Lion’s Mane (Hericium erinaceus) is unique in the mushroom family both in appearance and function. Lion’s Mane Mushroom is extremely effective at stimulating Nerve Growth Factor (NGF) in the brain.
Known for its powerful effects as a “brain tonic”, Lion’s Mane is said to have been used as a tea for thousands of years by Buddhist monks. To enhance brain power, and heighten their ability to focus during meditation.
Lion’s Mane as a nootropic, is a powerful catalyst for brain cell regeneration helping improve memory and cognition.
The primary active compounds in Lion’s Mane are hericenones and erinacines. Erinacines help your brain produce more Nerve Growth Factor. Erinacines easily cross the blood-brain barrier to boost the production of neurons.
Lion’s Mane helps:
- Nerve Growth Factor. Lion’s Mane Mushroom prevents and treats nerve damage in the brain. Once past the blood-brain barrier, Lion’s Mane stimulates enzyme production that release Nerve Growth Factor (NGF). Nerve regeneration helps relieve neurodegenerative disease symptoms such as Alzheimer’s, dementia, and Parkinson’s Disease.
- Neurogenesis. Lion’s Mane stimulates the repair and creation of neurons. Boosting neurotransmitters and signaling that effects memory, learning, recall, and mood.
- Brain Optimization. Lion’s Mane helps eliminate brain fog. Restoring memory and mental alertness. And improves anxiety and depression symptoms.
Table of Contents
Overview
Lion’s Mane (Hericium erinaceus) is a medicinal mushroom proven to benefit the brain, nerves and immune system.
Unlike other mushrooms sporting a cap and stem, Lion’s Mane has long, flowing, white tendrils. Resembling a lion’s mane. Other names include Monkey’s Head, Bearded Tooth, Pom Pom Blanc, Hedgehog Mushroom and Satyr’s Beard.
This parasitic fungus grows hanging off logs and trees. And is native to North American, Europe and Southeast Asia. In Japan, it’s called yamabushitake or “those who sleep in mountains”. Referring to the Shugendo sect of hermit monks and their long, flowing robes.
As a nootropic, Lion’s Mane has been shown to be particularly effective in stimulating Nerve Growth Factor (NGF) in the brain.
NGF is produced in the hippocampus throughout life. Modulating cholinergic receptors and neuroplasticity.[i] And is essential for learning.
Nerve Growth Factor are special proteins that function to regenerate neurons. Lion’s Mane contains two unique classes of NGF’s – hericenones and erinacines which easily cross the blood-brain barrier.
Lion’s Mane, like other medicinal mushrooms, contain high amounts of the antioxidant beta-glucoxylan and four other polysaccharides and polypeptides. Having a significant impact on enhancing your immune system. And decreasing tumor growth.
Lion’s Mane has also been studied in reducing amyloid plaques. These clumps of beta-amyloid proteins block signals between neurons. And are implicated in Alzheimer’s and other neurodegenerative diseases.
Lions’ Mane is also used to treat Lyme’s Disease, and digestive tract issues.
Here we’re talking about Lion’s Mane Mushroom and its effects on brain health and chemistry.
How does Lion’s Mane Work in the Brain?
Lion’s Mane boosts brain health and function in several ways. But two in particular stand out.
- Lion’s Mane Mushroom stimulates the synthesis of Nerve Growth Factor (NGF). NGF is a protein that plays a major role in the maintenance, survival and regeneration of neurons.
NGF is required by your brain to keep neurons strong and healthy. When various neurological disorders occur, your brain is unable to produce its own internal source of NGF.
In a study done in Kuala Lumpur in 2013, scientists showed that Lion’s Mane extract induced NGF synthesis and promoted neurite outgrowth.[ii]
- Lion’s Mane is effective in reducing anxiety and depression. Some even call it the “smart mushroom” for its ability to improve cognition, memory and work as an anti-depressant.
A study by researchers in Japan worked with 30 women. The female subjects had been complaining about menopause, depression, sleep quality and other issues.
The women randomly received Lion’s Mane-laced cookies or a placebo for 4 weeks. The researchers found that Lion’s Mane “has the possibility to reduce depression and anxiety, and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus”. [iii]
How things go bad
Science once believed that the brain could not grow new brain cells. That once our brain developed during childhood, and we reached adulthood, we had all the brain cells we’d ever have.
Now we know that neurons can regenerate. But that doesn’t mean they will regenerate. A number of health issues can contribute to neurodegeneration.
