Lion’s Mane (Hericium erinaceus) is unique in the mushroom family both in appearance and function. Lion’s Mane Mushroom is extremely effective at stimulating Nerve Growth Factor (NGF) in the brain.
Known for its powerful effects as a “brain tonic”, Lion’s Mane is said to have been used as a tea for thousands of years by Buddhist monks. To enhance brain power, and heighten their ability to focus during meditation.
Lion’s Mane is a powerful catalyst for brain cell regeneration helping improve memory and cognition.
The primary active compounds in Lion’s Mane are hericenones and erinacines. Hericenones help your brain produce more Nerve Growth Factor. And erinacines easily cross the blood-brain barrier to boost the production of neurons.
Lion’s Mane helps:
- Nerve Growth Factor. Lion’s Mane Mushroom prevents and treats nerve damage in the brain. Once past the blood-brain barrier, Lion’s Mane stimulates enzyme production that release Nerve Growth Factor (NGF). Nerve regeneration helps relieve neurodegenerative disease symptoms such as Alzheimer’s, dementia, and Parkinson’s Disease.
- Neurogenesis. Lion’s Mane stimulates the repair and creation of neurons. Boosting neurotransmitters and signaling that effects memory, learning, recall, and mood.
- Brain Optimization. Lion’s Mane helps eliminate brain fog. Restoring memory and mental alertness. And improves anxiety and depression symptoms.
Table of Contents
Overview
Lion’s Mane (Hericium erinaceus) is a medicinal mushroom proven to benefit the brain, nerves and immune system.
Unlike other mushrooms sporting a cap and stem, Lion’s Mane has long, flowing, white tendrils. Resembling a lion’s mane. Other names include Monkey’s Head, Bearded Tooth, Pom Pom Blanc, Hedgehog Mushroom and Satyr’s Beard.
This parasitic fungus grows hanging off logs and trees. And is native to North American, Europe and Southeast Asia. In Japan, it’s called yamabushitake or “those who sleep in mountains”. Referring to the Shugendo sect of hermit monks and their long, flowing robes.
As a nootropic, Lion’s Mane has been shown to be particularly effective in stimulating Nerve Growth Factor (NGF) in the brain.
NGF is produced in the hippocampus throughout life. Modulating cholinergic receptors and neuroplasticity.[i] And is essential for learning.
Nerve Growth Factor are special proteins that function to regenerate neurons. Lion’s Mane contains two unique classes of NGF’s – hericenones and erinacines which easily cross the blood-brain barrier.
Lion’s Mane, like other medicinal mushrooms, contain high amounts of the antioxidant beta-glucoxylan and four other polysaccharides and polypeptides. Having a significant impact on enhancing your immune system. And decreasing tumor growth.
Lion’s Mane has also been studied in reducing amyloid plaques. These clumps of beta-amyloid proteins block signals between neurons. And are implicated in Alzheimer’s and other neurodegenerative diseases.
Lions’ Mane is also used to treat Lyme’s Disease, and digestive tract issues.
Here we’re talking about Lion’s Mane Mushroom and its effects on brain health and chemistry.
How does Lion’s Mane Work in the Brain?
Lion’s Mane boosts brain health and function in several ways. But two in particular stand out.
- Lion’s Mane Mushroom stimulates the synthesis of Nerve Growth Factor (NGF). NGF is a protein that plays a major role in the maintenance, survival and regeneration of neurons.
NGF is required by your brain to keep neurons strong and healthy. When various neurological disorders occur, your brain is unable to produce its own internal source of NGF.
In a study done in Kuala Lumpur in 2013, scientists showed that Lion’s Mane extract induced NGF synthesis and promoted neurite outgrowth.[ii]
- Lion’s Mane is effective in reducing anxiety and depression. Some even call it the “smart mushroom” for its ability to improve cognition, memory and work as an anti-depressant.
A study by researchers in Japan worked with 30 women. The female subjects had been complaining about menopause, depression, sleep quality and other issues.
The women randomly received Lion’s Mane-laced cookies or a placebo for 4 weeks. The researchers found that Lion’s Mane “has the possibility to reduce depression and anxiety, and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus”. [iii]
How things go bad:
Science once believed that the brain could not grow new brain cells. That once our brain developed during childhood, and we reached adulthood, we had all the brain cells we’d ever have.
Now we know that neurons can regenerate. But that doesn’t mean they will regenerate. A number of health issues can contribute to neurodegeneration.
↓ Decrease in Nerve Growth Factor = Decrease in Long-Term Potentiation affecting long-term memory[iv]
↓ Brain cells die and are not replaced
↓ Neuroplasticity declines resulting in poor memory
↓ Neurotransmitters decline resulting in anxiety, poor mood and depression
All of these age-related changes are contributing factors to neurodegenerative diseases like Alzheimer’s, Parkinson’s and others. And anxiety, depression and mood disorders that affect quality of life.
Lion’s Mane to the rescue.
At least a dozen peer-reviewed studies have been published on Lion’s Mane benefits to brain health since 1991. Dr. Kawagishi of Japan was first to identify Nerve Growth Factor properties in Lion’s Mane Mushroom.[v]
In one double-blind, placebo-controlled trial, researchers in Japan worked with 50 – 80 year old men and women. All suffered from mild cognitive impairment.
The trial subjects received four 250 mg tablets containing 96% of Yamabushitake (Lion’s Mane) dry powder three times a day for 16 weeks. The men and women were tested at 4, 8, 12 and 16 weeks.
At each of the testing periods, the subjects who had used Lion’s Mane showed a significant improvement in cognitive scores. And their scores were increasing while on Lion’s Mane supplementation. But 4 weeks after stopping Lion’s mane supplementation, their cognitive scores decreased significantly.
The researchers concluded that Lion’s Mane Mushroom is effective in improving mild cognitive impairment.[vi]
How does Lion’s Mane feel?
You may not experience the effects of supplementing with Lion’s Mane Mushroom immediately. But many users report with continued use of Lion’s Mane, a boost in mood and mental energy.
Some report it increases depth perception. And an improvement in sense of smell.
Others testify to improved decision-making, the ability to solve problems and learning. Likely due to Lion’s Mane ability to improve neuroplasticity.
The overall consensus is Lion’s Mane Mushroom’s ability to lessen anxiety, reduce depression, and improve concentration.
The Research
Lion’s Mane Mushroom has been used as a food and herbal medicine since ancient times in East Asia. And it has been reported in scientific research that Lion’s Mane promotes Nerve Growth Factor both in the petri dish as well as in animal and human test subjects.
Lion’s Mane Prevents Cognitive Dysfunction
In this study, researchers examined the effects of Lion’s Mane on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Amyloid β(25-35) peptide is implicated in diseases like Alzheimer’s.
Mice were injected with the peptide on days 7 and 14 of the trial. And they were fed a diet containing Lion’s Mane over 23-days of the experiment. The results showed that Lion’s Mane prevented short-term and visual recognition memory reduction normally induced by amyloid β(25-35) peptide.
They concluded that Lion’s Mane Mushroom “may be useful in the prevention of cognitive dysfunction”.[vii]
Lion’s Mane Induces Nerve Growth Factor
In this trial, mice were fed Lion’s Mane 5% freeze-dried powdered extract for 7 days. Researchers found an increase in the level of Nerve Growth Factor (NGF) in the hippocampus of the mice. Concluding that Lion’s Mane “contains active compounds that stimulate NGF synthesis”.[viii]
Lion’s Mane Repairs Nerves
In this study done with rats, Lion’s Mane extract was able to promote neuron regrowth after injury. Rats with gluteal nerve damage were able to walk again after consuming water containing Lion’s Mane extract.
The researchers concluded that Lion’s Mane regenerates damaged nerve cells. In this case, the reversal was so profound, the rats went from being totally disabled to walking again.[ix]
Dosage Notes
Dosing of Lion’s Mane Mushroom depends on the strength of the extract. It’s available in capsule or powder form.
For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day.
Other retail extract dosage of Lion’s Mane ranges from 300 mg to 3000 mg dosed 1 – 3 times per day. Check the label and see what the manufacturer recommends. And when first using the supplement, start with the lowest dose and see how your body reacts.
Side Effects
Lion’s Mane Mushroom is non-toxic and considered very safe. So there are very few side effects reported.
Some neurohackers report itchy skin from higher doses. Likely attributable to a boost in Nerve Growth Factor.
Lion’s Mane has been tested in animals showing no side effects or toxicity even up to 5 grams per kilogram.
Available Forms
Lion’s Mane Mushroom (Hericium erinaceus) as a supplement is usually offered as an extract. In powdered form, or in a capsule.
Lion’s Mane Mushroom can be found in some of higher quality pre-formulated nootropic stacks. For example, Mind Lab Pro® contains 11 brain enhancing nootropic compounds including Lion’s Mane with the full fruit spectrum including hericenones and erinacines.
