Bacopa Monnieri

Bacopa Monnieri (Brahmi) is a perennial, creeping, aquatic herb. Originally from the wetlands of India and other Southeast Asian countries.

Bacopa, also known as water hyssop, is often referred to as “Brahmi”. Named after the supreme god Brahma.

The nootropic benefits of Bacopa Monnieri were first revealed in ancient Ayurvedic texts. It was recommended to devotees to help memorize long passages of text. And enhance cognition.

And Bacopa Monnieri is an adaptogen. It helps prevent the chemical and physical effects of stress. Instead of just suppressing them like many modern antidepressants.

Bacopa Monnieri helps:

• Neurotransmitters. Bacopa affects brain levels of acetylcholine, which is important for memory and cognition.
• Cognition. Bacopa has antioxidant effects that enhance cognitive function. Bacopa extract helps prevent arterial plaque that can lead to heart attack, stroke, and other neurodegenerative diseases.
• Anxiety and stress. Bacopa has a significant anxiolytic (anti-anxiety) effect. It appears to modulate brain levels of the neurotransmitter serotonin. This affects mood regulation.

What is Bacopa Monnieri?

Bacopa Monnieri (Brahmi) is an aquatic herb native to the wetlands and marshy areas of Southeast Asia and India.

Bacopa, also known as water hyssop, is often referred to as “Brahmi”. Named after the supreme god Brahma.

Ancient Ayurvedic texts talked about Bacopa. It was recommended to devotees to help memorize long passages of text.

In the West, Bacopa Monnieri is often used to reduce anxiety, depression, and stress. But it’s gaining popularity in the nootropic community as a powerful memory and cognition booster.

The active compound Bacoside A in Bacopa easily crosses the blood-brain barrier.

How does Bacopa Monnieri Work in the Brain?

Bacopa Monnieri boosts brain health and function in several ways. But two in particular stand out.

1. Bacopa Monnieri boosts memory. Bacopa’s two active components are bacosides A and B. They improve the signaling of electrical impulses between neurons in your brain. Bacosides also help rebuild damaged neurons.

Bacopa Monnieri helps you learn and remember things more easily. In one study, researchers gave 54 volunteers in Portland, Oregon, 300 mg of B. Monnieri per day for 12 weeks.

After the 12-week study, the people taking Bacopa had:

• Better word recall
• Better attention
• Better memory scores
• A greater ability to focus while learning
• Less anxiety and lower heart rates[i]

2. Bacopa Monnieri reduces stress. Bacopa has traditionally been used in Ayurveda as a tonic for the nervous system. It helps to reduce anxiety.

Research at Banaras Hindu University in India showed Bacopa to be as effective for anxiety as the benzodiazepine drug lorazepam. One of the side effects of lorazepam is memory loss. Bacopa monnieri, on the other hand, reduced anxiety while boosting cognition.[ii]

How things go bad

Chronic stress and cortisol can damage your brain. Neuroscientists at the University of California, Berkeley, found that chronic stress triggers long-term changes in brain structure and function.[iii]

Chronic stress damages neural networks. Certain proteins are over-expressed, damaging neurons as a result.

Toxins invade cells, hijacking their normal, healthy function. And oxidative damage by free radicals harms brain cells if they’re not removed.

↓ Chronic stress reduces memory capacity

↓ Toxins kill brain cells from the inside

↓ Free radicals destroy neurons and synapses

Under conditions of chronic stress, your brain loses the capacity to transmit signals between neurons efficiently. Memory, cognition, and decision-making all suffer as a result.

Bacopa Monnieri benefits

Bacopa Monnieri for better learning and memory. Animal studies show that Bacopa Monnieri Extract increases dendrite length and dendritic branching.

More and healthier dendrites typically lead to improved spatial learning performance and enhanced memory retention.

Bacopa Monnieri also undoes damage to the brain caused by chronic stress. And helps keep it healthy. This is a little complicated, so stay with me here.

Your brain is protected by heat-shock protein 70 (Hsp70), cytochrome enzymes EROD and PROD, and superoxide dismutase (SOD).

Hsp70 helps proteins in cells retain normal structure so they remain functional. EROD (7-ethoxyresorufin-O-deethylase) and PROD (7-pentoxyresorufin-O-dealkylase) are detox enzymes. They protect your brain by converting bad toxins into less harmful compounds. And SOD battles destructive free radicals called superoxides. And converts them into harmless organic compounds.

Bacopa Monnieri Keeps Your Brain Healthy Under Stress

When you are under stress, levels of Hsp70 increase in all regions of your brain. But research shows that animals pretreated with Bacopa for 7 days showed a reduction in this increase in Hsp70. Particularly in brain regions responsible for memory.

This means that by producing less Hsp70 under stress, Bacopa makes your brain less susceptible to stress. Bacopa kept those regions of the brain in a non-stressed state. Even in the presence of stress.

Bacopa also has a preemptive action on EROD and PROD. Rats treated with Bacopa, but not under stress, saw an increase in these two enzymes.  Suggesting that Bacopa helps stockpile these protective enzymes to help you better deal with stress.

And when it comes to SOD, researchers said, “Bacopa helps in coping with the combined hypoxic, hypothermic, and immobilization stress, which could lead to an onslaught of free radicals.” So Bacopa supports SOD activity and prepares cells to withstand attacks from free radicals.[iv]

Translated, this all means Bacopa Monnieri helps your brain deal with stress. And helps boost memory.