↓ Decrease in Nerve Growth Factor = Decrease in Long-Term Potentiation affecting long-term memory[iv]
↓ Brain cells die and are not replaced
↓ Neuroplasticity declines resulting in poor memory
↓ Neurotransmitters decline resulting in anxiety, poor mood and depression
All of these age-related changes are contributing factors to neurodegenerative diseases like Alzheimer’s, Parkinson’s and others. And anxiety, depression and mood disorders that affect quality of life.
Lion’s Mane benefits
At least a dozen peer-reviewed studies have been published on Lion’s Mane benefits to brain health since 1991. Dr. Kawagishi of Japan was first to identify Nerve Growth Factor properties in Lion’s Mane Mushroom.[v]
In one double-blind, placebo-controlled trial, researchers in Japan worked with 50 – 80 year old men and women. All suffered from mild cognitive impairment.
The trial subjects received four 250 mg tablets containing 96% of Yamabushitake (Lion’s Mane) dry powder three times a day for 16 weeks. The men and women were tested at 4, 8, 12 and 16 weeks.
At each of the testing periods, the subjects who had used Lion’s Mane showed a significant improvement in cognitive scores. And their scores were increasing while on Lion’s Mane supplementation. But 4 weeks after stopping Lion’s mane supplementation, their cognitive scores decreased significantly.
The researchers concluded that Lion’s Mane Mushroom is effective in improving mild cognitive impairment.[vi]
How does Lion’s Mane feel?
You may not experience the effects of supplementing with Lion’s Mane Mushroom immediately. But many users report with continued use of Lion’s Mane, a boost in mood and mental energy.
Some report it increases depth perception. And an improvement in sense of smell.
Others testify to improved decision-making, the ability to solve problems and learning. Likely due to Lion’s Mane ability to improve neuroplasticity.
The overall consensus is Lion’s Mane Mushroom’s ability to lessen anxiety, reduce depression, and improve concentration.
The Research
Lion’s Mane Mushroom has been used as a food and herbal medicine since ancient times in East Asia. And it has been reported in scientific research that Lion’s Mane promotes Nerve Growth Factor both in the petri dish as well as in animal and human test subjects.
Lion’s Mane Prevents Cognitive Dysfunction
In this study, researchers examined the effects of Lion’s Mane on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Amyloid β(25-35) peptide is implicated in diseases like Alzheimer’s.
Mice were injected with the peptide on days 7 and 14 of the trial. And they were fed a diet containing Lion’s Mane over 23-days of the experiment. The results showed that Lion’s Mane prevented short-term and visual recognition memory reduction normally induced by amyloid β(25-35) peptide.
They concluded that Lion’s Mane Mushroom “may be useful in the prevention of cognitive dysfunction”.[vii]
Lion’s Mane Induces Nerve Growth Factor
In this trial, mice were fed Lion’s Mane 5% freeze-dried powdered extract for 7 days. Researchers found an increase in the level of Nerve Growth Factor (NGF) in the hippocampus of the mice. Concluding that Lion’s Mane “contains active compounds that stimulate NGF synthesis”.[viii]
Lion’s Mane Repairs Nerves
In this study done with rats, Lion’s Mane extract was able to promote neuron regrowth after injury. Rats with gluteal nerve damage were able to walk again after consuming water containing Lion’s Mane extract.
The researchers concluded that Lion’s Mane regenerates damaged nerve cells. In this case, the reversal was so profound, the rats went from being totally disabled to walking again.[ix]
Lion’s Mane Dosage
Wondering how much Lion’s Mane to take? Dosing of Lion’s Mane Mushroom depends on the strength of the extract.
For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day. This means that if you choose a daily dose of 1,000 mg of Lion’s Mane extract, you should take 500 mg in the morning, and another 500 mg at noon.
Other retail extract dosage of Lion’s Mane ranges from 300 mg to 3000 mg dosed 1 – 3 times per day. Check the label and see what the manufacturer recommends. And when first using the supplement, start with the lowest dose and see how your body reacts.
Lion’s Mane Side Effects
Lion’s Mane Mushroom is non-toxic and considered very safe. So there are very few side effects reported.
Some neurohackers report itchy skin from higher doses. Likely attributable to a boost in Nerve Growth Factor.
Lion’s Mane has been tested in animals showing no side effects or toxicity even up to 5 grams per kilogram.
