The best nootropic supplements for 2023 cover the fundamentals for supporting great cognitive function, performance, and brain health.
Natural nootropic supplements for attention deficit hyperactivity disorder (ADHD), boost decision-making, enhance cognitive function, learning & memory, focus, energy, and motivation.
And supplements that for many, can reduce anxiety, depression, OCD, PTSD, or age-related cognitive decline.
I have also found over years of hacking my own brain, that we can simplify the list of supplements we use if we narrow our choices down to only 5 categories for brain optimization.
Those brain hacking categories look like this …
Best Nootropics for … |
Recommended nootropics |
Processing speed, Decision-Making, Focus, Flow, & Thinking |
Acetyl-L-Carnitine, CDP-Choline, Lion’s Mane, Magnesium, L-Tyrosine, B-Complex |
Learning & Memory |
Bacopa Monnieri, CDP-Choline, DHA (Omega-3), Magnesium, Phosphatidylserine (PS), Pine Bark Extract, L-Tyrosine, B-Complex |
Anxiety & Depression |
CDP-Choline, Bacopa Monnieri, Magnesium, Rhodiola Rosea, B-Complex, Saffron |
Energy & Motivation |
Caffeine, Acetyl-L-Carnitine, CoQ10, L-Theanine, MCT Oil, Rhodiola Rosea |
Brain Repair & Maintenance |
Acetyl-L-Carnitine, Astaxanthin, CDP-Choline, DHA, Lion’s Mane, Magnesium, Phosphatidylserine (PS), Rhodiola Rosea, Pine Bark Extract, Saffron |
Table of Contents
Best Nootropic Supplements in 2023
I have my favorite nootropics after 17-years of trial and error. And I’ll share what I’ve found and use in this article. Because what works for me may work well for you too. The nootropics I’m talking about here are what I use every day.
You’ll notice in the categories above that some of the most popular nootropic supplements work in multiple areas of cognitive enhancement. This means you can use fewer capsules in a well-rounded nootropic stack.
I encourage you to invest a little time and learn how each nootropic works in your brain. Because you’ll find that many of these compounds work in synergy. This translates to smaller doses of each supplement for a bigger benefit.
The key to success with nootropics is having the willingness and determination to experiment and find out what works best for you.
And there is no “one pill” solution for repairing and optimizing your brain. It often takes several carefully chosen supplements to get the job done.
Pre-Made Nootropic Stack Benefits
Fortunately, I found the best pre-made nootropic stack in late 2015 which includes most of the nootropics I’d selected for my stack. All packed into 2 capsules in a natural pre-made nootropic stack called Mind Lab Pro® v4.0.
I’ll talk more about Mind Lab Pro® v4.0 in a few minutes and how it ties into my brain hacking goals.
The company that makes Mind Lab Pro® also produces a line of dietary supplements called Performance Lab®.
They also make a nootropic snack bar that I use when I need an energy boost. They are called Nu:tropic® bars.
And before I go to the gym, I mix a glass of Pre Lab Pro®. It contains ingredients for mental clarity, more energy, improves cognitive function, better muscle performance and growth, and quicker recovery,
get Performance Lab® Caffeine+
get Nu:tropic® bars
get Pre Lab Pro®
Choose the Best Nootropic Supplement Stack for You in 2023
If you are new to nootropics, or have years of experience but need a refresher on building your own nootropic stack, see my articles:
Beginners Guide to Nootropic Stacks
How to Create the Best Nootropic Stack
Improve Brain Function with the Best Nootropic Supplements to buy in 2023
Each of the nootropics I detail below contain links through to my full review. When you click through to each individual nootropic supplement review you’ll find more detail on what it is, why we use it as a nootropic, how it feels, the mechanism of action in your brain, potential side effects, recommended dosages, and the best supplement to buy.
You’ll also notice in the table above and each nootropic listed below that many of these ingredients are conveniently encapsulated in the Mind Lab Pro® v4.0 formula of two capsules per day.
Or in Performance Lab® Energy or Performance Lab® Caffeine+ or Nu:tropic® bars or Pre Lab Pro®.
Each of these nootropic supplement stacks are generally regarded as safe and non-toxic at recommended doses. Your mileage may vary.
