s rapidly stopped after prolonged supplementation?
Mark, NAC is the N-acetyl derivative of the naturally occurring amino acid L-cysteine already present in your system. It is needed for glutathione synthesis. Supplemental NAC works primarily by helping restore the body’s natural antioxidant glutathione.
The only negative from long-term use of NAC is depletion of zinc in your body. You can counteract that by using zinc and low dose copper.
If you stop using NAC all of a sudden, likely the only thing that will happen is the next time the flu or a cold bug goes around you’ll get sick like everybody else.
Hii david , can i take n acetyl cysteine and mind lab pro together?
Prakash, absolutely you can take them together. I have for years.
Thank u david
Hi David
I want to start on NAC. Can you recommend a brand for me ?
Kong, I’m currently using NAC by Nutricost because it has the least amount of additives I could find so far. https://amzn.to/2IYfnWp
Thanks. Any good brand of ashwagandha to recommended. There are limited brands in IHerb and some amazon cannot be ship to my country.
Kong, I suggest looking for products containing either KSM-66 or Sensoril extracts. Then you can be sure you know what you are getting.
Hi David,
I want to start taking NAC for a type of OCD disorder called trichotillomania, as it seems to have helped some. I purchased a bottle from Source Naturals (1000 mg) in 2018 that I have not opened until now, but it smells eggy and tastes a bit bitter. Is this normal? my second question is, will NAC trigger panic attacks? I am extremely sensitive to some medications (a psychiatrist tried putting me on different meds for anxiety and one of them interacted with my norepinephrine levels and cause me to have panic attacks). These days I am only taking vitamin C (from berries), and biotin. Thank you for your time!
Sandra, NAC is a slightly modified version of the sulfur-containing amino acid L-Cysteine. So NAC in powder form can have an unpleasant smell. I’m not aware of reports that NAC could cause panic attacks. It does modulate dopamine receptors by keeping them health. But it doesn’t boost your natural levels of dopamine.
Hi David,
As a Ritalin user, I wonder how often do you use Ritalin
and if you came with a way to keep using it and prevent tolerance or minimize the long term side effect that everyone is taking about.
thanks for all the great info and the videos in Youtube!
Tal, I use Ritalin 10 mg at 5 AM, 20 mg at 8 AM and another 20 mg at noon. And I follow the protocol in this post to prevent tolerance or an afternoon crash: https://nootropicsexpert.com/best-nootropics-for-adhd-add/
Hi David,
I bought some NAC and a supplement that contains both zinc and copper among other minerals. I bought the latter because the website where I bought it said it contained 15mg zinc (oxide) and 1mg copper, but it’s the nutritional value of three tablets, not one. I’d like to take one, one and a half, or at most two tablets a day. What dose do you suggest? I think I’ll take 600mg of NAC twice a day, I won’t be taking it thrice very often
Calle, the supplement you mention contains 400 mg of magnesium in 3 tablets which is the recommended daily dosage of magnesium. It’s entirely up to you of course on how many tablet you are willing to use per day. And 600 mg of NAC 2-times per day is ideal as well.
I want to know drug use in schizophrenia patient.
Are you asking if NAC is safe to use with a schizophrenia patient?
Hi David,
What do you think about the new sustained release version of NAC? It’s a product by Jarrow Formulas?
600mg 1/3 quick release, 2/3 Sustained Release?
Thanks!
Dan, “Other Ingredients” is the problem with Jarrow’s Sustained release NAC. I personally prefer a supplement that contains only the ingredient I want and nothing else.
Hello,
In my country NAC is available in a form of effervescent tablets (600 mg), indicated for mucolytic therapy. Same nootropic benefits as other forms?
Thanks
Aleksandar, it should be the same supplement. Double check the label to make sure.
Hi David,
I am currently studying nutrition, and this has been a great place to use for research purposes, so thanks.
I have 2 questions, firstly does NAC help with someone trying to stop taking drugs, like cannabis and alcohol? Or should they consider some kind of detox approach?
Second, would you recommend someone like myself to supplement with NAC even though I don’t currently have any particular health issues, except my GGT levels are slightly high (tested using Kinesiology in class).