I recommend Mind Lab Pro because it addresses all aspects of anxiety resistance, memory and cognitive enhancement, stabilizes mood, brain repair, and maintenance.
This premium nootropic stack is designed to affect neurotransmitters, cognitive energy, brain waves, neuroprotection, and regeneration. See my Mind Lab Pro review for a detailed report.
When choosing a Lion’s Mane supplement, there’s debate over the best form of extraction to achieve the mushroom’s full medicinal benefit. Some say your best option is a hot water extraction. Another says alcohol extraction. Another claims both are necessary.
But when it comes to mushrooms, saying that one is “more potent” than another is just too simplified to be true. This is as much an art as it is science.
Look at the manufacturer’s literature and marketing material. And read the reviews on shopping sites as well as forums. And find out what works best for you.
Types of Lion’s Mane available:
- Plain Lion’s Mane: Pure, powdered mushroom. Often freeze-dried, and the cheapest form available. Can be added to water, juice or smoothies.
- Lion’s Mane Extracts: A more potent form of mushroom. Often presented as 14:1 or 10:1 extracts (14 pounds or 10 pounds reduced to 1 pound of extract).
- Standardized Lion’s Mane: Processed to provide exact levels of active ingredients. You can get Lion’s Mane standardized to 30% and 50% polysaccharides (including the active secondary metabolites hericenones and erinacines).
- Lion’s Mane tea: Since this is a popular mushroom in the kitchen, the taste is acceptable. But it’s hard to get a handle on how much actual active ingredient you’re getting.
- Amycenone®/PLM-Fraction: This “branded” product is standardized to Hericenones 0.5%, Amyloban 6%. It seems to target a lesser-known Lion’s Mane active ingredient–Amyloban–which is positioned as a mushroom compound that fights beta-amyloid proteins. Originating in Japan, it is extremely expensive, and may be found in a supplement called Amyloban®3399.
And if you decide to pick your own, before consuming any wild mushroom, make sure that it is accurately identified. Mushroom poisoning is a real problem if you pick the wrong one.
For a full list of Mycology societies that may be able to help you, go to the North American Mycological Association website (www.namyco.org).
Nootropics Expert Recommendation
Lion’s Mane 500 mg per day
We recommend using Lion’s Mane as a nootropic supplement.
Your body does not make Lion’s Mane on its own. So you need to take it as a supplement.
Lion’s Mane is especially helpful for regenerating brain cells. It prevents neurodegenerative diseases like Alzheimer’s and Parkinson’s.
And it boosts long-term potentiation for memory and mental sharpness. By stimulating Nerve Growth Factor.
Lion’s Mane also helps boost mood, tame anxiety and relieve depression. For a better quality of life.
We suggest starting with a dose of 500 mg daily. The best human study used 3000 mg per day. But another researcher found lower concentrations may stimulate NGF better than higher concentrations.[x]
Start at 500 mg per day and see how it works for you. If you don’t experience a benefit, boost Lion’s Mane in small increments of 250 mg per day until you notice an improvement.
You can buy individual Lion’s Mane supplements. Or you could try my favorite pre-formulated nootropic stack Mind Lab Pro® which includes the full fruit spectrum including hericenones and erinacines found in Lion’s Mane Mushroom.
Mind Lab Pro contains a synergistic blend of 11 brain enhancing nootropics covering all aspects of cognition and brain health. See my full Mind Lab Pro review for more.
Lion’s Mane is a great compliment to a nootropic stack including Aniracetam, Alpha GPC and Omega-3’s for an immediate cognitive boost.
[i] Conner J.M. et. Al. “NGF Is Essential for Hippocampal Plasticity and Learning” The Journal of Neuroscience 2 September 2009, 29(35): 10883-10889 (source)
[ii] Lai P.L., Naidu M., Sabaratnam V., Wong K.H., David R.P., Kuppusamy U.R., Abdullah N., Malek S.N. “Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.” International Journal of Medicinal Mushrooms. 2013;15(6):539-54. (source)
[iii] Nagano M., Shimizu K., Kondo R., Hayashi C., Sato D., Kitagawa K., Ohnuki K. “Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.” Biomedical Research. 2010 Aug;31(4):231-7. (source)
[iv] Kelly A., Conroy S., Lynch M.A. “Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus.”Neuropharmacology. 1998 Apr-May;37(4-5):561-70. (source)
[v] Kawagishi H., et. Al. “Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum” Tetrahedron Letters Volume 35, Issue 10, 7 March 1994, Pages 1569–1572 (source)
[vi] Mori K., Inatomi S., Ouchi K., Azumi Y., Tuchida T. “Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.”Phytotherapy Research. 2009 Mar;23(3):367-72. (source)
[vii] Mori K., Obara Y., Moriya T., Inatomi S., Nakahata N. “Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.” Biomedical Research. 2011 Feb;32(1):67-72. (source)
[viii] Mori K., et. Al. “Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells” Biology Pharmaceutical Bulletin September 2008 31(9) 1727—1732 (2008) (source)
[ix] Wong K.H., Naidu M., David P., Abdulla M.A., Abdullah N., Kuppusamy U.R., Sabaratnam V. “Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae).” Evidence-Based Complementary and Alternative Medicine. 2011;2011:580752. (source)
[x] Sabaratnam V., Kah-Hui W., Naidu M., David P.R. “Neuronal Health – Can Culinary and Medicinal Mushrooms Help?” Journal of Traditional and Complimentary Medicine 2013 Jan-Mar; 3(1): 62–68. (source)
Hello David, Ive started taking the 8:1 powdered extract from Nootropicdepot and I started having insufferable headaches from it. I really dont want to stop taking it, what should I do?
Alex, switch brands. There is no reason Lion’s Mane should cause headaches.
Lions mane can be dangerous. I had an experience where on the first night of taking it, I had a bit of A-fib (the first ever). The second day, I took less but again my heart rate went all over the place and I was hospitalized and had to do cardio-conversion. I have read others have experienced very rapid heart rates and heart rhythm issues using lions mane. Please be careful
Karen, I don’t doubt what you are saying. But in all of my research into Lion’s Mane I never came across anything like what you describe. And looking at the mechanism of action for Lion’s Mane I still don’t see how it can cause what happened to you. This sounds more like an adulterated supplement. And not pure Lion’s Mane.
Hi! I have been searching for so long for an answer to this question… Using the alcohol jar method of extraction, If I left my lion’s mane in the alcohol for a year, is it ok to use and continue to the water extraction method? What happens to the mushrooms and the alcohol it if it sits that long? The only thing about it i can find says to let sit up to a month. one site said 3 months is ok. But i can’t find a site that tells me why only that long and what happens if its forgotten. I can’t imagine im the only person who has forgotten about something like this, right? or maybe i am. who knows. I would love to gain some insight on this! much appreciated!
Sarah, anything left in alcohol for a year is likely safe to use but I can’t imagine any benefit to doing it. And I’ve never seen any value in trying to create my own extract from something like Lion’s Mane when it is so readily available to buy.
The sites that you mention are likely bloggers doing their own experiments. So please be careful what you use from sites like that. Safer to leave it to the professionals who have figured extracts out and sell it as a supplement.
I am desperately looking for a supplement that will help with focus and concentration, without the caffeine jitters! I love to read, but cannot stay focused without my mind wondering away! Please, please any recommendations?
Sonya, you’ve six choices near the top of this post: https://nootropicsexpert.com/how-to-improve-memory-and-concentration/.
But chances are one supplement won’t do it for you. It will take a combo of 3 – 4 supplements to get the quickest and best result.
I suggest trying; CDP-Choline, NALT or L-Tyrosine, and Phosphatidylserine (PS) to start. Or get them for less and in one capsule with Performance Lab Mind: https://www.performancelab.com/products/mind
Is it possible and effective to sublingual administer lion’s mane extract?
Dave, that’s not the way Lion’s Mane works. The minimum dose of Lion’s Mane is 500 mg and your body needs to digest it to extract the active compounds. That would be impossible if you injected it directly into your bloodstream.
I’ve just started taking a lion’s mane supplement – 1000 MG at night before bed. I am on thyroid medication… And have found that I am having heart palpitations at night time. (Feels like hyperthyroidism symptoms). Does lions mane affect the thyroid? Do you know – Is this something I should be taking when I am on desiccated thyroid to treat hypothyroidism? My TSH is very low due to medication … just wondered if Lions Mane is a ‘thyroid booster’ and could be interfering with my meds. Thanks!
Michelle, it’s a little more complicated than that.
Apparently, Lion’s Mane can influence Th1 and/or Th2 cells. These are T-helper cells that when activated, send out a signal for your system to produce cytokines to attack inflammation.
There is some evidence that those dealing with Hashimoto’s for example may be “dominant Th1” (https://pubmed.ncbi.nlm.nih.gov/15249726/). Which can react negatively to certain supplements. Including Lion’s Mane apparently.
