What are you looking for in a nootropic stack to help you achieve your goals in 2022? That’s the question I asked of the Nootropics Expert® community. And this is what you said.
You were asking for specific nootropic stacks for cognitive issues including:
- Mental clarity
- Mental/chronic fatigue
Experienced neurohackers will tell you that each of these cognitive issues can be helped with nootropic supplements. But there is no one-pill solution. It will take a stack of at least 4 – 5 nootropics to resolve each cognitive issue.
You can buy individual supplements and build your own stack from scratch to resolve each of these issues. Or you can do what tens of thousands have found to be equally effective but for a lot less money.
The best pre-made nootropic stack will save you money in 2022. And you’ll find you’ll use smaller doses of each ingredient. Because the right combination of supplements work in synergy for a more effective result.
I have personally tried dozens of different pre-made nootropic stacks over the last 15 years. Then in 2015 I was introduced to an UK-based supplement company called Mind Lab Pro®. It is by far the best pre-made nootropic stack I have used so far.
In this post I’ll give you a brief explanation for each pre-made nootropic stack the two companies produce including what makes each one unique. And why I think these supplements are the best options you’ll find anywhere in the world in 2022.
Table of Contents
The Best Pre-Formulated Nootropic
Supplement Stacks to Buy in 2022
Mind Lab Pro®
I’ve been using Mind Lab Pro® as the base for the supplement stack I use every day since late 2015. It has since become the market leader and one of the most widely used and respected pre-made nootropic stacks on the market today.
Mind Lab Pro® v4.0 is a great overall or ‘universal’ nootropic supplement with 11 premium ingredients that support 6 different cognitive pathways.
It covers all aspects of cognition in all types of people. Including athletes, professionals, students and seniors.
What Makes it Special
Most pre-made nootropic stacks on the market today take a narrow-minded approach. And target or support just one segment of cognition; focus, or memory, or energy. Ignoring the rest of your brain’s potential.
Mind Lab Pro® v4.0 on the other hand works as a whole-brain optimizer. Each of the 11 ingredients is a multi-tasker. Collectively boosting memory, processing speed and focus, mood balance and stress resistance, repair and maintenance for longevity.
The Mind Lab Pro® box and bottle tell you exactly how much of each of the 11 ingredients is in each 2-capsule dose. You’re not left guessing what you’re using compared to other supplement manufacturers who hide behind “proprietary formulas”.
Only premium ingredients are used in Mind Lab Pro® v4.0. Including branded or patented nutrient forms, standardized herbs, and metabolically active, nature-identical vitamins.
Mind Lab Pro® v4.0 contains only pure ingredients with no additives or fillers. Delivered in 100% natural vegan NutriCaps® capsules. Other companies use gelatin capsules or HPMC veggie caps which may look natural. But are actually a form of semi-synthetic polymer made from wood pulp.
Why You Want It
Mind Lab Pro® v4.0 can do more with less because of the way each ingredient compliments the other ingredients in this stack.
- Focus – using L-Theanine (as Suntheanine®) which provides a calm focus, attention and flow-state style creativity by boosting alpha brain waves
- Memory – using Citicoline and Bacopa Monnieri which increases acetylcholine and keeps it active longer for enhanced learning and memory
- Motivation – using N-Acetyl L-Tyrosine and NutriGenesis® B-Vitamins for increasing dopamine
- Longevity – using Pine Bark Extract and Lion’s Mane Mushroom extract for boosting cerebral circulation for better oxygen and nutrient delivery to brain cells. And increased brain-derived neurotrophic factor (BDNF) and Nerve Growth Factor (NGF) for enhanced neurogenesis, long-term potentiation (LTP) and better myelination of neuronal axons
- Energy – using Rhodiola Rosea extract and Phosphatidylserine (PS) (as Sharp PS® Green) for less fatigue and quicker reaction time and mental clarity. And Citicoline works with Rhodiola Rosea in this stack for more brain ATP energy synthesis and reduced stress-induced cortisol
- Mood – using L-Theanine (as Suntheanine®) and NutriGenesis® B-Vitamins for enhanced catecholamine synthesis and alpha brain waves for an anxiolytic (anti-anxiety) effect for better mood and emotional control
The innovative stacking strategy used in designing Mind Lab Pro® v4.0 makes in my opinion the single best nutritional supplement for enhancing brain health and cognitive function available today.
Get Mind Lab Pro® v4.0 or
Performance Lab® Energy
Performance Lab® Energy is a unique nootropic energy supplement because it provides 6 key ingredients that help protect, restore, multiply and optimize energy production in mitochondria.
This supplement offers crash-free energy for your body and brain while building long-term health for longevity. A much better choice compared to other energy products that use caffeine. Which is just a short-term energy boost that inevitably results in a stimulant crash.
