Vitamin B6 (P-5-P) dosage

Vitamin B6 (Pyridoxine)

David Tomen
David Tomen
15 minute read
Vitamin B6 is known to enhance alertness, cognition, energy, elevate mood, lower anxiety and normalize homocysteine levels

Vitamin B6 (Pyridoxine, Pyridoxal, Pyridoxamine) is one of 8 B-vitamins. B6 is water-soluble and found in every single cell in your body.

Vitamin B6 a required coenzyme for the synthesis of dopamine, epinephrine, GABA, melatonin, norepinephrine, and serotonin.[i]

As a nootropic, Vitamin B6 is crucial for the synthesis of these neurotransmitters. Even mild deficiency results in down-regulation of GABA and serotonin synthesis. Leading to poor sleep, behavior, cardiovascular function, and the loss of hypothalamus-pituitary control of hormone secretion.[ii]

Vitamin B6 was first isolated in the 1930’s. The “6” in Vitamin B6 refers to six common forms, namely pyridoxal, pyridoxine (pyridoxal), pyridoxamine, and their phosphorylated forms.

Pyridoxal phosphate (pyridoxal 5′-phosphate, P-5-P, PLP), the active form of Vitamin B6 is said to be the most versatile organic cofactor in biology. More than 140 distinct enzyme activities in your body and brain depend on PLP.[iii]

The biochemical reactions in your body by PLP-dependent enzymes include the making of hemoglobin, amino acid synthesis and fatty acid metabolism.

PLP also functions as a coenzyme that catalyzes the release of glucose from stored glycogen. Turning it into the type of energy your brain cells can use for fuel.

Vitamin B6 (Pyridoxine) helps:

  • Cerebral Circulation: Vitamin B6 is needed to regulate homocysteine. High homocysteine levels are linked to inflammation that can lead to blood vessel damage. And possible plaque buildup leading to heart attack or stroke.
  • Neurotransmitters: Vitamin B6 is a cofactor in the synthesis of neurotransmitters dopamine, epinephrine, GABA, norepinephrine, and serotonin. Affecting alertness, cognition, learning and memory and mood.
  • Mood: Vitamin B6 helps increase brain serotonin and dopamine levels. Decreasing anxiety, depression, fatigue and pain.


Vitamin B6 (Pyridoxine, Pyridoxal, Pyridoxamine) is one of 8 water-soluble B-vitamins that are absolutely vital to the highly optimized brain. And is essential to all forms of life.

Vitamin B6 (pyridoxal 5′-phosphate)

Vitamin B6 is found in every cell in your body and brain. Vitamin B6 is a necessary cofactor in the folate cycle. And contributes to the synthesis of neurotransmitters dopamine, GABA, melatonin, norepinephrine, and serotonin.

Vitamin B6 has a direct effect on your immune system, gene transcription and expression. And is involved in glucose regulation.

Vitamin B6 protects your blood-brain barrier by regulating homocysteine levels. Excess homocysteine can damage blood vessel linings and neurons, resulting in cognitive decline. B6 also helps form myelin, the fatty sheath that surrounds and protects neurons.

Pyridoxal phosphate (pyridoxal 5′-phosphate, P-5-P, PLP), the active form of Vitamin B6 helps control inflammation in your brain. Low levels of PLP are associated with severe inflammation in the brain.[iv] Leading to neurodegenerative diseases like Alzheimer’s and Parkinson’s. And contributes to heart disease, arthritis, inflammatory bowel disease and diabetes.

Foods rich in Vitamin B6 include bananas, beef, chickpeas, pistachios, pork, potatoes, and turkey.

Even mild Vitamin B6 deficiency can deplete neurotransmitters which leads to cognitive decline. Resulting in brain fog, anxiety, depression and overall poor mental performance.


How does Vitamin B6 (Pyridoxine) work in the Brain?

Vitamin B6 (Pyridoxine) boosts brain health and function in several ways. But two in particular stand out.

  1. Vitamin B6 is a cofactor in neurotransmitter synthesis. Vitamin B6 and its role in amino acid metabolism makes it a critical component for the synthesis of all major neurotransmitters including dopamine, GABA, melatonin, norepinephrine and serotonin.