Deni, I would suggest using NAC while detoxing because it helps boost glutathione and dopamine. I think NAC is a great supplement for most people because it helps increase glutathione. I personally find that when using NAC and while others around me are getting sick with the flu or a cold I manage to stay well.
And BTW, Lithium Orotate, L-Glutamine, SAM-e, Picamilon, L-Carnosine, and Aniracetam have all been used one way or another in the treatment of alcoholism or the damage caused by alcohol.
Check out the reviews of each of these nootropics because at least one or two as I recall helps in relieving cravings for alcohol and some other drugs. Not sure about cannabis however.
Hi David,
I have only recently started taking NAC, but am alarmed to read in several places that you should not take it if you have mercury fillings because this could result in mercury ending up in your brain. As I have quite a lot of mercury fillings, in your opinion, should I stop taking the NAC?
Thank you
Ellie, this is news to me. Please point me to an authority site like PubMed or other peer-reviewed site that provides evidence of this. And I’ll gladly update my Side Effects section in this review.
Hi David,
Thanks for your response. Apologies, but I may have overreacted. Having looked into this further none of the mentions I’ve seen are from authoritative sites like PubMed, so what I have seen may have been based on supposition rather than fact.
Hi David,
The specialist treating my Bipolar has highly recommended NAC since there are a mass of studies on it specifically for mood disorders. We’re testing NAC as stand alone with the lower doses of psychotropics I’m using. Specifically to enhance mood, lift brain fog and curb anxiety. I feel I have noticed these positive effects almost immediately. My dose is 600 mg 3 times per day.
But I’ve heard elsewhere that folks are saying NAC is either not safe to use in those doses or that it’s better to use Glutathione. I trust your opinion so was hoping to hear your thoughts on these assumptions I’ve heard elsewhere.
Thanks in advance.
Gabriella, my research is based on clinical studies and my personal experience. As you noted in your comment there have been a “mass of studies”. NAC as a precursor to glutathione is more effective that dosing with glutathione. So please be critical of everything you read on the Internet and in books. And base your decisions on real evidence. Not what others are saying.
Hi David,
Just a quick question on NAC…
Is it fat or water soluble?
Thanks!
NAC is water soluble.
Hello David! My 19 year old daughter was diagnosed with Major Depression more than a year ago. The Psychiatrist gave her various combinations of medicines but had started with Fluoxetine from day one. At present she is taking the following medication:
Fluoxetine – 40mg (morning), 40mg (noon).
Buspirone – 10mg (morning), 10mg (noon), 10mg (night).
Amisulpride – 75mg (night)
At present her depression is under control and panic attacks have stopped but with a lot of side effects which have made her life (and our’s too) miserable. She now has very poor concentration & memory which are effecting her studies badly. If she is able to concentrate for some time then she gets frequent headaches. Mood swings & irritability are also major issues. After going through your website I have shortlisted the following supplements for her:
Acetyl L-Carnitine (ALCAR), Alpha GPC, N-Acetyl L-Cysteine, N-Acetyl L-Tyrosine, Curcumin.
Please advice whether above supplements would be suitable, keeping in view the prescription medicines she is already taking.
Thanks & Regards.
Ratan, your daughter will likely continue dealing with these side effects no matter what nootropics you try. It’s like trying to plug a big hole in the bottom of a boat with a wine cork. This is heavy duty medication that has a major impact on how the brain functions.
The best way to check for contraindications with prescription meds and natural nootropic supplements is to first learn the exact mechanism of action of each drug. Wikipedia is good place to find that information because it is usually easy to understand.
Then compare the mechanism of action of each drug with the mechanism of action for each nootropic as described in each review here on Nootropics Expert. The biggest red flag is when a drug and nootropic do the same thing or affect the same part of the brain. That amplifies the effect of the drug and could lead to life threatening problems.
Next, search the contraindications for each drug here > https://www.drugs.com/drug_interactions.html. That website provides interactions between prescription drugs as well as dietary supplements.
Thanks for your reply David.
Hi David, you mentioned that you take NAC daily but its not in your post “What I Take”, have you stopped taking it. And if yes why?
