Noopept

Noopept

David Tomen
Author:
David Tomen
Robert Iafelice, MS, RDN, LDN
Fact Checked:
Robert Iafelice, MS, RDN, LDN
16 minute read
Noopept is known for boosting memory, learning, perception, logical thinking, mood, and improved cognitive function.

Key Takeaways

  1. Noopept is a potent cognitive enhancer with various benefits for memory, learning, perception, and mood.
  2. It differs from traditional racetam compounds but still produces similar effects.
  3. It is up to 1000 times more potent than Piracetam and offers additional benefits, such as lower effective doses and influencing memory consolidation and retrieval.
  4. Noopept is considered safe within the recommended dosage range of 10 – 30 mg per day.
  5. In the USA, the best place to buy Noopept is Cosmic Nootropic – Noopept or Science.bio-Noopept Powder or Science.bio-Noopept Solution


Noopept (n-phenylacetyl-l-prolylglycine ethyl ester or GVS-111)
is an ampakine nootropic similar in action to the racetam-class of compounds. Noopept is up to 1000-times more potent than the original racetam, Piracetam.

Noopept was patented by Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals in 1996. Research shows Noopept has similar effects, but works differently than other nootropics in the racetam-family.

Noopept is not considered a true “racetam” because it doesn’t have a 2-oxo-pyrrolidine core.

Noopept does not appear in blood samples when taken as a supplement. Instead it elevates concentrations of cycloprolylglycine (CPG) in the brain.[i]

CPG is a dipeptide consisting of proline and glycine which acts as a modulator of acetylcholine transmission and AMPA receptor function.

Noopept is patented in both Russia and the USA. It is sold as a prescription drug in Russia, and other countries that were part of the Soviet Union. And as a supplement in the United States.

Neurohackers use Noopept to boost cognition, memory and learning. And to improve reflexes, perception, logical thinking and mood.

Noopept helps:

  • Brain Optimization: Noopept increases Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). Critical for neuroplasticity and Long-Term Potentiation. Brain health gets a boost along with long-term memory.
  • Neuroprotection: Noopept prevents the release of excess glutamate in your brain. Glutamate is the brain’s primary excitatory neurotransmitter. When there’s a lack of oxygen in the brain, neurons can’t receive glutamate. This leads to toxic levels of glutamate within brain cells. And can result in neuron damage and death. Diminishing this neurotoxic overload with Noopept is potent neuroprotection.[ii]
  • Brain Waves: Noopept boosts Alpha and Beta brain wave activity. You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.

Overview

Noopept (nphenylacetyllprolylglycine ethyl ester or GVS-111) is often included in the racetam-family of nootropic compounds. But is not a true “racetam” because it does not have a 2-oxo-pyrrolidine nucleus.

Noopept
Noopept

Noopept was developed in Russia where it is called Ноопепт or GVS-111. Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals synthesized Noopept in 1996 based off the endogenous neuropeptide cycloprolylglycine (CPG).

Researchers in Moscow found Noopept similar to Piracetam in not only it’s nootropic effect, but also anxiolytic activity.[iii]

Noopept is a water-soluble ampakine nootropic. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic) refers to one of three glutamate receptors in your brain.[iv]

Noopept could also be considered a Cholinergic compound because it affects acetylcholine levels in the brain.

One of the newer synthetic nootropic compounds, Noopept is known as a cognitive enhancer. And is known for its anxiolytic, or anti-anxiety effects.

As a cognitive enhancer, Noopept is considered to be up to 1000-times more potent than Piracetam. As an ampakine nootropic, it helps increase attention span, alertness and boosts all three levels of memory. Memory formation, retention and recall.

Ampakines tend to have a stimulant effect. But do not produce the same stimulant side effects as Ritalin or coffee from prolonged use.

Noopept vs. Piracetam: What’s the Difference?

Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals developed Noopept in the late 1996 as a peptide analogue of the original nootropic Piracetam.[v]Both Noopept and Piracetam are able to improve learning and memory. And both are able to repair brain damage.