How you respond to each of these compounds depends on a host of variables including:
- Genetics
- Interactions with prescription meds
- Current state of health
So please click through to each nootropic and read the side effects, drug interactions and any other notes or warnings. But in general, these are among the safest cognitive enhancers we know of.
Read more about Nootropics Safety and Side Effects
ALCAR helps transport fatty acids into mitochondria for the creation of adenosine triphosphate (ATP). [i] ATP is your main energy source throughout your day and can boost physical and mental energy.
ALCAR is a necessary cofactor for acetylcholine formation.[ii] Which boosts memory, cognitive function, mental alertness, and fluid thought.
The antioxidant properties of Acetyl-L-Carnitine provide neuroprotection. And ALCAR boosts Brain-Derived Nerve Growth Factor (BDNF) and promotes cerebral blood circulation.
Astaxanthin is one of the few antioxidants that can cross the blood-brain barrier and blood-retinal barrier, benefiting both your brain and vision.[iii]
As a nootropic, Astaxanthin is a potent antioxidant and anti-inflammatory providing protection from Alzheimer’s, Parkinson’s disease, and other neurodegenerative disease.[iv]
Astaxanthin protects your cells from the destructive effects caused by free radicals and protects cognitive function by increasing cerebral blood flow for better memory, cognitive abilities, and overall cognitive performance. [v]
And supplementing with Astaxanthin helps reduce cortisol, a biomarker for stress and mental fatigue.
Bacopa Monnieri has been used in Ayurvedic medicine for thousands of years and is one of the best nootropics for studying.
Researchers at Banaras Hindu University in India showed Bacopa Monnieri as effective for anxiety as the benzodiazepine drug lorazepam.
And unlike benzodiazepines, Bacopa Monnieri did not cause memory loss. In fact, it boosted mental function.[vi]
Another study done in Portland Oregon demonstrated that 300 mg of Bacopa Monnieri per day for 12 weeks:
- Improved word recall
- Increased attention
- Enhanced processing speed
- Boosted memory
- Improved focus while learning
- Lowered anxiety and heart rate[vii]
Caffeine is the main active compound found in a cup of coffee and is an adenosine antagonist which is why it helps prevent you from getting sleepy. Which in turn influences acetylcholine, epinephrine (adrenaline), serotonin and it boosts the use of dopamine. Providing the stimulant effect you feel when consuming caffeine.[viii]
Caffeine assists in the gene expression of brain-derived neurotrophic factor (BDNF) which boosts neurogenesis.
And caffeine increases the density of GABA receptors, potentiates dopamine, and causes some serotonin receptors to be more responsive. Which in turn improves mood within an hour of consumption.[ix]
A valuable addition to any potent nootropic stack, the cholinergic compound CDP-Choline is a multitasker which boosts cognition, mental processing, cognitive function, and brain power, improves focus and motivation, and reduces fatigue.
CDP-Choline aids in the synthesis of acetylcholine, and the release of dopamine.[x] Both neurotransmitters involved in learning and memory.
CDP-Choline also helps repair of brain cell membranes. The cytidine in CDP-Choline converts to uridine in your brain. And works as a bridge between choline and neuron membrane synthesis.
Uridine is needed to synthesize phosphatidylcholine (PC) needed to repair damaged neuron membranes.[xi]
Choline is so vital to cognitive functions, cognition and nerve function that, without it, we couldn’t move, think, sleep, or remember anything. And one the best ways to provide your brain and body with the choline it needs is supplementing with CDP-Choline.
DHA (docosahexaenoic acid) is an omega-3 fatty acid. DHA is crucial for the healthy structure and function of your brain. Your brain is made up of 60% fat. And much of that fat is DHA.
DHA enhances brain-derived neurotrophic factor (BDNF). Improving neuroplasticity leading to better learning and memory. And DHA acts as an anti-inflammatory by reducing the enzyme COX-2.
If you suffer from chronic depression, within a few weeks of adding DHA to your nootropic stack, you should feel the depression lift. You’ll think clearer and quicker. Your memory and ability to learn will improve. And you’ll likely have more energy and motivation.