Thanks
Graeme
Graeme, I do use NAC daily and guess I forgot to include it in my post on “What I take”. Thanks for the headsup! I appreciate when you guys keep me in line. I’ll add it today.
Can you explain in more detail how using NAC can “protect dopaminergic nerve terminals from chronic methamphetamine use”? Also, do you have any recommendations of nootropics that can aid in stopping the use of and recovery from meth use? I have read in online forums that Semax and Memantine can be helpful in regards to this issue. Neither, however, are on your list… what are your thoughts on those? Thank you so much for your reply…. and for this website!
Trevin, NAC is a potent antioxidant primarily because it’s a precursor to the glutathione which is considered by many to be the master antioxidant in your body.
This study done in Japan with monkeys showed that NAC helped their brains recover from methamphetamine neurotoxicity: https://www.ncbi.nlm.nih.gov/pubmed/15542721/. So it would make sense that it should work in humans as well.
I’ve been using Ritalin for nearly 12 years and use NAC daily. And have not suffered from any type of dopamine receptor damage normally associated with stimulant use.
Semax and Memantine are considered prescription drugs which is the reason I’ve not reviewed them here on Nootropics Expert. And never will. Because our policy here is to stay as close as possible to natural nootropic supplements that can easily be purchased by most anywhere in the world without a prescription.
NAC worked great for a few days to boost energy, then it seemed to stop working. Why would that be? Is that a common reaction?
John, NAC is not known or used for increasing energy levels. You may have experienced more energy for a short while because higher glutathione levels helps repair dopamine neurons and receptors.
You’ll need much more than a single nootropic to increase energy levels. You need to give your brain more of the nutrients it needs for fueling ATP in mitochondria, increasing neurotransmitters (like dopamine and norepinephrine), increasing blood flow to provide more nutrients and oxygen to brain cells.
Thanks. I’ve been trying PQQ as well. It seems to be working. I’ve also tried B complex. It doesn’t seem to boost energy at all, but it may have other benefits. I also tried CoQ10, wasn’t a big fan, didn’t seem to do anything.
John, the thing with PQQ is you need to dose it high enough. My doc prescribed 20 mg of PQQ per day which seems to have helped. And depending on your age, you may not get anything from regular CoQ10 (ubiquinone) and my find that “ubiquinol” works better for you: https://nootropicsexpert.com/coenzyme-q10/
Another thing to try is the new Performance Lab Energy that contains PQQ, CoQ10, Acetyl L-Carnitine (ALCAR) and R-Lipoic Acid: https://nootropicsexpert.com/performance-lab-energy-review/. One of my favorite new nootropic stacks.
Back again. Are so actually saying NALT and L-Tyrosine replace dopamine?
Do I understand that you would recommend that someone with Parkinson’s should take NAC, NALT,
L-Tyrosine, ALCAR, and either Alpha GPC or CDP-Choline, along with zinc and copper?
Jim, N-Acetyl L-Tyrosine and L-Tyrosine are precursors to the synthesis of dopamine. So they give your brain the ingredients needed for the production of dopamine and the other catecholamines. You can use one or the other. It’s not necessary to use both.
And yes, your suggested stack would be good for relieving some of the symptoms of Parkinson’s. You may also want to consider Mucuna Pruriens: https://nootropicsexpert.com/l-dopa/
But like with all nootropics, please make sure you are clear on drug interactions and avoid combining certain nootropics with prescription meds where the combo could cause harm.
Hello David
I am 39 years old man, i was diagnosed with Adhd, as a kid. I took ritalin from 7 to 11 years old , then i did all my life without going back to my adhd diagnosis! I was able to study and become a computer technician and have my Adhd brain ( Multitask) work well for this job!But i find recently in the last 2 years, that i also struggle with other smal behavior issue that come with adhd, impulsivness, not always listening in a conversation , cutting the person in a conversation, a lot of good and high energy days, but sometime days when i feel off, common thing in a ADHD brain…!
