phenylethylamine nootropic effects

Phenylethylamine (PEA)

David Tomen
Author:
David Tomen
12 minute read
Phenylethylamine enhances working memory, executive function, creative flow states, stress reduction, better mood, anti-anxiety and lessens symptoms of ADHD  

Key Takeaways

  1. Phenylethylamine (PEA) is a trace amino acid with stimulant and mood-enhancing effects, synthesized from L-Phenylalanine and found in certain foods and chocolate.
  2. PEA activates TAAR1 and TAAR2 receptors, leading to increased serotonin and dopamine release, potentially helping with anxiety, depression, and ADHD.
  3. Aging can lead to decreased PEA levels, which may be linked to ADHD, addiction, and neurodegenerative diseases.
  4. PEA shows promise as an antidepressant and a potential alternative to SSRIs, with ongoing studies for ADHD treatment.
  5. PEA has a short half-life, which can be extended by using it with a MAO-B inhibitor, and potential side effects include the “cheese effect” and other amphetamine-class side effects.

 

Phenylethylamine (PEA, 2-phenylethylamine, beta phenylethylamine / β-phenylethylamine, phenethylamine) is a trace amino acid. Your brain naturally converts L-Phenylalanine into Phenylethylamine (PEA).

PEA is not at the top of most nootropic stack choices because its effects are so short-lived. But some neurohackers love PEA for its stimulant and mood enhancing qualities.

The most famous promoter of phenylethylamine was Dr. Alexander Shulgin and his wife Anna. Dr. Shulgin published ‘PiHKAL: A Chemical Love Story’ in 1991. PiHKAL is short for “Phenethylamines I Have Known and Loved”.

Phenylethylamines are a group of phenethylamine derivatives which contain PEA as a backbone. These derivative compounds are formed by replacing one or more hydrogen atoms in the core structure.

This class of PEA compounds include amphetamines, empathogens, stimulants, psychedelics, appetite suppressants, bronchodilators, nasal decongestants, and antidepressants.

One of the more famous PEA derivatives is Methylenedioxymethamphetamine (MDMA or Ecstasy).

Dr. Shulgin developed, tested, and published the formulas for 179 different compounds largely based around the structure of PEA in his book PiHKAL.

In this review we investigate how phenylethylamine (PEA) works in the human brain.

Phenylethylamine helps:

  • Anxiety & Depression. PEA activates TAAR1 and TAAR2 receptors which in turn prevents the uptake and boosts the release of the ‘feel-good’ neurotransmitters serotonin and dopamine.
  • Neuroprotector. Monoamine oxidase inhibits the catecholamines like dopamine and norepinephrine. Decreases in dopamine levels are implicated in diseases like Parkinson’s. PEA helps boost dopamine and norepinephrine levels. Reducing the symptoms of neurodegenerative diseases.
  • Attention Deficit Disorder (ADHD). PEA prevents the reuptake of dopamine and norepinephrine and inhibits their transport. Like the mechanism of action provided by ADHD stimulant meds. Some have found supplementing with PEA as a nootropic has decreased the symptoms of ADHD.

Overview

Phenylethylamine (PEA, 2-phenylethylamine, β-phenylethylamine, phenethylamine) is a trace amine naturally synthesized from L-Phenylalanine in your brain that links to your brain’s trace amine-associated receptor.

Phenylethylamine (PEA) chemical structure
Phenylethylamine (PEA)

Aromatic amino-acid decarboxylase converts phenylalanine to phenylethylamine. This is the same enzyme that converts phenylalanine into dopamine. And it converts it at a rate comparable to the synthesis of dopamine.

But PEA is not retained in neuronal vesicles like dopamine is stored. Instead, monoamine oxidase-B (MAO-B) quickly degrades PEA.[i]

Despite its short half-life, PEA as a nootropic seems to be effective for increasing catecholamine activity by boosting dopamine and norepinephrine.[ii]

PEA can be found naturally in many cacao, algae, fungi, and bacteria as well as clover, beans, peas, and some food products such as Natto and eggs.

PEA is also found in chocolate where it is produced during cacao’s fermentation and roasting process.[iii]

PEA binds to C-protein-coupled receptors TAAR1 and TAAR2, receptors reserved specifically for trace amine use.[iv] These receptors are not used by other major neurotransmitters like dopamine or norepinephrine.

