Melatonin sleep dosage

Melatonin

David Tomen
Author:
David Tomen
14 minute read
Melatonin is known for helping insomnia, is a powerful antioxidant and anti-inflammatory, protects against neurodegenerative diseases, stroke and brain trauma

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone primarily produced in the pineal gland. This gland is a pea-sized organ located in the center of your brain and shaped like a tiny pine cone (hence its name).

Your pineal gland is filled with cells that respond to light and darkness. Many Eastern traditions refer to the pineal gland as the “third eye” for this reason.

Your pineal gland acts as your body’s central clock through its secretion of melatonin. Telling your brain, body and organs when it’s time to be active and when it’s time to rest. This is the reason why melatonin is referred to as the “sleep hormone”.

Melatonin is also a powerful antioxidant. It scavenges free radicals and reactive nitrogen species. It protects mitochondrial ATP synthesis. And melatonin is set apart from many other supplemental antioxidants because it easily crosses the blood-brain barrier.

Age-related decline in melatonin is a primary contributing factor to several neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS, Huntington’s Disease, stroke and brain trauma.[i]

Melatonin helps:

  • Sleep. Melatonin is a powerful sleep aid and is registered as a drug in Europe for that purpose.[ii]
  • Neuroprotection. Melatonin helps protect neurons by reducing the damage caused by amyloid proteins and tau proteins linked to Alzheimer’s Disease. Melatonin protects against the harmful effects of aluminum.[iii] And melatonin scavenges free radicals of oxygen and nitrogen, neutralizes other toxic radicals, stimulates gene expression of other antioxidants, and protects ATP synthesis.[iv]
  • Neurotransmitters. Melatonin modulates dopamine production and pathways in areas of your brain involved in movement disorders such as Parkinson’s Disease and tardive dyskinesia. Melatonin also interacts with dopamine’s role to your body’s biological clock.[v]

Overview

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone produced in your pineal gland. Melatonin is often referred to as the “sleep hormone”. As your body’s central clock, melatonin tells your body, brain and organs when to be active and when to take a break and rest.

melatonin
melatonin

Melatonin and the neurotransmitter serotonin are both derived from the amino acid L-tryptophan. First L-tryptophan is hydroxylated by the enzyme tryptophan hydroxylase. The intermediate is decarboxylated by PLP and 5-hydroxy-L-tryptophan (5-HTP) to produce serotonin (5-HT or 5-hydroxytryptamine).

Serotonin acts as a neurotransmitter on its own. But is also converted into N-acetyl-serotonin by the enzymes serotonin N-acetyl transferase and Acetyl-CoA. Hydroxyindole O-methyl transferase and SAMe convert N-acetyl-serotonin into melatonin through methylation of the hydroxyl group.[vi]

l-tryptophan-serotonin-melatonin-conversion

This process is first fueled by the tryptophan you get from foods like turkey, chicken, tuna, oats, bananas, peanuts and chocolate. Or from a L-tryptophan supplement.

You can also supplement with 5-HTP to produce serotonin which will create melatonin. Or supplement with SAMe to produce melatonin. Or you can take a melatonin supplement on its own and bypass this entire process.

Besides acting as your body’s biological clock, melatonin is also a potent free-radical scavenger. And a wide-spectrum antioxidant. The beauty of melatonin as an antioxidant is its ability to easily cross the blood-brain barrier.

Adding melatonin to your nootropic stack gives you a head-start in protecting yourself against Alzheimer’s and Parkinson’s Disease, decreases your chance of stroke, and helps reverse the brain damage caused by stroke or brain injury.

The bonus is a good night’s sleep and feeling refreshed the next day. With your brain firing on all cylinders.

melatonin-protects-your-brain

How does Melatonin work in the Brain?

Melatonin helps brain health and function in several ways. But two in particular stand out.

  1. Melatonin promotes quality sleep. Your pineal gland acts as your body’s central clock by secreting melatonin. This action tells your brain and other organs when it’s time to be active, and when it’s time to rest. Melatonin helps regulate other hormones and maintains your body’s circadian rhythm.[vii]

Your pineal gland responds to darkness by producing melatonin. Blood levels of melatonin are low during the day, with peak levels occurring from 2 – 4 AM.[viii]

One study at Duke University Hospital surveyed clinical trials from 1948 – 2009. Researchers found that children with ADHD using melatonin doses of 3 – 6 mg showed improvement in how fast the kids went to sleep. And significantly better quality of sleep.[ix]

Another extensive survey of clinical trials was conducted by the U.S. Department of Health and Human Services on melatonin use for sleep disorders.