But it is very likely you won’t think to attribute these improvements to adding DHA to your nootropic stack. Something else will get the credit. 😊
The thing is you cannot get these benefits from fish oil or most Omega-3’s on the market. Because the dosage of DHA is far too low. And purity is a problem.
Best to get your DHA from the source. The same place fish and other marine life get their DHA. And that’s from algae.
A recent addition to my nootropic stack, and thousands in our community, is the Performance Lab® Omega-3. It provides 540 mg DHA and 270 mg EPA made from Algal Oil (from life’s™ Omega 60) in two NutriGels® vegan softgels.
Lion’s Mane Mushroom is well-known for its neuroprotective effects. It’s an ancient Chinese remedy and traditional medicine for improving cognitive performance, and overall health.
In our modern world, Lion’s Mane makes it into some of the best nootropic stacks. Why?
Because Lion’s Mane stimulates enzyme production that releases Nerve Growth Factor (NGF).[xii] It stimulates the repair and creation of neurons (neurogenesis). Boosting neurotransmitters and signaling that may effect memory, improve cognitive function, learning, recall, and mood.
And Lion’s Mane helps eliminate brain fog. Restoring function from cognitive impairments, memory, and mental alertness. And lowers anxiety and depression symptoms.[xiii]
Lion’s Mane is a great compliment to any nootropic stack for an immediate cognitive boost.
L-Tyrosine is a precursor to the synthesis of the catecholamine-triad of neurotransmitters dopamine, norepinephrine, and epinephrine. As your dopamine levels increase, you’re better able to concentrate, organize your thoughts, and stay productive.
L-Tyrosine can be an effective for attention deficit hyperactivity disorder (ADHD) symptoms. L-Tyrosine works in synergy with Smart Drugs like Ritalin and Adderall by boosting extracellular levels of dopamine. Helping these drugs be more effective. And mitigating side effects like crashes when these smart drugs wear off.
Tyrosine also improves memory and cognition under acute stress.[xiv] It helps improve decision making, ‘flow state’ and creativity, cognitive flexibility, acts to support cognitive function, and working memory.
L-Tyrosine is a great addition to any nootropic stack, especially if you’re dealing with ADHD or ADD.
For more tips on how to deal with ADHD and ADD symptoms, see my article:
Best Nootropics for ADHD/ADD
Phosphatidylserine is one of the best nootropics because:
- PS helps the efficient transfer of proteins, enzymes, nutrients, oxygen, and glucose into and out of each cell
- PS is involved in the formation and sending of signals within neurons
- PS promotes healthy nerve growth factor (NGF)
- PS supports the neurogenesis needed for long-term potentiation (LTP)
- PS is involved in building mitochondria which are the energy centers of each brain cell.
Phosphatidylserine (PS) is arguably one of the most effective and important nootropics we have available today. It has a reputation for improving alertness, attention, cognition, cognitive function, memory, recall and mood.[xv]
Maritime Pine Bark Extract is one of the best nootropics around but relatively unknown to the nootropic community. It’s a naturally derived standardized herbal extract of French maritime pine bark.
Pine Bark Extract helps prevent increases in dopamine, norepinephrine, and the glutathione (GSH) to GSH-disulphide reductase (GSSG-R) ratio. Neurotransmitter problems which contribute to hyperactivity in attention deficit hyperactivity disorder (ADHD).[xvi]
Pine Bark Extract helps by increasing blood flow to and within your brain for better overall brain health.[xvii] By increasing nitric oxide (NO) which helps dilate blood vessels. And helping repair and maintain the health of the lining of blood vessels. Crucial to overall brain health, maintaining signaling pathways and leading to improved cognitive function and learning and memory.
And Maritime Pine Bark Extract also helps prevent the accumulation of oxidatively damaged proteins. Which may reduce the risk of diseases like Parkinson’s, Alzheimer’s, and Huntington’s.
In Russia, Rhodiola Rosea is widely used as a remedy for fatigue, poor concentration, and decreased memory. It’s also believed to make workers more productive.
As one of the best nootropics around, this adaptogen helps reduce stress and fatigue, cognitive function, increase energy, alertness, and stamina, while boosting mental performance under periods of chronic stress.
Research shows Rhodiola Rosea can increase attention to detail-oriented tasks by improving concentration over a prolonged period. Making it one of the best nootropics for studying.