The synthesis of these neurotransmitters is entirely dependent on B6 levels in your brain. Even mild deficiency results in less GABA and serotonin synthesis. Resulting in poor sleep patterns, irritability, anxiety, depression, panic attacks and stress.

Low dopamine and norepinephrine levels due to lack of Vitamin B6 leads to depression and loss of memory.

B-Vitamins play a crucial role in optimized cognition. And should be part of every nootropic stack. Unfortunately, there is very little talk in nootropic circles of these vitamins.

A review of vitamin intakes in Germany, the UK, the Netherlands and the USA was conducted to compare vitamin intake to national recommendations. And the study found intake was below recommendations of even the most critical of vitamins. Including B-Vitamins.

The authors of the study noted that this gap exists in vitamin intake and national recommendations for a significant portion of the population. Even though diverse foods were available.[v]

  1. Vitamin B6 helps reduce inflammation. B6 along with Vitamin B12 and folate help control homocysteine. High levels of homocysteine have been implicated in inflammation leading to damage of blood vessels. Causing heart and neurodegenerative disease.

But homocysteine is not the bad guy when it’s in balance. We need this amino acid for the synthesis of cysteine which is a precursor to the master antioxidant glutathione.

It’s when homocysteine gets out of control that causes problems in our brain and our cardiovascular system. One of the issues with aging is brain shrinkage. Gray matter shrinkage in key areas of the brain have been identified in Alzheimer’s Disease.

Professor David Smith at Oxford University in England conducted a study with 156 elderly patients (age 70+) who were suffering mild memory loss and higher than average levels of homocysteine. High levels of homocysteine are typically the result of deficiencies in Vitamins B6, B12 and folic acid.

For 2 years, the elderly patients received 20 mg of Vitamin B6, 0.5 mg of Vitamin B12 and 0.8 mg of folic acid (folate). The findings of this study were dramatic. Those who took only placebo experienced brain atrophy of 5.6% over those 2 years. Brain shrinkage in those who took the B-Vitamins had only 0.6% brain shrinkage.

This study showed a 7-fold difference in gray matter shrinkage in just 2 years. Vitamin B6 along with B12 and folic acid helped protect brain density. And specifically in the areas of the brain vulnerable to Alzheimer’s.[vi]

How things go bad

Vitamin B6 deficiency is a lot more common than you’d expect in our modern society. B6 from diet alone, especially for vegetarians and the aged is not adequate to supply what our body and brain needs.

Concentration, memory, learning, and recall decline

↑ Anxiety, confusion, irritability, and depression increase

↑ Homocysteine and inflammation increases

↓ Energy levels decline

Vitamin B6 is critical for nerve function. And a deficiency can result in psychiatric disorders, seizures, migraines, chronic pain and mood disorders like depression.

Vitamin B6 (Pyridoxine) benefits

Vitamin B6 is involved in the regulation of cognition function and mood. B6 is a cofactor in the neurotransmitters directly related to alertness, anxiety, attention, concentration, memory and mood.[vii]Vitamin B6 improves concentration and focus

When you add Phenylalanine to your stack to boost the neurotransmitters dopamine, epinephrine, norepinephrine and melatonin, it will not work without Vitamin B6. B6 is a critical cofactor in the synthesis of these neurotransmitters.

The same holds true for any nootropic you use with the intention of boosting any of the major neurotransmitters in your brain. Vitamin B6 is absolutely required if you want them to do their job.

You need Vitamin B6 to help control inflammation in your brain. B6 suppresses the inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).[viii]

Vitamin B6 is essential for controlling elevated homocysteine levels which can damage blood vessels crucial for optimal cerebral circulation.

A 2008 review of research in the previous 10 years covering a total of 77 studies and 34,000 subjects demonstrated the relationship between cognitive deficits and dementia and the status of folate, or vitamins B12, or B6 and homocysteine levels.[ix]

Vitamin B6 is a coenzyme involved in the synthesis of Heme, an iron-containing component of hemoglobin. Hemoglobin is found in red blood cells and is critical to their ability to transport oxygen throughout your body and brain.

Vitamin B6 concentrations in your brain are about 100-times higher than levels in your blood. B6 is critical to the highly optimized brain.

How does Vitamin B6 (Pyridoxine) feel?

Vitamin B6 improves moodVitamin B6 is water-soluble, and has been shown to improve energy and mood. Both men and women report a boost in libido when supplementing with B6.

