Turmeric Curcumin Dosage

Turmeric

David Tomen
Author:
David Tomen
15 minute read
Turmeric has been shown to increase Brain-Derived Neurotrophic Factor, fight depression, improve cognition, focus and libido, and protect the brain from inflammation.

Turmeric (Curcuma longa) is one of the most studied herbs in Ayurvedic, Siddha, Unani and Chinese healing. Turmeric has remarkable nootropic properties. And stands far above many modern medicines used to treat neurodegenerative diseases like depression, Alzheimer’s and stroke.

Turmeric (Curcuma longa)
Turmeric (Curcuma longa)

Turmeric is a perennial shrub native to southern Asia. It is a member of the ginger family (Zingiberaceae). And the Chinese name, jianghuang, literally means “yellow ginger.”

Most of the turmeric we get is grown in India. But turmeric is also cultivated in China, Taiwan, Japan, Myanmar (Burma), Indonesia and throughout Africa.

The primary chemical component in turmeric are a group of compounds called curcuminoids, which include curcumin (diferuloylmethane), desmethoxycurcumin, and bisdemethoxycurcumin. The best studied is curcumin which I’ll make reference to throughout this post on turmeric.

Turmeric also contains other important volatile oils including a- and b-turmerone, ar-turmerone, a-curcumen, and zingiberene. Some of which will also be referenced in this post.

Turmeric works on a molecular level to enhance neurogenesis. It boosts the neurotransmitters serotonin and dopamine. And is a powerful antioxidant helping to protect your brain from chronic, excess inflammation.

Turmeric is also used to treat digestive disorders, skin conditions, cancer, diabetes, heart disease, obesity, liver function, protect from damage to DNA, and treat chest and abdominal pain.

Here we’re going to explore how Turmeric benefits your brain.

Turmeric helps:

  • Brain-Derived Neurotrophic Factor (BDNF): Research shows that the curcumin in turmeric boosts neurogenesis. The production of new neurons in your hippocampus is essential for learning, memory and mood. Low BDNF can lead to major depression, OCD, schizophrenia, and dementia.
  • Neurotransmitters: The curcumin in turmeric boosts the feel good neurotransmitters serotonin and dopamine. These neurotransmitters are critical for mood, cognition, libido and focus. Curcumin functions very much like antidepressant MAOI’s and SSRI’s used to treat depression and Alzheimer’s Disease. Curcumin can actually enhance the effect of antidepressants like Prozac and Effexor.
  • Neuroprotection: The curcumin in turmeric is a potent antioxidant and helps protect your brain from inflammation. Chronic inflammation has been linked to depression and dementia. Curcumin also reduces the formation of plaques that are associated with Alzheimer’s Disease.

Overview

Turmeric (Curcuma longa) is one of the most powerful natural remedies in Ayurvedic and Chinese medicine.  This ancient herbal remedy has been used for at least 6,000 years.[i]

The major constituent of turmeric is curcumin (diferuloylmethane), which constitutes up to 90% of total curcuminoid content, with desmethoxycurcumin and bisdemethoxycurcumin comprising the remainder.

Turmeric Herb Yellow Powder And Fresh Turmeric.
Turmeric

Turmeric is used extensively in several countries as part of their system of national medicine. Turmeric is listed in the official Ayurvedic Pharmacopoeia of India. In the Pharmacopoeia of the People’s Republic of China. In the Japanese Herbal Medicines Codex.

In Germany, turmeric is listed in the Drug Codex, approved in the Commission E monographs, and in the form of tea in the official German Standard License monographs.

Curcumin and turmeric have been extensively researched for their anti-tumor, antioxidant, anti-inflammatory and analgesic (pain-relieving) properties. In fact, a search of the U.S. PubMed database for research on turmeric returns 5,334 clinical trials on animals and humans.[ii]

And yet the National Center for Complementary and Integrative Health which is part of the same U.S. National Institutes of Health has this to say about turmeric:

“There is little reliable evidence to support the use of turmeric for any health condition because few clinical trials have been conducted.”[iii]

That statement by an official medical resource in the USA tells you something about the American health care system. And its view of alternative medicines. And why sites like Nootropics Expert® is so important for our nootropics community. So we can make our own decisions on how to boost our cognitive health.

