5-HTP helps fibromyalgia

5-HTP

David Tomen
Author:
David Tomen
13 minute read
5-HTP is known for relieving depression and anxiety, fibromyalgia, insomnia, migraines, obesity, and symptoms of Parkinson’s Disease

5-HTP (5-Hydroxytryptophan or oxitriptan) is an amino acid that is naturally produced in your body. 5-HTP is synthesized from the amino acid tryptophan which we get from food.

5-HTP is the immediate precursor of serotonin. And as a nootropic and dietary supplement, 5-HTP is popular with those who advocate its effectiveness in treating depression. Along with a number of other serotonin-related diseases.

But using 5-HTP for treating depression and anxiety is not supported by science. The research is contrary to how 5-HTP is viewed by many, including medical doctors.

When we dig into the research, we find that 5-HTP may be contraindicated for depression in those whom marketers advocate its use.[i]

We’re all for boosting neurotransmitter levels and optimizing cognitive performance here at Nootropics Expert®. But now and again I run into a nootropic or dietary supplement that may be popular. But also may be a particularly bad idea.

We’re going to get to the bottom of how 5-HTP works in your brain in this review. We’ll examine why it’s critical for brain health. And reasons why you may want to find another way to boost serotonin levels in your brain.

5-HTP helps:

  • Anxiety & Depression. 5-HTP is synthesized into serotonin in brain cells. Elevating levels of serotonin can help relieve the symptoms of anxiety and depression.
  • Neurotransmitters. 5-HTP is a necessary ingredient for serotonin synthesis which boosts mood and social behavior, improves memory, regulates appetite and digestion, sleep, sexual desire and function.
  • Brain Optimization. A critical balance of the primary neurotransmitters serotonin and dopamine are needed for the highly optimized brain. When these neurotransmitters are not in balance it affects mood, memory, cognition, decision-making, sexual desire, and a host of other critical life functions.

Overview

5-HTP (5-Hydroxytryptophan or oxitriptan) is an amino acid that’s synthesized from the essential amino acid tryptophan.

5-HTP
5-HTP

Tryptophan is hydroxylated by tryptophan hydroxylase to 5-HTP (5-hydroxytryptophan), then decarboxylated to serotonin (5-hydroxytryptamine or 5-HT).[ii]

Tryptophan → 5-HTP → serotonin

80-90% of your body’s serotonin is made in your intestines. But serotonin cannot cross the blood-brain barrier. So all the serotonin that your brain needs has to be made within the brain. This is where 5-HTP comes in…

5-HTP crosses the blood-brain barrier more readily than tryptophan. And gets synthesized into serotonin at a faster rate than from tryptophan.[iii]

As a neurotransmitter, serotonin influences directly and indirectly, the majority of brain cells. So if you want to boost serotonin in your brain, some find that supplementing with 5-HTP is better than taking tryptophan.

Tryptophan, which your body uses to make 5-HTP, can be found in turkey, chicken, milk, potatoes, pumpkin, sunflower seeds, turnip and collard greens, and seaweed.

5-HTP as a nootropic supplement is a naturally occurring amino acid derived from seed pods of Griffonia simplicifolia, found in West and Central Africa. 5-HTP content in extracts of this plant vary from 2 – 20.83% (from seeds obtained in Ghana).[iv]

5-HTP nootropic for depression

How does 5-HTP work in the Brain?

5-HTP is a precursor to serotonin. The neurotransmitter serotonin plays a role in sleep, appetite, learning & memory, mood, and sexual function.

When tryptophan’s role in converting to 5-HTP for boosting serotonin doesn’t work efficiently, the result is often depression, chronic headache and insomnia.

An open-label trial was conducted in Italy to determine the efficacy of using 5-HTP in young subjects with high levels of “romantic stress”.

Serotonin has been linked to human romantic attachment. So researchers in this study set out to determine brain levels of Brain-Derived Neurotrophic Factor (BDNF) and serotonin in relation to changes in romantic stress during the study.

15 healthy subjects (mean age 23.3 years) who had a “romantic breakup” took part in the study. Participants received 60 mg of Griffonia simplicifolia extract containing 12.8 mg 5-HTP daily for 6 weeks.

The subjects were evaluated for BDNF and serotonin levels at the beginning of the study, at 3 weeks and then again at the end of the 6-week trial.