Women report that Vitamin B6 helps control mood swings resulting from PMS.

Neurohackers report that Vitamin B6 helps sleep and creates vivid dreams. Many prefer it over melatonin for sleep.

Those suffering with carpal tunnel syndrome have consistently found relief in symptoms by using Vitamin B6. Many find B6 useful for tendonitis and other joint pain.

Some report that supplementing with Vitamin B6 helps prevent sunburn. And a few have found relief from tinnitus by using B6.

Those dealing with ADHD have found that using Vitamin B6 has helped reduce the reliance on ADHD meds. Likely because B6 is a cofactor in the synthesis of dopamine and norepinephrine.

Vitamin B6 boosts neurotransmitters

Vitamin B6 Clinical Research

Vitamin B6 (Pyridoxine) promotes vivid dreams

Read the reviews of those supplementing with Vitamin B6 and you’ll come across several reports of improved sleep and vivid dreams. And we have science to back this up.

12 college students participated in a double-blind, placebo-controlled trial to examine the various claims that Vitamin B6 increase dream vividness, and the ability to recall dreams.

The students were given 100 or 250 mg of Vitamin B6 or a placebo prior to bedtime for 5 consecutive days. Morning reports indicated a significant difference in ‘dream-salience scores’. This is a composite score measuring dream vividness, bizarreness, emotionality and color.

The study suggests that Vitamin B6 may act by increasing arousal during rapid eye movement (REM) sleep. The researchers hypothesized it had something to do with the conversion of tryptophan to serotonin.[x]

Vitamin B6 (Pyridoxine) may prevent Parkinson’s Disease

A study out of the Netherlands suggests that Vitamin B6 could cut the risk of Parkinson’s Disease in half.

Researchers in Rotterdam recruited 5,289 people over the age of 55 and assessed their dietary intake using food questionnaires. This study looked into reports that increased levels of the amino acid homocysteine might promote Parkinson’s Disease.

Numerous studies have reported that higher intakes of folate, Vitamin B12 and Vitamin B6 decrease blood homocysteine levels and could offer protection from Parkinson’s.

It has also been proposed that Vitamin B6 could provide antioxidant effects. And could reduce the risk factor for Parkinson’s by a mechanism that is not related to homocysteine.

After 9.7 years of follow-up, 72 new cases of Parkinson’s Disease had been diagnosed. The average Vitamin B6 intake was 1.63 mg per day, average B12 intake was 5.3 mcg per day, and average folate intake was 218.7 mcg per day.

No significant reductions in the risk of Parkinson’s were found for folate or Vitamin B12. But when the researchers limited their calculations to the 66% of participants who were smokers, they found that the protective effects of high Vitamin B6 intake appeared limited to this group.

The researchers noted that several studies indicate the protective effects of nicotine on brain cells, and reduced the risk of Parkinson’s. Which suggests that Vitamin B6 plus nicotine provides mutually reinforcing beneficial effects.

Since folate and Vitamin B12 showed no relationship to reduced Parkinson’s, the researchers concluded it was not homocysteine that was behind the newly diagnosed patients.

The study authors said that the apparent benefits of B6, “may point towards an alternative mechanism… because several lines of evidence suggest neuroprotective properties of Vitamin B6 through antioxidant capacities”.

Oxidative stress has been shown to be prominent in Parkinson’s Disease, and higher Vitamin B6 intake may reduce Parkinson’s risk through its antioxidant effects.[xi]

Vitamin B6 (Pyridoxine) to beat Panic Attacks

Reduced serotonin levels are known as one of the causes of panic attacks and hyperventilation attacks. Serotonin is synthesized from tryptophan. And for the synthesis of serotonin, you need Vitamin B6 and iron.

The clarify how this works, researchers at Atago Hospital in Japan checked the blood levels (vitamins B2, B6, and B12 and iron) of patients who came into the ER with a panic attack or hyperventilation attack.

The team measured parameters in 21 patients compared to 20 healthy volunteers. The study found that both Vitamin B6 and iron levels were significantly lower in the panic and hyperventilation attack people than in the healthy volunteers.