Turmeric, also known as “Indian Saffron”, has been used for thousands of years in traditional South Asian cuisine, and is the basic ingredient in curry.

One recent study with 1,010 elderly Asian subjects found that those who ate curry “often” or “very often” had significantly higher cognitive performance.[iv]

Turmeric has potent antidepressant qualities. And has been found to be more potent than the antidepressant Prozac. Researchers think Turmeric works by reducing the stress hormone cortisol while increasing levels of the neurotransmitter serotonin.

Turmeric’s main active component curcumin provides protection against Alzheimer’s, major depression, epilepsy, and other neurodegenerative disorders. Scientists believe that much of this protective action comes from curcumin’s anti-inflammatory and antioxidant properties.

Curcumin modulates neurotransmitter levels in your brain. And on a molecular level is a potent inhibitor of reactive astrocyte expression which prevents apoptosis (cell death) in your brain.[v]

Turmeric-curcumin-increases-brain-derived-neurotrophic-factor

How does Turmeric Work in the Brain?

Turmeric boosts brain health and function in several ways. But two in particular stand out.

  1. Turmeric enhances neuroplasticity. Brain-Derived Neurotrophic Factor (BDNF) is a growth hormone responsible for the creation of new neurons (neurogenesis) in your brain. Higher levels of BDNF can increase mood, intelligence, memory and productivity. And can reduce risks for neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Using turmeric or its active compound curcumin can boost your intelligence and memory. And can elevate your mood especially if you’re prone to depression. Several studies have shown that turmeric or its active component curcumin significantly boosts BDNF.[vi]

Researchers found that curcumin activated extracellular signal-regulated kinases (ERKs) and p38 kinases, cellular signal transduction pathways known to be involved in the regulation of neuronal plasticity and stress responses.

Administration of curcumin to mice in this study increased the number of newly generated cells in the hippocampus. Showing that curcumin enhances hippocampus neurogenesis. And that curcumin activity in the brain enhances neuroplasticity and repair of brain cells.[vii]

Another study using the turmeric volatile oil Ar-turmerone showed this compound also supported regeneration of brain cells. Scientists discovered that when neural stem cells were bathed in Ar-turmerone, up to 80% more stem cells grew into neurons or other cells.

Scientists then injected this turmeric extract into a part of rat’s brains where these cells are located. And witnessed a similar increase in growth of stem cells into neurons.[viii]

  1. Turmeric boosts dopamine and serotonin levels in the brain. These are the ‘feel good’ neurotransmitters in your brain. Turmeric and its active compound curcumin has been studied, and used effectively as an anti-depressant for centuries.

Researchers in India set out to establish how curcumin worked in the brain to provide this antidepressant action. In this study they investigated both curcumin and its ability to boost mood as well as the effect of Piperine as a bioavailability enhancer.

The scientists found that curcumin increased serotonin and dopamine levels in the brain. And inhibited monoamine oxidase enzymes (both MAO-A and MAO-B) just like popular prescription antidepressant MAOI’s. Curcumin even enhanced the effectiveness of popular SSRI antidepressants Prozac, Effexor, and Zyban.

The team found no increase in norepinephrine when using curcumin to boost neurotransmitters. Avoiding the irritability and other symptoms of an over-amped fight-or-flight response.

And the scientists found that stacking curcumin with Piperine significantly boosted bioavailability. They concluded that curcumin combined with Piperine was a “potent natural antidepressant approach to managing depression”.[ix]

How things go bad

Chronic stress, anxiety and free radicals (oxidation) damage your brain. This damage can manifest in several ways including memory loss, brain fog, anxiety, depression, and even neurodegenerative diseases like Alzheimer’s and Parkinson’s.Turmeric-relieves-Depression

Chronic stress reduces memory

Toxins kill brain cells

Free radicals destroy neurons and synapses

↓ Serotonin and dopamine decline

↓ Brain-Derived Neurotrophic Factor declines

Under conditions of chronic stress or depression your brain loses the capacity to transmit signals between neurons efficiently. Memory, cognition and decision-making all suffer as a result.

