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David Tomen
David Tomen
11 minute read
Centrophenoxine helps boost cognition & memory and has significant anti-aging benefits preventing and reversing neuronal decay.

Centrophenoxine (Lucidril® or meclofenoxate) is one of the original nootropics. Developed in France in 1959, Centrophenoxine is a combination of DMAE (dimethylethanolamine) and pCPA (parachlorphenoxyacetic acid).

DMAE is an amine naturally produced in small amounts in your brain. Researchers speculate that DMAE may increase acetylcholine (ACh) levels in the brain by inhibiting choline metabolism in peripheral tissues.

By preventing the use of choline by other tissues (including synthesis into acetylcholine), DMAE increases choline levels in the bloodstream.

But DMAE on its own does not easily cross the blood-brain barrier. Combining DMAE with pCPA seems to help this bioavailability issue.

pCPA is a synthetic version of auxins (plant growth hormones). Auxins act like natural growth factor in plants.

Once digested, Centrophenoxine breaks down into DMAE and pCPA in the liver. This combination was found to make DMAE more bioavailable in the body. And helps DMAE cross the blood-brain barrier more readily.

Centrophenoxine helps:

  • Neurotransmitters. Centrophenoxine seems to temporarily boost acetylcholine in the brain.[i] Which could have an effect on cognitive performance and memory.
  • Neuroprotectant. Centrophenoxine reduces lipofuscin in the brain. Lipofuscin is a cellular waste product that accumulates in cells as we age. It’s the same waste product that causes brown liver spots on skin. Centrophenoxine eliminates nearly half of the accumulation of brain lipofuscin in just 8 weeks.
  • Brain Energy. Centrophenoxine improves cerebral blood flow and oxygen in the brain.


Centrophenoxine (meclofenoxate) is one of the original nootropics. And it’s backed by 50 years of research.

Centrophenoxine is sold as the prescription medication Lucidril® in some parts of the world. In other countries like the USA it’s sold as an OTC supplement.


Centrophenoxine is an ester (chemically-derived) compound of DMAE and pCPA. DMAE seems to increase choline levels by preventing uptake of choline in peripheral tissues in the body. Since choline is a precursor to acetylcholine, more choline in your brain may raise acetylcholine levels. pCPA is a synthesized version of a plant growth hormone.

This combination helps DMAE cross the blood-brain barrier more easily than just supplementing with DMAE.

Centrophenoxine may be a good addition to your nootropic stack. It’ll increase your brain energy levels by boosting oxygen flow. It helps flush out dangerous free radicals and cellular waste. And will help improve memory and cognition.

Centrophenoxine increases brain energy

Centrophenoxine vs. DMAE: What’s the Difference?

DMAE is used to make Centrophenoxine. DMAE is found in small amounts in your brain. A good food source of DMAE is fish.

But there is little evidence that DMAE as a supplement actually crosses the blood-brain barrier. And if it provides the brain enough choline needed to make acetylcholine.

Centrophenoxine seems to solve the blood-brain barrier problem. Adding pCPA to DMAE helps DMAE enter your brain. And this combination also seems to be an effective way to boost acetylcholine.

If you’re considering adding DMAE to your stack, Centrophenoxine may be a better alternative.

How does Centrophenoxine Work in the Brain?

Centrophenoxine boosts brain health and function in several ways. But two in particular stand out.

  1. Centrophenoxine helps improve memory.[ii] It does it in part by boosting the enzyme acetylcholinesterase in the brain.[iii] This is the enzyme needed for breaking down acetylcholine once it does its job in the post-synaptic neuron. The choline is then liberated to be taken up by the pre-synaptic neuron where acetylcholine is once again synthesized with the help of Acetyl-CoA and choline acetyltransferase.

Researchers set out to prove this in a clinical trial using lab rats. In this study they compared Centrophenoxine with DMAE. And determined that DMAE was about half as potent as Centrophenoxine in boosting choline and ACh levels.[iv]

Increased acetylcholine activity helps short-term memory, concentration, and learning.