What Makes it Special
One of the easiest and first things we do for an energy boost is grab a coffee or energy drink.
But the caffeine in coffee or an energy drink that we associate with an energy boost is not truly a boost in energy at all. It’s simply a decrease in sleepiness.
Performance Lab® Energy on the other hand goes right to the cellular energy source – your mitochondria.
Mitochondria within cells take nutrients from food, break them down, and produce ATP which is the fuel for all metabolic processes.
The problem is over time, mitochondria are damaged by free radicals. Causing them to malfunction and decline in number. It’s called mitochondrial dysfunction. And it leads to fatigue, depression, memory loss, insulin resistance, metabolic syndrome and other problems.
The nootropic ingredients in Performance Lab® Energy support mitochondrial function and health. The result is stimulant-free, clean energy with no crash.
The company uses only premium ingredients in Performance Lab® Energy. Including branded or patented nutrient forms.
Performance Lab® Energy has only pure ingredients with no additives or fillers. Delivered in 100% natural vegan NutriCaps® capsules. Other companies use gelatin capsules or HPMC veggie caps which may look natural. But are actually a form of semi-synthetic polymer made from wood pulp.
Why You Want It
Performance Lab® Energy can provide the energy boost you need without the negatives associated with stimulant-based drinks and energy shots.
- Acetyl-L-Carnitine (ALCAR) – which donates acetyl groups to form Acetyl-CoA needed for the synthesis of acetylcholine, is required for the transport of long-chain fatty acids across mitochondrial membranes to fuel creation of ATP, and shuttles fatty acids out of mitochondria to flush out toxic byproducts from energy production
- Coenzyme Q10 (as MicroActive® Q10) – which helps convert food into ATP energy, protects mitochondria from damaging free radicals naturally created during ATP energy generation, and increases mitochondria genesis
- PQQ (as BioPQQ®) – which works in synergy with CoQ10 to improve the function of existing mitochondria in your cells, promotes the growth of new mitochondria, and boosts nerve growth factor (NGF) needed for new neurons
- R-Lipoic Acid (as Bio-Enhanced® Na-RALA) – which activates choline acetyltransferase and increases glucose uptake for synthesis of acetylcholine, regenerates existing antioxidants like Vitamins C & E, glutathione and CoQ10, reduces inflammation, gets rid of heavy metals, and increases insulin sensitivity
- Piperine (as BioPerine®) – black pepper extract which improves the absorption of the other ingredients in this energy stack
- Magnesium – required for ATP energy production in mitochondria, synthesis of DNA and RNA, and regulating ion channels and synaptic plasticity for learning and memory
The innovative stacking strategy used in designing Performance Lab® Energy makes this the single best nutritional supplement for boosting energy available today.
Admittedly, you will not feel the kind of energy surge that you normally associate with an energy drink. You can check out the next pre-made stack in this list for that. But by using this energy nootropic stack daily, you’ll find you won’t need to reach for an energy shot either.
Because you’ll have ample energy all day long and avoid afternoon fatigue. Performance Lab® Energy is stimulant-free, clean energy with no crash.
Performance Lab® Caffeine+
I reach for a capsule of Performance Lab® Caffeine+ whenever I need an extra temporary energy boost. And find I prefer it over the lift I get from a cup of coffee or energy drink.
You get the cognitive benefits of caffeine with the calming effects of L-Theanine.
The problem with this stimulant solution is it’s not complete. And some of the side effects of caffeine as a nootropic are still evident.
Performance Lab® saw an opportunity and redesigned this most basic of stimulant nootropic stacks in 2019. It’s since become a bestseller in the neurohacker community.
This is the most advanced caffeine + L-Theanine formula around. A stimulant stack that works.
What Makes it Special
Neurohackers know that caffeine on its own is an effective nootropic. It’s an adenosine antagonist which prevents us from getting sleepy.
Regular use of caffeine depletes these critical neurotransmitters, stimulates your adrenal glands to produce more cortisol, raises blood pressure, and its diuretic effect causes you to lose water-soluble B-Vitamins that your brain needs.
Performance Lab® recognized that to get all the benefits caffeine has to offer as a nootropic, a stack needed to be designed to counterbalance these negatives.
The result is the purest and cleanest stimulant stack on the market – Performance Lab® Caffeine+.
Why You Want It
Performance Lab® Caffeine+ provides a short-term, clean energy boost. Without the negatives you normally associate with regular caffeine or energy drink use.
- Natural caffeine (from Coffea Robusta seeds) – acts by blocking adenosine receptor subtypes A1 and A2A which in turn increases wakefulness. Instead of becoming sleepy, you are more alert.
This action on adenosine also influences acetylcholine, epinephrine, serotonin and boosts the use of dopamine which also provides a stimulant effect
- L-Theanine (Suntheanine®) – increases Alpha brain waves which provides an alert calming effect. It boosts the neurotransmitters serotonin, dopamine and GABA and counters the negatives associated with caffeine. And helps relieve the stress of excess cortisol caused by caffeine.