Best type of Lion’s Mane to buy
Lion’s Mane Mushroom (Hericium erinaceus) as a nootropic supplement is usually offered as an extract. In powdered form, or in a capsule.
Lion’s Mane Mushroom can be found in some of higher quality pre-formulated nootropic stacks. For example, Mind Lab Pro® contains 11 brain enhancing nootropic compounds including Lion’s Mane with the full fruit spectrum including hericenones and erinacines.
I recommend Mind Lab Pro® because it addresses all aspects of anxiety resistance, memory and cognitive enhancement, stabilizes mood, brain repair, and maintenance.
This premium nootropic stack is designed to affect neurotransmitters, cognitive energy, brain waves, neuroprotection, and regeneration. See my Mind Lab Pro review for a detailed report.
When choosing a Lion’s Mane supplement, there’s debate over the best form of extraction to achieve the mushroom’s full medicinal benefit. Some say your best option is a hot water extraction. Another says alcohol extraction. Another claims both are necessary.
But when it comes to mushrooms, saying that one is “more potent” than another is just too simplified to be true. This is as much an art as it is science.
Much more important is choosing a supplement that includes the mycelium of Lion’s Mane Mushroom. In this mushroom, the fruiting body does not contain erinacines which is the compound that boosts Nerve Growth Factor (NGF).
The nootropic benefits of hericenones only found in the fruiting body or top of the mushroom help support your immune system and get rid of Amyloid β(25-35) peptide implicated in diseases like Alzheimer’s.
The challenge is getting a Lion’s Mane Mushroom extract that contains the full spectrum found in both the mycelium and fruiting body. But the mushroom must be grown in liquid and not a solid substrate like grain. Otherwise you’ll get ground up grain without the important erinacines needed for increased NGF.
Look at the manufacturer’s literature and marketing material and find out how their Lion’s Mane is grown. And read the reviews on shopping sites as well as forums.
Types of Lion’s Mane available:
- Plain Lion’s Mane: Pure, powdered mushroom. Often freeze-dried, and the cheapest form available. Can be added to water, juice or smoothies.
- Lion’s Mane Extracts: A more potent form of mushroom. Often presented as 14:1 or 10:1 extracts (14 pounds or 10 pounds reduced to 1 pound of extract).
- Standardized Lion’s Mane: Processed to provide exact levels of active ingredients. You can get Lion’s Mane standardized to 30% and 50% polysaccharides (including the active secondary metabolites hericenones and erinacines).
- Lion’s Mane tea: Since this is a popular mushroom in the kitchen, the taste is acceptable. But it’s hard to get a handle on how much actual active ingredient you’re getting.
- Amycenone®/PLM-Fraction: This “branded” product is standardized to Hericenones 0.5%, Amyloban 6%. It seems to target a lesser-known Lion’s Mane active ingredient–Amyloban–which is positioned as a mushroom compound that fights beta-amyloid proteins. Originating in Japan, it is extremely expensive, and may be found in a supplement called Amyloban®3399.
And if you decide to pick your own, before consuming any wild mushroom, make sure that it is accurately identified. Mushroom poisoning is a real problem if you pick the wrong one.
For a full list of Mycology societies that may be able to help you, go to the North American Mycological Association website (www.namyco.org).
Nootropics Expert Recommendation
Lion’s Mane 500 mg per day
I recommend using Lion’s Mane as a nootropic supplement.
Your body does not make Lion’s Mane on its own. So you need to take it as a supplement.
Lion’s Mane is especially helpful for regenerating brain cells. It prevents neurodegenerative diseases like Alzheimer’s and Parkinson’s.
And it boosts long-term potentiation for memory and mental sharpness. By stimulating Nerve Growth Factor.
Lion’s Mane also helps boost mood, tame anxiety and relieve depression. For a better quality of life.
We suggest starting with a dose of 500 mg daily. The best human study used 3000 mg per day. But another researcher found lower concentrations may stimulate NGF better than higher concentrations.[x]
Start at 500 mg per day and see how it works for you. If you don’t experience a benefit, boost Lion’s Mane in small increments of 250 mg per day until you notice an improvement. And make sure you are using a supplement containing the mycelium and fruiting body that is grown in a liquid medium.
You can buy individual Lion’s Mane supplements. Or you could try my favorite pre-formulated nootropic stack Mind Lab Pro® which includes the full spectrum including hericenones and erinacines found in Lion’s Mane Mushroom.