So that has cause me some stability issue ( jobs friends)etc.. in my life as well as sometimes racing taught..! I found out that adhd is a familly issue… 85 % of the people who have ADHD does not know about it, are Add are ADHI, which is the third one, the i stand for impulsivness, as you get older your personality crystalyse..My dad was a Physical Education teacher and he had ADHD all of his life without knowing it… and left untreated to… I have a cousin she is a psychotherapist and has ADHI, SO IT runsns in my familly, my mom has also mild form of adhd, both my parents overcome some of their issue in life and became teacher… But in those days it was a lot undiagnosed and left untreated..
2 years ago i went back to that diagnosis, and recently with all my studies on the case, i went on Omega 3 + i take L-Pheynylaline + l-tyrosine together + i also take lysine for working out but as anti anxiety as well it help me control the boost from l-phenylaline and l-tyrosine! I also take Subnflower Lecithin, because it is known to have a better dha absortion to the brain and is a source of choline! I take b vitamin also! I also take l-proline but it’s for joint and prevention of good heart health etc…I take -l-Citruline also for working out!
I take curcuma also and glocosamine and msm for the joints! I saw all great benefith from all this in my mind and body!
3- My question is :” Why in you ADHD stack do you take Alcar and Nalt instead of NAC ( n-acétylcystéine)?
Which is the better ACEThyl-ltyrosine ?( so i stopp my l-tyrosine) are NAC ( n-acétylcystéine) here ? I heard NAC IS GREAT FOR ADHD ? So why d’ont you take it in your adhd stack but instead have ALCAR AND NALT ?
Thank you in advance
Sincerely Gabriel
P.S I write to you from Quebec Canada here, my first language is french so i might have a few english error 🙂
Gabriel, I use N-Acetyl L-Cysteine (NAC) because it helps repair dopamine neurons. But it does not directly boost dopamine like NALT or L-Tyrosine.
And I use ALCAR because it helps boost acetylcholine and the flow of information into and out of brain cells.
Some find that NALT works better and some find that L-Tyrosine works better for dopamine. Try each separately and see which works better for you.
This is a very simplified explanation so …
I suggest going to this post: https://nootropicsexpert.com/best-nootropics-for-adhd-add/ and clicking through to each nootropic. Near the top of the post is a summary of how that supplement works in the brain.
I also suggest you try something like Alpha GPC or CDP-Choline for boosting acetylcholine. Sunflower lecithin is not a good source of choline or DHA.
And you may want to change out your Omega-3 to a supplement that is higher in DHA and provides 1000 mg of DHA per dose.
I have severe osteo arthritis in one hip – dI am now on NAC and have found pain has been eased. 1000mg works best for me. How owuld NAC reduce pain? could you explain?
Uma, pain is often a result of inflammation. NAC is a precursor to the powerful anti-oxidant glutathione (GSH) which is a potent anti-inflammatory. It’s possible you have less pain because of reduced inflammation.
When is the best time to take NAC, 1/2 hr before food/after food, on an empty stomach?
I’ve only just started taking NAC – this is for neurological damage / bipolar disorder / anxiety / depression. The label on the back of the bottle (1000mg) says take 1-3 daily. So I opted with 3000mg, I don’t know if that’s too much to begin with but that’s what it says on the label… Can you take the 3 all in one go or is it best to take it at different times of the day?
I’m also told to take it in conjunction with vitamin C in equal amount. Someone who knows a lot about this sort of thing told me 5000mg of vit c is the kind of amount that actually helps and does something more overtly positive to your body. So I opted to take 5000mg of it with NAC at the same time.
Do you have any thoughts on this?
Last question, how long does it take to experience any discernible differences, how long does it take to kick in etc?
Any advise would be much appreciated, many thanks 🙂
My research shows NAC is safe to use up to 1,800 mg daily. So if they are 1,000 mg tablets I suggest taking one in the morning and one before bed. Research also shows that high dosages of NAC can deplete stores of zinc in your body. So you should be supplementing with additional zinc and low dose copper.
I’ve not seen any research on NAC being more effective with the use of Vitamin C. But it certainly wouldn’t hurt. 1 – 2,000 mg of Vitamin C with each dose of NAC.
Do you recommend 50mg of zinc and 2mg of copper.
yes
I was diagnosed with Parkinson’s in the spring of 2012. I have also been diagnosed as bi-polar for myears. At the time of my Parkinson’s diagnosis my psychiatrist recommended I start tacking NAC. I started at the dosage of 600mg a day.