Rhodiola Rosea boosts mood by influencing serotonin and norepinephrine levels in your brain, and the feel-good opioids like beta-endorphins.
It also helps with neurogenesis by repairing and growing new neurons. As well as activating the synthesis and re-synthesis of ATP, your body and brain cell’s main energy source.
One more reason to add Rhodiola Rosea to your nootropic stack – it helps reduce inflammatory C-reactive protein. And salidroside, one of many components of this incredible herb, protects neurons from oxidative stress-induced cell death.
Saffron is the dried stigma of the Crocus sativus plant native to the Middle East. And is the world’s most expensive culinary spice largely due to the way it must be grown and harvested (by hand).
Saffron has been used for thousands of years as an anxiolytic, sedative, and antidepressant.
Recent studies show Saffron as effective as some popular prescription antidepressants. And can even help alleviate the sexual dysfunction caused by these drugs.[xviii]
Saffron extracts (crocin & safranal) inhibit the uptake of dopamine and norepinephrine in the brain which helps improve mood.
Saffron inhibits the deposit of amyloid-β which is associated with the progression of Alzheimer’s disease. Saffron also inhibits the breakdown of acetylcholine (acetylcholinesterase) just like the current medication (donepezil) approved to treat Alzheimer’s.[xix]
Saffron is also a very effective vision supplement. Driving at night is easier on your eyes. And the flicker caused by screens and monitors won’t leave you with eye fatigue later in the day.[xx]
Saffron improves the oxygen and nutrient supply required for healthy eyes. By boosting blood flow in the retina and choroid of your eyes.[xxi]
For the best vision supplement on the market, get: Performance Lab® Vision. I’m serious. Get it!
L-Theanine is an amino acid and one of the main natural substances you get from green and oolong tea. Many consider it the best nootropic when combined with caffeine for the synergistic effect of lowering blood pressure, rejuvenate and relax, boost thinking ability and cognitive function, improve focus and put you in a better mood.
This amazing amino acid:
- Boosts alpha brain waves (8-12Hz) promoting alert relaxation.[xxii]
- Increases GABA, serotonin, and dopamine use in your brain. Producing an energizing and calming effect helping you go into flow. And improving cognition and memory.
- Is an antagonist of NMDA receptors and can inhibit synaptic release of glutamate. Protecting your brain from over-stimulation caused by glutamate, and possible glutamate toxicity.
- Boosts the use of neurotransmitters serotonin, dopamine, and GABA in your brain. As well as increasing Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF).[xxiii]
Most neurohackers report a calming effect within 30 – 45 minutes of taking L-Theanine. Cognition gets a boost, and energy levels rise without the jitteriness caused by stimulants like caffeine.
Some report L-Theanine has stopped their anxiety and panic attacks.
-
Vitamin B-Complex
The B-Vitamins are essential vitamins that should be part of every nootropic stack and they include:
- Vitamin B1 (Thiamine) – needed to produce ATP within mitochondria and is a cofactor in acetylcholine synthesis
- Vitamin B3 (Niacin) – used in the synthesis of acetylcholine and cerebral blood flow
- Vitamin B5 (Pantothenic Acid) – needed to make acetylcholine
- Vitamin B6 (P-5-P) – required for the synthesis of dopamine, epinephrine, GABA, melatonin, norepinephrine, and serotonin[xxiv]
- Vitamin B8 (Inositol) – regulates cell volume, signaling pathways in brain cells, DNA repair, long-term potentiation, is a component of cell membranes, regulates cellular metabolism and cellular energy consumption
- Vitamin B9 (Folate) – involved in DNA and RNA synthesis, cognitive function, gene expression, amino acid synthesis, myelin synthesis and repair, and required for synthesis of dopamine, epinephrine, and serotonin.
- Vitamin B12 (Methylcobalamin) – required for the synthesis of the neurotransmitters dopamine, GABA, norepinephrine, and serotonin.