There was no significant difference in Vitamin B2 or B12. The study concluded that low blood concentrations of Vitamin B6 and iron are involved in panic and hyperventilation attacks.[xii]

Vitamin B6 recommended dosage

Recommended dosage of pyridoxal 5′-phosphate (P-5-P) form of Vitamin B6 is up to 100 mg per day. P-5-P is the only ‘active’ form of B6 available and preferred for nootropic usage. (see “Side Effects” for toxicity with Vitamin B6).Vitamin B6 (P-5-P) dosage

The enzyme L-dopa decarboxylase depends on P-5-P to convert L-DOPA into dopamine. And is involved in the final stages of serotonin synthesis.[xiii]

An analysis of data collected in the USA in 2003-2004 indicated that Vitamin B6 intake from food averaged about 1.9 mg per day.[xiv] The problem is some forms of Vitamin B6 from plants (pyridoxine glucoside) are not very bioavailable.

In most cases, and certainly that of neurohackers using nootropics to boost neurotransmitters or improve mood, Vitamin B6 from diet alone is not enough.

The study mentioned above shows that even those supplementing with 2 mg per day of Vitamin B6 or less had blood levels of B6 much too low.

Vitamin B6 is water-soluble and you excrete it in urine, so supplementation daily is critical.

Women taking birth control pills, or who are menstruating are usually low in Vitamin B6. Those following a strict vegetarian diet are also typically deficient in B6.

Drugs like L-DOPA, anti-tuberculosis medications, metal chelators, methylxanthines to treat respiratory conditions, and long-term use of NSAIDs, anti-convulsants, and phenobarbital all inhibit Vitamin B6 metabolism. If you are using any of these drugs you are likely low in B6.

You can safely dose up to 100 mg per day of Vitamin B6 with no toxic effects.

Vitamin BSide Effects

Vitamin B6 (Pyridoxine) is non-toxic at recommended doses. So is considered well-tolerated and safe.

Side effects are rare but very high single doses can include stomach upset, nausea or diarrhea.

Pyridoxine neuropathy is a form of nerve damage caused by high doses of Vitamin B6 when taken for extended periods. Symptoms are loss of coordination, extreme skin sensitivity, bone pain, muscle weakness, and numbness.

Pyridoxine neuropathy has been reported in doses of Vitamin B6 of 200 mg to 5 grams per day for extended periods. When dosing was stopped, symptoms usually disappeared.[xv] [xvi]

This nerve damage has been identified as the destruction of axons and neurons which is reversible at lower levels of toxicity. And irreversible at higher levels of Vitamin B6 toxicity.[xvii] [xviii]

Type of  Vitamin B6 to buy

Vitamin B6 from food and supplements comes in the form of Pyridoxine, Pyridoxal, and Pyridoxamine.

These forms of B6 are considered ‘inactive’, but are converted in your liver and intestines into the active form of Vitamin B6 called pyridoxal 5′-phosphate (P-5-P).

For nootropic use, look for a P-5-P supplement or a B-Complex formula that uses P-5-P.

Most multivitamins also include some form of Vitamin B6 in their formula. But many of these multis don’t contain enough for optimum health. And many have an inactive version of this nutrient.

The Performance Lab® NutriGenesis Multi offers a nature-identical form of Vitamin B6 and is now my favorite daily multivitamin/mineral supplement.

I prefer the Performance Lab® multi because it’s more potent, it’s biologically active and I’ve found to be a far more effective multi compared to every other multivitamin supplement I’ve ever used.

Performance Lab® uses their own priority NutriGenesis® vitamins and minerals which are grown on probiotic, plant and yeast cultures in a state-of-the-art lab.

Nootropics Expert Recommendation

Vitamin B6 as pyridoxal 5′-phosphate (P-5-P) up to 100 mg per day

Nootropics Expert Tested and ApprovedI recommend using Vitamin B6 as a nootropic supplement.

Your body does not make Vitamin B6 on its own. So to get its benefits you must get it from food, or take it as a supplement.

Vitamin B6 is especially helpful for those suffering from low energy levels, anxiety, depression, and chronic pain.

Experience shows Vitamin B6 helps stop and reverse the symptoms associated with high homocysteine levels. B6 in combination with folic acid and Vitamin B12 will lower high homocysteine implicated in heart disease and Alzheimer’s.

Vitamin B6 is also particularly helpful to students and executives who want to boost cognition, learning, memory and mood. Because it raises dopamine, GABA, norepinephrine, epinephrine and serotonin levels in your brain.