- L-Tyrosine (Ajipure®) – replaces the catecholamines dopamine, norepinephrine and epinephrine that were impacted by caffeine use. Resulting in better working memory, quicker thinking even under pressure, a boost in multitasking performance, stress resistance and no crash.
- NutriGenesis® B-Complex – counterbalances the vitamin depletion caused by the diuretic effect of caffeine by including bioidentical NutriGenesis® Vitamins B2, B6, B9 and B12.
The innovative formulation used in designing Performance Lab® Caffeine+ makes this the best stimulant nootropic stack on the market today.
You’ll feel the boost of pure, clean energy right when you need it. And you’ll find you won’t need to reach for an energy shot or cup of strong coffee.
Performance Lab® Mind
Performance Lab® Mind is a unique nootropic stack with only four premium perfectly dosed ingredients.
It’s designed to support focus, mental processing speed, cognition while you’re under stress, multitasking, motivation, memory and cognitive recovery.
What Makes it Special
The nootropic ingredients in the Performance Lab® Mind stack have been clinically shown to support brain energy metabolism, cerebral blood circulation, brain cell regeneration, neurotransmitter synthesis and signaling, and long-term cognitive health.
- Memory – using Citicoline (as Cognizin®) which donates choline to phosphatidyl, forming phosphatidylcholine (PC) used to build brain cell membranes and synapses. And it increases levels of acetylcholine, and supports cerebral blood circulation for learning, attention and memory
- Mental processing speed – using Phosphatidylserine (as Sharp PS® Green) which promotes neurogenesis, neuroplasticity, neuron repair and maintenance, and brain cell signaling. Supporting processing speed, problem-solving, focus, concentration and verbal fluidity
- Multitasking – using L-Tyrosine (as Ajipure®) which is a precursor to the synthesis and replenishment of dopamine, epinephrine and norepinephrine. Helping reverse the negative consequences of stress on cognition, and promoting sharp mental function under pressure
- Cerebral circulation – using Pine Bark Extract which helps release nitric oxide for relaxing blood vessels for better blood flow. Promoting more efficient delivery of nutrients, glucose and oxygen needed for brain energy and metabolism. More mental energy and better long-term brain health
Performance Lab® uses only premium ingredients in Performance Lab® Mind. Including branded or patented nutrient forms, and standardized herbs.
Performance Lab® Mind has only pure and patented ingredients with no additives or fillers. Delivered in 100% natural vegan NutriCaps® capsules. Other companies use gelatin capsules or HPMC veggie caps which may look natural. But are actually a form of semi-synthetic polymer.
Why You Want It
The innovative stacking strategy used in designing Performance Lab® Mind makes this an excellent but less pricey option to Mind Lab Pro®.
But to experience the full benefit of this nootropic stack, Performance Lab® Mind should be used with a quality multivitamin. Because certain vitamins and minerals are required for the synthesis of neurotransmitters and are required nutrients for producing ATP energy for brain cells.
I prefer the Performance Lab® NutriGenesis Multi because it’s more potent, it’s biologically active and I’ve found it to be a far more effective multi compared to every other multivitamin supplement I’ve ever used.
Performance Lab® uses their own priority NutriGenesis® vitamins and minerals which are grown on probiotic, plant and yeast cultures in a state-of-the-art lab.
Nootropics have seen explosive growth as a market sector in 2021. I have at least a dozen different stacks in a desk drawer as I write this. For manufacturers asking for reviews (which I began in 2018 and will continue to review in 2022).
Do a search for “best pre-formulated nootropic stacks” and you’ll come across brands that didn’t even exist a year ago.
Mind Lab Pro® v4.0 has a respectable track record and has set a new bar that other supplement manufacturers are still trying to match. The company who makes MLP has been designing and producing the highest quality, purest supplements for years.
The nootropic stacks I’ve covered in this post for 2022 are very effective for enhancing brain health and function. And are generally safe to use for most people. Even for long-term use.
One thing I have noticed is the trend away from prescription smart drugs and synthetic brain enhancers to more natural herbs and compounds. Especially during this world-wide pandemic. Which is a good thing in my opinion. Easier on your system and they nearly always work better than the artificial stuff.
And my experience with Mind Lab Pro® v4.0 and the Performance Lab® stacks is proof these supplements can be used as the base for more complex nootropic stacks. Depending on your needs and the health issues you are facing this year.
As the author of Nootropics Expert®, I’ve had the opportunity to try and test many pre-made nootropic stacks. But I keep coming back to the favorites I’ve reviewed in this post.
Try them and let me know what you think in the comments section below.
This article may contain affiliate links for which I receive a small commission and you are doing your part to support the work of Nootropics Expert.