Noopept and Piracetam are both water-soluble. And both Noopept and Piracetam are cognitive enhancers. Both have neuroprotective and anxiolytic (anti-anxiety) qualities.[vi] Both racetams are able to improve learning and memory. And both are able to repair brain damage.

But Noopept has additional benefits not shared with Piracetam. First, the effective dose of Noopept compared to Piracetam is 1,000-times lower. A typical dose of Noopept is 10 – 30 mg while Piracetam is often dosed up to 3 or 4,000 mg.

Second, Piracetam facilitates only the early stages of the memory process. On the other hand, Noopept influences memory consolidation AND retrieval steps as well. But if someone claims “is Noopept a stimulant” it’s simply not true.

So Noopept helps you develop the memory, retain the memory, and then recall what you have stored in memory.[vii]

Noopept also has additional selective anxiolytic (anti-anxiety) action. Researchers believe this is due in part to Noopept’s antioxidant effect, anti-inflammatory action, and the ability to prevent the neurotoxic effect of too much calcium and glutamate.

Noopept can restore the harmony of glutamate and acetylcholine function which can boost cognition, memory, learning, recall, mood and relieve anxiety.

How does Noopept work in the Brain?

Noopept boosts brain health and function in several ways. But two in particular stand out.

  1. Noopept modulates AMPA and NMDA receptors and acetylcholine (ACh) transmission. Noopept boosts the level of cycloprolylglycine (CPG) in the brain. CPG is a dipeptide consisting of proline and glycine which acts as a modulator of acetylcholine transmission, and AMPA and NMDA receptors.

When brain cells are starved of oxygen, glutamate which is your brain’s primary excitatory neurotransmitter, does not work efficiently with neuroreceptors. The result can be a toxic buildup of glutamate within brain cells. Causing neuron damage and ultimately, neuron death.

Noopept modulates neuroreceptor function keeping glutamate transmission at normal levels. Protecting neurons and other brain cells from glutamate damage.

Noopept has also been shown to modulate acetylcholine flow in your brain. Restoring the harmony of glutamate and acetylcholine function not only protects your brain from damage. It can boost cognition, memory, learning, recall, mood and relieve anxiety.

  1. Noopept increases Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and mRNA. NGF and BDNF are directly related to neuroplasticity. This ability to repair and even grow new brain cells can have profound implications. Particularly with someone with neurodegenerative brain damage like Parkinson’s or Alzheimer’s. And even affecting Long-Term Potentiation needed for long-term memory development.

mRNA affects the expression of genes and intracellular communication in brain cells. This ongoing brain signaling and gene expression within brain cells is required for healthy cognition.

One study conducted in Moscow showed long-term use of Noopept boosted NGF, BDNF and mRNA. The animal subjects in this study showed no sign of tolerance. And long-term use of Noopept even potentiated the neurotrophic effect.[viii]

How things go bad

Glutamate is an excitatory relative of GABA. While GABA has a calming effect, glutamate stimulates. Glutamate is the most common neurotransmitter in the central nervous system.Noopept increases Nerve Growth Factor and BDNF which helps reduce age-related cognitive decline.

But glutamate can be toxic to neurons. And too much of it in your brain can kill brain cells. Lou Gehrig’s Disease for example, is caused by excess glutamate.

But glutamate is a pivotal neurotransmitter in the brain. It links the brain circuits involved in memory, learning and perception.

↑ Too much glutamate can kill neurons

↓ Too little glutamate can cause problems with memory, learning and perception

↓ Acetylcholine levels decline

↓ Nerve Growth Factor declines

↓ Brain-Derived Neurotrophic Factor declines

All of these changes can happen at any age. And are a product of the food we eat, what we drink, lifestyle habits, the air we breathe and more.

So Noopept can help for age-related cognitive decline, as well as a student looking to do better in school. By boosting NGF, BDNF and acetylcholine, and controlling glutamate in the brain.