Turmeric benefits

A member of the ginger family of herbs, turmeric is the seasoning that gives curry powder its yellow color. It’s long been known for its anti-inflammatory and antioxidant properties. And is actively studied today for applications as a nootropic.

Turmeric or anyone of its several active compounds including curcumin and Ar-turmerone undoes damage to your brain caused by depression or chronic stress.

Turmeric and curcumin boosts neuron regrowth (neurogenesis), increases dendrites, repairs DNA, reduces inflammation, counters free radical damage, and boosts neurotransmitters.

Turmeric inhibits monoamine oxidase enzymes (both MAO-A and MAO-B) just like popular prescription antidepressant SSRI’s and MAOI’s. Research shows that curcumin or turmeric can boost the effects of some popular antidepressants.

Boosting the ‘feel-good’ neurotransmitters serotonin and dopamine can alleviate depression, improve mood, boost alertness, cognition, decision-making, memory and even libido.

Curcumin, the most active component of turmeric, activates genes to produce a huge array of antioxidants that serve to protect your mitochondria.

Curcumin also improves glucose metabolism, which is great for maintaining a healthy balance of gut bacteria. This critical microbiome in your gut directly influences how well your brain functions.

Turmeric-curcumin-antianxiety

How does Turmeric feel?

Curcumin is the main active component of turmeric. So most of the positive reviews and studies have been conducted using curcumin.

Curcumin is known to possess antimicrobial, anti-inflammatory, anti-hypertensive, anti-hyperlipidemic, anti-tumor, anti-cancer, anti-phlogistic, anti-diabetic, anti-psoriasis, anti-thrombotic, anti-hepatotoxic and a host of other useful properties.

If you are in perfect physical and mental health you may not feel the effects of supplementing with turmeric or curcumin. Turmeric’s neuroprotective qualities may not be felt if your brain is in perfect working order. But the effects of long-term supplementation will help you ward off diseases like Alzheimer’s and Parkinson’s.

The most frequent comment from supplementing with turmeric comes from those dealing with chronic pain. Turmeric relieves the pain of osteoarthritis and fibromyalgia.

Chronic pain usually results in insomnia or poor sleep quality, loss of memory, depression, and other stress-related symptoms. Adding curcumin or turmeric to your nootropic stack can help relieve chronic pain. You’ll sleep better and feel more alert the next day.

Supplementing with turmeric or curcumin improves attention, working memory, and mood. And is reported to relieve the symptoms of migraine headaches.

Turmeric Clinical Research

Eat Your Curry

Curcumin, from the curry spice turmeric, has been shown to have antioxidant and anti-inflammatory properties. And can reduce beta-amyloid plaques that are associated with Alzheimer’s Disease. But scientists were not satisfied with the evidence of turmeric’s benefits in real life.Turmeric curry improves cognition

So in 2003, a research team in Singapore recruited 1,010 non-demented elderly Asian people aged 60 – 93 years. The authors of the study compared Mini-Mental State Examination (MMSE) scores for three categories and regular curry consumption.

The scientist found that those who consumed curry “occasionally” and “often or very often” had much higher MMSE scores than those who “never or rarely” consumed curry.

The study authors reported that regular curry consumption was evidence of better cognitive performance. The bottom-line → eat your curry.[x]

Turmeric as an anti-depressant

A study conducted in India looked at the efficacy and safety of using curcumin, one of the active ingredients found in turmeric, for treating major depression.

60 patients diagnosed with major depressive disorder were chosen to receive either 20 mg of fluoxetine (Prozac®), 1000 mg of curcumin, or a combination of both daily for 6 weeks.

The study found that the best response (77.8%) was with the group of patients treated with a combination of curcumin and Prozac. The Prozac only group experienced a 64.7% improvement in depression symptoms. And the curcumin only group came in at 62.5%.

The researchers concluded that curcumin could be used as an effective and safe treatment for patients with major depression.[xi]

Curcumin Reduces Stress

Turmeric has long been used in traditional Chinese medicine to manage stress and depression-related disorders. Scientists had already figured out turmeric’s antidepressant effects in animal and human studies. So they imagined that curcumin may also alleviate stress caused by HPA (hypothalamic-pituitary-adrenal) dysfunction.