This is news to me and I wasn’t aware of any association between hypothyroidism and Lion’s Mane until you asked this question. Now I find comments in forums all over the place with people talking about it.
I’m severely hypothyroid and use Lion’s Mane. And never had a problem. So it appears that Lion’s Mane effects some of us and not others. Sounds like you are one of the unlucky ones who need to avoid Lion’s Mane.
Hello David,
Good article you wrote up. I just started taking lion mane about 2 weeks now. I started with 250mg then slowly moved up. So far I haven’t really notice much. I take it in the morning.
I have 2 questions for you
1. Does body weight matter on the dosage, and stacking it with other nootropic matter?
2. Should I be taking another dosage of 500mg or less on the same day?
(I don’t have issue falling asleep when taking supplements)
Below is my current stack I’m taking.
Morning 9 am.
550mg – Lion’s Mane Mushroom Powder | 8:1 Dual Extract | Whole Fruiting Body | Hericium erinaceus — from NootropicDepot.
300mg Alpha-GPC 90% powder. — NootroopicDepot
10:30am
Modafinil 100mg – for my ADHD that my doctor gave me.
I’m taking this stack to improve my short term and long term memory. Need to be able to recall information when taking exams online. that’s my goal if you have any suggestions please let me know.
Thank you,
Lou, Lion’s Mane dosage of 1 gram is good. But like anything that boosts Nerve Growth Factor, it’ll take 2 or 3 weeks before you begin noticing its effects.
If you’re using Modafinil, I suggest supporting its use with my ADHD regimen which you’ll find here: https://nootropicsexpert.com/best-nootropics-for-adhd-add/
Hello David, could you perhaps tell me why i get the following side effect when taking lion’s mane supplements: if i take 1 lion’s mane pill, within 1 hour it makes me extremely drowsy and i want to sleep, if i take it in the evening, the next day i feel great almost spaced out, though sometimes i get this terrible headache like i have some kind of hangover especially if the lion’s mane interrupts my sleep in the middle of the night (even though it makes me drowsy at the beginning stage).
Lion’s mane is the only supplement i take. I cannot take lion’s mane in the morning because it knocks me out.
Thank you. Dave
Dave, “the current research on antidepressant effects by H. erinaceus is relatively still at an early stage, and the specific mechanisms underlying the antidepressant-like activities require further investigation.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982118/
So far nobody knows but there is speculation that certain extracts of Lion’s Mane act like an MAOI which affects dopamine, norepinephrine and serotonin.
I think you are right, i looked up the side effects of MAIO and they seem familiar to me. When i stopped taking lion’s mane for only 1 or 2 days i get a hangover.
I tried cordyceps, this is much better, what i have read it activates HIF-1 so your body and brain gets adapted to a low oxygen environment and get better oxygen intake like the ethiopian marathon runners training in high altitude low oxygen environment. It also activates VEGF and induces angiogenesis for better blood circulation in your brain and body. It is a great nootropic too, it enhances BDNF and nerve growth factor and it is also anti-inflammatory.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849494/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201515/
https://www.hindawi.com/journals/bmri/2013/569206/
Dave, Cordyceps is an impressive mushroom. Did you see the bit I wrote about it here? https://nootropicsexpert.com/the-nootropic-benefits-of-medicinal-mushrooms/#cordyceps-(cordyceps-militaris)
Hi and nice to meet you!
Recently I started taking Lion’s Mane bu Earth’s Nurture. My problem is Meniere’s desease, constant dizzines and vertgio, nausea from gastritis and severe daily panic attacks and depression. Also I have very big problems with the memory and absolute lack of concentration, for as long as I remember I could never study, I can’t focus and I am always restless. I had an MRI done, everything was ok there. I am currently taking 500mg once daily lion’s mane + 250mg x 2 ashwaganda and Q10 200mg + K2 and vit D. I am 29 years old, 176cm tall and 48kg, do you think I can mix all those and is the dosage ok?I want to try also l-lysine but I dont if it save to add to this mix now?
Sarah, you have a lot going on and there’s no simple answer to what may help. You first need to figure out the cause of your depression. And whatever that is may also be the cause of your lack of concentration and poor memory.
I’d like you to spend some time with this article on depression: https://nootropicsexpert.com/best-nootropics-for-depression/. Your depression could be caused by problems with neurogenesis (growth of new neurons), you could be low in acetylcholine, GABA, dopamine, glutamate, or serotonin, or it could be caused by chronic stress.
The only way to get to the root of this is to start experimenting with nootropics that assist each of these. You’ll find suggestions in that article. You’ve already started by using Lion’s Mane for neurogenesis, Ashwagandha for anxiety, and CoQ10 which is part of how your body produces energy.
And keep in mind that some of these supplements work quickly and you’ll feel its effects right away. While others like Lion’s Mane take awhile before you’ll experience anything noticeable. And even then it may be subtle and you’ll only notice that your memory is a little better because of something you remembered one day. And it was something that didn’t happen before.
One more thing: after you wrap your brain around what you need to do to figure out your depression I suggest taking a look at this article on boosting concentration and memory: https://nootropicsexpert.com/how-to-improve-memory-and-concentration/. You’ll notice some overlap between the two articles. That’s how our brains work. Everything is connected and each part depends on the other to be healthy and working as intended.
If this too overwhelming for you the next best option may be scheduling a consultation with me: https://nootropicsexpert.com/personal-consultations/
Hey again and thank so much for replying. I actually have tried almost all of the suggested supplements in the article and nothing really worked. I tried: nootropil ( it is the only one that is found in my country), ginko biloba, fish oil, 5-HTP, rhodiola, st. john’s worth from which I’ve felt very sick and had heart palpitations, tryptophan, turmeric, maca, and mix all the aino acids. I am currently taking B complex vitamins and magnesium citrate everyday and also betahistine for the Meniere. The cause of my depression is not really known because I have an amazing life, all the clinical blood tests show that I am very healthy, I have no traumas, my job is very calm, I have no idea why I am always anxious and dizzy with a heart rate over 130 bpm sometimes and a lot of nights I can’t really sleep well, which is why I thought ashwaganda will help me. I was wondering if those dosages are good for me and how many supplements can I mix at the same day? The only thing that actually really helps me immediately was valerian root, but I heard i can’t mix it with ashwagamda?
Sarah, if Valerian worked for you then why not continue using it? And “I heard” from where and from whom?
The next thing I wanted to try is the NAC, but again I dont know if I can mix all of those?
Sarah, mix all of what? It’s why I suggested a consultation. There’s only so much I can do by replying to this thread.
Hello David,
Is Nootropics Depot a good choice for lions mane?
Thank you,
Christine
Christine, I can’t vouch for them because they’ve never reached out to me. But they do say their Lion’s Mane uses the fruiting body with a minimum content of 25% Beta-Glucan. Reviews seem to be good and they say they have a comprehensive testing program in place.
My first choice for Lion’s Mane is Mind Lab Pro (https://www.mindlabpro.com/?a_aid=5c0957016035e&a_bid=a2ad38c1) which contains 500 mg of whole fruiting body. And I can say I know it works because I’ve been using it for the last 5 years.
My second choice for a standalone Lion’s Mane supplement would be HR Supplements (https://www.hrsupplements.com/mushroom-complex-capsules-1000mg-30-beta-glucan-min-60-count-whole-fruiting-body/?afmc=NOOTROPICS) who offer a 30% Beta Glucan Minimum content extracted from whole fruiting body. And they have a QR Code on the label the supplement you receive that you can scan for a Certificate of Analysis for that particular batch.
But you should know as well that both of the above are affiliate links and I get paid a little if you buy either one.
Its said that when you stop using lion’s mane mushroom, the newly grown neurons goes away.. do stopping lion’smane degenerate the pre-existing neurons, which were there before taking lion’smane musroom
Hussain, Lion’s Mane boosts neurogenesis. This is a ongoing process in your brain naturally. Lion’s Mane just helps the process. New neurons will not vanish if you stop using it. Think about this logically for a minute. Decide for yourself if that type of rumor makes any sense to you.
the new neurons do not go away, however, a degenerative disease CAN eliminate further neurons. this can be counteracted with ANTHOCYANINS, which arrests neural degeneration.
Agreed
Hi,
I took lions mane in February hoping it would help me with my studies.
Lion’s mane didn’t help me and it coincided with some personal stress that happened at the time. I also experienced really bad sadness and dysphoria while I was taking it. I suffered for a months with really bad OCD about the events that took place.
It turns out that it contains a “kappa opioid agonist” which is known to cause dysphoria by disrupting the dopamine system, and this may have blown my emotional response to the stressors way out of proportion.
This made me worry that the NGF production had caused “long-term potentiation” on distressing memories that made them much harder to get over hence the OCD.
Now I still have some OCD about the effects the lions mane had on me and about the OCD itself, and I constantly pine to return to the state I was in before I ever tried this supplement.