You may not realize the full benefit of a nootropic stack containing CDP-Choline, Acetyl-L-Carnitine, any of the racetams, or any nootropic for that matter without adding a good quality bioactive B-Vitamin Complex. These essential vitamins are possibly the most important and least expensive addition to your stack.
get Performance Lab® Caffeine+
get Nu:tropic® bars
get Pre Lab Pro®
Check Your Oil
Some nootropic supplement labels recommend taking it with a meal. The implication behind this recommendation is that the nootropic is fat-soluble. And requires some fat for proper absorption and to increase bioavailability.
Each of the nootropics above have links through to a full review which includes information about solubility – fat or water soluble.
To make sure all fat-soluble ingredients in my stack are absorbed, I use one tablespoon of organic Performance Lab® MCT oil with my nootropic stack. But you can use unrefined coconut oil as well.
This healthy oil provides the fat I need for better absorption of fat-soluble supplements. And I don’t have to worry about taking it with a meal.
Using MCT or unrefined coconut oil with my stack does not interfere with water-soluble supplements either. It’s a win-win.
Choose the Clear Path to Improved Performance in 2023
I’ve tried a lot of different nootropic stacks in the last 17 years. But in late 2015, I finally found one high quality pre-made stack that covered all the bases. That stack is Mind Lab Pro® v4.0.
I’ve used Mind Lab Pro® as the “base” for my personal nootropic stack since 2015. And continue to use it in 2023. It’s that good.
In fact, in 2017 Mind Lab Pro® upgraded their formula. Their B-Vitamins are now their own proprietary NutriGenesis® vitamins. ‘Nature-identical’ nutrients that your body recognize as food.
Then in 2018, their sister company introduced an entire new supplement brand called Performance Lab®. The company recognized the demand for more choices when it comes to brain optimization. And the need to support the rest of your body.
Performance Lab® offers the pre-formulated nootropic stacks Performance Lab® Mind, Performance Lab® Caffeine+, and Performance Lab® Energy.
Their nootropic stacks are supported by the Performance Lab® NutriGenesis Multi which I also use daily. This multi contains nature-identical NutriGenesis® vitamins and minerals for whole-body and brain performance.
This is now my preferred multivitamin supplement which works very well with Mind Lab Pro® v4.0.
In early 2018, I switched from using individual supplements to Performance Lab® Energy. Because this stack contains the Acetyl L-Carnitine (ALCAR), Coenzyme Q10, PQQ, and R-Lipoic Acid that I was buying and using separately which was more expensive.
Performance Lab® Energy uses the patented, clinically-tested forms of each ingredient in NutriCaps® vegan-friendly capsules and no additives. Just pure, tested nutrients that work.
In 2019 I added Performance Lab® Caffeine+ which I use occasionally when energy is running a little ragged. And I need that extra boost to finish what I’m doing.
Because it contains Natural Caffeine (from Coffea Robusta seeds) 50 mg, L-Theanine (Suntheanine®) 100 mg, Ajipure® L-Tyrosine 250 mg, supported by NutriGenesis® Vitamin B2, Vitamin B6, Vitamin B9 & Vitamin B12. For alert clean energy without the negative side effects like the jitters.
Or a get a quick boost by using a Nu:tropic® bar which contains Norwegian Black Oats, NutriGenesis® Choline, DHA (Omega-3) 150 mg, Prebiotic fiber, Phosphatidylserine (PS), NutriGenesis® Magnesium, and NutriGenesis® Vitamins D3, K2, B2, B3, B6, B9 & B12.
Performance Lab® also offers supplement stacks for Vision, Sleep, Prebiotic, Flex, and Pre Lab Pro® which I use just before I go to my gym for a workout.
And they make an effective T-Booster for men.
Conclusion – Best Nootropic Supplements
If you’re feeling frustrated finding your ideal stack, my hope is this page provides the pointers you need to create your best nootropic stack.
Each nootropic I’ve featured on this page works. How do I know? Because I use them every single day.
But I’m not the only one. 100’s of thousands of people just like you and I have found success with these nootropics too.
I encourage you to try each of them in your nootropic stack in 2023. Or save some money on your monthly supplement purchases and try some of the pre-formulated stacks like Mind Lab Pro® v4.0 and the Performance Lab® supplements. The company even offers a money-back guarantee if you try one of their supplements and are not happy with it.
My attitude is that once I’ve found a nootropic supplement company that puts out high quality product, I keep using them until something better comes along.