Noopept benefits

Noopept modulates AMPA and NMDA receptors. AMPA receptors are associated with how glutamate and calcium is used in your brain. As a neuroprotective agent Noopept, it’s more of a neuroprotective role.Noopept boosts Alpha and Beta brain wave activity. You become calmer and more creative. And it’s easier to go into a flow state.

Similar to the AMPA receptor, the NMDA receptor is also associated with glutamate and calcium use in your brain.  They work together to modulate how neurons use glutamate.

Noopept modulates levels of glutamate within and between neurons. It prevents glutamate toxicity, and influences Long-Term Potentiation (LTP). LTP is associated with neuroplasticity that allows long-term memories to form.

There is clinical evidence that Noopept boosts communication and neuron signaling. By boosting Alpha and Beta brain wave activity. You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.

Noopept produces an anxiolytic (anti-anxiety) effect. It stimulates dopamine receptors (D2 and D3) and acetylcholine nicotinic receptors. And Noopept also seems to modulate some serotonin receptors. All contributing to a better mood and less anxiety.

Noopept has been shown in the lab to boost Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). NGF and BDNF are both involved in neuroplasticity, and the repair and replacement of damaged brain cells. Resulting in overall better brain health, memory and cognition.[ix]

Noopept is water-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.

How does Noopept feel?

Nootropics users report:

  • Noopept as a study aid. On its own, Noopept increases focus and attention for many neurohackers. Mental arithmetic and grasping difficult concepts is easier.
  • Increased verbal fluidity. Your conversation skills could increase with Noopept. Vocabulary comes easier. Being able to focus contributes to a more balanced dialogue. Neurohackers report being more outgoing, friendly and less self-conscious.
  • Improved mood. With Noopept you may find yourself better able to deal with stressful situations and work issues that normally get you down. Once you get past the first few weeks of unpleasant memories related to PTSD you may find overwhelming emotions will subside. You could feel detached in a pleasant way from painful memories.
  • Music appreciation. Many users report increased pleasure when listening to music while using Noopept. For some it takes music to a different plane. Distinguishing between instruments in sound tracks is easier. As a whole, music sounds better.
  • Long-term memory. Noopept affects NGF and BDNF which affects long-term potentiation. Some neurohackers report memories long forgotten suddenly spring up. Which could be good or bad I suppose depending on the memory. But reports say memories are clear. And if they’re unpleasant there is an emotional detachment shielding from unpleasant feelings.

You should be able to experience the effects of Noopept soon after you take it. It’s water-soluble and enters your cells quickly especially if you take it sublingually.

A word of caution however; don’t go over the recommended 10 – 30 mg per day dose! You will not experience any added benefit, and could bring on unwanted side effects.

There is some debate on the water-solubility of Noopept. It’s not truly fat-soluble but it certainly doesn’t hurt to use a quality “good fat” when taking your Noopept dose.

Clinical studies show Noopept may help prevent the development of Alzheimer’s disease in patients with mild cognitive impairment.

Noopept Clinical Research

Noopept increases Nerve Growth Factor & BDNF

A study published by the Russian Academy of Medical Sciences in Moscow shows that Noopept stimulates Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).

In this study, researchers studied the effect of single and long-term treatment (28 days) of Noopept. They found that one-time treatment boosted mRNA in the cerebral cortex of rats. mRNA is a molecule in brain cells that carries codes from DNA where they specify the amino acid sequence of proteins.

And long-term treatment of Noopept increased Brain-Derived Neurotrophic Factor (BDNF).  The researchers speculated that this sequence of events in the brain plays a role in the restoration of neurons.

Improving neurotrophic synthesis in the hippocampus boosts cognitive function. Particularly consolidation and delayed memory retrieval.

The research team concluded that Noopeptholds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment”.[x]

Noopept boosts Brain Waves

Researchers in Moscow studied the effects of injecting Noopept in rats to see how it would affect brain waves.