  1. Centrophenoxine takes out the cellular trash. Lipofuscin are more commonly known as age pigments.[v] They show up as “age spots” or “liver spots” on aging skin. And they hide in cells throughout your body. Including your brain, liver, kidneys, heart, adrenals and nerve cells.

Lipofuscin are the product of oxidation of unsaturated fatty acids. They also contain other cellular heavy metal waste like mercury and aluminum.Centrophenoxine removes brain cell waste and lipofuscin

The buildup of this toxic mess is caused by a breakdown of your normal cellular waste disposal function. Centrophenoxine helps remove lipofuscin from brain cells. And from cells throughout your body.

The beneficial effects of Centrophenoxine were observed in several lab studies on older animals. Administration to these animals significantly increased life-span, and it boosted learning ability compared to age-matched controls.[vi]

How Things Go Bad

As we get older, our brain chemistry and energy metabolism changes.

↓ Brain cell membranes degenerate from toxic buildup

↓ Memory, recall, reaction time and mood diminish

↓ Acetylcholine levels decline

All of these age-related changes are contributing factors to the neurodegenerative diseases of aging. Including Alzheimer’s and dementia.

But even if you’re not concerned with anti-aging, Centrophenoxine can help.

Centrophenoxine benefits

Centrophenoxine is one of the oldest and most studied nootropics available today. It was developed in France in 1959. Primarily in the search for Centrophenoxine to the rescuesomething to combat age-related cognitive decline.

Centrophenoxine is a combination of pCPA and DMAE. Some studies show that DMAE may boost acetylcholine levels in the brain by preventing choline uptake in the peripheral system in the body. Thus providing more choline which could be used to synthesize acetylcholine. But there’s very little evidence that it can cross the blood-brain barrier. pCPA seems to solve that transport problem.

Centrophenoxine is water-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.

Centrophenoxine gets to work right away by temporarily boosting acetylcholinesterase in parts of the brain. This enzyme is needed for the synthesis of acetylcholine. And it gets busy clearing cells of free radicals and lipofuscin.

How does Centrophenoxine feel?

Centrophenoxine offers a gentle brain energy boost when you take it first thing in the morning. You’re able to remember things a little easier. Recall when you need it seems effortless.

Some neurohackers report that Centrophenoxine works well stacked with Aniracetam, Noopept, and Piracetam. It may work in part by providing some of the extra acetylcholine racetams demand when you take them.

And if you dose half in the morning, and the other half early afternoon, you should feel a brain energy boost throughout your day.


Centrophenoxine Clinical Research

Centrophenoxine Relieves the Symptoms of ADHD

A prescription form of DMAE called Deanol was used in the 1960’s and 70’s to treat learning and behavioral problems in children. What’s now known as ADHD.

A 3-month, double-blind, placebo-controlled trial involving 74 children was conducted in 1975. They were split into groups and given 40 mg. of Ritalin or 500 mg of Deanol (DMAE). Positive results from this trial showed DMAE comparable to Ritalin in effectiveness in controlling ADHD.[vii]

Centrophenoxine is Anti-Aging

Centrophenoxine is not only an effective cognition booster, it helps reverse the effects of aging in your brain. Much of brain cell membrane is made of phospholipids (fat). And it oxidizes as we age. In other words, free radicals build up. And are not removed from cells efficiently the older we get.

Aging brain cells also get clogged up with lipofuscin. Lipofuscin are the product of oxidation of unsaturated fatty acids. They also contain other cellular heavy metal waste like mercury and aluminum. You see lipofuscin show up as ‘age spots’ on older skin. The same thing happens in your brain.

Studies have shown that Centrophenoxine helps ‘flush out’ free radicals and lipofuscin from brain cells.[viii] And used by younger neurohackers, helps this cellular waste from building up in the first place.[ix]

Researchers in Hungary conducted a double-blind clinical trial with 50 people suffering from dementia. Average age was 77 years. They gave one group 2 grams of Centrophenoxine for 8 weeks.

