Lion’s Mane

Lion’s Mane (Hericium erinaceus) is unique in the mushroom family both in appearance and function. Lion’s Mane Mushroom is extremely effective at stimulating Nerve Growth Factor (NGF) in the brain.

Known for its powerful effects as a “brain tonic”, Lion’s Mane is said to have been used as a tea for thousands of years by Buddhist monks. To enhance brain power, and heighten their ability to focus during meditation.

Lion’s Mane is a powerful catalyst for brain cell regeneration helping improve memory and cognition.

The primary active compounds in Lion’s Mane are hericenones and erinacines. Hericenones help your brain produce more Nerve Growth Factor. And erinacines easily cross the blood-brain barrier to boost the production of neurons.

Lion’s Mane helps:

• Nerve Growth Factor. Lion’s Mane Mushroom prevents and treats nerve damage in the brain. Once past the blood-brain barrier, Lion’s Mane stimulates enzyme production that release Nerve Growth Factor (NGF). Nerve regeneration helps relieve neurodegenerative disease symptoms such as Alzheimer’s, dementia, and Parkinson’s Disease.
• Neurogenesis. Lion’s Mane stimulates the repair and creation of neurons. Boosting neurotransmitters and signaling that effects memory, learning, recall, and mood.
• Brain Optimization. Lion’s Mane helps eliminate brain fog. Restoring memory and mental alertness. And improves anxiety and depression symptoms.

Overview

Lion’s Mane (Hericium erinaceus) is a medicinal mushroom proven to benefit the brain, nerves and immune system.

Unlike other mushrooms sporting a cap and stem, Lion’s Mane has long, flowing, white tendrils. Resembling a lion’s mane. Other names include Monkey’s Head, Bearded Tooth, Pom Pom Blanc, Hedgehog Mushroom and Satyr’s Beard.

This parasitic fungus grows hanging off logs and trees. And is native to North American, Europe and Southeast Asia. In Japan, it’s called yamabushitake or “those who sleep in mountains”. Referring to the Shugendo sect of hermit monks and their long, flowing robes.

As a nootropic, Lion’s Mane has been shown to be particularly effective in stimulating Nerve Growth Factor (NGF) in the brain.

NGF is produced in the hippocampus throughout life. Modulating cholinergic receptors and neuroplasticity.[i] And is essential for learning.

Nerve Growth Factor are special proteins that function to regenerate neurons. Lion’s Mane contains two unique classes of NGF’s – hericenones and erinacines which easily cross the blood-brain barrier.

Lion’s Mane, like other medicinal mushrooms, contain high amounts of the antioxidant beta-glucoxylan and four other polysaccharides and polypeptides. Having a significant impact on enhancing your immune system. And decreasing tumor growth.

Lion’s Mane has also been studied in reducing amyloid plaques. These clumps of beta-amyloid proteins block signals between neurons. And are implicated in Alzheimer’s and other neurodegenerative diseases.

Lions’ Mane is also used to treat Lyme’s Disease, and digestive tract issues.

Here we’re talking about Lion’s Mane Mushroom and its effects on brain health and chemistry.

How does Lion’s Mane Work in the Brain?

Lion’s Mane boosts brain health and function in several ways. But two in particular stand out.

1. Lion’s Mane Mushroom stimulates the synthesis of Nerve Growth Factor (NGF). NGF is a protein that plays a major role in the maintenance, survival and regeneration of neurons.

NGF is required by your brain to keep neurons strong and healthy. When various neurological disorders occur, your brain is unable to produce its own internal source of NGF.

In a study done in Kuala Lumpur in 2013, scientists showed that Lion’s Mane extract induced NGF synthesis and promoted neurite outgrowth.[ii]

2. Lion’s Mane is effective in reducing anxiety and depression. Some even call it the “smart mushroom” for its ability to improve cognition, memory and work as an anti-depressant.

A study by researchers in Japan worked with 30 women. The female subjects had been complaining about menopause, depression, sleep quality and other issues.

The women randomly received Lion’s Mane-laced cookies or a placebo for 4 weeks. The researchers found that Lion’s Mane “has the possibility to reduce depression and anxiety, and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus”. [iii]

How things go bad:

Science once believed that the brain could not grow new brain cells. That once our brain developed during childhood, and we reached adulthood, we had all the brain cells we’d ever have.

Now we know that neurons can regenerate. But that doesn’t mean they will regenerate. A number of health issues can contribute to neurodegeneration.

↓ Decrease in Nerve Growth Factor = Decrease in Long-Term Potentiation affecting long-term memory[iv]

↓ Brain cells die and are not replaced

↓ Neuroplasticity declines resulting in poor memory

↓ Neurotransmitters decline resulting in anxiety, poor mood and depression

All of these age-related changes are contributing factors to neurodegenerative diseases like Alzheimer’s, Parkinson’s and others. And anxiety, depression and mood disorders that affect quality of life.

Lion’s Mane to the rescue.

At least a dozen peer-reviewed studies have been published on Lion’s Mane benefits to brain health since 1991. Dr. Kawagishi of Japan was first to identify Nerve Growth Factor properties in Lion’s Mane Mushroom.[v]

In one double-blind, placebo-controlled trial, researchers in Japan worked with 50 – 80 year old men and women. All suffered from mild cognitive impairment.