I live in a small city west of Memphis in Arkansas. On three occasions since my diagnosis and most recently in April of this year I temporarily stopped taking it due to my failure to travel to my source in Memphis.
Each time I ceased taking NAC my Parkinson’s symptoms got noticeably worse. This linkage really did not connect with me till this most recent period. During the most recent period I had moments when I could hardly walk. Each time I have restarted the NAC my Parkinson’s symptoms got better.
After this last period l found a source for 1,000mg tablets on Amazon. I started taking one tablet a day. Within a week my symptoms returned to the status before cessation. I then noticed the that the bottle said I could take up to 3 tablets a day. That would be 3,000mg a day. It seems that since I started this regimen my symptoms have been remarkably reduced. As you can tell I am in a more is better phase.
Do you think there is a danger in taking 3,000mg a day?
Can you recommend a source for the zinc and copper?
By the way my Bi-polar symptoms have gotten much better, too.
Jim, you are another testament to the power of nootropic supplements. And your description of alleviation of symptoms just verified what I found in clinical trials when researching this article.
I’ve been using 2,000 mg of NAC daily for years so you should not have any problems with 3,000 mg. But studies do show that long-term heavy usage of NAC depletes zinc.
Please see this post I wrote on minerals for the brain and pay particular attention to the very last section: https://nootropicsexpert.com/13-minerals-essential-for-the-optimized-brain/.
It’s critically important to use the correct form of these minerals. Find a “chelated” version, or one that is made using yeast. Albion minerals is a good source and any manufacturer who uses their minerals. Blue Bonnet comes to mind. You’re going to need more than the RDA so please check out the individual review for zinc here: https://nootropicsexpert.com/zinc/. And don’t forget about the copper!
When I first tried this I found it made me very angry and I am not typically at all, which is strange cause most say it has the opposite effect. I switched to a time released version that does not seem to have that anger effect on me and have been taking 600 2x per day for about 6 months. It does not have any noticeable effect so far either though. Do you know if the time release is a good thing for NAC or does it lower efficacy?
Rebekah, NAC boosts dopamine levels which is likely what caused anger issues when you first tried it. If NAC is released slowly and you do not react it means that it didn’t ‘dump’ dopamine and norepinephrine into your system and cause a negative reaction.
I think the most important function of NAC is boosting glutathione and increasing your antioxidant levels. While this will not produce any noticeable immediate sensation, you’ll likely find that you won’t get sick as often.
thank you so much David. I will continue with the sustained release and increase dosage to 600 3x per day instead of 2 and see what happens. cheers.
Can i put NAC in my current stack: Alpha-Gpc, Bacopa Monnieri, vinpocetine, L-theanine and Ginkgo Biloba?
PS: current stack within recommended dosage. I alter the stack per convenience.
Appy, you can definitely add NAC to your stack. Just follow the dosage recommendations for NAC in this review. Dosage instructions apply to everything else in your stack because each has a separate function in your brain. See dosage in each individual review.
Hi David,
When I take NAC, I get what I call “brain burning.” This happens even at the smallest doses. Can you explain why? Thank you!
NAC is a very potent method of increasing the major natural antioxidant in your system called glutathione. Antioxidants go after and eliminate reactive oxygen species (ROS). If your brain is low in oxidative stress (i.e. low ROS) then NAC could be too much for you at any dose.
This is speculation on my part because you don’t mention the exact dose of NAC you are using, other medications or medical conditions.
Here is a very comprehensive report on NAC > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967529/. Scroll down to the section called, “Pharmacokinetics and side effects” for more on possible NAC side effects.
My son has symtoms of overfocussed ADD.Ihave given him L-Tyrosine 500& 5HTP50mg.He still has difficulty in focussing,has obsessive symtoms.Can I add NAC
Bhaskar, NAC is likely an excellent choice for your son. I have Adult ADD and use NAC twice per day with great results.