Since you’re answering questions, I just wanted to ask if you’d consider warning about the dysphoria people face with lions mane. And also consider there are situations you really don’t want to artificially inflate NGF levels in the brain. I stayed miserable on them a long time because I didn’t realize this was a side effect of the drug.
Kind regards,
Andy
Andy, this is the first time after thousands have read my Lion’s Mane review that there’s a slim chance it could cause dysphoria. And I regret that this happened to you. But this isn’t a common side effect for this supplement. Which is why I didn’t include it.
One of the most common sayings you’ll hear from experienced biohackers is YMMV. It means “your mileage may vary”. Each of the nootropics reviewed on Nootropics Expert can affect two people standing side by side differently. My wife who would not consider herself a bio- or neurohacker calls it an “allergy” to mushrooms.
The thing is every single nootropic reviewed here will cause a negative in someone somewhere on earth. Even the supplements classified as “non-toxic and safe”. While I include the main side effects and contraindications for each supplement, it’s up to each person to decide if it will work for them.
BTW, Lion’s Mane doesn’t “artificially” increase Nerve Growth Factor. It provides what the brain needs to increase NFG. Very effectively and extremely beneficially to many people. LTP is primarily dependent on brain-derived neurotrophic factor (BDNF) and it’s unlikely that your experience is permanent because of long-term potentiation.
While there’s no natural Kappa opioid antagonist, you may want to try supporting dopamine receptors. Possibly Aniracetam or Ashwagandha may help.
Okay thanks for your reply.
This is reassuring about the LTP but I always thought NGF was meant to enhance LTP?
One thing I realize I didn’t mention here is that I actually took a large dose of psilocybin a month after ceasing lion’s mane hoping it might help me but that was when it turned from sadness to obsession. I currently have stabilized mood but the obsession is still there after two months. I’m unable to truly distract myself from thinking about how I’ve screwed up my mental health.
I started all this because I completely bought the hype on lions mane and psilocybin from Paul Stamets’ interview on the Joe Rogan podcast.
Do you know what effect the psilocybin might have had?
Paul Stamets advocates people mix the two but I wasn’t able to find out what the supposed interaction is.
My worry now is that the Psilocybin finished off whatever the lions mane started if that makes sense.
Just FYI I am seeking psychiatric help very soon.
Andy, long-term potentiation is largely dependent on a very complex interplay between proteins and enzymes which is best described by the team a McGill University in Montreal: https://thebrain.mcgill.ca/flash/a/a_07/a_07_m/a_07_m_tra/a_07_m_tra.html
But now that you mention psilocybin, your symptoms make much more sense. And whoever did the research for Wikipedia summed up the psychiatric research nicely: https://en.wikipedia.org/wiki/Psilocybin. Turns out you are not alone in experiencing this change. I just wish people did more diligent research before messing around with things like this.
Well it looks like some combination of lions mane and psilocybin have screwed up my brain. I can’t sleep and I’m growing weaker day by day.
Psilocybin is likely the culprit and it could have just pushed you over the edge of an underlying condition you were not aware of.
But all is not lost. It’s just going to take some experimenting on your part to back in shape. But very careful experimenting. And I can’t help you with that part without know a lot more about you and your situation. Set up a consultation if you think it a good idea and we’ll spend an hour hashing through this together. No promises that it’ll work but it may be worth trying.
Hi David, I’ve seen mixed reviews concerning the time of day to take Lion’s Mane. In your opinion, what is the best daily schedule to take Lion’s Mane for the maximum effectiveness of the noortropic?
Ryan, timing on Lion’s Mane dosage is up to the individual and how you react to it.
Some find that it’s stimulating and if that’s you, you’d want to use it before late afternoon so it doesn’t interrupt sleep.
If your experience is not stimulating then you can use it anytime. Either way, long-term daily use will provide the most benefit.
the link to lions mane repains nerves in legs
can you send it to me
Lois, this is the study on nerve regeneration I mentioned: https://www.ncbi.nlm.nih.gov/pubmed/21941586
Hi,
I have given Lions Mane exact power to my 7 year son with the morning smoothie. The only purpose has been to increase immunity and maybe support learning in the school… But as a positive side effect I have noticed impoved hand eye coordination when we try to play tennis.. So have you heard that Lions Mane could impove childs motor skills?
I haven’t come across that but given Lion’s Mane mechanism of action it’s no surprise.
Hi David, i have got some question about the Lion’s Mane mushroom form. I am about to buy fruiting bodies mushroom powder capsules, it is not a extract ( in the label it does not appear), so, what are the compounds in the powder? It is different for the body absorption? Does the powder got all the spectrum of the mushroom compounds?
I will be very grateful for your response. Greetings
Geronimo
Geronimo, the type of Lion’s Mane you describe should contain the full spectrum of what’s supposed to be in Lion’s Mane. But it varies depending on what it is grown on. This information can only come from the manufacturer.
Hi David,
Is Lion’s mane taken every day or as needed?
Rifat, Lion’s Mane is used daily for best results. Keep in mind how this nootropic works in your brain. We use it primarily to increase nerve growth factor which is needed for repair and neurogenesis. Both are ongoing throughout the day and night in your brain.
Hi David, I know there’s a lot of study on lion’s mane about the mycelium verse to fruiting body and some supplements are pure mycelium. What is your experience with mycelium vs. Fruiting body and what to look for on the label does I have looked at Host defense brand and others
Chris, for Lion’s Mane I prefer an extract with the full fruit spectrum including hericenones and erinacines. And not isolated to one compound.
Thank you so much for creating this resource! I’ve just started supplementing with Lions Mane and have noticed many of the benifits that have been documented.
Hi David, Im Raghbir Singh from India. I want to know if Lion’s Mane caps help in regenerating/help,in any way, damaged leg nerves , due to diabetes. My email : [email protected]
Thanks
Raghbir Singh
Raghbir, Lion’s Mane should help and I know of people who use it and experience less pain.
Take a look at one of the studies in the “Research” section of this review. https://nootropicsexpert.com/lions-mane/#lions-mane-repairs-nerves.
That study was done with rats but it had a profound effect on healing gluteal nerves in animals. So all indications are it would help human nerve repair as well. Try it and see how it works for you.
Will taking this cause you to fail a random drug test for work such as the military, machine operators, pilots, etc. Does how you take like as a food, tea, or supplement make a difference in the drug testing,
Rosemary, Lion’s Mane will not register on any drug test that I’ve ever seen or am aware of.
Is it ok to take with bacopa?
Yes
Can a product be taken by a child of 12 years with autism Is it safe?
May, I’ve not seen anything to show there would be a problem. Try doing a general Internet search for [“autism” AND “Lion’s Mane”] and see if anything turns up. Use that exact phrase that is inside the brackets.
What an excellent resource you have created at this website David. I want to say I appreciate your time and effort, as well as generosity answering questions. Peter.
Hi David,
Thanks for the informative write up, I have a question I think you could help with.
Ive been taking 500mg of lions mane every morning for the last 2 months, its helped me with mild depression and stress and i feel like a different person which is amazing. But since Ive been taking it ive had a craving which i cant pinpoint, its quite intense and I cant figure out what it is, wether its glucose or a mineral/vitamin. Also the first month i felt great! I started running and had loads of energy throughout the day but Ive noticed my fitness declining no fatigue in my normal day but mainly stamina during exercise? like if you hadnt eaten enough food or something, but i am eating enough calories. Is there anything else you should be taking with lions mane if you are taking it daily? Ive read some people take creatine?
Thanks for your help!
Matty, this is not a normal side effect of using Lion’s Mane. It’s possible the supplement you are using has something else that you are not aware of. What brand are you using and do they guarantee their testing program?
Thanks for the reply, Im also taking vit c & iron, Vit D and curcumin. ive stopped them and going to add each one to see what it is whats causing it.
Regards,
Matt.
Hi David,
You write “the active hericenones and erinacines are metabolites of polysaccharides” but this is not the case, sorry.
Polysaccharides are water-soluble carbohydrates (sugars) and some of them are bioactive (beta-glucans).
Hericenones and erinacines however are not carbs but alcohol-soluble terpenoids. They will only be present in an alcohol-extracted Lion’s Mane supplement, not in the more common water extracts optimised for polysaccharides or beta-glucans.
Yildiz, you’re likely technically correct. But when making a statement like this it’s helpful to provide clinical evidence or some kind of “scientific proof” of what you are stating. Would you please provide evidence of what you wrote?
Polysaccharides: wikipedia explanation: https://en.wikipedia.org/wiki/Polysaccharide
Beta-glucan: wikipedia explanation:
https://en.wikipedia.org/wiki/Beta-glucan
Below is an article describing the NGF-inducers in Lion’s Mane:
https://www.tandfonline.com/doi/full/10.1080/21501201003735556
Take care !
Yildiz, thank you for responding. I consider the Mycology Journal that you linked to as an authority. But not Wikipedia. Possibly some of the clinical studies linked to in each Wikipedia article but not the Wiki article itself.