The half-life of PEA taken as a nootropic supplement is only 5 – 10 minutes.[v] Because it’s quickly degraded by monoamine oxidase-B (MAO-B).

Many neurohackers prolong the effects of PEA by using it with a monoamine oxidase-B inhibitor (MAOI) like selegiline (L-Deprenyl), hordenine, or Oat Straw.

phenylethylamine nootropic effects

How does Phenylethylamine work in the brain?

Phenylethylamine boosts brain health and function in several ways. But two in particular stand out.

  1. Phenylethylamine decreases depression. PEA naturally boosts the ‘feel-good’ neurotransmitters in your brain called serotonin and dopamine. Studies have shown that depressed patients when tested have lower levels of PEA.[vi]

In fact, some suggest that a PEA deficit may be the cause of depression in the first place. One study had 14 patients with major depression take up to 60 mg per day of Phenylethylamine (PEA) along with 10 mg of selegiline (L-Deprenyl) for up to 50 weeks.

Researchers found that “PEA produces sustained relief of depression in a significant number of patients, including some unresponsive to the standard treatments. PEA improves mood as rapidly as amphetamine but does not produce tolerance.”[vii]

  1. Phenylethylamine is a mesencephalic enhancer. PEA is considered a mesencephalic enhancer which is defined as “enhancer-sensitive neurons in the brain capable of working in a split-second on a high activity level due to endogenous enhancer substances”.[viii]

This means that PEA stimulates the release of dopamine, norepinephrine, and serotonin in the brain. But unlike stimulant drugs like amphetamine, which release a flood of these neurotransmitters in an uncontrolled manner.

PEA instead only increase the amount of neurotransmitters that get released when a neuron is stimulated by receiving an impulse from a neighboring neuron.

In other words, the pattern of the neurotransmitter release in not changed. But when the neuron would normally release a neurotransmitter, a larger than normal amount is released.[ix]

The result is nearly instantaneous improvements in cognitive performance, attention, awareness, pleasure, libido, and a sense of well-being.

Phenylethylamine is an endogenous (natural or ‘built-in’) amphetamine. This mechanism of action is how prescription ADHD stimulants like Adderall work. And the basis for many Schedule 1 drugs like MDMA[x], LSD, mescaline, and (crystal) methylamphetamine.[xi]

How things go bad

Phenylethylamine (PEA) is naturally metabolized by monoamine oxidase-B (MAO-B). But as we get older, MAO-B levels rise and suppress healthy levels of PEA.

Low PEA levels have been linked to several neurological diseases. And may result in:

Increased chance of ADHD

Increased chance of addiction

Energy levels decline

Working memory and mood decline

Contributing to Parkinson’s Disease

On the other hand, excess levels of PEA has been linked to migraines and paranoid schizophrenia.

Phenylethylamine central nervous system benefits

Phenylethylamine (PEA) quickly crosses the blood-brain barrier once you take it. And you feel its effects right away.

phenylethylamine nootropic dosageActivation of TAAR1 receptors inhibit the uptake and induces the release of dopamine, norepinephrine, and serotonin. It’s like turning up the volume of neuron activity.

A higher concentration of all of these neurotransmitters increase feelings of pleasure, boosts motivation, improves memory and cognition, and reinforces impulse control.

PEA naturally maintains and regulates neuronal activity. Preventing over- or under-stimulation. When working as designed, PEA and other trace amines prevent metabolic dysfunction and neurological disorders.

As a neurotransmitter, PEA acts like, and looks similar to amphetamines. And produces effects normally associated with taking a stimulant (like the drug amphetamine Adderall). But unlike amphetamines, and because PEA is endogenous to the brain, side effects and tolerance are avoided.

PEA works in an area of the brain associated with emotions. Resulting in feelings of pleasure, more drive and impulse control, heightened creativity, and better sensory perception.

PEA improves libido, social behavior, a sense of wellbeing, and better overall performance.

PEA is currently being studied and used for the treatment of ADHD, depression, bipolar disorder, cognitive dysfunction like brain fog and poor concentration. And PEA looks promising for treating addiction and eating disorders.

phenylethylamine (PEA) for ADHD

How does Phenylethylamine feel?