You did not mention if your son is using any ADD medications like Ritalin or Adderall. That could make a significant difference on which nootropic supplements may help him. Have you closely studied the post I did on ADD here? https://nootropicsexpert.com/best-nootropics-for-adhd-add/
The nootropics I mention in the ADD post have been proven to help reduce the symptoms of ADD and ADHD. They work for me and thousands of others with ADD and ADHD. Including coconut or MCT oil, DHA (Omega-3), ALCAR and NALT. The NALT in this case would replace the L-Tyrosine you are currently using.
I also suggest re-thinking your choice of 5-HTP. Please read my review on 5-HTP including the side effects and my recommendations for alternatives > https://nootropicsexpert.com/5-htp/
Hi David, I am considering getting this for my addict sister due to its liver protecting properties, as well as for the anxiety and depression that pushes her to drink and take drugs. One question I have is that NAC has been shown to be a mild chelator. Do you think it could have negative effects by moving mercury around her body? She has a huge amount of fillings and a terrible diet. Thank you
Mari, I doubt the chelation effects of NAC are high enough to cause problems.
David, my son won’t take meds for his bipolar 2 disorder after he experienced bad effects from them. After tons of research, I recommended NAC 2000 per day and magnesium glycinate 400mg a day which he says is really helping with the racing thoughts, depression and spacing out the hypomania episodes. Is there any possibility NAC will stop working at some point? Or is there a supplement that could prevent that from happening? Thanks in advance!
Jeanne, you cannot build a tolerance to NAC that I’m aware of. I’ve been using it every day for years with great results.
Please use the search function top right on this page in quotes for “bipolar disorder” and “bipolar”. And see what turns up. And take close look at Lithium Orotate, zinc, CBD Oil, and possibly Methylene Blue among others.
Start with the nootropic supplements you can easily get on places like Amazon or your local vitamin shop. Try one at a time and see how your son responds. You should see results within a day or two if it works. If it doesn’t then try the next one.
Thank you, David. I have one more question; I’ve read that NAC can cause kidney stones when taken long term so it should be taken with equivalent or higher doses of vitamin C to prevent it. Do you agree?
Jeanne, someone somewhere sounded the alarm about NAC and kidney stones. And once it was out there in the wild every blogger who does not do their research simply parrot what someone else said. I can find zero clinical evidence that N-Acetyl L-Cysteine causes kidney stones from long-term usage. If someone can point directly to that research I would appreciate it. And would love to update the potential side effects section of this review.
One thing I did find since writing this review is the potential for long-term usage of NAC depleting zinc. https://www.ncbi.nlm.nih.gov/pubmed/1529808. So if you are using NAC everyday and long-term you should also be supplementing with zinc and very low dose copper. I will update this review to include this research.
What do you think about “Milk Thistle” ? Recently, they have found that the silymarin in Milk Thistle, not only helps protect the liver, but more recently they found it reduces the inflammation in the lungs and can reverse some of the effects of Emphysema (COPD) and fibrosis ?
Do you know anything about this? Also the milk thistle from Life Extension or others like Dr. Mercola use it with N-Acetyl L Cysteine which protects the liver from alcohol and has a detoxifiying effect ? Can it also (either one also work on the endothelium of heart muscle in any beneficial way ?
Dr. Wisotsky, I personally use Milk Thistle to help boost the absorption of Berberine. And it has been shown to help prevent possible telomere shortening/DNA damage caused by long-term Berberine use. I use Berberine to prevent insulin resistance.
I have not done a review on Milk Thistle because Nootropics Expert is devoted primarily to brain health and optimization. But Milk Thistle has plenty of research for liver detox, anti-inflammatory, anti-tumor and antioxidant benefits. In this case I defer to Life Extension, Dr. Mercola, and Examine.com for extolling all of Milk Thistle benefits.
David, I am allergic to antibiotics that are made from sulfa.
I also get confused about the difference between sulfa and sulfur are they the same? I want to try NAC but I want to know if it could cause a allergic reaction.?Thanks
Tammy, please read this page on Medscape on this subject. Specifically the 5th paragraph > http://www.medscape.com/viewarticle/870347#vp_2.
According to Medscape, cysteine is a sulfa-containing amino acid. And is not allergenic in patients with antimicrobial sulfonamide hypersensitivity. It also provides a link to the clinical study supporting this statement. Hope this helps.