They found that Centrophenoxine rehydrated ‘intracellular mass’. Proving this compound as a powerful free radical scavenger. It removed free radicals from aging brain cells. And restored them to a healthy state.[x]

In another study in India, researchers worked with male Wistar rats aged 4, 8, 16 and 24 months. They used these ages because they correlate with human aging from young to elderly.

Just like in humans, lipid oxidation and lipofuscin concentration increased with age. The experiment also showed that cellular free radical damage and lipofuscin buildup happened at the same time.

This buildup of cellular waste contributes to age-related decline in neuronal electrical activity (neural signaling). Cognition, memory and learning are all affected. The research team found that Centrophenoxine had no effect on younger rat brains. But in the two older age groups they saw a significant decrease in lipid oxidation and lipofuscin concentration.

Showing conclusively the anti-aging action of Centrophenoxine.[xi]

Centrophenoxine Improves Memory

Centrophenoxine boosts neuronal glucose and oxygen uptake in the brain. And helps the production of RNA and protein. RNA is derived from DNA in the cell nucleus. And enable neurons to form proteins. Which help encode memory and repair damage to brain cells.

Centrophenoxine improves memoryIn one double-blind clinical trial, researchers worked with 50 people suffering from ‘dementias of medium level’. They gave the group 2 grams of Centrophenoxine, or a placebo for 8 weeks. 48% of the group that received Centrophenoxine showed improvements in memory.[xii]

Another study was made of the effects of Centrophenoxine on the learning and memory of old mice. One group of mice were treated for 3 months and the other group received a placebo. The treated animals showed a significant improvement in memory and learning.[xiii]

Centrophenoxine Recommended Dosage

Centrophenoxine dosage is typically 500 mg to 1 gram daily.

If you’re stacking it with a racetam, split your dose. So a 1-gram dose would be 500 mg first thing in the morning, and the other half early afternoon.

Centrophenoxine seems to help increase choline and acetylcholinesterase in the brain. Which is needed for the synthesis for acetylcholine.

But keep this in mind; Centrophenoxine and DMAE are related to choline. They are not the same as choline. Centrophenoxine should not replace a regular choline source like Alpha GPC or CDP-Choline. But Centrophenoxine can be stacked with a choline source.

And yet some neurohackers take Centrophenoxine as a choline source to include in their racetam stack. Or use it as a nootropic on its own. Experiment and see what works best for you. YMMV.

Centrophenoxine Side Effects

Centrophenoxine has been used as a nootropic for nearly 50 years. So it’s safety is well established. It’s non-toxic and should be well tolerated by most neurohackers.

Some reported side effects include stomach upset, body odor, drowsiness, confusion, increased blood pressure, moderate depression, and irritability.[xiv]

If you deal with epilepsy or bipolar disorder you should avoid Centrophenoxine entirely.

Centrophenoxine could cause a boost in acetylcholine. So an excess of acetylcholine could cause the above-mentioned side effects.

Cycling Centrophenoxine with 5 days using it, and a 2-day break should eliminate any acetylcholine toxicity.

Where to buy Centrophenoxine

Centrophenoxine comes in powder form and capsules. Capsules are typically 250 – 400 mg.

I recommend buying Centrophenoxine from because their product is pure and they provide a Certificate of Analysis verifying that purity. Buy Centrophenoxine here: PureNootropics – Centrophenoxine. (Amazon)

Centrophenoxine is water-soluble so it’s not necessary to take it with a fat or oil. You may find it absorbs better or more quickly when taken with food.

Nootropics Expert Recommendation

Centrophenoxine 500 – 1,000 mg per day.

Nootropics Expert Tested and ApprovedWe recommend using Centrophenoxine as a nootropic supplement.

Your body does not make Centrophenoxine on its own. And it’s not available from food. This nootropic is a combination of DMAE and pCPA, and is only available in supplement form.

In some countries Centrophenoxine is prescribed as Lucidril® for treatment of Alzheimer’s or age-related cognitive decline.