The wikipedia articles are well referenced so I’d say they’re trustworthy.
That aside, in this case the subjects (polysaccharides, beta-glucans) are very basic. It is not advanced science, a simple Google search would give 1000s of similar results.
the gentleman is correct. you will find very enhanced neurotic properties by FERMENTING lions mane, using yeast. this produces about 1-2% alcohol if done correctly, but also extracts what is mentioned. in archeological evidence this works in beer, hence the banning of fermented mushrooms in the german purity laws.
Before finding your guide, I have been trying Lion’s Mane 500 mg capsules. After taking it in the morning, around 4PM, I get extremely tired/sleepy and nap for up to 2 hours. This does not happen if I do not take the capsule. Could this be caused by the Lion’s Main and a deficiency of Choline?
Greg, there’s nothing in Lion’s Mane that could cause that type of side effect. Unless there was something else in that capsule that shouldn’t have been in there.
OK Thanks David
I mean if it’s 1000mg per capsule, if I’ll take two capsules a day is it too much?
Thanks David
Mick, for Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day. So according to my research you are good up to 3 grams per day of Lion’s Mane extract.
Hi David
I would like to try Lion’s Mane Mushroom and I just received my first order. Before trying it I would like your opinion on it.
On the label it says:
GNP HEALTH
120 capsules
1000mg in 1 capsule
Lion’s Mane Mushroom 13:1 Ratio
Serving size 2 capsules
Servings Per Container 60
Directions: Take one to two capsules daily with a meal.
David, how many times per day should I take this nootropic?
Thank You
Mick
Hi david, good day can you help me. Lion’s Mane can help me to my illness right mesial temporal sclerosis?
Ryan, I don’t think anyone knows the answer to this because my understanding is that “mesial temporal sclerosis” changes in the brain include “selective loss of
inhibitory interneurons, abnormal spouting of axons, reorganization of neural transmitter receptors, alterations in second messenger systems, and hyperexcitability of the granule cells” (http://www.ajnr.org/content/ajnr/19/1/15.full.pdf).
If this is true then simply boosting BDNF with Lion’s Mane in general may or may not help. Because we’re not talking about simply growing new neurons or repairing damaged neurons.
It appears that there is abnormal growth of axons, loss of only some neurons, reorganization of receptors, and secondary messenger systems are messed up.
There is no harm in trying Lion’s Mane and other nootropics that support the growth, repair and maintenance of neurons, receptors and axons. But will they work? I honestly don’t know. Keep on searching Nootropics Expert for ways to boosts the things I mention in this comment.
But please make sure you check contraindications with any prescription meds you are using. And if you try something and it does work please report back with your experience. It could help a lot of other people around the world.
I have been giving my 4 year old son Lion’s Mane extract (powder) in hope that it will help with NGF. When he was 3, he caught a cold then became paralyzed 48 hours later. His dx is Acute Flaccid Myelitis, with his MRI showing damage at T-10 and below. Is there a brand of a powder or liquid extract that you can recommend that is just Lion’s Mane? He cannot swallow pills, so I have to mix it into a beverage. We have been giving him 1g a day.
If I schedule a consult on his behalf, do you work with children at all? I have been trying to put together a stack for nerve damage, neuropathy and spinal cord damage.
Mike, there are only a few vendors I trust and Hard Rhino in Nevada is one of them. They have Lion’s Mane capsules but not sure about powder. You can always open the capsules and dump the powder out. Here is my link to their store: https://www.hardrhino.com/?afmc=NOOTROPICS
I have worked with some parents with autistic children. And they told me they were satisfied with the work we did together. Keep in mind that I’m not a doctor. Don’t even play one on TV! My experience comes from 1,000’s of hours of reading the neuroscience and trying stuff out. I’d be happy to work with you putting together a stack. Just let me know when …
How true is this comment left by an amazon reviewer for a Lion’s Mane powder. It needs to have 50% Polysaccharides and more than 27% Beta-Glucan to be effective.
Keenan, not entirely true. A higher polysaccharide content is better which is why we get an extract. But more importantly is how the mushroom is grown according to supplement manufacturers I’ve spoken to.
Hi David, a MRI scan showed that I have a lot of scarring in my brain. This is probably due to migraines that I suffer from. I have no neurological issues or brain fog or symptoms that would point to something like a stroke or MS. I am wondering if I need a supplement like Mind Lab Pro, or just Lion’s mane to help heal my brain. What do you think of Host Defence Lion’s mane? Much appreciated.
Michelle, I know personally that using Mind Lab Pro daily for years do wonders for my brain. And I’ve done a lot of damage along the way too. So it will help.
But Lion’s Mane is specifically tailored to boosting growth factors and BDNF. It’s been proven in clinical trials. So I would use both for max brain repair. Mind Lab Pro and a separate Lion’s Mane supplement.
I happen to prefer Neuro-Stack because I know the type of Lion’s Mane the manufacturer uses is the highest quality. http://www.akualife.com/?aff=15 (full disclosure, that is an affiliate link so I make a bit if you buy from them). But I do use it daily as well.
Yo, my comment was removed. I just wanted an answer.
Undelete it. I want him to answer.
Vytautas, I cannot find the comment or question you are referring to. Would you please redo it?
Basically I was asking if I will need to depend on the mushroom for the rest of my life, or are any really long term ”fragments” of the main boost/effect even if I stop using it? I mean, if I use it for over 6 months or even over a year consistently, every day, there are bound to be SOME structural and maybe even biochemical changes in the brain, right? I dont expect a miracle, obviously, but I do think that with such faithful use of it your baseline performance should increase even if you stop using it. I made an argument that the same is with books – one book might make some changes in the brain, and you might have a feeling of some focus or even depth in your head after you finish reading it, but that will go away eventually if you stop with that one book… but if you continue to read them consistently and frequently, then the changes in the brain would become more permanent, and would stay there even after you stop. Of course, there is also aging to consider, but… you know.
I really dont want to depend on it forever, and if whatever I gain from it will completely disappear afyer I stop using it, no matter how long I use it, then there is no point in me even trying it. Im not interested in anything that is not more permanent. I mean, nature could make it easier… -_- I do understand that whatever neural regeneration and generation has already happened will stay with me (until they get replaced……. -_- ), so maybe that will get me closer to how I used to be mentally, but seriously, I was hoping for something more permanent. Even if it would take long time to gain it, and only little by little, as long as its cumulative and actually affects my baseline performance, I would be happy.
Is it all really just temporary?
Would it be more permanent if I engaged my brain
mentally while using it?
Any advice?
Vytautas, nothing that we do with nootropics to the brain is “permanent”. If a nootropic is used long enough there will be long-term structural changes and improvement.
But life will continue to throw insults at the brain. Changes in blood flow, nutrients, oxidative damage, etc. will continue to assault the brain.
All we can do is continue to make daily contributions to its health and realize if you want a health brain until you die you need to nourish it every single day.
I’ve bought some to help with my neuropathy. Here is my main concern – if i take Lions Mane for a period of time and then stop taking it, will i regress to worse than before? I’ll give you an example – if lions mane encourages rebuilding of nerves, and then without it, my body forgets how to rebuild nerves, will that mess up my body’s chemistry and makeup? Another example would be lions mane making you smarter, then making you dumber than you were after you stop taking it. I feel like there is a catch with all these drugs, and im trying to figure it out.
John, the repair facilitated by Lion’s Mane is as permanent as any natural process can be. You will not ‘regress’ if you stop taking Lion’s Mane. You just won’t continue the repair of ongoing cellular damage that happens every minute of every day and gets progressively worse as you age.
David
Thanks for your responding so quickly. I understand the nerves that are healed will be permanent. I understand that my body already has a natural regeneration process. Just curious if taking something like this will impair my body’s original natural regeneration process once i stop. I’m recovering from addiction from opiate/painkillers and am more wary about long term effects to body/brain chemistry pre/post drugs or supplements.
John, in this case you have nothing to worry about. Using Lion’s Mane will in no way impede your body’s natural abilities to heal itself. It will support it.
David – you are awesome! Thank you.
HI. I tried Lions Mane (Host Defense brand) about 4 years ago. The results were amazing with memory recall after about 1 week. The only issue was that I had sleep issues. I could not continue. I then tried again about 1 year ago with the same results. No other variables were added in to effect my sleep. I’m 55 and I need help with my memory. I really want to use this again, but is there a different brand or “form” of lions mane I could test ? It seems like I’m the only one that has experienced this issue. I’m willing to experiment with different forms as I know lions mane is very effective for brain support. thank you
Terry, have you tried a different brand of Lion’s Mane and still have the same insomnia issue?
Dear David. Thank you for the great article!
Are there any differences in efficacy depending on how I take them? I recently boil this mushroom in water and drink it like tea. (Cut organic Lion’s mane into several pieces and use one at a time.) How is this method compared to taking Lion’s mane in the form of supplements?