The scientists observed significant improvements in romantic stress scores from weeks 0 through 3. So far, 5-HTP seems to be working. But no further improvement was seen from weeks 3 through 6. Even though the young people had significantly higher levels of BDNF and serotonin.[v]

More Involved in Depression and Stress than Serotonin

This “romantic breakup” study is a classic illustration of why using 5-HTP alone to treat depression and stress may not work. And if it does work, why it may not work for long.

5-HTP for romantic stress

Depression is often more than simple serotonin dysfunction. Depression can also be associated with catecholamine dysfunction, including dopamine and/or norepinephrine. Or a combination of serotonin and catecholamine dysfunction.

When you take 5-HTP alone, you are also depleting dopamine, norepinephrine, and epinephrine. Synthesis of serotonin from 5-HTP, and dopamine from L-DOPA is catalyzed by the same enzyme, L-aromatic amino acid decarboxylase (AAAD).

Dopamine and serotonin precursor supplementation must be taken in proper balance. Because when you use only 5-HTP, it dominates dopamine at the AAAD enzyme synthesis level.

Blocking dopamine synthesis at the AAAD enzyme through competitive inhibition will lead to depletion of dopamine and the rest of the catecholamines.[vi]

Going back to our Italian study of young people dealing with “romantic stress”, the subjects stopped responding to 5-HTP in the 2nd half of the study. Likely because their catecholamines became depleted through continuous 5-HTP supplementation.

Studies have found that when dopamine is depleted enough, 5-HTP will no longer function.[vii]

Catecholamine Dysfunction Affects More Than Just Depression

When catecholamine neurotransmitter levels (dopamine and/or norepinephrine) influence depression, supplementing with 5-HTP alone is not the way to go. Because you may deplete dopamine and norepinephrine, worsening the disease and its underlying cause.

But this contraindication is not exclusive to depression. It extends to all other diseases where catecholamine dysfunction has been implicated. Including ADHD[viii], obesity, anxiety, seasonal affective disorder  (SAD), and Parkinson’s Disease.[ix]

How things go bad

5-HTP boosts serotonin levelsAmino acid precursors of serotonin (i.e. 5-HTP) and dopamine (i.e. L-Tyrosine) work together during synthesis, metabolism and transport to the point that they function as one system.

When serotonin and dopamine are properly balanced, functions that are regulated only by serotonin, can be regulated by manipulating dopamine levels. And functions regulated only by dopamine in this balanced state can be regulated by manipulating serotonin.[x]

When you mess with this balance and improperly supplement with serotonin or dopamine precursors, you don’t get the desired effect of using that nootropic. And you increase the possibility of side effects with too much serotonin.

If you supplement with only one precursor (i.e. 5-HTP to boost serotonin) that dominates the other system (i.e. dopamine synthesis), depletion of the dominated system will occur (i.e. depleted dopamine).

And if this effect is pronounced enough, you will not get the benefit you were aiming for when supplementing with the original precursor (i.e. 5-HTP).

A powerful example of this effect is in the management of Parkinson’s Disease where the effects of L-DOPA are no longer observed over time due to serotonin depletion.[xi]

Since serotonin and dopamine cannot cross the blood-brain barrier, the number of serotonin and dopamine molecules in the brain is a function of the amount of nutrients (amino acid precursors) that are available to be synthesized into new neurotransmitter molecules.

Optimizing brain function with minimal side effects is NOT a function of supplementing until you get sufficiently high amino acid levels. It’s a function of achieving the proper balance between serotonin and dopamine.

5-HTP improves mood

5-HTP benefits

5-HTP is absolutely critical for synthesis of serotonin in your brain. But supplementing with 5-HTP to boost serotonin does not work well.

Using 5-HTP to treat depression has had very little success over the last few decades of clinical trials and biohacking.

Integrating 5-HTP into your nootropic stack is much more complicated than simply adding some 5-HTP in order to boost serotonin.

5-HTP alone will not work for depression, or any other issue you’re dealing with involving the catecholamines (dopamine, norepinephrine, epinephrine) because of 5-HTP’s tendency to deplete those neurotransmitters.

5-HTP will boost serotonin in your brain.[xii] But 5-HTP must be carefully stacked with precursors for dopamine and norepinephrine or you risk making the situation worse.

You must avoid supplementing with only one of the serotonin or dopamine amino acid precursors. When amino acid precursors are not in balance, you end up with decreased effectiveness of that nootropic, increased side effects, and depletion of the non-dominant system.