The overall conclusion of this research showed melatonin effective in improving quality of sleep and how fast a person went to sleep. This study included those who did not suffer with insomnia, those who did, and others who had messed up circadian rhythm patterns due to shift work and jet lag.[x]

  1. Melatonin prevents neurodegenerative disease. Melatonin improves longevity by increasing the longevity gene called SIRT1. This gene plays an important role in maintaining metabolism and neuroplasticity.[xi]

Melatonin is a powerful antioxidant protecting your brain from free radicals and oxidative damage. It stimulates gene expression of intracellular antioxidant systems. And melatonin helps relieve the free radical damage that occurs after traumatic brain injury or stroke.[xii]

Research has found that melatonin levels and Alzheimer’s Disease are closely linked. Greatly reduced melatonin levels have been found in Alzheimer’s patients.[xiii]

High levels of melatonin are maintained throughout your youth and middle age. But as you age and melatonin levels drop you are at greater risk for brain damage both now and in the future. Your chances of having a stroke greatly increase as melatonin levels decline.[xiv]

How things go bad

Low levels of Melatonin are associated with a variety of health problems. Much more than just insomnia.melatonin-reduces-insomnia

↑ Insomnia, restlessness and poor sleep quality (sundowning)

↓ Circadian rhythm goes out of sync

↑ Agitation and activity increases later in the day (sundowning)

Benzodiazepines like Valium® and Xanax® suppress melatonin levels[xv]

↑ Stroke risk increases

Melatonin deficiency is one of the earliest indicators of Alzheimer’s Disease.[xvi] Abnormal oxidation and inflammatory protein accumulation can lead to Parkinson’s Disease. And is associated with low levels of melatonin in the brain.

Low levels of melatonin lead to increased free radical production and risk of stroke goes up. And oxidative damage to brain cells is a leading culprit in traumatic brain injury.

Melatonin benefits

Melatonin is both a neurotransmitter and hormone. This ‘neurohormone’ is produced in your pineal gland from the neurotransmitter serotonin with the assistance of SAMe and other enzymes.Melatonin is an antioxidant and anti-inflammatory

Melatonin is the mechanism used by your pineal gland to function as your body’s biological “clock”. And is in charge of the “circadian rhythm” that tells your system when to be active, and when to rest.

As a nootropic supplement and sleep aid, melatonin exerts its effects by acting as a ‘phase re-setter’ rather than as a hypnotic-type drug.

Supplementing with inexpensive melatonin helps restore your body’s natural antioxidant protection. Guarding against age-related changes in your brain.

Melatonin protects cholinergic neurons from the amyloid and tau protein buildups related to Alzheimer’s Disease.

Melatonin offers potent antioxidant protection for your brain. Supplementing with melatonin helps protect your brain against neurodegenerative disease, reduces stroke risk and guards against brain trauma.

How does Melatonin feel?

I no longer use melatonin to help me sleep. Instead, I prefer Performance Lab® Sleep which contains 100 mg of Magnesium (as Magnesium Bisglycinate, Magnesium Taurate, and BioGenesis® Magnesium), 500 mg of tart cherry extract (as CherryPURE®), and 250 mg of L-Tryptophan (as TryptoPure®).

Montmorency tart cherry contains the richest natural source of melatonin. Identical to the hormone secreted by the pineal gland in your brain.

Melatonin as a sleep aid has mixed reviews among neurohackers. And for good reason. Melatonin is a hormone that your body naturally produces from serotonin. Too much melatonin is not good.

And part of the problem could be attributed to the synthetic melatonin marketed to promote sleep. A study published in the Journal of Sleep Medicine found that synthetic melatonin content ranged from -83% to + 478%. Contrary to what was claimed on sleep supplement labels. And 8 of the 31 supplements tested contained undisclosed serotonin.

Some find that supplementing with melatonin works well, and others find it disrupts sleep patterns. If you are perfectly healthy and do not deal with insomnia on a regular basis you don’t need to supplement with melatonin.

Everyone’s body chemistry is unique. Some find that ½ a mg of melatonin works well. And others require 5 mg. Experimentation is key with this hormone.