Thank you in advance for your answer!
Jay, I cannot find any evidence that heat damages the efficacy of Lion’s Mane. Much more important is how it’s grown: https://www.ncbi.nlm.nih.gov/pubmed/30641994
Are you familiar with the Oriveda Lion’s Mane ? They have an alcohol extract standardised for terpenes and since the brain-boosting bioactives are all alcohol soluble terpenes that seems to make a lot of sense
All the others are just talking but nobody will tell you what is REALLY in their pills
Chalm, Lion’s Mane extract labels should indicate the percentage (%) of polysaccharides it is standardized to. And the relevant metabolites in this mushroom for cognitive health are hericenones and erinacines. They may be ‘alcohol soluble’ but that doesn’t necessarily mean they are extracted using alcohol.
hericenones are erinacines are both terpenes/terpenoids, says the research. I linked in a later comment to an overview of that specific research but I guess it was filtered out as spam or so, I don’t see it ?
Terpenes will be lacking mostly in a water extract because such extracts only contain the water solubles, the rest is mostly or completely filtered out AFAIK. No matter what having a guaranteed % of terpenes in a powdered LM extract seems like a good thing to me for LM which was the reason for my comment here.
Polysaccharides is a very broad term and also includes many useless things such as chitin, starch and additives such as dextrin.
Only beta-glucans are relevant polysaccharides says research, but that said, glucans are also not relevant for the brain boosting you’re expecting from a Lion’s Mane extract I think. They are immune modulators, not NGF-inducers, right ?
Specifying polysaccharides was a quality marker 5 years ago but no more now that we have the Megazyme assay which can accurately determine beta-glucan % !
the relevant metabolites in this mushroom for cognitive health are hericenones and erinacines.
But those are terpenes (mero-terpenes and diterpenes, resp.).
Polysaccharides, with all due respect, are irrelevant here because they serve another purpose (and ‘polysaccharides’ is no longer a quality marker for mushroom extracts I think since starch and dextrin and chitin are also polysaccharides, but utterly useless).
I guess you mean ‘beta-glucans’, a type of polysaccharides which modulate the immune system.
Chalm, you’ve done your research and I agree with your assessment. Mushroom research is ongoing and I’m finding out more and more on this subject. Including a fascinating conversation with a manufacturing client of mine who gave me a lecture on growing substrates and how that affects quality.
Yes substrate composition affects the quality and the composition of the metabolites in a mushroom, but in what way ?
Wouldn’t it be great if manufacturers would share the lab test reports and guarantee the -lab-test backed- percentages of the relevant bio-actives to support their supplement quality claims ? Transparency is what I”m talking about.
Instead we get this talk about ‘organic’ and ‘premium quality’ and/or some great story about history and research and whatnot.
But the truth is in the numbers not in fact-free lectures and the marketing stories we see everywhere.
We need more transparency !
Hello David – my apologies if this was already addressed in a previous post or question, but it seems that the world of medical mushrooms is a huge topic of it’s own, and I was wondering if you had any plans to review more of these, especially Reishi. Perhaps it isn’t particularly remarkable from a nootropic perspective and that’s why it has not been addressed up to this point.
Dan, thanks for bringing this up. I do plan on doing more research on other mushrooms and cognition.
Thank you for the article, very helpful! I started taking lion’s mane powder in capsules about 2 weeks ago and i have seen an improvement in my mood and anxiety has reduced. Coffee was one of the things that would trigger the anxiety and i have had a cup each of the past 3 days with no anxiety!! I love coffee! Anyway, i am wondering if you have advice on how long this should be taken. I have no diagnose of any disease, just the anxiety thing and I have 3 kids, which has left my brain fried. Thank you! (=
Liza, good to here you are confirming what others are saying about this amazing nootropic. As long as you are following dosage recommendations and not experiencing any side effects you can use Lion’s Mane for life.
But quality is the most important thing about this mushroom. Lion’s Mane grown in grain spawn is not as effective as mushrooms grown in their natural substrate. If you get a product that smells like grain then you’ll know how it was grown. It’s not dangerous, just not as effective.
Hello David, thank you for great work, I’d have a question. I just bought a 5:1 Lion’s Mane extract (30% polysacharides), 600mg per capsule. I’m curious about the extract ratio particularly. Does 600mg of 5:1 extract means it works like a 3000mg of pure powder? I wonder how much the “extract ratio” really brings to the table. I’ve seen 100:1 and 200:1 extracts (that was Tongkat Ali, le testosterone fixer) – does it mean plain powder is practically useless compared to the extracts?
By the way, I’ve heard that LM inhibits some receptor (or something else…) related to libido, that wasn’t mentioned in your article. Just a hint, I think it’s worth checking out how serious it is.
If a little offtop is permitted: what do you think about potentially dangerous additives to some supplements – for example magnesium stearate and titanium dioxide? Is it something to worry about? Solgar and other big companies use them almost everywhere.
Raffaello, looks like your math is correct. It will take much more plain Lion’s Mane powder to achieve the same effect you would from an extract.
But in this case, it’s best to leave it up to the manufacturer for specific dosage recommendations depending on their extract.
I’m interested in a link to a peer-reviewed clinical study about Lion’s Mane and libido if you can find it.
Additives in supplements are a major pet-peeve of mine and the reason I prefer getting my supplements from someone like Opti Nutra who make Mind Lab Pro and the Performance Lab line.
Otherwise I make my own capsules from powder for nootropics not available from Opti Nutra. This is such a serious problem in my humble opinion that I wrote a post about “Choosing the Highest Quality Nootropic Supplements” here > https://nootropicsexpert.com/7-tips-for-choosing-the-highest-quality-nootropic-supplements/
Hi, thanks for your work, I appreciate that you try to be honest and not only selling for the sake of merchandising… Youtube have a lot of pseudo “neurohacker”. I’ll always appreciate honesty and impulse the work of people striving for it.
I live in France ( food quality )
this is my current intake of food/lifestyle :
– ( lot of fruit ( bananas, kiwi ( everyday ) // Option : apple, perry, clementine, others fruits. )
– ( more than 5 vegies per day ) based 60% & :
“mid quality” : meat / fish (20% )
– dairy/flour based product (pasta) (20%)
– Everyday : ( meditation, sport, stretching (1h~)
Currently stacking :
– (900mg Taurine (5/7 days)
– D3 ( in the morning ) ( 3 drops in the morning ~10 000UI ) ) ( I work inside everyday )
in the futur I’ll add :
– Hericium 650mg
– Ptérostilbène 50 mg
– Zink ( maybe once in a week ? )
– Coenzyme Q10 ( maybe 5 times a week )
Optionnal :
– L tyrosine ( when I need a “coffee boost” I suppose )
– Valériane 400mg to fall asleep ( maybe not everyday, depend my sleepiness )
Of course I don’t take any others drugs and drink only water everyday since 4 years. ( no sugar drink )
I did get out of any sugar product as I can ( no process food or sugar candy ) My favorit sugar is dark chocolate with a tiny stewed fruit 4 times in a week.
Sometimes I eat the healthy sugary baked from bakery ( or mum ) but it’s never in excess. ( I didn’t put a foot in a mac shit, since more than 4 years )
All my supplements are non gmo, full organic, vegans caps, without any metal. ( from germany “qualitat” )
my current focused brands are : “Fair & Pure” the other is “Vitabay”
( or french product )
I m 25 years old and have no health problem, apparently I m adhd, but another psych told me I was not.
I should probably do a blood test, it has been 5 years without doing one.
doing this, because I always liked biology/zoology & futur science.
I m doing my own report/review in my files and take notes everyday ( as I m currently doing )
Taurine seams very efficient currently, maybe I’ll not need to stack everything, everyday. ( try & see )
( I m an artist/ drawer:musician “mainly” but I like to read a lot. )
I hope to share my own review with people after my own self experimentation.
My past if curious :
I did use ritalin for 1 year last year. ( it comes out being a very BAD DRUG ), prior this year, I was 4 years on smoking weed for “anxiety” something I get out of it, by thinking more harder on what really it is about.
( quit 6 month ago, because it doesn’t worked anymore for me in my work )
– Smoking weed seams not a good idea in the end, I heard about cbd for anxiety/muscular problem, but it’s still forbidden in my country.
I always drinked a lot of water and try to be on a good diet since I m 20 years old.
I use aswell another good website for review, call’d “examine.com”
I wish you do a review on : Reishi / Cordyceps ( both mushroom )
anyway thanks for your website and your work !
I’ll follow your channel closely on youtube as I appreciate your format and your way of presenting nootropics.