The team found that Noopept increased Alpha and Beta brain wave activity throughout the brain.

You experience Alpha waves as you become more relaxed. Alpha waves are associated with super-learning, flow state and joy. Beta waves are associated with concentration, alertness and cognition.

The researchers observed that NMDA receptors were involved with a single injection of Noopept. While AMPA receptors were activated after longer-term use of Noopept.[xi]

NMDA receptors are associated with Long-Term Potentiation (long-term memory) and neuroplasticity. AMPA receptors are associated with increased brain signaling activity. Boosting cognition and memory.

Noopept improves memory

Noopept is known within the nootropic community to enhance cognitive function and memory. And dozens of studies support this claim of better memory when using Noopept.

One study done at the Russian Academy of Medical Sciences in Moscow conducted animal studies, experimenting with Noopept on rats. The animals were trained in passive avoidance response.

The animal’s ability to both form a memory and retain a memory was impaired. But once the rats received a dose of Noopept, they were able to retain a memory and retrieve that memory later.

In other words, their cognitive functions improved. Noopept normalized learning capacity in animals that had damage done to their cerebral cortex. And promoted training ability in rats who started with a hereditary learning deficit.

The researchers noted that “Noopept improves all three stages of memory”. And was most pronounced in those with impaired memory function.[xii]

Another study, again done with rats noted that Noopept stimulated learning after just a single administration. And repeated administration actually increased the number of successful learners among the animals who failed the initial training.[xiii]

Noopept Dosage

Recommended Noopept dosage is 10 – 30 mg per day.

Noopept is very bioavailable and easily crosses the blood-brain barrier.[xiv]Noopept dosage for better learning and memory.

Noopept is sold in tablet, capsule and powder form. Tablets and capsules are usually 10 mg each.

Noopept is primarily water-soluble nootropic, but won’t easily dissolve in water or juice. So it may help if you take it with a meal containing healthy fats. Or with a tablespoon of extra virgin, expeller cold-pressed coconut or olive oil. Or other similar healthy fat to ensure quick absorption.

For even quicker absorption you can use Noopept sublingually. Let the tablet or powder dissolve under your tongue so it can go straight into your bloodstream, and into your brain. Bypassing your digestive system completely.

Noopept Side Effects

Is Noopept safe to use? Noopept is a synthetic nootropic and consider non-toxic. So is considered well-tolerated and safe. As long as you stay within the recommended dosage.

Side effects are rare but can include fatigue, headaches, insomnia or stomach upset. Side effects are often a result of unusually high doses of the nootropic.

Recent research has found that Noopept promotes the level of the Hypoxia-inducible factor 1 (HIF1α) protein. This action helps increase oxygen supply to areas where oxygen levels are low. But it also means that increasing the oxygen supply to tumor cells helps those tumors to proliferate. So, if you have cancer of any kind you should not use Noopept.

Headaches from using Noopept typically happen when you forget to combine it with a good choline supplement. Headaches are often a symptom of a choline deficit in your brain.

Where to buy Noopept

Noopept is sold in tablet, capsule and powder form. Tablets and capsules are usually 10 mg each.

In the USA, you can buy Noopept from Cosmic Nootropic – Noopept

And you can also get Noopept powder or liquid from Science.bio, who have just opened their store again. Science.bio-Noopept Powder or Science.bio-Noopept Solution who sell Noopept as a “research” compound. It is sold to be used in an academic laboratory research setting. They go on to state “nothing we sell is intended for nor is it manufactured for diagnostic or therapeutic purposes in humans.”

In Russia and some other Eastern European countries, Noopept is a prescription drug.

Frequently Asked Questions

Students who use Noopept as a study aid say it helps them with focus and attention. Mental arithmetic and grasping difficult concepts is easier. Many say Noopept helps with verbal fluidity. They report being more outgoing, friendly and less self-conscious.