Vitamin B6 can help those dealing with ADHD because it helps synthesize dopamine and serotonin in your brain. ADHD symptoms should decline and you may be able to cut back on your ADHD meds.

Vitamin B6 is a must have addition for any nootropic stack. If you are using any nootropics to raise dopamine, GABA or serotonin levels, you absolutely need extra Vitamin B6.

At the very minimum every neurohacker should be using a multivitamin every day that includes Vitamin B6. The best multi I’ve found and use every day is the Performance Lab® NutriGenesis Multi for men or women.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Clayton P.T. “B6-responsive disorders: a model of vitamin dependency.” Journal of Inherited Metabolic Disease. 2006 Apr-Jun;29(2-3):317-26. (source)

[ii] Kennedy D.O. “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review” Nutrients. 2016 Feb; 8(2): 68. (source)

[iii] Percudani R., Peracchi A. “A genomic overview of pyridoxal-phosphate-dependent enzymes” EMBP reports 2003 Sep; 4(9): 850–854. (source)

[iv] Sakakeeny L., Roubenoff R., Obin M., Fontes J.D., Benjamin E.J., Bujanover Y., Jacques P.F., Selhub J. “Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults.” Journal of Nutrition. 2012 Jul;142(7):1280-5. (source)

[v] Troesch B., Hoeft B., McBurney M., Eggersdorfer M., Weber P. “Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries.” British Journal of Nutrition. 2012 Aug;108(4):692-8 (source)

[vi] Douaud G., Refsum H., de Jager C.A., Jacoby R., Nichols T.E., Smith S.M., Smith A.D. “Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment” Proceedings of the National Academy of Sciences USA vol. 110 no. 23 (source)

[vii] Malouf R., Grimley Evans J. “The effect of vitamin B6 on cognition.” Cochrane Database System Revue. 2003;(4):CD004393. (source)

[viii] Huang S.C., Wei J.C.C., Wu D.J., Huang Y.C. “Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis” European Journal of Clinical Nutrition (2010) 64, 1007–1013 (source)

[ix] Smith A.D. “The worldwide challenge of the dementias: a role for B vitamins and homocysteine?” Food Nutrition Bulletin. 2008 Jun;29(2 Suppl):S143-72. (source)

[x] Ebben M., Lequerica A., Spielman A. “Effects of pyridoxine on dreaming: a preliminary study.” Perceptual and Motor Skills. 2002 Feb;94(1):135-40. (source)

[xi] De Lau L.M.L., Koudstaal P.J., Witteman J.C.M., Hofman A., Breteler M.M.B. “Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease” Neurology July 25, 2006 vol. 67 no. 2 315-318 (source)

[xii] Mikawa Y., Mizobuchi S., Egi M., Morita K. “Low serum concentrations of vitamin B6 and iron are related to panic attack and hyperventilation attack.” Acta Medica Okayama. 2013;67(2):99-104. (source)

[xiii] Allen G.F., Neergheen V., Oppenheim M., Fitzgerald J.C., Footitt E., Hyland K., Clayton P.T., Land J.M., Heales S.J. “Pyridoxal 5′-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states.” Journal of Neurochemistry. 2010 Jul;114(1):87-96 (source)

[xiv] Morris M.S., Picciano M.F., Jacques P.F., Selhub J. “Plasma pyridoxal 5′-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004.” American Journal of Clinical Nutrition. 2008 May;87(5):1446-54. (source)

[xv] Parry G.J., Bredesen D.E. “Sensory neuropathy with low-dose pyridoxine.” Neurology. 1985 Oct;35(10):1466-8. (source)

[xvi] Dalton K., Dalton M.J. “Characteristics of pyridoxine overdose neuropathy syndrome.” Acta Neurologica Scandinavia. 1987 Jul;76(1):8-11. (source)

[xvii] Xu Y., Sladky J.T., Brown M.J. “Dose-dependent expression of neuronopathy after experimental pyridoxine intoxication.” Neurology. 1989 Aug;39(8):1077-83. (source)

[xviii] Perry T.A., Weerasuriya A., Mouton P.R., Holloway H.W., Greig N.H. “Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy.” Experimental Neurology. 2004 Nov;190(1):133-44. (source)

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Join The Discussion - 111 comments

February 12, 2024

hi david

life extension has 250mg of B6, is it okay to take it ?