Some have found that melatonin helps regulate disrupted circadian rhythms caused by jet lag or night shift work.

melatonin-for-sleep-when-to-take

Melatonin Clinical Research

Melatonin Lowers Cholesterol

Melatonin levels decrease as we age, and the possibility of heart disease increases. And studies in the last 10 years show that melatonin and your cardiovascular system are linked. Patients with cardiovascular disease have decreased melatonin levels.

Studies also show that people with heart disease have high levels of LDL-cholesterol. Research has found that supplemental melatonin decreases cholesterol by 38%. And reduces LDL accumulation by 42%.

One study demonstrated that just 1 mg of melatonin reduced blood pressure within 90 minutes of supplementation. Melatonin reduces blood pressure through its antioxidant properties, by decreasing norepinephrine and epinephrine, and relaxing the smooth muscle of the heart aorta wall.[xvii]

Melatonin helps Reduce Insomnia

Studies show that sleep disorders affect 50 – 70 million Americans, or about 20% of the population. A sleep disorder exists whenever a lower quality of sleep results in impaired functioning, or excessive sleepiness. Insomnia is the most common sleep disorder affecting 6 – 12% of the adult population.

A double-blind placebo-controlled study in France worked with 244 adults with primary insomnia. Patients received prolonged-release melatonin nightly for up to 12 months of the trial, followed by a 2-week withdrawal period.

Outcome was measured based on the patient’s sleep diary, adverse events, vital signs and lab tests recorded at each visit. The study concluded that prolonged-release melatonin was helpful in relieving insomnia during the trial. And patients did not experience any adverse events or withdrawal symptoms when they stopped using melatonin.[xviii]

Melatonin Relieves Mild Cognitive Impairment

Mild cognitive impairment (MCI) is often the final step before dementia. Approximately 12% of MCI patients convert to Alzheimer’s Disease or other dementia disorders every year.

Researchers in Argentina took a look at the first and final assessment of 50 MCI patients, 25 of whom had received a daily dose of 3-9 mg of melatonin at bedtime for 9 – 18 months.

Patients who took melatonin showed significantly better performance in the mini Mental State examination and the cognitive test used to assess Alzheimer’s. The team conducted several other tests and found better performance in every test but one.

The researchers concluded that melatonin can be a useful drug for treating mild cognitive impairment.[xix]

Melatonin Replaces Benzos for Sleep

Many people use benzodiazepines for sleep. Drugs like Xanax®, Valium® and Ativan® all have nasty side effects. And studies going back 25 years show benzos depress natural melatonin levels.[xx]

This is a problem because drugs taken for sleep are depleting the very hormone your body uses for sleep. To make matters worse, regular benzodiazepine use is now recognized as putting you at greater risk for dementia.[xxi]

This study done in Argentine had subjects use fast release melatonin 3 – 9 mg daily for 3 years just before bedtime. And it significantly improved cognitive and emotional performance. Including the daily sleep-awake cycles of patients.

A follow up study was done with 91 MCI patients. 61 patients received 3 – 24 mg of fast release melatonin at bedtime for 15 to 60 months. Patients given melatonin showed significantly better cognitive performance and every other parameter tested.

Depression scores in the patients also decreased. And showed an improvement in quality of sleep and wakefulness. Before the study began, 62.8% of the patients were using benzodiazepines to help them sleep. At the conclusion of the study only 9.8% were using benzos to help them sleep along with melatonin.[xxii]

Our recommendation is if you are using one of these drugs for sleep, it would be wise to start using melatonin instead. And start weaning yourself off the benzos.

Melatonin Recommended Dosage

Unlike all the other nootropics I talk about on Nootropics Expert, there is no recommended dosage for melatonin supplementation. Everyone has different responses to its effects.Melatonin sleep dosage

Lower doses like ½ mg of melatonin work well for some who are especially sensitive. And higher doses of melatonin can cause anxiety and irritability.

The best approach is to start with very low doses of melatonin (i.e. ½ mg) and see how your body reacts.

The right dose should produce a restful night’s sleep with no irritability or fatigue the next day.

For jet lag: ½ – 5 mg of melatonin an hour before bedtime at your final destination.

Melatonin Side Effects

Melatonin is considered very safe when taken in normal recommended low doses.

Some may experience nightmares or vivid dreams when supplementing with melatonin.

Melatonin can cause drowsiness if taken during the day. And if you experience a “sleep hangover” the next day, you took too much melatonin the night before.

Other side effects include abdominal cramps, dizziness, headache, irritability, decreased libido, breast enlargement in men and reduced sperm count.