How does 5-HTP feel?

Reactions to supplementing with 5-HTP vary considerably but the one consistent theme is initial feelings of well-being, better sleep, less need for sleep, improved mood, less social anxiety, lower appetite, improved tolerance for stress and improved cognitive function.5-HTP helps fibromyalgia

And after a couple of weeks of dosing 5-HTP  – side effects begin. Serotonin overload results in dopamine and norepinephrine depletion.

Side effects include feelings of lethargy, depression, brain fog, stomach pain, and possibly a chronic tension type of headache. Worst case scenario is nausea, vomiting and even blacking out.

Neurohackers who report consistent success supplementing with 5-HTP stack it with B-Vitamins, a dopamine precursor like L-Tyrosine, and only use 5-HTP as needed.

Those who have a bad experience with 5-HTP from the start often have no idea why they’ve reacted badly. But an educated guess is their depression was catecholamine (dopamine, norepinephrine, epinephrine)-related. And boosting serotonin made their dopamine-related issues worse. Very quickly.

One huge word of WARNING: Do NOT take 5-HTP with any antidepressant medication. You put yourself in the very real danger of Serotonin Syndrome which can ultimately kill you.

does 5-htp work for depression?

5-HTP Clinical Research

5-HTP supplements are heavily marketed as a natural remedy for depression. But the science does not support using 5-HTP for depression. We have decades of clinical trials available. And there is no evidence of the efficacy in using 5-HTP for depression.

5-HTP instead of selective serotonin reuptake inhibitors

The Department of Public Health at the University of Queensland Medical School in Australia did a systematic review of literature dating from 1966 – 2000 for “5-HTP” and “depression”.

The researchers found 108 clinical studies of which only 2 studies, one with serotonin (5-HT) and one with L-Tryptophan for a total of 64 patients met sufficient quality criteria to be included. These studies suggest serotonin (5-HT) and L-Tryptophan are better than placebo at alleviating depression.

But the researchers noted “the small size of the studies, and the large number of inadmissible, poorly executed studies, cast doubt on the results from potential publication bias, and suggests that they are insufficiently evaluated to assess their effectiveness.”[xiii]

5-HTP for Fibromyalgia

A double blind controlled study in Italy studied the efficacy of using 5-HTP in treating fibromyalgia symptoms.

50 patients with primary fibromyalgia syndrome were selected for this study. This 1990 study did not publish the amount of 5-HTP used. But the researchers found a significant improvement in fibromyalgia symptoms with only mild and transient side effects.[xiv]

5-HTP for Treatment of Depression

Insufficient activity of the neurotransmitters serotonin and norepinephrine is a central element of the model of depression most widely held by neurobiologists today.

In the late 1970’s and 1980’s, numerous studies were performed in which depressed patients were treated with the serotonin precursors L-Tryptophan and 5-Hydroxytryptophan (5-HTP), and the dopamine and norepinephrine precursors Tyrosine and L-Phenylalanine.

A summary published in the Alternative Medicine Revue looked at the data from all these studies. The author noted that the nature of the studies makes it difficult to draw firm conclusions regarding the efficacy of neurotransmitter precursors for treating depression.

While there is evidence that precursor loading could work, particularly for serotonin precursor 5-HTP, more studies of suitable design and size “might lead to more conclusive results”.[xv]

Those studies have not materialized since that report was published 22 years ago.

5-HTP Recommended Dosage

Recommended dosage of 5-HTP if you’re going to try it is 50 mg 1 – 3 times per day.5-HTP nootropic dosage

Some studies have used higher doses than the recommended dose, but 5-HTP can be toxic for your central nervous system at high doses.

For anxiety or depression, 5-HTP is dosed at 150 – 300 mg per day total.

To relieve post MDMA (Ecstasy) depression, 5-HTP 100 mg on Day 3-7 after MDMA use.[xvi]

Successfully supplementing with 5-HTP requires stacking it with a dopamine precursor like L-Tyrosine or L-DOPA along with B-Vitamins (for synthesis), and one of the sulfur-containing amino acids (methionine, cysteine, homocysteine, or taurine).

And you must monitor the effects this stack is having on your body. If you start experiencing side effects of any kind, it’s a good indication that either serotonin or dopamine is out of balance.

DO NOT combine 5-HTP with any kind of antidepressant medication.