    David Tomen
    February 12, 2024

    Salem, only if it is the active form of Vitamin B6 called pyridoxal 5′-phosphate (P-5-P)

      February 12, 2024

      hi David,

      i checked it, its pyridoxine HCl … whats difference ?

        David Tomen
        February 13, 2024

        pyridoxine is synthetic and P-5-P is natural (the same form you would get from food).

Andrew Richardson
December 6, 2023

I want to take B6 unfortunate I cant get vitamin b6 levels checked in my country for some stupid reason
now all i am concerned about is toxicity.

the issue is too high or too low can cause the same issues!

so sometime when i take a full b-complex I feel i get too much energy
I eat plenty of chicken and chick pea so maybe it fine

so if i took it once a week at 100MG would this be safe

also you said B6 alone can cause heart attack how much realistically would you have to take to cause this

i try to make sure i take b6 and b12 at the same time tho

    David Tomen
    December 7, 2023

    Andrew, doing labs on your B-Vitamins is not that important. What is critical is B6, B9 & B12 work in synergy to keep homocysteine levels healthy. A deficiency in any one of those 3 will drive up homocysteine levels which increased blood pressure which can lead to a heart attack. Better to use a BioActive B-Complex. But depending on your age you may be better off using a BioActive Multi instead which will contain the methyl versions of those B-Vitamins.

Andrew Richardson
December 4, 2023

iI have vitamin B6 at 20MG i take it once a week with a b12 supplement however its thew active form p5p my question is i have no idea if i have the MTHFR mutation

some people say vitamin b6 is toxic if im taking 20MG once a week an the daily recommended intake is 2mg that’s giving my body what it needs an is not over doing it correct . im worry about this particular one as some people talk about b6 toxicity so if my body say is methylating to quick is the active form worse ? or is it always best to take the active form regardless

    David Tomen
    December 9, 2023

    Andrew, Pyridoxine neuropathy has been reported in doses of Vitamin B6 (Pyridoxine) of 200 mg to 5 grams per day for extended periods. When dosing was stopped, symptoms usually disappeared. This has NOT been a problem if you are using the natural form pyridoxal 5′-phosphate (P-5-P).

    Using them once per week does not make any sense because these vitamins are water soluble. And what your body does not use goes into the toilet or urinal the same day. Better to sue a BioActive B-Complex daily.

    If you are worried about a MTHFR mutation I suggest Googling “what does a MTHFR mutation feel like?“.

Jamie Hogs
November 13, 2023

Vitamin B6 has truly been a mood-lifter for me. It’s amazing how this little nutrient can make such a difference in how I feel and handle the daily challenges of family life. It’s my daily support for combating fatigue and staying positive. I’ve found that a high-quality Vitamin supplement is a must for busy moms like me.

    David Tomen
    November 13, 2023

    Jamie, individual B-Vitamins can have an amazing benefit depending on what you’re dealing with. But you are correct that they should not be used solo. Because increasing Vitamin B-6 and not Vitamin B-9 and/or B-12 will increase homocysteine which can cause a hypertensive crisis (i.e. heart attack).

September 18, 2023

Very informative posts/articles written by an ND owner, using research, I’m sure a lot of new information for your article.

    David Tomen
    September 22, 2023

    Dan, this is already covered in my above review and is summarized in that reddit thread as “Pyridoxine is the issue, not P5P”.

September 18, 2023

What about Pyridoxamine and other interesting forms of vitamin B6? Or are all active forms absolutely interchangeable in all functions?

    David Tomen
    September 22, 2023

    See my other comment.

August 27, 2023

Is it possible to have permanent neuronal damage from this? I unknowingly took 2 times 200 mg of pyridoxine hydrochloride and both times I had very strange unpleasant and powerful tingling and weakness sensations, especially in my legs.

    David Tomen
    August 31, 2023

    Dan, scroll up and read the section called “Vitamin B6 Side Effects”.

June 29, 2023

Doses of about 50 mg per day help many people to reduce unreasonably high prolactin.
At the same time, their sleep, on the contrary, improves greatly.

    David Tomen
    July 2, 2023

    Daniel, show me the proof that Vitamin B6 reduces prolactin levels. I mean peer-reviewed clinical studies. Not some other blog.

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