For this study the scientists used rats. They subjected the animals to stress for 20 days by putting them through several tasks known to stress a rat.

Putting rats through this unfortunate (for the rats) series of events produced the kind of symptoms you would see in humans subjected to ongoing, chronic stress.

The rats had abnormal adrenal gland weight, increased thickness in the adrenal cortex, elevated cortisol levels, and reduced glucocorticoid receptor (GR) mRNA expression. These changes were reversed by giving the rats curcumin in their food.

The research team also found that chronic stress down-regulated BDNF levels, and reduced the ratio of cAMP to CREB levels in the hippocampus and frontal cortex of the rats. Giving the rats curcumin blocked all these stress-induced physical responses in their brains.

The scientists concluded that these results provided compelling evidence that the behavioral effects of curcumin in chronically stressed animals, and by extension humans, could be related to the modulating effects of curcumin on the HPA axis and neurotrophin expressions.[xii]

Turmeric Dosage

You cannot get the immediate therapeutic and nootropic benefits of turmeric by simply eating more curry. Or adding turmeric to your food. Turmeric root contains only about 3% curcumin.Turmeric Curcumin Dosage

The most convenient way to start experiencing the benefits of turmeric is to get a high quality, 100% organic turmeric extract that contains at least 95% curcuminoids.

But curcumin and turmeric on their own are poorly absorbed by your gut. You must boost the bioavailability and absorption of this potent nootropic.

And the most efficient way to boost bioavailability is to combine turmeric or curcumin with Piperine. One study showed combining curcumin with 20 mg of Piperine increased bioavailability by 2000%![xiii]

Turmeric is fat-soluble so you must take it with a high quality fat for maximum absorption. You can use organic, cold-pressed coconut or olive oil.

Standardized turmeric or curcumin extract (95% curcuminoids) 750 mg 3-times per day.

Turmeric liquid extract (1:1) 30 – 90 drops per day.

Tincture (1:2) 15 – 30 drops 4-times per day.

Dried turmeric root powder 2.5 – 4 grams per day.

Turmeric Side Effects

Turmeric is natural and considered non-toxic and safe when taken at recommended doses.

Taking large amounts of turmeric for extended periods can cause stomach upset, and possibly ulcers.

If you have gallstones or obstruction to your bile passages you should not supplement with turmeric.

Turmeric may lower blood sugar levels which could be a problem for diabetics.

Pregnant and breastfeeding women should not supplement with turmeric.

And because turmeric can act as a blood thinner, stop supplementing with turmeric 2 weeks before surgery. Turmeric can also strengthen the effects of blood thinning medications.

Types of Turmeric to Buy

Turmeric is available as a powder, tablets, capsules, tincture and tea. And is preferred over curcumin if you’re using it for inflammatory conditions like arthritis, tendonitis, or an autoimmune condition.

Curcumin is a natural chemical found in, and extracted from turmeric. Several companies have developed their own version of this powerful nootropic.

Sabinsa’s Curcumin C3 Complex® boasts the most clinical studies of any of the patented forms of curcumin. This curcumin product is standardized to 95% Curcuminoids. Sabinsa also produces the standardized Piperine extract called BioPerine®. And supplement makers who feature Curcumin C3 Complex® from Sabinsa also typically include BioPerine® in their formula.

BCM95® by DolCas Biotech is a standardized extract of turmeric containing curcumin-essential oil complex of 86% curcuminoids and 7-9% essential oils. As far as I can tell this is the only extract that includes turmeric volatile oils which is important to cognitive health. Recall from earlier in this article that turmeric volatile oil Ar-turmerone supported regeneration of brain cells

Longvida® is a standardized curcumin extract that the company claims is at least 67-285 times more bioavailable than standard 95% curcumin. But does not contain any of the volatile oils found in natural turmeric. One study showed that this extract increases synapses in mice.[xiv] Another study in humans showed Longvida® significantly improved attention, working memory, and mood compared to placebo.[xv]

Meriva® is another patented form of curcumin combined with soy lecithin. The two compounds are a 1:2 ratio with microcrystalline cellulose added. The company claims that the addition of soy lecithin improves bioavailability of curcumin. Total curcumin in each capsule is 20%. Much higher doses of this curcumin extract are needed for optimizing cognition. And is primarily targeted at bone, joint, eye and skin health.