With Noopept you may find yourself better able to deal with stressful situations and work issues that normally get you down. Many users report increased pleasure when listening to music while using Noopept.  And Noopept seems to help reconnect brain circuits so it is easier to remember long-lost memories. And I personally find that when I use Noopept, I’m more productive.

Noopept really does work. See the section above on How does Noopept feel? And see what real users say about their experience with Noopept for studying, listening to music, improving verbal fluidity, and putting them in a better mood.

Noopept has not been approved by the FDA in the USA as a dietary supplement. So supplement bottles will often say the contains contain a “research compound”. It is NOT illegal to buy or own Noopept in America.

Noopept is not a banned substance in America. Neither has it been approved by the FDA as a dietary supplement. Noopept has not been “scheduled” in Australia, is available OTC in Brazil, but Noopept may be held up in customs in Canada, and so on. For other countries around the world, see my article Are Nootropics Legal in My Country? 

Nootropics Expert Recommendation

Noopept 10 – 30 mg per day

Nootropics Expert has Tested and Approved the use of Noopept as a nootropic supplement.I recommend using Noopept as a nootropic supplement.

Your body does not make Noopept on its own. So to get its benefits you must take it as a supplement.

Noopept is especially helpful for those looking to boost cognition, memory and recall. This nootropic helps boost the activity of acetylcholine in your brain. It modulates glutamate receptors which normalizes optimal neurotransmitter function. And increases Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) which helps the neuroplasticity needed for Long-Term Potentiation.

Noopept is also particularly useful to students and executives who want to boost cognition, learning and memory. My experience using Noopept shows it helps boost study scores, workflow, learning and memory.

Noopept also helps improve verbal fluidity and sociability. Words seem to come easily, and vocabulary you didn’t know you had access to come into play.

Music sounds richer and fuller, and your listening experience enters a new level of music appreciation.

You should stack Noopept with a good choline supplement like Alpha GPC or CDP-Choline. It helps boost neural acetylcholine, so demands the presence of more choline in your brain.

You should not exceed Noopept doses of more than 30 mg per day. This nootropic supplement is highly bioavailable and passes through the blood-brain barrier quite easily. Start with 10 mg and see how you respond.

In the USA, you can buy Noopept from Cosmic Nootropic – Noopept

And you can also get Noopept powder or liquid from Science.bio, who have just opened their store again. Science.bio-Noopept Powder or Science.bio-Noopept Solution

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Gudasheva T.A. et. Al. “The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine.” European Journal of Drug Metabolism and Pharmacokinetics. 1997 Jul-Sep;22(3):245-52. (source)

[ii] Us K.S., Klodt P.M., Kudrin A., Sapronova Ya., Ostrovskaya R.U., Ugryumov M.V., Rayevsky K.S. “The effect of the synthetic neuroprotective dipeptide noopept on glutamate release from rat brain cortex slices” Neurochemical Journal June 2007, Volume 1, Issue 2, pp 138-142 (source)

[iii] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)

[iv] Purves D., Augustine G.J., Fitzpatrick D., et al., editors. “Glutamate Receptors” Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. (source)

[v] Ostrovskaya R.U., Mirsoev T.K., Romanova G.A., Gudasheva T.A., Kravchenko E.V., Trofimov C.C., Voronina T.A., Seredenin S.B. “Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.” Bulletin of Experimental Biology and Medicine. 2001 Oct;132(4):959-62. (source)

[vi] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)

[vii] Ostrovskaia R.U., Gudasheva T.A., Voronina T.A., Seredenin S.B. “[The original novel nootropic and neuroprotective agent noopept].” in Russian Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. (source)

[viii] Ostrovskaya R.U., Gudasheva T.A., Zaplina A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., Seredenin S.B. “Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bulletin of Experimental Biology and Medicine. 2008 Sep;146(3):334-7. (source)

[ix] Ostrovskaia R.U., Vakhitova Iu.V., Salimgareeva M.Kh., Iamidanov R.S., Sadovnikov S.V., Kapitsa I.G., Seredenin S.B. “[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].” in Russian Eksp Klin Farmakol. 2010 Dec;73(12):2-5. (source)