PEA is rapidly broken down by monoamine oxidase-B (MAO) so unless you stack PEA with a brain chemical like a MAO-B inhibitor, don’t expect its effects to last. Most experience a peak within 15 minutes and sustained energy for 30 min. to an hour.

If you’re ADHD or ADD, you should see an improvement in mood, attention span, focus and mental clarity. Not quite the same effect you’d get from something like Adderall but with a side benefit of more sociability.

Neurohackers report taking a monoamine oxidase inhibitor (MAOI) supplement 15 minutes before a PEA dose and the effects should last about 2 hours. And there’s no crash like you’d normally experience with a stimulant. Just a general feeling of well-being once it wears off.

Some have reported PEA helped kick the habit of Phenibut or caffeine without going through withdrawal.

As a pre-workout supplement, PEA provides a more intense and focused workout.

Older neurohackers seem to feel even more benefit when using PEA. Likely because monoamine oxidase levels over-power dopamine the older you get. And using PEA, especially with a MAOI helps restore dopamine, the brain chemical called serotonin, and other neurotransmitters that are typically depressed with age.

PEA is a great nootropic for study because you should feel less anxiety, fewer panic attacks and less stress. And more motivation, a better mood, easier to maintain focus, and more energy.

Some report food cravings subside and it’s easier to lose weight.

phenylethylamine (PEA) nootropic supplement

Phenylethylamine Clinical Research

Phenylethylamine as an Antidepressant

Depression is the 2nd leading cause of disability among ages 15 – 44. By 2030, the World Health Organization predicts depression will be the leading cause of disability worldwide.[xii]

Selective serotonin reuptake inhibitors (SSRI) are the most popular antidepressants prescribed worldwide. SSRIs work by blocking the serotonin transporter and inhibiting the reuptake of the neurotransmitter in your brain called serotonin. Resulting in an increase of serotonin in synapses.

But the problem is SSRIs are slow to act. And come with a host of side effects. The sustained antidepressant effect of Phenylethylamine (PEA) may be an alternative to SSRIs.

A study done in 2008 showed that PEA alters serotonin transporters by interacting with TAAR receptors. Increasing serotonin levels by preventing their reuptake just like prescription SSRIs.

The study suggested that PEA may be a safer treatment for depression than SSRIs.[xiii]

Phenylethylamine for ADHD

The diagnosis of attention deficit hyperactivity disorder (ADHD) has traditionally been done by analysis of symptoms. But measuring PEA levels instead has recently been described as a possible biomarker for diagnosing ADHD.[xiv]

This discovery of a relationship between PEA levels and ADHD has excited researchers. Because it will hopefully improve levels of confidence during ADHD diagnosis. And reduce misdiagnosis and over-medication.

One study of ADHD children medicated with methylphenidate (Ritalin) had significantly higher PEA levels when using methylphenidate.[xv]

PEA binds to the TAAR1 receptor which alters monoamine transporter function. And leads to the inhibition of the reuptake of dopamine, serotonin, and norepinephrine. Which then increases the concentration of these neurotransmitters in neuron synapses.[xvi]

This increase in synaptic concentrations of dopamine can be accomplished by directly blocking the dopamine transporter. Which is how drugs like methylphenidate work to boost dopamine.

So if you are ADHD and crave chocolate, it’s likely because cocao supplies PEA.

Some naturopaths are beginning to prescribe PEA instead of stimulants like amphetamines or methylphenidate to treat ADHD.

Phenylethylamine Dosage

Phenylethylamine (PEA) to boost libidoPhenylethylamine (PEA) suggested dosage for cognitive benefit is 500 mg up to 3-times per day.

PEA has a half-life of 5 – 10 minutes.[xvii] But the effects of PEA can be extended by using it with a MAO-B inhibitor.

If you do use a potent MAOI like selegiline (l-deprenyl) make sure you keep the dose low (i.e. 2.5 mg) or you’re in danger of inhibiting MAO-A as well. More on the “cheese effect” next.

Dosing more than recommended is NOT a good idea because you’ll likely feel jittery, irritable, get a headache, feel nausea, and very possibly force your heart rate to dangerous levels.