Combining SSRI’s, Tricyclics or MAOI’s with 5-HTP will cause Serotonin Syndrome. An extremely dangerous condition involving severe mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma leading to death.

Serotonin Syndrome can kill you. And I’m not kidding here.

5-HTP Side Effects

5-HTP supplementation can cause heartburn, heart palpitations, headache, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems and muscle issues.

5-HTP can also cause some pretty radical mood changes including agitation, aggressiveness, anxiety, euphoria, poor decision-making, irritability, psychosis, restlessness and insomnia.

5-HTP can make the symptoms of schizophrenia, bipolar disorder and other mental disorders worse.

Serotonin Syndrome

And I can’t emphasize this enough so I’m going to repeat it here in case you missed it…

DO NOT combine 5-HTP with any kind of antidepressant medication. Or with carbidopa. 

Combining SSRI’s, Tricyclics or MAOI’s with 5-HTP will cause Serotonin Syndrome. An extremely dangerous condition involving severe mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma.

And combining 5-HTP with carbidopa also has the potential of causing Serotonin Syndrome.

Serotonin Syndrome can kill you. And I’m not kidding here.

Type of 5-HTP to Buy

5-HTP is made from tryptophan in your body.

5-HTP as a nootropic supplement is made from extracts of the African tree Griffonia simplicifolia. 5-HTP supplements are typically in tablet or capsule form.

You’ll often find 5-HTP in many ready-made vitamin and herbal formulas.

If you are going to stack low-dose 5-HTP with L-Tyrosine I suggest: Natrol 5-HTP Fast Dissolve Tablets (Amazon). Cut the 100 mg tablet into quarters using a pill splitter and dissolve 25 mg 5-HTP under your tongue (sublingually).

Nootropics Expert Recommendation

5-HTP 50 mg up to 3-times per day

Nootropics Expert - Tested and Not ApprovedI DO NOT recommend using 5-HTP as a nootropic supplement.

Your body does synthesize 5-HTP on its own to make serotonin in your brain. And you can’t get 5-HTP from food. But you can get L-Tryptophan from food which is synthesized into 5-HTP in your body.

5-HTP may help you if you’re dealing with depression. But you must stack if with a dopamine amino acid precursor along with B-Vitamins and a sulfur-containing amino acid. See the “5-HTP Recommended Dosage” in this review above.

IF you are going to try 5-HTP, I suggest starting with a dose of more than 50 mg daily. You may want to take it in the evening because it could help sleep disorders.

Short-term dosing of 5-HTP of no more than 2 weeks seems to provide the most benefit if you’re going to benefit from this nootropic.

Or try using 5-HTP only on an “as needed” basis. For a mood boost, reduce social anxiety, and provide a short-term boost in cognition.

5-HTP supplementation on its own is NOT recommended. Nor is it recommended for long-term use.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Hinz M., Stein A., Uncini T. “5-HTP efficacy and contraindications.”Neuropsychiatric Disease and Treatment. 2012;8:323-8. (source)

[ii] Turner E.H., Loftis J.M., Blackwell A.D. “Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.”Pharmacology and Therapeutics. 2006 Mar;109(3):325-38. (source)

[iii] Birdsall T.C. “5-Hydroxytryptophan: a clinically-effective serotonin precursor.” Alternative Medicine Revue. 1998 Aug;3(4):271-80. (source)

[iv] Lemaire P.A., Adosraku R.K. “An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia.” Phytochemical Analysis. 2002 Nov-Dec;13(6):333-7. (source)

[v] Emanuele E., Bertona M., Minoretti P., Geroldi D. “An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.” Neuro Endocrinology Letters. 2010;31(5):663-6. (source)

[vi] Hinz M., Stein A., Uncini T. “APRESS: apical regulatory super system, serotonin, and dopamine interaction.” Neuropsychiatric Disease and Treatment. 2011;7:457-63. (source)

[vii] Hinz M., Stein A., Uncini T. “Relative nutritional deficiencies associated with centrally acting monoamines.” International Journal of General Medicine. 2012;5:413-30 (source)

[viii] van Praag H.M. “n search of the mode of action of antidepressants. 5-HTP/tyrosine mixtures in depressions.”Neuropharmacology. 1983 Mar;22(3 Spec No):433-40. (source)

[ix] Hinz M., Stein A., Uncini T. “5-HTP efficacy and contraindications”Neuropsychiatric Disease and Treatment. 2012; 8: 323–328. (source)