Mind Lab Pro contains a synergistic blend of 11 brain enhancing nootropics covering all aspects of cognition and brain health. See my full Mind Lab Pro review for more.
Lion’s Mane is a great compliment to a nootropic stack including Aniracetam, Alpha GPC and Omega-3’s for an immediate cognitive boost.
[i] Conner J.M. et. Al. “NGF Is Essential for Hippocampal Plasticity and Learning” The Journal of Neuroscience 2 September 2009, 29(35): 10883-10889 (source)
[ii] Lai P.L., Naidu M., Sabaratnam V., Wong K.H., David R.P., Kuppusamy U.R., Abdullah N., Malek S.N. “Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.” International Journal of Medicinal Mushrooms. 2013;15(6):539-54. (source)
[iii] Nagano M., Shimizu K., Kondo R., Hayashi C., Sato D., Kitagawa K., Ohnuki K. “Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.” Biomedical Research. 2010 Aug;31(4):231-7. (source)
[iv] Kelly A., Conroy S., Lynch M.A. “Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus.”Neuropharmacology. 1998 Apr-May;37(4-5):561-70. (source)
[v] Kawagishi H., et. Al. “Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum” Tetrahedron Letters Volume 35, Issue 10, 7 March 1994, Pages 1569–1572 (source)
[vi] Mori K., Inatomi S., Ouchi K., Azumi Y., Tuchida T. “Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.”Phytotherapy Research. 2009 Mar;23(3):367-72. (source)
[vii] Mori K., Obara Y., Moriya T., Inatomi S., Nakahata N. “Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.” Biomedical Research. 2011 Feb;32(1):67-72. (source)
[viii] Mori K., et. Al. “Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells” Biology Pharmaceutical Bulletin September 2008 31(9) 1727—1732 (2008) (source)
[ix] Wong K.H., Naidu M., David P., Abdulla M.A., Abdullah N., Kuppusamy U.R., Sabaratnam V. “Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae).” Evidence-Based Complementary and Alternative Medicine. 2011;2011:580752. (source)
[x] Sabaratnam V., Kah-Hui W., Naidu M., David P.R. “Neuronal Health – Can Culinary and Medicinal Mushrooms Help?” Journal of Traditional and Complimentary Medicine 2013 Jan-Mar; 3(1): 62–68. (source)
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Dear David,
Can lion’s mane be taken at pm vs am? Would there be any difference in cognitive benefits?
Best regards,
Jamie
Lion’s Mane increases NGF and it is best used morning and noon.
Dear David,
I notice cognitive benefits from Lion’s mane, but when I increase dosage beyond 500mg, I start getting extreme dry mouth and I need to drink ridiculous amount of water. Could this mean maybe Lion’s mane isn’t working for me and should look for an alternative cognitive enhancer?
Best,
Jamie
Jamie, I think you are correct. The main mechanism of action the provides Lion’s Mane benefits are boosting Nerve Growth Factor. So I suggest trying alternative methods of boosting NGF and/or BDNF. Here are some suggestions: https://nootropicsexpert.com/13-nootropics-to-boost-bdnf/
Hi David, Merry Christmas
I wanted to know your opinion, please.
– I asked Bulk Supplements for their product:
Bulk Supplements-Lions Mane Mushroom Extract
About the number / range extract of this Lion’s Mane Mushroom, and they replied
“is standardized to no less than 30% Polysaccharides . It does not have an extract ratio.”
Do you think that even if it does not have a number / range extract, it is good enough?
– And there is a lot of difference compared to the one standalone Lion’s Mane extract supplement that you use?
Peter, see this section of my article on medicinal mushrooms: https://nootropicsexpert.com/the-nootropic-benefits-of-medicinal-mushrooms/#polysaccharides-does-not-equal-mushroom-quality
The problem is Polysaccharides are not a measure of mushroom quality. You need to ask Bulk Supplements what their beta-glucan content is because as you can see the amount of Polysaccharide content tells you nothing.
So I am considering this update my stack for a change around, really just adding lion mane the rest
just checking with the expert before I do
DHA 1000MG
ALCAR 500MG twice a day
NAC 500MG 2 times a day
L-theanine 200MG before bed
B-complex active 100MG for most stuff
Vitamin D 4000UI
inositol 500MG twice a day
lion mane 500MG
probiotic and prebiotics
COQ10 – 200MG
PPQ 10MG
magnesium 200MG before bed
I hope this is not over doing it
anything conflicting in there please let me know
Andrew, I suggest doing NAC 3-times per day and increasing your Lion’s Mane to twice per day. The rest looks good.