[x] Ostrovskaya R.U., Gudasheva T.A., Zaplina A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., Seredenin S.B. “Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bulletin of Experimental Biology and Medicine. 2008 Sep;146(3):334-7. (source)

[xi] Vorobyov V., Kaptsov V., Kovalev G., Sengpiel F. “Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors.” Brain Research Bulletin. 2011 May 30;85(3-4):123-32. (source)

[xii] Romanova G.A., Shakova F.M., Gudasheva T.A., Ostrovskaya R.U. “Impairment of learning and memory after photothrombosis of the prefrontal cortex in rat brain: effects of Noopept.” Bulletin of Experimental Biology and Medicine. 2002 Dec;134(6):528-30. (source)

[xiii] Ostrovskaya R.U., Mirsoev T.K., Romanova G.A., Gudasheva T.A., Kravchenko E.V., Trofimov C.C., Voronina T.A., Seredenin S.B. “Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.” Bulletin of Experimental Biology and Medicine. 2001 Oct;132(4):959-62. (source)

[xiv] Boiko S.S., Ostrovskaya R.U., Zherdev V.P., Korotkov S.A., Gudasheva T.A., Voronina T.A., Seredenin S.B. “Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration.” Bulletin of Experimental Biology and Medicine. 2000 Apr;129(4):359-61. (source)

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Join The Discussion - 186 comments

yang
March 25, 2024

Which nootropic drug best improves computational logic abilities

    David Tomen
    March 27, 2024

    L-Tyrosine, Bacopa Monnieri extract and Lion’s Mane Mushroom extract.

Daniel
March 25, 2024

studies suggest that the pharmacological properties of Noopept are derived from its action as an activator of Hypoxia-inducible factor (HIF-1).
https://doi.org/10.1134/S1607672920050129
https://doi.org/10.32607/20758251-2016-8-1-82-89

Will you update the article?

    David Tomen
    March 27, 2024

    Daniel, I will update my review of Noopept to reflect this finding. But in the Side Effects section on this review. Because while Noopept does activate HIF-1 this also means that it is a cancer promoter if that cancer already exists. This increase in oxygen supply to tumor cells helps them to grow. Researchers are now trying to find HIF-1 inhibitors for exactly this reason.

Kacper
October 8, 2023

I’ve been taking noopept for two years, but I keep having trouble with when I should stop taking it. I have read that noopept should be taken for about 3 months, followed by a break of about a month. This is quite inconvenient due to the duration of the academic year, and above that, the article above mentions that tolerance to noopept has not been observed. In that case, could I take it continuously for 9 months of the year with possible weekly breaks during? Or are breaks not necessary at all? Another question that puzzles me is whether it is worth discontinuing noopept during the three-month holiday break, or continuing at least the minimum dose to maintain long-term effects?

    David Tomen
    October 10, 2023

    Kacper, the half life of Noopept is approx. 10 minutes. So, you’ll get its benefits for max. a couple of hours. There is no reason to cycle Noopept because it does not last long in your system.

      Dert
      February 15, 2024

      I think it makes sense, because it can change the brain, and also affect cyclic proline-glycine and Igf1. And other mechanisms, I think cyclic intake/reception in courses is a good solution.

John
September 23, 2023

Some studies suggest that the pharmacological properties of Noopept are derived from its action as an activator of Hypoxia-inducible factor (HIF-1).
https://link.springer.com/article/10.1134/S1607672920050129
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837574/

    David Tomen
    September 23, 2023

    John, great find and further explains why Noopept is so effective. Looks like I need to further update my review of Noopept. Thank you.

Alic
May 26, 2023

Hi,

I have anxiety disorder, social anxiety, lack of confidence, lack of verbal fluidity and mood swings.
Would like to know:

1. Which would be better, Noonpept or Aniracetam? Or can take both?
2. If I take Noonpept would be fine to take 30 mg capsules? No other option in my country.