So far that has not happened. I’m confident you’ll like and appreciate the pre-formulated nootropic stacks on this page. The company puts out amazing products.
When it comes to brain optimization and what I put in my body, “good enough” isn’t nearly good enough until I’m performing my best. In all areas of life.
The right combination of nootropics in the right amounts have helped me get to the point where I feel I’m performing better than ever.
Near the beginning of this page we identified the main points that lead to better cognitive ability, cognitive function, cognition, decision-making, focus, flow, thinking, memory, anxiety, depression, energy, motivation, brain repair and maintenance.
What I love about the nootropic supplements outlined on this page is that it covers each of those categories.
And to help you fine-tune your nootropic stack even further. Spend some time with each of the following articles I have written on individual areas of brain optimization here.
Best Nootropics for Learning & Memory
Best Nootropics for Social Anxiety
Best Nootropics for Depression
Best Nootropics for Motivation
Best Nootropics for Hacking a Flow State
Psychobiotics: The Gut-Brain Connection
How to Select the Best Multivitamin for Brain Function
[i] Berg J.M., Tymoczko J.L., Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. (source)
[ii] White H.L., Scates P.W. “Acetyl-L-carnitine as a precursor of acetylcholine.” Neurochemical Research 1990 Jun;15(6):597-601. (source)
[iii] Galasso, C., Orefice, I., Pellone, P., Cirino, P., Miele, R., Ianora, A., Brunet, C., & Sansone, C. (2018). On the Neuroprotective Role of Astaxanthin: New Perspectives?. Marine drugs, 16(8), 247. (Source)
[iv] Nakagawa, K., Kiko, T., Miyazawa, T., Carpentero Burdeos, G., Kimura, F., Satoh, A., & Miyazawa, T. (2011). Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. The British journal of nutrition, 105(11), 1563–1571. (Source)
[v] Lobos, P., Bruna, B., Cordova, A., Barattini, P., Galáz, J. L., Adasme, T., Hidalgo, C., Muñoz, P., & Paula-Lima, A. (2016). Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers. Neural plasticity, 2016, 3456783. (Source)
[vi] Bhattacharya S.K., Ghosal S. “Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study.” Phytomedicine. 1998 Apr;5(2):77-82 (source)
[vii] Calabrese N.D., Gregory W.L., Leo M., Kraemer D., Bone K., Oken B. “Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial” Journal of Alternative and Complimentary Medicine 2008 Jul; 14(6): 707–713. (source)
[viii] Walker J., Rohm B., Lang R., Pariza M.W., Hofmann T., Somoza V. “Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12).” Food and Chemical Toxicology. 2012 Feb;50(2):390-8 (source)
[ix] Gjorness T.E., Greene R.W. “Adenosine and Sleep” Current Neuropharmacology. 2009 Sep; 7(3): 238–245. (source)
[x] Adibhatla R.M., Hatcher J.F., Dempsey R.J. “Citicoline: neuroprotective mechanisms in cerebral ischemia.” Journal of Neurochemistry 2002 Jan;80(1):12-23 (source)
[xi] Wang L., Pooler A.M., Albrecht M.A., Wurtman R.J. “Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats.” Journal of Molecular Neuroscience 2005;27(1):137-45. (source)
[xii] Lai P.L., Naidu M., Sabaratnam V., Wong K.H., David R.P., Kuppusamy U.R., Abdullah N., Malek S.N. “Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.” International Journal of Medicinal Mushrooms. 2013;15(6):539-54. (source)
[xiii] Nagano M., Shimizu K., Kondo R., Hayashi C., Sato D., Kitagawa K., Ohnuki K. “Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.” Biomedical Research. 2010 Aug;31(4):231-7. (source)
[xiv] Coull N.A., Watkins S.L., Aldous J.W., Warren L.K., Chrismas B.C., Dascombe B., Mauger A.R., Abt G., Taylor L. “Effect of tyrosine ingestion on cognitive and physical performance utilising an intermittent soccer performance test (iSPT) in a warm environment.”European Journal of Applied Physiology. 2015 Feb;115(2):373-86. (source)
[xv] Crook T.H., Tinklenberg J., Yesavage J., Petrie W., Nunzi M.G., Massari D.C. “Effects of phosphatidylserine in age-associated memory impairment.” Neurology 1991 May;41(5):644-9. (source)