Active ingredients of Turmeric include curcuminoids and volatile oils. Look for the percentage of active ingredients listed on the bottle or package. Your best option is choosing a standardized extract of at least 95% curcuminoids.

Unless the supplement contains a patented compound from the companies listed above, you can assume that the extract has been processed using toxic solvents to extract curcumin from turmeric (not good).

And avoid supplements that list “other ingredients” on the label. Look for Certified Organic to ensure the root used to make your Turmeric supplement is free of heavy metals, pesticides and herbicides.

Nootropics Expert Recommendation

Turmeric Extract (95% curcuminoids) 750 mg 3-times per day

Nootropics Expert Tested and ApprovedI recommend using Turmeric or Curcumin as a nootropic supplement.

Your body does not make Turmeric on its own. So to get its benefits you must take it as a supplement.

Turmeric is the anti-Alzheimer’s spice. Studies show that in parts of India where curries are eaten most often, Alzheimer’s disease is extremely rare.

Turmeric is especially helpful for those suffering from depression or chronic pain.

Turmeric has a combination of curcuminoids, volatile oils and proteins that make it anti-bacterial, anti-cancer, anti-inflammatory, and anti-septic.

Some neurohackers maintain that turmeric or curcumin is the best nootropic. You can increase the bioavailability of turmeric by combining it with Piperine (black pepper extract) and a healthy fat like olive or coconut oil.

You can safely take up to 3,000 mg of Turmeric extract daily if needed. Most get all the benefit they need with 750 mg. Dosed 3-times per day.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Slominski A., Zmijewski M., Pawelek J. “L-tyrosine and L-DOPA as hormone-like regulators of melanocytes functions” Pigment Cell Melanoma Research. 2012 Jan; 25(1): 14–27. (source)

[ii] Woods S.K., Meyer J.S. “Exogenous tyrosine potentiates the methylphenidate-induced increase in extracellular dopamine in the nucleus accumbens: a microdialysis study.” Brain Research. 1991 Sep 27;560(1-2):97-105. (source)

[iii] Hase A., Jung S.E., aan het Rot M. “Behavioral and cognitive effects of tyrosine intake in healthy human adults.” Pharmacology, Biochemistry and Behavior. 2015 Jun;133:1-6. (source)

[iv] Magnusson I., Ekman L., Wångdahl M., Wahren J. “N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans.” Metabolism. 1989 Oct;38(10):957-61. (source)

[v] Coull N.A., Watkins S.L., Aldous J.W., Warren L.K., Chrismas B.C., Dascombe B., Mauger A.R., Abt G., Taylor L. “Effect of tyrosine ingestion on cognitive and physical performance utilising an intermittent soccer performance test (iSPT) in a warm environment.”European Journal of Applied Physiology. 2015 Feb;115(2):373-86. (source)

[vi] Colzato L.S., Jongkees B.J., Sellaro R., Hommel B. “Working memory reloaded: tyrosine repletes updating in the N-back task.”Frontiers in Behavioral Neuroscience. 2013 Dec 16;7:200. (source)

[vii] Hinz M., Stein A., Neff R., Weinberg R., Uncini T. “Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation”Neuropsychiatric Disease and Treatment. 2011; 7: 31–38. (source)

[viii] Deijen J.B., Orlebeke J.F. “Effect of tyrosine on cognitive function and blood pressure under stress.” Brain Research Bulletin. 1994;33(3):319-23. (source)

[ix] Steenbergen L., Sellaro R., Hommel B., Colzato L.S. “Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance.” Neuropsychologia. 2015 Mar;69:50-5 (source)

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Join The Discussion - 235 comments

David
September 17, 2023

Hi David. You recommend BCM95® by DolCas Biotech. What distributor would you recommend purchasing this from. Everyone claims BCM95, but who to trust? Thanks.
Also, 1 year post TBI. Had CSF drained over 5 days, some shearing, and small hematoma as a result. The aftermath has been brutal and the doctors are corruptly ignorant. They just want you to take anti-depressants and go away. I have been taking almost everything on your list from a few weeks after. See anything wrong with taking Phenylpiracetam to help with massive brain fog and focus and rebuilding receptors?
Thanks in advance, David.