AerisV
Aeris, I’ll add Reishi and Cordyceps to my list to review here on Nootropics Expert. I just came across some very positive studies on how they work in the human brain. And they look like promising additions to many nootropic stacks. So thank you.
well my pleasure, hope to give you soon my own review on my stack. Hungry for your review on those mushroom 🙂
I bought Solgar Lion’s Mane… Well – maybe it’s coincidence but I improved my memory during those few days. My mind was clear and I was perfectly organised… What worries me – I wake up in the middle of the night with strange feeling in my head – like ants or something… Loose feeling in hands for few minutes like after stop of blood circulation?:-o And when some of it got on my tongue (I tried it half from the capsule as a powder) it left me with something similar to painful infection and sore throat… :/
I never had problems with edible mushrooms.
Some people have reported itchy skin at higher doses. Likely has something to do with it’s affect on BDNF. But that is the only side effect I can across in all the studies. It could be that Lion’s Mane is just not for you.
Hi David, I was wondering if you could shed some light regarding the decreased cognitive function of the patients that stopped supplementation you referred to in your video. Was the regression comparable to their cognitive ability before taking lion’s mane or was the significant decrease you spoke of pointing to an ultimately negative effect? Basically I’d like to try it out but don’t want to have my base line cognitive ability suffer if i’m unable to keep up constant supplementation.
Kind Regards
Robert
Robert, the clinical study you are referencing was done with patients suffering “cognitive impairment”. Their cognition improved while using Lion’s Mane but returned to their baseline when they stopped using it.
Your concern is legitimate to a point because most people who start using nootropic supplements find that their brain starts working better. And are reluctant to stop using nootropics because they may go back to the same cognitive issues they were dealing with before they discovered nootropics.
But that’s our choice. Either support our brain by using nootropics. Or continue suffering with whatever issues we are dealing with now. Nootropics saved my life. So I’ll continue to use them for the rest of my life. Because I don’t want to go back to the way I was feeling 6 years ago.
Hello David I love the job that you do and it’s really changing the life of me, my family, parents, friends and relatives. Please can you put references about the studies that you mention.
Renos, the references are as Roman numerals beside each study. Scroll to the bottom of the review to the “REFERENCES” section accordion. Click the arrow and all the clinical studies are there including “source” links to the original studies.
Thank you for the very insightful article on Lion’s mane. I have a question concerning the compound of lion’s mane. One product of Lion’s mane (Lion’s mane mushroom extract) that can be purchased online from a reliable seller is said to contain “40% whitanolides”. I find that a bit odd since nowhere did I see whitanolides being mentioned in association with lion’s mane. According to what I know, and also according to all other sources, including your article as well, lion’s mane contains polysaccharides, among other compounds, but not whitanolides, which are actually the main bioactive compound found in another adaptogen, Ashwagandha. Am I missing something? Or are whitanolides a compound which is also found in lion’s mane in some form? I’d appreciate your comment on this, Mr. Tomen. Thank you.
Victor, you are not “missing anything” and thank you for closely checking labels. Whitanolides are mostly found in the nightshade family of plants. And Lion’s Mane Mushroom is clearly not in the nightshade family. Either someone made a mistake in their label copy. Or are trying to full a “fast one” on the unwary supplement buyer.
Thank you for your reply and clarification! I contacted the seller prior to writing my comment here and, yes, they said a mistake was made because their graphic designer used the template for Aswagandha, which they sell as well, and forgot to change the ingredients; it’s supposed to be “40% polysaccharides”, not “40% whitanolides”. They said the mistake would be corrected as soon as possible.
I forgot to ask can all these also effect her kidneys and liver? Shes diabetic and takes insulin and ecotrin. Also iron for anemia
Hi
My mom has severe dementia. She screams non stop. Ive been trying several different supplements to try and help. Here they are
#1. Amyloban- 6 pills per day
#2. Lions mane powder by purity 30:1 concentrated. 1 teaspoon
#3 tonic tintures lion mane 1-3 squeezes of the bulb
All lions mane for protection and ngf
#4. Longvida optimized curcumin 400 mg by nootropics depot. 1 pill daily to tackle plaque 5. Panax notoginseng by health smart with 30% rg1 and 30% rb1 (bace 1 inhibitor) 2 pills daily
#6. Sensoril ashwaganda -10% withanolides by nootropics depot 1 or 2 pills daily
#7. Egcg- by swanson 90% ecgc 1 or 2 pills daily to tackle beta amyloid plaque
#8. Bulk supllements black coshosh powder (inhibitor y secretase) 800 mg daily
#9 nature botanicals ashwaganda 10:1 powdered extract. 1/4 teaspoon daily
Not given if i give the sensoril
And i just ordered synapse bacopa monierri might give two daily to cut down beta amyloid plaque
Im just kinda worried this all might be too much? Can all these thin her blood out and lower her blood pressure too much? And
CY, you should be OK using these adaptogens but I highly recommend checking out the side effects section for each of these individual reviews here on Nootropics Expert. You can scroll through the list and click through to the full review for each here: https://nootropicsexpert.com/nootropics-list/
Next, I suggest you do a general search of Nootropics Expert using the search function top right for the keyword “dementia” and then for “Alzheimer’s”. Lithium Orotate comes to mind as one way to calm outbursts in mood. You’ll also likely find that some of the very basics may help including certain vitamins and minerals.
I just bought some Lion’s Mane tablets and wanted to know how many I should take. Mine are 400 mg each so I think I’ll start with 2 per day and work my way up to 3 in a few weeks. Thanks for the info!
Tim, is the Lion’s Mane standardized? If not then definitely one 400 mg tablet twice per day. You can safely double that dose.
Is it safe to use small doses of valium and lions mane?
Marius, I’m not aware of any contraindications with Lion’s Mane and valium. Here is another way to check for potential interaction problems: https://www.drugs.com/drug_interactions.html
David I have something called idiopathic intracranial hypertension. Would be great if you already know what this is but if you don’t and it’s too much CFS and the Brain causing extreme pressure which in turn causes cognitive issues with memory and such. The pressure also causes problems with vision do to deterioration of the optic nerves,which eventually can cause blindness. I have lost some peripheral vision but thank God I have not gone blind. However the excessive fluid has caused me to have cognitive issues with function and memory. I am desperate to find an alternative solution and then what the conventional doctors recommend. Their treatment is with usually two different kinds of medication one called Diamox he has her Topamax both have horrible side effects and also causes more loopiness. If those don’t work their next solution is to do a brain shunt which is basically put into the brain to drain the fluid which then is drained by a tube into your stomach. I am looking for an alternative. Doctors don’t know why there is too much CSF fluid being produced in the brain and seems they have no care to find out why. Their approaches very textbook and seems they must receive a lot of money for shunt surgery as that is always the end result for all these poor people that have this. I refuse to go that route and I am looking for Alternatives and that’s why I am here. Lion’s mane looks like a great solution to the memory and the cognitive issues but can you suggest anything else maybe for the optic nerves and for the excessive CSF fluid?
Natalie, Lion’s Mane may be a good option to start. Keep in mind that I’m not a doctor so please do your own research on each of these suggestions. And make sure they do not interact with any meds or other supplements you are using.
Ashwagandha is one option: https://nootropicsexpert.com/ashwagandha/, and
Bacopa Monnieri is another: https://nootropicsexpert.com/bacopa-monnieri/.
The best supplement combination I’ve ever used for eye and vision health is here: https://nootropicsexpert.com/performance-lab-vision-review/
Hi David,
i have purchased the Lions Mane powder extract and i have started to take 1/4 teaspoon twice daily. Would you have any idea how much this would be in milligrams? I’m just not sure if I’m taking enough.
Thanks for your help.
Kathy
Kathy, the only way to know exactly how much in mg of Lion’s Mane your getting from that powder is to get it tested in a lab.
It’s the reason I prefer extracts from reputable companies. Or patented products by reputable companies that are supported by clinical trials.
Hi , I recently picked up a 50g packet of Lions mane powder at a health show. I have post concussion syndrome and have fatigue, and a whole load of other symptoms that show up when I’m over tired. Is this appropriate for pcs? the guy on the stall said it was but he was trying to sell it to me… I have had pcs since an accident 2 yrs ago, how long would I need to take it for before I start noticing any difference? The problem I find with all this stuff is the cost. I am on benefits as cant work because of pcs. I can’t currently afford to start having loads of this unless I am very sure it will help me. It feels like gambling! Thanks in advance for your advice, Sarah
Sarah, Lion’s Mane should be an ideal supplement for post concussion syndrome. Did you see my post for treating Traumatic Brain Injury here? https://nootropicsexpert.com/best-nootropics-for-traumatic-brain-injury/
I have tested and plan on doing a review for a nootropic stack called Neuro-Stack which provides 1,400 mg of Lion’s Mane per dose. If you are interested you may want to check out the reviews here: https://amzn.to/2KT5Orv
Omg, that Mind Lab Pro is too expensive for me so can you recommend another that will probably yield the same results for under $25. I killed my brain cells from all this stressing which in turn has cause me Adrenal Fatigue along w/Periomenopause for the past probably 5yrs. Doctors wanted to make me mentally insane but I knew it was not that and so glad I refused rx drugs. Im so glad I found this article and your wisdom.