The trial subjects received four 250 mg tablets containing 96% of Yamabushitake (Lion’s Mane) dry powder three times a day for 16 weeks. The men and women were tested at 4, 8, 12 and 16 weeks.

At each of the testing periods, the subjects who had used Lion’s Mane showed a significant improvement in cognitive scores. And their scores were increasing while on Lion’s Mane supplementation. But 4 weeks after stopping Lion’s mane supplementation, their cognitive scores decreased significantly.

The researchers concluded that Lion’s Mane Mushroom is effective in improving mild cognitive impairment.[vi]

How does Lion’s Mane feel?

You may not experience the effects of supplementing with Lion’s Mane Mushroom immediately. But many users report with continued use of Lion’s Mane, a boost in mood and mental energy.

Some report it increases depth perception. And an improvement in sense of smell.

Others testify to improved decision-making, the ability to solve problems and learning. Likely due to Lion’s Mane ability to improve neuroplasticity.

The overall consensus is Lion’s Mane Mushroom’s ability to lessen anxiety, reduce depression, and improve concentration.

The Research

Lion’s Mane Mushroom has been used as a food and herbal medicine since ancient times in East Asia. And it has been reported in scientific research that Lion’s Mane promotes Nerve Growth Factor both in the petri dish as well as in animal and human test subjects.

Lion’s Mane Prevents Cognitive Dysfunction

In this study, researchers examined the effects of Lion’s Mane on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Amyloid β(25-35) peptide is implicated in diseases like Alzheimer’s.

Mice were injected with the peptide on days 7 and 14 of the trial. And they were fed a diet containing Lion’s Mane over 23-days of the experiment. The results showed that Lion’s Mane prevented short-term and visual recognition memory reduction normally induced by amyloid β(25-35) peptide.

They concluded that Lion’s Mane Mushroom “may be useful in the prevention of cognitive dysfunction”.[vii]

Lion’s Mane Induces Nerve Growth Factor

In this trial, mice were fed Lion’s Mane 5% freeze-dried powdered extract for 7 days. Researchers found an increase in the level of Nerve Growth Factor (NGF) in the hippocampus of the mice. Concluding that Lion’s Mane “contains active compounds that stimulate NGF synthesis”.[viii]

Lion’s Mane Repairs Nerves

In this study done with rats, Lion’s Mane extract was able to promote neuron regrowth after injury. Rats with gluteal nerve damage were able to walk again after consuming water containing Lion’s Mane extract.

The researchers concluded that Lion’s Mane regenerates damaged nerve cells. In this case, the reversal was so profound, the rats went from being totally disabled to walking again.[ix]

Dosage Notes

Dosing of Lion’s Mane Mushroom depends on the strength of the extract. It’s available in capsule or powder form.

For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day.

Other retail extract dosage of Lion’s Mane ranges from 300 mg to 3000 mg dosed 1 – 3 times per day. Check the label and see what the manufacturer recommends. And when first using the supplement, start with the lowest dose and see how your body reacts.

Side Effects

Lion’s Mane Mushroom is non-toxic and considered very safe. So there are very few side effects reported.

Some neurohackers report itchy skin from higher doses. Likely attributable to a boost in Nerve Growth Factor.

Lion’s Mane has been tested in animals showing no side effects or toxicity even up to 5 grams per kilogram.

Available Forms

Lion’s Mane Mushroom (Hericium erinaceus) as a supplement is usually offered as an extract. In powdered form, or in a capsule.

Supplement makers of nootropic stacks sometime include Lion’s Mane as well. For example, Mind Lab Pro includes 500 mg of the full fruit extract in their formula. Each formula will be different depending on synergy with the stack, and type of extract used.

When choosing a Lion’s Mane supplement, there’s debate over the best form of extraction to achieve the mushroom’s full medicinal benefit. Some say your best option is a hot water extraction. Another says alcohol extraction. Another claims both are necessary.

But when it comes to mushrooms, saying that one is “more potent” than another is just too simplified to be true. This is as much an art as it is science.

Look at the manufacturer’s literature and marketing material. And read the reviews on shopping sites as well as forums. And find out what works best for you.

Types of Lion’s Mane available:

• Plain Lion’s Mane: Pure, powdered mushroom. Often freeze-dried, and the cheapest form available. Can be added to water, juice or smoothies.
• Lion’s Mane Extracts: A more potent form of mushroom. Often presented as 14:1 or 10:1 extracts (14 pounds or 10 pounds reduced to 1 pound of extract).
• Standardized Lion’s Mane: Processed to provide exact levels of active ingredients. You can get Lion’s Mane standardized to 30% and 50% polysaccharides (the active hericenones and erinacines are metabolites of polysaccharides).
• Lion’s Mane tea: Since this is a popular mushroom in the kitchen, the taste is acceptable. But it’s hard to get a handle on how much actual active ingredient you’re getting.
• Amycenone®/PLM-Fraction: This “branded” product is standardized to Hericenones 0.5%, Amyloban 6%. It seems to target a lesser-known Lion’s Mane active ingredient–Amyloban–which is positioned as a mushroom compound that fights beta-amyloid proteins. Originating in Japan, it is extremely expensive, and may be found in a supplement called Amyloban®3399.

And if you decide to pick your own, before consuming any wild mushroom, make sure that it is accurately identified. Mushroom poisoning is a real problem if you pick the wrong one.

For a full list of Mycology societies that may be able to help you, go to the North American Mycological Association website (www.namyco.org).