How does Bacopa Monnieri feel?

The effects of Bacopa are not felt immediately. But it seems to build over time. Some users report a pronounced anti-anxiety effect within 2 – 4 days of supplementing with Bacopa.

In one study conducted in Australia, results were measured at 5 and 12 weeks of Bacopa use. The results showed improved information-processing speed and increases in learning and memory. Maximum reduction in anxiety was realized after 12 weeks of use.[v]

Some neurohackers say they feel the effects of Bacopa Monnieri sooner than 4 weeks. And the effects seem to keep working even after stopping supplementation. The effects are long-term.

Long-term users say they consistently feel calmer, think more quickly, and have better memory.

Bacopa Monnieri Clinical Research

Bacopa Monnieri as a Nootropic

This double-blind, placebo-controlled investigation was done at Swinburne University in Australia. 107 healthy participants were given 300 mg of Bacopa Monnieri extract for 90 days.

After 90 days, the people who took B. Monnieri extract showed significant improvements in spatial memory, memory accuracy, and the ability to process visual information.[vi]

Bacopa Monnieri for Stress Reduction

Bacopa is likely best known for reducing stress. Recent research at Swinburne University of Technology in Australia confirmed this in a lab setting.

In this double-blind, placebo-controlled cross-over study, 17 healthy volunteers were given 320 mg or 640 mg of Bacopa extract. The study reported significant improvements in mood and decreases in cortisol levels.

This study demonstrated Bacopa’s adaptogenic qualities. Bacopa Monnieri counteracted the effects of stress by regulating hormones involved in the stress response.[vii]

Bacopa Monnieri for Longevity

Long-term exposure to aluminum can increase your risk of Alzheimer’s Disease by 60 percent.[viii] (So check your underarm deodorant label before you read the rest of this article).

Research shows that Bacopa Monnieri can protect you from toxins that are harmful to your brain. Including aluminum.

It prevents the buildup of toxins between and inside neurons. And prevents damage to the hippocampus. The area of your brain is critical for learning, memory, and cognitive power.

Scientists at Jawaharlal Nehru University in India laced rats’ drinking water with aluminum chloride. The same aluminum that’s toxic to your brain. Some of the rats in this study had the protective effects of Bacopa Monnieri.

Bacopa Monnieri protected the rat’s brain from oxidative damage from aluminum. And it worked as well as the Alzheimer’s drug selegiline. Bacopa restored the enzyme superoxide dismutase (SOD) to near-normal levels. Indicating Bacopa Monnieri’s anti-aging potential.[ix]

Bacopa Monnieri Recommended Dosage

There is no ‘right’ dosage of Bacopa. Each person’s body is unique. In general, use the lowest dosage that works for you. And Bacopa works better if taken a few days in a row rather than just once.

The recommended dosage of Bacopa Monnieri containing 45% bacosides is 200–450 mg per day.

The recommended dosage of Bacopa Monnieri containing 20% bacosides is 750 mg per day.

Higher doses should be divided equally, with your first dose in the morning and the next dose in the early afternoon.

Bacopa is fat-soluble, so it should be taken with a healthy fat source, such as organic, cold-pressed virgin olive oil or coconut oil. Fat helps your body absorb the compounds in Bacopa that provide benefits. And helps deliver it into your brain cells.

Bacopa Monnieri Side Effects

Side effects of Bacopa Monnieri are rare when taken as directed. But it can include fatigue and an upset stomach.

Bacopa Monnieri has been shown to increase thyroid T4 (thyroxine) by 41%, which can cause a problem if you are dealing with hyperthyroidism. It can also inhibit cytochrome isoenzymes CYP3A, CYP2C, CYP1A2, and CYP2C19, which are responsible for the metabolism of amitriptyline, agomelatine, and Moclobemide.  This can be a problem when using those types of drugs.

Bacopa monnieri is also an acetylcholinesterase inhibitor, which may increase acetylcholine levels. Causing problems if you are using ACE inhibitors.

Types of Bacopa Monnieri to buy

The bioactive component of Bacopa Monnieri is Bacoside A. Which is a mixture of saponins with bacoside A3, bacopaside II, and jujubogenin isomer of bacopasaponin C.

Pay close attention to what you are buying, because Bacopa Monnieri products labeled as “Brahmi” can be accidentally or intentionally adulterated with Gotu Kola, which is also referred to as “Brahmi“.  One study in 2023 tested 18 Bacopa products labeled as “Brahmi” purchased in India and found that 22% were adulterated with Gotu Kola and 44% contained zero Bacopa Monnieri.

I come across several studies showing adulterated Bacopa products around the world. But you can be sure the Bacopa Monnieri extract found in Mind Lab Pro^® contains 11 brain-enhancing nootropic compounds, including pure Bacopa Monnieri extract with 24% bacosides and all the bioactive saponins and isomers listed above.

I recommend Mind Lab Pro^® because it addresses all aspects of anxiety resistance, memory and cognitive enhancement, mood, brain repair, and maintenance. And you can get a Certificate of Analysis from a 3rd-party testing facility showing that what’s on the label is what you’ll get in two capsules of Mind Lab Pro^®.

This premium nootropic stack is designed to affect neurotransmitters, cognitive energy, brain waves, neuroprotection, and regeneration. You can get it here: Click for Mind Lab Pro^®.

Bacopa supplements are also available as powders, capsules, and tablets. Check the label for the concentration of Bacosides. A Bacopa extract with a higher Bacoside concentration requires a lower dose.