Be Blessed
Debra, you can get started on brain cell repair by using Lion’s Mane. I just checked and found at least two options for under $25 from reputable vendors on Amazon. But my experience over the last 10 years is it’ll take far more than $25/mth. to repair a damaged brain.
Hi Debra,
In case this is still relevant – I had significant adrenal fatigue and thyroid problems. I followed the Stop the Thyroid Madness protocol and got better. (There’s a website – just google stop the thyroid madness.) You do need a doctor to prescribe some of the recommendations, and you do need to get some labs run, but I found it to be worth it. There’s also a facebook group called Adrenal Fatigue and Thyroid Care that is full of helpful people. I’m not trying to sell anything and I am not connected to the author of the website, I’m just sharing something that helped me.
I have advanced CIDP with lots of nerve damage. Will lion’s mane helpregrow mylin and damaged nerves.
I’ve been taking 1 ml Host Defense 2X a day for one month. No change yet.
Bob, Lion’s Mane helps repair and generate new neurons. But not myelin. The only nootropics I’m aware of that have been shown to restore myelin are Sulbutiamine: https://nootropicsexpert.com/sulbutiamine/. And some of the B-Vitamins. Use the search function top right of this site and search for “myelin”.
You’ll have to read each search result carefully because some mention “myelin” but don’t actually help repair it.
I found one research paper that suggests Lion’s Mane might help repair myelin. I was bindge reasing about Lion’s Mane and found this paper. This research experiment shows that it helps cultured brain cells of mice to grow myelin faster. I don’t know what that translates to for humans. It might help though. https://pdfs.semanticscholar.org/14e2/7efb714718cc0262bf32b5adaaa75e68d729.pdf
Kevin, that’s a good find. Myelin is the sheathing surrounding each one of the axons in your brain. It’s a lot like electrical tape providing a protective sheath around electrical wire.
But recent research shows myelin does so much more including promoting better brain cell signaling. Which would have a positive effect on learning and memory, and cognition (quicker thinking).
Hi David,
I enjoyed your video on Lion’s Mane Mushroom, This is a nootropic I have heard of before but just thought I would give it a try but upon looking for chemical named you mentioned, I was unable to find anything similar and found different brands have different ingredients.
So I am dumbfounded what will be the best quality to optimize my brain. As you said 1-10 20% (a chemical name I can’t pronounce nor spell ) I could not find anything similar on any labels.
one product’s label was this:ORGANIC FERMENTED LION’S MANE MUSHROOM – (HERICIUM ERINACEUS)(MYCELLIUM/ORGANIC WHOLE OAT BIOMASS)
1,000 Mg
Another looked like this:LION’S MANE FRUITING BODY EXTRACT BLEND – (HERICIUM ERINACEUS)
1,000 Mg
N/A*
MAITAKE FRUITING BODY STANDARDIZED EXTRACT, TD-FRACTION
100 Mg
And the others looked different as well.
What should I be looking for, Are the mentioned above decent quality?
Thanks for your feedback, Your channel is extremely informative and well researched, When I ask my Doctor or any dr about supplements they are quick today they can not comment as they are not FDA approved = They don’t pay me so I will not recommend them.
I know how much research goes into tour work and if you ever start a patreon page please link it in your videos as I would love to keep this channel going and expand into other areas of nutrition and supplementation.
I read a lot myself but as you know you will read one article about a supplement or food that raves about its benefits only to read another that list nothing but negatives.
That is why I would love to see you expand on that, I hope I am not rambling, I just want to be a supporter of the channel.
I bring this up because of as I am a daily eater on Tofu, I have read some articles that eating Tofu leads to memory loss, even dementia- I don’t know how much proof there is to that if any so I got concerned as I consume a lot of it daily.
Thanks for the informative videos!
Justin, I will be publishing a “where to buy” post in the next couple of months. So stay tuned …
Meanwhile, I’m not familiar with the products you mentioned in your comment. And the thing is no one has a definitive claim to having the most effective Lion’s Mane. At the moment the best I can suggest is read the “Available Forms” section of this post. Then compare the “Types of Lion’s Mane Available” bullet list (the first three bullets) with label descriptions on the supplement bottles you are considering.
Once you’ve narrowed down your list of 2 -3 Lion’s Mane supplements then read the reviews for each closely. I realize this is a very ‘unscientific’ method of selecting a supplement. But the bottom-line is we want something that works. Reviewers are often the best source of that information.
Hi David, i just wanna thank you for this amazing website and the wonderful book you gave us, thank u.
thou i need some clarifications on some supplements that i’m currently using to heal and repair my brain;
i’ve ben using bacopa monnieri (brand: nature’s answer) one capsule with breakfast and lion’s mane (brand: Host defense) 2 capsules after breakfast, and my main daily supplements are also b vitamins and Mega-DHA and these 2 i’ve been using for the last year and i felt good on them but this last month and a half i introduced the bacopa and lion’s mane which they had a total diverse effects on which i’m taking them for, i lack concentration and i feel a little bit depressed and sedative all day, no energy and my brain is fogy AND i lack motivation, and i’m afraid if i keep using them it will get worst, that’s why i need you expert opinion, should i discontinue using them or is it just the way the brain heals and i just have to stick with it till this period passes , i really don’t know what to do and i really have classes and a very demanding job which requires me to be sharp minded and productive all the time,
i’m looking forward to hear your advice and thank you so much,
oh, and also i sue magnesium at night only 150mg cause i eat a lot of food containing magnesium, thank you again
Rashed, it could be Bacopa that is causing your problems. Try eliminating Bacopa for 2 – 3 days and see what happens. If there is no change then eliminate Lion’s Mane and see if you experience an improvement.
Are there any other ingredients included in either supplement you are using? Or are they both plain extracts?
One thing I’ve learned over and over again is not every supplement is right for everyone. Each of us is unique. And how we respond to various supplements.
Hi,
thanks for all the useful info and research!
Any brands that you recommend and trust for effective lion’s mane supplements?
i’m a bit overwhelmed by the options and the many contradicting reviews.
thanks!
Ronen, great question and this is an ongoing issue with finding quality supplements. Please see the article I wrote recently on choosing quality supplements here > https://nootropicsexpert.com/7-tips-for-choosing-the-highest-quality-nootropic-supplements/. I know the Lion’s Mane Mushroom in Mind Lab Pro has been verified and guaranteed.
You can try a search for “Lion’s Mane Mushroom” AND “USP Verified” and see what turns up in your part of the world.
First look for “USP Verified” or “NSF International” on the label. And “Certified USDA Organic”. Some supplement manufacturers like Swanson Vitamins do in-house and third party testing. Then put their own seal “guaranteeing” that what’s advertised is actually in the bottle.
Finally, after you find a winning contender check out the customer reviews and see if verified buyers agree to the company claims of potency.
There is a mistake in the article
Instead of
“The best human study used 750 mg per day.”
Should be:
“The best human study used 3000 mg per day.”
Because, as is written earlier in the article: “The trial subjects received _ _ _ four _ _ _ 250 mg tablets containing 96% of Yamabushitake (Lion’s Mane) dry powder three times a day for 16 weeks.”
250 x 4 x 3 = 3000 /day
Your are absolutely right. My mistake. Math was never one of my strong subjects in school. Much appreciated and it has been changed.
I had been inline speed skating to strengthen my legs and ankles for tennis for several years on skates that were too tight. This was at age 55. As a result I developed compression neuropathy on both feet after a few hundred hours of skating. The pain became very intense and I tried everything but nothing seemed to work so I did some research and discovered Lion’s Mane. Since I fully understand the potential of mushrooms to do some amazing things(FSU 77 LOL), I was confident it would help somewhat. I ordered it along with Super B’s and after 6 weeks or so, both feet were 80-90% back to normal. There is no more pain!!! That was 3 years ago and I have taken a two month dose twice since then. At 62 I am almost as quick as ever and I am quite fast around a tennis court so am looking to play another National Tournament soon. I have not taken a new IQ test lately but am sure it might have raised it even a few more points. After all, growing a few more neurons in the brain is a good thing.
Thanks Peter for sharing your experience with Lion’s Mane and the B-Vitamins. I’ve had amazing success in turning around my health using nootropic supplements. And why I started Nootropics Expert. It’s always gratifying to hear from someone who shares some of the benefits that I’ve experienced.
Are there an concerns with substantial doses of b-1 50-100 mg and lions mane 500mg?
John, not the I’m aware of. Please let me know if you’ve found something to the contrary.
Im confused how much Lions Mane do I take.
I have it in powder form would 2 teaspoons a day work.
No directions on pack can someone please help Im so keen to use.
Colin, check the manufacturer’s website and see if they have dosage instructions for their Lion’s Mane. You can safely use up to 3 grams per day. But you may want to get yourself a small scale to weigh it.