Patrick
August 24, 2023

Hi David, you mention that curcumin functions as a MAOI, and recommend taking it with piperine, another MAOI. Could taking these supplements in the recommended doses lead to dangerously high tyramine levels, as is the case with prescription MAOIs? I’m curious about trying these, but not sure I want to commit to a low-tyramine diet.

    David Tomen
    September 13, 2023

    Patrick, I have been using both for years without a problem.

Andy
August 4, 2023

Is it safe to to take a NSAID with turmeric/curcumin or lets say I take 1 250Mg NSAID etc 10 hours after taking my curcumin is that safe?

now not doing this daily but one off NSAID or on the od occasion or should i avoid turmeric that particular day if i wish to take a NSAID

Cheers

    David Tomen
    August 4, 2023

    Andy, the only thing I can think of is if that NSAID can cause stomach bleeding then Turmeric would not be a good idea because it is a blood thinner.

Andy
August 2, 2023

Hello David

I was just wondering if curcumin/Turmeric can cause or help insomnia?

Is it fine to take late in the even say 4-2 hours before bed would it interfere or enhance sleep

    David Tomen
    August 2, 2023

    Andy, it should not cause insomnia but it depends on how sensitive you are this supplement.

Ed
July 10, 2023

Hi David,

This is basically an extension of my question on your Forskolin page, but I figured for organization it would be better to post here. Basically, I wanted to see if the ingredients in this fat burning supplement called Burn Lab Pro would be safe to take with 3 grams of turmeric. Again, Burn Lap Pro contains:

GTF chromium
Calcium
HMB
ForsLean (forskolin)
Cayenne Pepper Extract
Black Pepper Extract

Again, here is a link to the extract ingredients and thier specific dosages/extract percentages (bottom of page):
https://bit.ly/2RAkrYH

Since online sources reccomend avoiding turmeric when taking diabeties meds like metformin, and since these ingredients in Burn Lab Pro seem to work on the metabolism (especially HMB and ForsLean, which seem to have a direct effect on insulin sensitivity/performance), I wanted to see if combining Burn Lab Pro is safe with turmeric (along with my Mind Lab Pro, CoQ10, Performance Lab Omega 3, grapseed extract, and multivitamin).

Basically, I’m worried about dangerously low blood sugar. I would love to get your thoughts!

Thank you,
Ed

    David Tomen
    July 10, 2023

    Ed, it has not been tested but you may be onto something. The only way to find out is to try it and watch your blood sugar levels. Burn Lab Pro is a great supplement.

MattD
April 17, 2023

Just wanted to pass this along, Life Extension website has the BCM-95 (Super Bio Turmeric) marked 50% off. I also like to go on knoji website and grab a coupon code to go with it 😉 If you google ‘Life Extension knoji” you’ll find it. Codes are near the bottom of the page. Stock up while it’s on sale

https://nootropicsexpert.com/go/life-extension-super-bio-curcumin/

    David Tomen
    April 18, 2023

    Thank you for the heads up Matt. Much appreciated!

Harry Rourke
March 27, 2023

Hi David,
Could Turmeric/Curcumin Extract interact with the SSRI drug Sertraline/Zoloft. I would like my friend with fibromyalgia/chronic pain/chronic fatigue to try it but there is mixed info on the web about whether it might interact. Could it cause serotonin syndrome or bleeding?
Kind Regards,
Harry Rourke

    David Tomen
    March 31, 2023

    Harry, Turmeric and Curcumin are not contraindicated with SSRIs. But turmeric can act as a blood thinner so if your friend has a bleeding disorder then it is the wrong supplement for them.

David
March 3, 2023

Hi david

Is it anything in your stack that you cycle on and off?

    David Tomen
    March 4, 2023

    No

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