[xvi] Dvoráková M., Jezová D., Blazícek P., Trebatická J., Skodácek I., Suba J., Iveta W., Rohdewald P., Duracková Z. “Urinary catecholamines in children with attention deficit hyperactivity disorder (ADHD): modulation by a polyphenolic extract from pine bark (pycnogenol).” Nutritional Neuroscience 2007 Jun-Aug; 10(3-4):151-7. (source)
[xvii] Nishioka K., Hidaka T., Nakamura S., Umemura T., Jitsuiki D., Soga J., Goto C., Chayama K., Yoshizumi M., Higashi Y. “Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans.” Hypertension Research. 2007 Sep;30(9):775-80. (source)
[xviii] Lopresti A.L., Drummond P.D., Inarejos-García A.M., Prodanov M. “affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study.” Journal of Affective Disorders. 2018 May;232:349-357 (source)
[xix] Banerjee S., Hellier J., Romeo R., et al. “Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.” Health Technology Assessment. 2013 Feb;17(7):1-166. (source)
[xx] Natoli R., Zhu Y., Valter K., Bisti S., Eells J., Stone J. “Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina.” Molecular Vision. 2010 Sep 3;16:1801-22. (source)
[xxi] Xuan B., Zhou Y.H., Li N., Min Z.D., Chiou G.C. “Effects of crocin analogs on ocular blood flow and retinal function.” Journal of Ocular Pharmacology & Therapeutics. 1999 Apr;15(2):143-52. (source)
[xxii] Mason R. “200 mg of Zen” Alternative and Complementary Therapies. July 2004, 7(2): 91-95. (source)
[xxiii] Yamada T., Terashima T., Wada K., Ueda S., Ito M., Okubo T., Juneja L.R., Yokogoshi H. “Theanine, r-glutamylethylamide, increases neurotransmission concentrations and neurotrophin mRNA levels in the brain during lactation.” Life Sciences. 2007 Sep 29;81(16):1247-55. (source)
[xxiv] Clayton P.T. “B6-responsive disorders: a model of vitamin dependency.” Journal of Inherited Metabolic Disease. 2006 Apr-Jun;29(2-3):317-26. (source)
Hi David. I landed here because a friend mentioned methylene blue and I was eventually led to your website. . . . I seek ways to heal my mother’s brain as it relates to vision impairment. Would a consultation with you be helpful? Is what I describe below an area that you get involved with? My understanding is that you do not provide medical or disease-specific advice, which is fine. Any further referrals would be taken very seriously.
My 81-year-old mother suffered a stroke in late March of this year, and some indications are that she may have a brain tumor. I am getting the imaging on that reevaluated, as it shows contradictory information.
I have taken her this far, to better cognition (with room for improvement) and healing of bruises and fractured ribs from a car accident that occurred when her right vision went bad. We have engaged a holistic/integrative doctor/friend through my own practice as a holistic health consultant and referral source, and he has put her on supplements, some of which you mention.
Her biggest issue is the impaired vision. This is definitely brain related and does not originate from the eyes themselves. The problem is not only visual but in her comprehension of what she sees. Even though it is hard for her to explain, I have personally (fortunately or unfortunately) been afflicted with this at very rare times over more than 20 years – said recently to be symptoms of stroke in me (yikes!) – so I fully empathize with how frustrating and disorienting it can be. It’s like a scrambling of the visual field.
The dementia comes and goes. She is understandably stressed.
Mom can no longer read; she doesn’t see the right side of each word. She has trouble remembering what day it is. Her mobile phone and TV remotes are sources of constant struggle, requiring me to be around to help or she gets very confused and frightened.
Having lived with her for a few years, I recognize also the emotional component of this and see clearly how that has contributed to this event. I’m working on some help for that, but it must be her own decision to pursue it. At the least, putting her into a parasympathetic state, often, seems wise.
Beth, I’m not a doctor nor have I played on on TV. So can only suggest you spend some time reading the article on this website. Here are a couple to start with:
https://nootropicsexpert.com/best-nootropics-for-the-aging-brain/
https://nootropicsexpert.com/performance-lab-vision-review/
What are your thought on taking Mucuna Pruriens (Velvet Bean) to increase energy and dopamine, as well as libido supplement.