Studies show Centrophenoxine helps stop or reverse brain degeneration by clearing out free radicals and lipofuscin from brain cells. Making Centrophenoxine one of the primary anti-aging nootropics.

Centrophenoxine also boosts available choline.  And a few studies show it can at least temporarily increase acetylcholinesterase. The enzyme needed for the synthesis of acetylcholine. Which would boost cognition, memory, recall and learning.

But we do not recommend using Centrophenoxine as your primary source of choline in your nootropic stack. We have much better acetylcholine precursors available to us including Alpha GPC and CDP-Choline.

We suggest starting with a dose of 500 mg daily. Possibly more depending on your racetam usage.

Age-related cognitive disorders like Alzheimer’s may want to up the dose to 2,000 mg per day.

I recommend buying Centrophenoxine from because their product is pure and they provide a Certificate of Analysis verifying that purity. Buy Centrophenoxine here: PureNootropics – Centrophenoxine. (Amazon)

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Georgiev V., Chavdarov D., Petkov V., Kirilov B. “Effect of centrophenoxine on acetylcholine release in perfused cerebral ventricles of cats under dynamic electrophysiological control.” Acta Physiologica et Pharmacologica Bulgaria. 1979;5(3):59-66. (source)

[ii] Marcer D., Hopkins S.M. “The differential effects of meclofenoxate on memory loss in the elderly.” Age and Ageing. 1977 May;6(2):123-31. (source)

[iii] Sharma D., Singh R. “Centrophenoxine activates acetylcholinesterase activity in hippocampus of aged rats.” Indian Journal of Experimental Biology. 1995 May;33(5):365-8. (source)

[iv] Wood P.L., Péloquin A. “Increases in choline levels in rat brain elicited by meclofenoxate.” Neuropharmacology 1982 Apr;21(4):349-54. (source)

[v] Katz M.L., Robison W.G. Jr. “What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies.” Archives of Gerontology and Geriatrics. 2002 May-Jun;34(3):169-84. (source)

[vi] Nandy K., Bourne G.H. “Effect of centrophenoxine on the lipofuscin pigments in the neurones of senile guinea-pigs.” Nature. 1966 Apr 16;210(5033):313-4. (source)

[vii] Lewis J.A., Young R. “Deanol and methylphenidate in minimal brain dysfunction.” Clinical Pharmacology and Therapeutics. 1975 May;17(5):534-40. (source)

[viii] Roy D., Pathak D.N., Singh R. “Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain.”Experimental Gerontology. 1983;18(3):185-97. (source)

[ix] Ludwig-Festl M., Gräter B., Bayreuther K. “[Increase in cell metabolism in normal, diploid human glial cells in stationary cell cultures induced by meclofenoxate].” Arzneimittel-forschung. 1983;33(4):495-501. (source)

[x] Fülöp T. Jr., Wórum .I, Csongor J., Leövey A., Szabó T., Pék G., Zs -Nagy I. “Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial.” Archives of Gerontology and Geriatrics. 1990 May-Jun;10(3):239-51. (source)

[xi] Sharma D., Maurya A.K., Singh R. “Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine.” Neurobiology of Aging. 1993 Jul-Aug;14(4):319-30. (source)

[xii] Pék G., Fülöp T., Zs-Nagy I. “Gerontopsychological studies using NAI (‘Nürnberger Alters-Inventar’) on patients with organic psychosyndrome (DSM III, Category 1) treated with centrophenoxine in a double blind, comparative, randomized clinical trial.” Archives of Gerontology and Geriatrics. 1989 Jul;9(1):17-30. (source)

[xiii] Nandy K. “Centrophenoxine: effects on aging mammalian brain.”Journal of the American Geriatrics Society. 1978 Feb;26(2):74-81. (source)

[xiv] Casey D.E. “Mood alterations during deanol therapy.”Psychopharmacology (Berlin). 1979 Apr 11;62(2):187-91. (source)

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Join The Discussion - 104 comments

April 12, 2024

Hello, where can I get centrophenoxine in Europe (Czech Republic)? Can DMEA be a good alternative?