Thank you : )

    David Tomen
    May 28, 2023

    Alic, I would not recommend either as a first attempt of relieving your symptoms. For example, studies and anecdotal reports show L-Theanine, Phosphatidylserine (PS), Uridine Monophosphate, and CDP-Choline are effective for improving verbal fluidity. You could try those supplements first and that may also take care of the other issues you mention.

    Then if you decide to try either, I recommend Aniracetam. It’s better for verbal fluidity than Noopept in my experience. But that is assuming a healthy brain. Start with the fundamentals first and get your brain back in good condition and then introduce more sophisticated nootropics.

      Chad
      June 22, 2023

      After reading this article I was just getting ready to ask why Noopept or something like NSI-189 isn’t a part of your beginner’s recommended stack. Looks like I might have found at least part of the reason why with your response here. Could I ask you to go into a little more detail about some of these seemingly more powerful nootropics or maybe point me to an article where you might have addressed that?
      Another question…I’ve been in and around healthy eating and natural and alternative medicine for years now. I’m an organic gardener and deliver weekly to health food stores around the state. Yet I’ve never run into or ever heard of “nootropics”. Strange. Just a few weeks ago a guy stopped by my house asking for directions. As we talked I found out he’s a biochemist with a doctorate degree who spent his career working for a company in California. It’s rare to have someone with that kind of credentials here in rural KY. He has an adult son that was damaged by vaccines as a child and so these kind of things are personal to him. After challenging him with ideas of CBD oil or where I heard of someone micro-dosing magic mushrooms he went into details about studies where maharaja and even LSD were micro-dosed before he settle on the more sensible idea, at least to me, of nootropics. Why is this not very well known among nutritionist and those into healthy eating and supplements? Is it that new or for some reason unwelcome amongst that crowd?

        David Tomen
        June 25, 2023

        Chad, unless you have broadband where you live chances are nootropic supplements have slipped by you. Take a look at my Big Nootropics List (https://nootropicsexpert.com/nootropics-list/) for 102 different supplements that support the human brain. Some on that list are likely not new to you but there are called “nootropics” because they support the brain.

        But you do not need things like Noopept or any of the racetams to get the job done. Those are nice “add-ons” once you have more experience with these supplements. But they are not necessary.

Glu
May 8, 2023

I wonder how effective it is for bdnf and ngf compared to other nootropics, maybe it is not as effective as many natural nootropics.
And its effect on glutamate, how strong is it? Can it be taken together with other racetams that affect glutamate and nmda receptors?

    David Tomen
    May 8, 2023

    It seems to be very effective. But we only have animal-based clinical studies and they’re all in Russian. Scroll down both of these studies and see the studies linked to below the main Abstract: https://pubmed.ncbi.nlm.nih.gov/21395007/ and https://pubmed.ncbi.nlm.nih.gov/12596521/

    There has been no comparison that I know of between Noopept and other natural supplements that increase NGF and BDNF.

    I’ve used Noopept while using Aniracetam for a month or two, and there was no problem. But I have not tried it with any of the other racetams. Maybe someone else reading this thread has and will comment.

Dan
April 20, 2023

Stimulates and/or increases BDNF, is this the same thing? If not, does stimulating BDNF result in decreased levels of something?

    David Tomen
    April 21, 2023

    Dan, Noopept stimulates the production of Nerve Growth Factor and BDNF according to studies. That would be an increase in BDNF.

George
April 12, 2023

Hi I am thinking of buying noopept.
I am wondering what is the difference in terms of performance between noopept and other racetams.
Will I feel the effects of noopept immediately or do I need to take it for a few days.
Will I build a tolerance to noopept if I take it regularly?

Thanks

    David Tomen
    April 18, 2023

    George, read the section above on “how does Noopept feel? and then read the same section for each of the racetams and you’ll have your answer.

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