[x] Hinz M., Stein A., Uncini T. “APRESS: apical regulatory super system, serotonin, and dopamine interaction.” Neuropsychiatric Disease and Treatment. 2011;7:457-63. (source)

[xi] Hinz M., Stein A., Uncini T. “Amino acid management of Parkinson’s disease: a case study” International Journal of General Medicine. 2011; 4: 165–174. (source)

[xii] Birdsall T.C. “5-Hydroxytryptophan: a clinically-effective serotonin precursor.” Alternative Medicine Revue. 1998 Aug;3(4):271-80. (source)

[xiii] Shaw K., Turner J., Del Mar C. “Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis.” Australia and New Zealand Journal of Psychiatry. 2002 Aug;36(4):488-91. (source)

[xiv] Caruso I., Sarzi Puttini P., Cazzola M., Azzolini V. “Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome.” Journal of International Medical Research. 1990 May-Jun;18(3):201-9. (source)

[xv] Meyers S. “Use of neurotransmitter precursors for treatment of depression.” Alternative Medicine Revue. 2000 Feb;5(1):64-71. (source)

[xvi]Wang X., Baumann M.H., Dersch C.M., Rothman R.B. “Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan.” Neuroscience. 2007 Aug 10;148(1):212-20. (source)

Subscribe to the Nootropics Expert newsletter

Keep up to date with the latest developments in the nootropics space.

Head First 2nd Editon

The Award Winning Guide to Healing & Optimizing Your Brain with Nootropic Supplements.

Head First 2nd Edition

NEW! Eliminate Brain Fog, Low Energy, Moodiness, Difficulty Sleeping, Memory Loss or Anxiety. Available on Amazon, Barnes & Noble, Apple Books, Walmart and more...



Where to Buy Nootropics

Wondering where to buy the best nootropic supplements? Well, you’re in the right place. Because here you will find the nootropic supplements that I personally use and recommend. Each supplement has a link to the company store and product that I use. I also include a link to my full review for each supplement here […]

The Definitive Guide to Nootropics

Nootropics can help increase your memory, boost learning ability, improve your mood and assist overall brain function. If you’re new to nootropics, or wonder about the difference between a nootropic and a smart drug, then this page is for you. Here you’ll find the definition of a nootropic, how to pronounce the word “nootropic”, the […]

The Most Comprehensive Nootropics List

This is our big list of the most popular Nootropics in use today. Here you’ll learn what each nootropic is, what it does and suggested dosages. What is this List of Nootropics About? Nootropic supplements are cognitive enhancers aiming to improve brain function. Whether you are looking to treat mild cognitive impairment, improve mental focus, or biohack […]



Free Secrets of the Brain 3rd Edition

Get “Secrets of the Optimized Brain,” 92 nootropics to help you plan your Nootropic Stack when you sign up for my newsletter:

Join The Discussion - 343 comments

Patricia Guerra
December 1, 2019

Hi David,

Thank you very much for being so helpful. I would like to check if I can take together 5-HTP (50 mg), NALT (350 mg) and GPC choline (300 mg). Are the amounts also okay? The 5-HTP I will take at night.

Thanks,
Patricia

    David Tomen
    December 2, 2019

    Patricia, the dosages are OK but NALT is likely too low. See how it works for you. And NALT should not be taken after 4 PM or it may cause insomnia.

Robert L
November 23, 2019

After we spoke – I worked on taking the stack suggested. I’m back to researching.
Here it’s mentioned that SE or DE can be out of balance.

agitation, aggressiveness, anxiety, decision-making, irritability, insomnia.

That reads me

How does one know which is off? And you mention not using 5-HTP but if stacked properly is it ok?

    David Tomen
    November 24, 2019

    Robert, dopamine and serotonin must be in balance. And the easiest and safest way to boost each one is; L-Tyrosine for dopamine; and L-Tryptophan for serotonin.

    5-HTP is not preferred because you cannot use it for more than 4 or 5 weeks. And it’s very difficult to find the right dosage. Unless you are very experienced using nootropics and especially messing with neurotransmitter levels it’s best to stay away from things like 5-HTP.

Mark
September 26, 2019

David, I’ve been taking quercetin at 500mg in the morning for several weeks now. I have noted a significant mood boost that persists for 2-3 hours afterwards. This seems to be explained by some information I’ve found that suggests quercetin can inhibit MAO. I’m wondering then if quercetin 500mg AM would be safe to take with 5-HTP 100mg at bedtime for sleep?