Melatonin can interfere with fertility if you’re trying to get pregnant. Do not use melatonin while you’re pregnant.

Melatonin can worsen symptoms of depression. So if you’re dealing with depression, or are using antidepressant medications you should avoid melatonin.

Remember that melatonin is a hormone. So if you have hormone-related issues you must be careful about using melatonin.

Melatonin may increase the risk of bleeding and should be avoided if you’re taking anticoagulant medications. Or are anticipating surgery.

Melatonin can interfere with steroids and immunosuppressant medications and cause them to lose their effectiveness.

Type of Melatonin to Buy

Melatonin is available in capsules, tablets and liquid. Capsules and tablets usually range from 1 – 5 mg.

See the section above called “How does Melatonin feel?” which details problems with melatonin supplements. And why you should be cautious about your choice of melatonin supplement if you choose to use it.

I recommend Montmorency Tart Cherry Juice concentrate which is nature’s best natural source of melatonin.

You can get 500 mg Montmorency Tart Cherry (as CherryPURE®) in Performance Lab® – Sleep which also contains 100 mg of Magnesium (as Magnesium Bisglycinate and NutriGenesis® magnesium) and 250 mg of L-Tryptophan for a great night’s sleep.

Nootropics Expert Recommendation

Melatonin 1 – 3 mg per day.

Nootropics Expert Tested and ApprovedI recommend using melatonin as a nootropic supplement. But see my review above on how melatonin supplements vary and how melatonin supplement labels can be misleading.

Your body does make melatonin on its own from serotonin in your brain. Most healthy people have an adequate supply of melatonin. But if you’re dealing with insomnia and need some extra help in getting to sleep and staying asleep, melatonin can help.

Melatonin easily crosses the blood-brain barrier, and takes effect in about 90 minutes. Avoid taking melatonin immediately before bed because you may have trouble falling asleep.

Melatonin is especially helpful to those dealing with jet lag or shift work that has you working nights. Disrupted natural circadian rhythms can be normalized by supplementing with melatonin.

I suggest trying a melatonin supplement first at a dose of ½ – 1 mg taken 90 minutes before bedtime. And see how you feel. If you readily fall and stay asleep until morning you know you’ve got the dose right.

Then adjust your dose up or down depending on how you react. Most people don’t need more than o.5 – 5 mg per night.

I recommend Montmorency Tart Cherry Juice concentrate which is nature’s best natural source of melatonin.

You can get 500 mg Montmorency Tart Cherry (as CherryPURE®) in Performance Lab® – Sleep which also contains 100 mg of Magnesium (as Magnesium Bisglycinate and NutriGenesis® magnesium) and 250 mg of L-Tryptophan for a great night’s sleep.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Pandi-Perumal S.R., BaHammam A.S., Brown G.M., Spence D.W., Bharti V.K., Kaur C., Hardeland R., Cardinali D.P. “Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.” Neurotoxicity Research. 2013 Apr;23(3):267-300. (source)

[ii] Fernández-Tresguerres Hernández J.A. in Spanish “[Melatonina: old molecule, new medicament]. Anales de la Real Academia Nacional de Medicina (Madrid). 2008;125(4):681-96 (source)

[iii] Lahiri D.K., Chen D.M., Lahiri P., Bondy S., Greig N.H. “Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases.” Annals of the New York Academy of Sciences. 2005 Nov;1056:430-49. (source)

[iv] Pandi-Perumal S.R., BaHammam A.S., Brown G.M., Spence D.W., Bharti V.K., Kaur C., Hardeland R., Cardinali D.P. “Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.” Neurotoxicity Research. 2013 Apr;23(3):267-300. (source)

[v] Zisapel N. “Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting.” Cellular and Molecular Neurobiology. 2001 Dec;21(6):605-16. (source)

[vi] “Pathway: serotonin and melatonin biosynthesis” MetaCycmetacyc.org (source)

[vii] Altun A., Ugur-Altun B. “Melatonin: therapeutic and clinical utilization.” International Journal of Clinical Practice. 2007 May;61(5):835-45 (source)

[viii] Lee C.O. “Complementary and alternative medicines patients are talking about: melatonin.” Clinical Journal of Oncology Nursing. 2006 Feb;10(1):105-7. (source)

[ix] Bendz L.M., Scates A.C. “Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder.” Annals of Pharmacotherapy. 2010 Jan;44(1):185-91 (source)

[x] “Melatonin for Treatment of Sleep Disorders” U.S. Department of Health and Human Services (source)