Greg, I normally recommend L-Tyrosine for increasing dopamine for any reason including boosting libido. How much L-DOPA you get from Mucuna Pruriens is low and even then is unpredictable. Can you trust the percentage declared on the label to what is in the capsule? With L-Tyrosine you know exactly what you are getting. And both increase dopamine.
My husband has Parkinson’s! In the last 12 months his cognitive skills have declined .Would Mind lab Pro be helpful or does he need a personal stack ? Do you have other Parkinson’s clients that u have helped ? Regards Jennifer Strong
Jennifer, I have done several consultation with Parkinson’s patients and am happy to help you if you are interested. Here is a link to my calendar: https://calendly.com/davidtomen/60-minute-consultation-with-nootropics-expert
Mind Lab Pro used long-term will provide your husband with some benefit. But there is not nearly enough N-Acetyl L-Tyrosine to take care of Parkinson’s symptoms. For that you need L-DOPA extracted from Mucuna Pruriens. But you need a 95% extract which are hard to find.
I can help with a supplement stack that has helped others including the right brain of L-DOPA.
Hi David,
Do u think Methylene blue and Huperzin A are important ingredients to be stacked along with the other nootropic drugs. I am already consuming MindLabPro. If methylene blue and Huperzin A are also important how do they help and what are the top brands in this category?
Regards,
Amit.
Amit, neither Methylene Blue nor Huperzine-A are ‘necessary’. They are optional and used to treat specific brain functions. But both can be used with Mind Lab Pro following dosage recommendations for each. Including only using Huperzine-A every 2nd day and not daily.
What do you think about combining pycnogenol and vinpocetine throughout the day, and maybe even ginkgo biloba?)
Dan, I use Pycnogenol and Vinpocetine 3-times per day. And recommend Ginkgo Biloba as well if it works for you.
Thanks David for your endless insight. Do you have a quality B-complex that you’d recommend?
Adam, here is my favorite BioActive B-Complex: https://nootropicsexpert.com/go/life-extension-bioactive-b-complex/
Hello David, I am thinking about adding SAM-e to my nootropics stack but it is very expensive to purchase a high quality product in Canada. Before I decide to make the financial commitment I would love to get your opinion on which of the above mentioned categories would SAM-e provide some benefit ? Would it be a worthwhile addition to my nootropics stack ?
Thank you for all of the work that you do, you really are the best source of information for anyone wanting to educate themselves and utilize nootropics to improve the quality of their lives.
David, you need adequate methionine to naturally produce SAM-e in your system. But methionine is not available as a supplement. Better to use a bioactive Multi like this one: https://bit.ly/347dm5M.
But some need to supplement with SAM-e and yes it is expensive no matter what country you get it. If you have problems with methylation and MTHFR the it is worth the investment.
Now foods sells good L-methionine, but I read that there can be side effects if you take more than the daily dose, up to worse brain and heart function
Dan, there is some evidence that indicates excess methionine can be harmful and can increase the risk of developing Type-2 diabetes, heart diseases, certain types of cancer, brain alterations such as schizophrenia, and memory impairment (https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-015-0057-0).
Sulbutiamine was on the 2022 list. I was wondering why it was removed from the 2023 list?
Onur, because there are some countries where Sulbutiamine is not available as a dietary supplement. I attempted to structure this list to reflect highly effective natural nootropics that anyone can get anywhere in the world without a prescription from their doctor.
It seems like benfotiamine also increases thiamine in the brain well. though not as effective as sulbutiamine.
Hi David,
Thank you for your article. It is very helpful for me. I have a question. My 14 yrs old daughter has OCD. She is active athlete and takes no medication for several months now but OCD symptoms are still here. We started supplementing with magnesium and b komplex recently. I would be very grateful to you if you can help us with choosing the best supplements for ocd. Thank you very much and I wish you good luck.
By by from Europe
Nika, try Saffron and Uridine Monophosphate. I have an entire list of supplements that can help with OCD. But have not had the time to write an article about it. I’m happy to share the entire list with you including explanations on how and why they work if you’d like to schedule a consultation.