    David Tomen
    April 12, 2024

    Matthew, I live on the USA so am not familiar with who may supply this nootropic in Europe. DMAE may work as a alternative. But please read my DMAE review first and compare them.

April 10, 2024

Hi David,
Taking choline supplements (irrespective of forms) makes me more depressed. I have tried various supplements as detailed on your website including B vitamins but no help. I researched more on this and found following link:

which explains why choline can make me depressed.

I assume I have more Acetylcholine or lack of acetylcholinesterase enzyme so adding choline/saffron/ashwagandha/B vitamins/Berberine etc is not helping me. You have mentioned centrophenoxine gets to work right away by temporarily boosting acetylcholinesterase in parts of the brain by breaking down acetylcholine I tried DMAE as well but it made me very low and caused sleep issues so I am keen to try Centrophenoxine as well.
Along with Centrophenoxine, can you please suggest any other supplements/ways to boost acetylcholinesterase or lower acetylcholine to see if it helps me?

Many Thanks for your great work.

    David Tomen
    April 10, 2024

    Alok, DMAE and Centrophenoxine are unique in their mechanism of action And there are not other supplements that I know of that can boost acetylcholinesterase. But using any of the racetams will lower acetylcholine.

      April 10, 2024

      Thanks David. So from your reply, I understand that Centrophenoxine works differently than DMAE and though DMAE did not work in my case as it has no impact on boosting acetylcholinesterase but Centrophenoxine has the potential to boost acetylcholinesterase , right? If yes, then I will try Centrophenoxine and will surely try racetams but without any choline supplements hoping it will reduce acetylcholine?
      I have 2 racetams as follows with me.
      Noopept Capsules 10mg
      Aniracetam Capsules 400mg
      kindly suggest which one to start with first and in which dose?

        David Tomen
        April 12, 2024

        Centrophenoxine will temporarily boost acetylcholinesterase.

        Start with 750 mg Aniracetam twice per day. That will definitely reduce acetylcholine. But make sure you are aware that you can reduce acetylcholine too much which will come back and bite you.

April 7, 2024 is unfortunately out of centrophenoxine. Have you tried the pure nootropics brand centrophenoxine? Is it effective? I have never tried this brand so I am skeptical. I took Nootropics Depot brand for years but they got rid of it.. Cognizin citocoline gives me unreliable side effects that centrophenoxine never has.

    David Tomen
    April 8, 2024

    Deneuve, I am not that familiar with Pure Nootropics. I suggest you ask them for a Certificate of Analysis for that batch of Centrophenoxine. If it is done by a good 3rd party testing site you’ll know what you are getting. But the key is “trustworthy” so do some research of the testing company they use.

Charles Nussbaumer
April 6, 2024

Over the past several months I have noticed supplies of Centrophenoxine going away. Trusted suppliers I have used in the past have discontinued it. I am leery of trying new ones without some independent verification of quality. I would like to try the product you cited in your comment of 14 March but it is out of stock. Do you have any idea why Centro seems to be disappearing?

    David Tomen
    April 8, 2024

    Charles, the supply chain for a lot of these supplements are still recovering from the disruption caused by COVID. And a lot of them including Centrophenoxine often come from China. Best to ask what happened to their supply and if they anticipate it being out of stock for long. I’ll also ask the affiliate manager there and see if I can get some answers and if I do I’ll report back.

March 14, 2024

I have just run out of my centrophenoxine supply and was trying to find it again to order. It has been amazingly helpful to me. Can anyone recommend a vendor that has it in stock – or will have it shortly?

    David Tomen
    March 14, 2024

    Terry, try this one:

      Thomas Bender
      March 21, 2024

      Hi David! Thanks fo all you do!

      My question is does Centrophenoxine work as well as DMAE in removing Lipofuscion from Alpha Lipoic Acid use, or is DMAE the best way to go?


        David Tomen
        March 21, 2024

        Thomas, yes it should provide the same benefit. In fact it may work even better for removing lipofuscin.

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