[xi] Chang H.M., Wu UI., Lan C.T. “Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats.” Journal of Pineal Research. 2009 Oct;47(3):211-20. (source)

[xii] Chen H.Y., Hung Y.C., Chen T.Y., Huang S.Y., Wang Y.H., Lee W.T., Wu T.S., Lee E.J. “Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats.” Journal of Pineal Research. 2009 Oct;47(3):260-70. (source)

[xiii] Cardinali D.P., Furio A.M., Brusco L.I. “Clinical Aspects of Melatonin Intervention in Alzheimer’s Disease Progression” Current Neuropharmacology. 2010 Sep; 8(3): 218–227. (source)

[xiv] Kitkhuandee A., Sawanyawisuth K., Johns N.P., Kanpittaya J., Johns J. “Pineal calcification is associated with symptomatic cerebral infarction.” Journal of Stroke and Cerebrovascular Diseases. 2014 Feb;23(2):249-53 (source)

[xv] McIntyre I.M., Burrows G.D., Norman T.R. “Suppression of plasma melatonin by a single dose of the benzodiazepine alprazolam in humans.” Biological Psychiatry. 1988 May;24(1):108-12. (source)

[xvi] Cardinali D.P., Furio A.M., Brusco L.I. “Clinical Aspects of Melatonin Intervention in Alzheimer’s Disease Progression” Current Neuropharmacology 2010 Sep; 8(3): 218–227. (source)

[xvii] Sewerynek E. “Melatonin and the cardiovascular system.” Neuro Endocrinology Letters. 2002 Apr;23 Suppl 1:79-83. (source)

[xviii] Lemoine P., Garfinkel D., Laudon M., Nir T., Zisapel N. “Prolonged-release melatonin for insomnia – an open-label long-term study of efficacy, safety, and withdrawal.” Therapeutics and Clinical Risk Management. 2011;7:301-11. (source)

[xix] Furio A.M., Brusco L.I., Cardinali D.P. “Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study.”Journal of Pineal Research. 2007 Nov;43(4):404-9. (source)

[xx] McIntyre I.M., Burrows G.D., Norman T.R. “Suppression of plasma melatonin by a single dose of the benzodiazepine alprazolam in humans.” Biological Psychiatry. 1988 May;24(1):108-12. (source)

[xxi] Gallacher J., Elwood P., Pickering J., Bayer A., Fish M., Ben-Shlomo Y. “Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS).” Journal of Epidemiology and Community Health. 2012 Oct;66(10):869-73 (source)

[xxii] Cardinali D.P., Vigo D.E., Olivar N., Vidal M.F., Furio A.M., Brusco L.I. “Therapeutic application of melatonin in mild cognitive impairment.”American Journal of Neurodegenerative Disease. 2012;1(3):280-91 (source)

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Join The Discussion - 68 comments

Chris
January 13, 2023

Hello David,
do you know anything about withdrawal symptoms of Melatonin?

It is quite hard to find something on the net, but it seems that some do exist, although rare and maybe in combination with other (mental) issues….

I am not quite sure what has happened but here’s my story: I stopped taking Melatonin (in combination with 150 mg Phenibut) sublingual after a few month in which I took 3 mg every evening for sleeping. The second day after stopping I developed an irrational fear of suffocating in my bed/sleep. I already have been one (1) time prone to that and fought it with Opipramol (Insidon).

I was wondering if there have been any substantial issues with withdrawal; as you are notoriously good informed I decided to ask you. 😉

Thank you as always for your huge efforts! It is really appreciated!

Many greetings,
Chris

    David Tomen
    January 18, 2023

    Chris, there is absolutely the high chance of going through withdrawal from Phenibut. And to a lesser extent with melatonin.

Daniel
January 8, 2023

Doesn’t taking melatonin worsen its self-production in the long run? I have a bunch of video sites claiming this…

    David Tomen
    January 10, 2023

    Daniel, there are all kinds of problems using Melatonin as a supplement. Some of which I have detailed in the review above. A far safer way to increase melatonin naturally is to use L-Tryptophan to increase serotonin. Your brain uses serotonin to make melatonin naturally and as it is needed.

      Dan
      February 8, 2023

      Thanks, I agree, I think there is not enough research yet and there are big problems with the quality of melatonin in supplements, it is not worth taking yet.

Piet
November 20, 2022

I have disthymia and have very strange dreams.So i wake up with a bad feeling and mood. Can this have something to do with serotonin? Because serotonin –>> melatonin. And how to ‘solve’ this?….