I forgot to Add Luteolin and rutin at 50MG each I didn’t artichoke extract so just took it like that instead
David, Lions Mane can cause or accelerate the hair loss?
Robert, how on earth could Lion’s Mane cause hair loss? It increases Nerve Growth Factor not hormones.
Hi David, I have taken Lions Mane in the past and really like the benefits. However, I am one of the 10% of people who develop cold sores when the herpes simplex virus that is dormant on my nerve endings wakes up. While taking LM I get an outbreak, every time. Do you have any suggestions? Perhaps another mushroom extract to restrain and keep it dozing.
Sal, the only nootropic I know of that is a strong antiviral is Quercetin: https://nootropicsexpert.com/quercetin/
Zinc. For sure.
One mushroom grower sells fresh lions mane mushrooms. How many can I eat? Or should I dry them, grind them and put them in my coffee? How many? 2-3 grams? Thank you for your answer. Kind regards.
Carlos scroll up to the section called “Lion’s Mane Dosage” as that is the best I can offer you. The grower can offer a better suggestion for his product when it comes to dosing than I.
Hi David,
I appreciate the informative piece but for transparency sake did Mind Lab Pro give you their product for review?
You only mentioned the discount link at the end but make no mention if the supplement was purchased by you and you are providing an unbiased opinion on the brand.
Cheers
Andy, I have been using Mind Lab Pro within a few months of it coming on the market almost 6 years ago. And have been using it every single day since then. I do make a small commission if you choose to click on my link to buy it. And if you do my family thanks you because this is how I make my living.
BTW, I buy the Mind Lab Pro that I use. It is not “given” to me.
Dear Mr. Tomen,
Could you please justify the differences in the following Lions Mane capsule products, so that I can make an optimised decision before buying for my stack?
1) 372.6mg capsule – 40% Polysaccharides. (20:1 Extract)
2) 640.8mg capsule – 4% Triterpenoids, 15% Polysaccharides. (30:1 Extract)
3) 451mg capsule – 25% Beta Glucans. (25:1 Extract)
Chris, can’t do it because they are using different labels. Beta Glucans are included in the broad category of Polysaccharides as are Triterpenoids.
The primary active compounds in Lion’s Mane are hericenones and erinacines which is what you are looking for. Ask the manufacturer of the 40% Polysaccharides how much of that is hericenones and erinacines.
I have only just started taking Lions mane in my coffee in the morning. After the first 1/4 teaspoon around 8 hours later, I had tingling all over my body, my eyesight seemed clearer, I felt a little bit energised and had a night sweat and thirst in the night! Now tonight I went to bed tired at 11pm now wide awake at 11.47pm!! Feel a bit tingly again and my mind is racing. Thought I would be tired as was up at 7.30am. Ah well…. See what day 3 brings….. I am using a good brand that is a powder, with fruiting body and mushroom of lions mane.
JoJo, the tingling you describe is a relatively rare side effect of Lion’s Mane and is usually caused by higher than normal doses of this nootropic. The sensation is likely due to an increase in Nerve Growth Factor which is what Lion’s Mane is known for.
it could be that Lion’s Mane is just the wrong supplement for you.
Thanks David I will continue for at least 3 weeks to see if any benefits outweigh the side effects. Last night after calming down I slept well until 7.30 I may reduce the amount as I tend to be pretty sensitive to anything! Do hallucinogenics permanently change brain chemistry? Asking for a friend! Tingling wasn’t as bad yesterday.
JoJo, hallucinogens will change brain chemistry if used often enough and long-term depending on the drug. Sometimes that can be a good thing. 🙂
I’ve been taking Lions Mane for over 2 weeks now I don’t feel any different, should I feel different, how long does it take to have an effect on me?
Jarrar, the effects of Lion’s Mane can be subtle and depending on your unique chemistry you may not “feel” anything at all.
This mushroom’s main mechanism of action of boosting Nerve Growth Factor (NGF). This is a natural growth factor in your brain which you cannot feel while it is repairing neurons, dendrites, axons and synapses. Or growing new neuronal connections need to encode memories.
On the other hand some report a better sense of smell, better mood, improved memory, etc. The bottom-line is you may or may not feel its benefit. But if you are using a high quality extract it’s doing its job whether you “feel” it or not.