Thanks very much!

    David Tomen
    September 27, 2019

    Mark, normally I’d say it should be safe when spread apart like that. But 100 mg 5-HTP might be pushing it. Serotonin Syndrome scares me so I’m not going to encourage you to try 5-HTP when using a MAOI .

      Mark Painter
      September 28, 2019

      David, thanks very much for the input. I’m a Licensed Professional Counselor and have worked in the behavioral health field for 20+ years and the prospect of serotonin syndrome alarms me as well. I’ve seen people discontinue meds and then later take bolus doses to treat withdrawal sxs symptoms and suffer serious fallout (though not death thankfully).

      Would you advise L-trytophan at bedtime as an alternative and could that be staked with perhaps GABA and glycine?

        David Tomen
        September 28, 2019

        Mark, L-Tryptophan is a safer alternative I think because it’s a longer path to serotonin synthesis. And yes to the latter two as well.

Karen Free
September 26, 2019

I was planning on stacking 5-HTP with Phenyl-GABA, Taurine, Tri-Methyl-Glycine (TMG) L-Tyrosine, and L-Theanine. I took this combination from a product with good reviews.

Do you think this combination would work to keep the serotonin in balance?

    David Tomen
    September 27, 2019

    Karen, it depends on how much 5-HTP they used in their stack and how much L-Tyrosine. The problem with these types of stacks is there’s no way to tell if this combination and dosages will work for you. Only way to find out is try it and see how it makes you feel.

maria
September 15, 2019

Is there not an adaptogen (bacopa comes to mind) which promotes both serotonin AND dopamine hence obliterating the need to take 2 different amino acids to balance the two neurotransmitters?

Or would taking such an adaptogen not be as strong as an effect as the aminos?

    David Tomen
    September 16, 2019

    Maria, adaptogens can take up to 3 – 4 weeks to work and none of them are direct precursors to serotonin or dopamine. They can’t be. Only L-Tryptophan or 5-HTP can make serotonin. And only L-Tyrosine or L-DOPA can make dopamine.

Jo
August 21, 2019

Hello, excellent article and video. I have however two questions. As you said the fact that 5htp supplementation tends to diminish catecholamines (such as dopamine and norepinephrine) by overusing the enzymes that catalyze its synthesis and thus, parallel administration of other neurotransmitter precursors is advised. Is this case valid also during supplementation of pure Tryptophan or this issue affects only immediate precursors ? If the case is same, what ratio of dose would you recommend of e.g. L-dopa/L-tyrosine – Tryptophan to eradicate the unbalanced competitive inhibition that will be resulted.

    David Tomen
    August 22, 2019

    Jo, it seems to be more a problem with using 5-HTP because it’s a direct precursor to serotonin. And a little goes a long way. It’s way to easy to use more than you should. Thus depressing dopamine.

    L-Tryptophan in my experience, and that of others, seems to be more ‘forgiving’. You can use 500 mg L-Tryptophan before bed and feel great the next day.

    But each person’s physiology is unique. You may find you’ll feel better if you used 500 mg L-Tyrosine the next morning. And the person next to you doesn’t need to. It really is a balancing act and the only way to find out is experiment.

Francesco
July 3, 2019

Hi, David,
Monday I will start taking 50 mg 5 HTP and 60 mg L-Dopa

I decided to take them for my dysthymia (and because ssri and snri were not effective).
I want to ask you: how long (about) does it take for 5 HTP and L-Dopa to start giving benefits for dysthymia (mild, but perennial, depression)?
A week?
Two?
Three weeks?
A month?

Dear greetings

    David Tomen
    July 4, 2019

    Francesco, if it’s going to work you should feel positive effects after the first or second dose.

David
June 30, 2019

Also is it safe to use racetams with 5 htp and tyrosine I tried one stack 700 mg oxiracetam 700 mg aniracetam 200 mg alcar and .015 mg noopept sublingual that worked quite well I was curious if addingn5 htp and or tyrosine would benefit the stack or not work

    David Tomen
    July 2, 2019

    David, it depends on if you are trying to solve a problem. Targeting all neurotransmitters would be counter-productive because you wouldn’t be able to identify the cause of your issue.

    And I’d recommend starting with only one racetam at at time and making sure you dosed it correctly including with a choline supplement.

Leave a Reply to Yida Cancel reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.