    David Tomen
    November 28, 2022

    Piet, as far as I can tell Dysthymia is a genetic condition where different areas of your brain do not form as they should (https://pubmed.ncbi.nlm.nih.gov/19351572/). There is no proof otherwise like it being caused by a serotonin dysfunction.

Tony
November 13, 2022

As an international airline pilot I used Solgar Melatonin for years dealing with time changes up to 12 hours differences and constantly flipping my sleep patterns due to flying red eyes and from flying in Asia. I take 5 mg a night now without any side effects except weird dreams. Mr. Tomen, Thank you for all of your great information. I have also seen a drop in LDL cholesterol since I started taking it. Although I think LDL Cholesterol has been given a bad rap. It’s essential for your body as long as it is not corrupted by lifestyle or dietin my research. My cholesterol has been over 300 my whole life but after taking melatonin every night it has dropped to 250.

    David Tomen
    November 16, 2022

    Tony, thanks for the report on your successful use of Melatonin. My opinion remains the same for this and any other supplement. If you find something that works then keep using it! Why break something that ain’t broke.

    The only caution and has been true for many years is most melatonin supplements are mislabeled. In other words, the contents of the capsule often do not match the claim on the label. This is why it is so important to buy supplements from a company you trust, tests their products before shipping to customers, and are supported by great user reviews.

Michael
September 1, 2022

Hi David! My GF is diagnosed with PTSD. In Hospital she were misdiagnosed with Multiple Sclerosis. Since that time she started to have big problems with melatonin production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910089/

I would like to support her sleep as chronic 2-3mg melatonin use (which works well for her right now) downregulates natural melatonin production. Nootropic Depot owner said this on reddit.

I thaught about tryptophan but 250mg dosages worsened her PTSD symptoms.

Tart Cherry in her case would be good idea? I found a lot of people saying, Tart Cherry have too little melatonin to have any effect, and better sleep is due to uric acid.

Thank you David.

    David Tomen
    September 1, 2022

    Michael, ‘normal’ people use 0.5 – 0.8 mg of melatonin during the night. But two things – that study shows those dealing with PTSD did not produce adequate amounts of melatonin during the night. AND, your girlfriend has good results with 2 – 3 mg of melatonin.

    Why break it if it works? It may be true the too much melatonin may downregulate natural melatonin production. But she doesn’t have enough “natural melatonin production”. Unless that changes any time soon I suggest keep doing what works. Because you cannot downregulate something that isn’t there.

Kyle Boyd
August 1, 2022

Hi there – Does anyone know if there are any confirmed issues re taking Melatonin (10 – 50mg) with Methylene Blue (under 2mg/Kg) – both oral route?
One MD states that as Melatonin is an Hormone this does not relate re Serotonin Syndrome issues re antidepressant MAOI inhibition. But with warnings re dubious suppliers of Melatonin containing Serotonin.
There are also various advocates re high/very high dose Melatonin on Youtube etc.
Many thanks for contributions.

    David Tomen
    August 2, 2022

    Kyle, that is the problem with melatonin. Because a lot of melatonin supplements do not contain what they say on the label. Your brain only uses .5 to .8 milligrams of melatonin at night. There is no reason to take any more than 1 milligram. I can’t even use that because it changes my mood the next day.

    There is no known contraindication between the two. This is the best list of drugs and supplement I know of for contraindications with Methylene Blue: https://www.drugs.com/drug-interactions/methylene-blue-index.html

MattD
July 11, 2022

Hi David,

With the liquid kind that goes under the tongue, would I take that closer to bed time rather than 90 minutes prior? My thought is that it kicks in faster than the pills I think.

Also, would it be ok to take the capsule/pill form right after dinner or should they be taken on an empty stomach?

Thanks

    David Tomen
    July 12, 2022

    Matt, used sublingually it’ll get to your brain within minutes. In capsule or tablet form it’ll take 60 – 90 minutes depending on your digestive system.

Alice
April 19, 2022

Hi David!

I take 1000mg of CherryPURE and I don’t feel this strong need to sleep as when I take just 0,3mg of synthetic melatonin. Should I increase cherry dosage even more? Or I’ve did something wrong 🙁

Thank you David <3

    David Tomen
    April 22, 2022

    Alice, that is a LOT of CherryPURE. But if it did not work for you and low dose synthetic melatonin did then I suggest continuing with what worked.

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