Phenylethylamine Side Effects

Cheese effect”: Phenylethylamine (PEA) is metabolized by the enzyme MAO-B. And when monoamine oxidase (MAO) is inhibited by eating cheese, or any other prescription or natural MAO inhibitor (MAOI), the combination can result in a potentially dangerous increase in blood pressure.[xviii]

Studies show that selective MAO-B inhibition does NOT produce this cheese effect.[xix]

Examples of MAO-B selective inhibitors include low-dose selegiline (L-deprenyl), hordenine, Polygala Tenuifolia, Oat Straw, Glycyrrhiza uralensis (Chinese licorice root extract), Phellondendron amurense (Amur cork tree bark), Ferula assafoetida extract (resin), and Psoralea corylifolia (Bu Gu Zhi).[xx]

Do not use Phenylethylamine (PEA) if you are using a prescription MAOI like Marplan, Nardil, Azilect or Parnate, or have used one in the last 14 days.

Do not use PEA if you have phenylketonuria (PKU).

Too much PEA can cause irritability, nausea, amplified heart rate, jitteriness, and could be extremely dangerous.

Remember, Phenylethylamine (PEA) is a (natural) endogenous amphetamine. And used irresponsibly could produce the same dangerous side effects as anything else in the amphetamine-class of compounds.

Where to buy Phenylethylamine

Phenylethylamine (PEA) is available in capsules, tablets, and as a bulk powder.

DO NOT make the mistake of buying Phenylalanine instead of Phenylethylamine (PEA). Because it’s NOT the same thing. And is easily overlooked when searching for this nootropic.

You can buy Phenylethylamine in powder form from Bulk Supplements.

If you buy PEA in powder-form, you should invest in a capsule machine and make capsules. Because PEA is a particularly nasty tasting nootropic supplement.

Nootropics Expert Recommendation

Nootropics Expert Tested and ApprovedPhenylethylamine 500 mg up to 3-times per day

I recommend using Phenylethylamine (PEA) as a nootropic supplement.

Your body does synthesize some Phenylethylamine from phenylalanine which comes from foods like beans, cacao, peas, Natto and eggs.

But most of us don’t get enough Phenylethylamine from our diet. So supplementation could help. Phenylethylamine is highly bioavailable, and quickly crosses the blood-brain barrier. So you should feel its effects soon after you take it.

Phenylethylamine is helpful for most neurohackers to combat anxiety, stress, and sleep deprivation. It’ll boost dopamine, norepinephrine, and serotonin levels.

It’s particularly helpful if you take Phenylethylamine prior to a stressful situation, workout, or physically demanding job. And it’s a great nootropic for studying.

Phenylethylamine could be helpful to those dealing with ADHD/ADD. It’s a possible substitute to stimulant meds like Ritalin or Adderall for some people.

PEA will provide the dopamine your brain needs. And doesn’t produce the stimulant crash when it wears off.

PEA works well when stacked with L-Tyrosine (for dopamine), and CDP-Choline and ALCAR (for acetylcholine).

PEA is quickly degraded by monoamine oxidase-B. So to prologue its effects, stack it with a low-dose MAOI-B.

You can buy Phenylethylamine in powder form from Bulk Supplements.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Janssen P.A., Leysen J.E., Megens A.A., Awouters F.H. “Does phenylethylamine act as an endogenous amphetamine in some patients?” International Journal of Neuropsychopharmacology. 1999 Sep;2(3):229-240. (source)

[ii] Miller G.M. “The Emerging Role of Trace Amine Associated Receptor 1 in the Functional Regulation of Monoamine Transporters and Dopaminergic Activity” Journal of Neurochemistry 2011 Jan; 116(2): 164–176. (source)

[iii] Granvogl M., Bugan S., Schieberle P. “Formation of amines and aldehydes from parent amino acids during thermal processing of cocoa and model systems: new insights into pathways of the strecker reaction.” Journal of Agriculture and Food Chemistry. 2006 Mar 8; 54(5):1730-9. (source)

[iv] Khan M.Z., Nawaz W. “The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system.” Biomedicine and Pharmacotherapy. 2016 Oct;83:439-449. (source)

[v] Shannon H.E., Cone E.J., Yousefnejad D. “Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog.” Journal of Pharmacology and Experimental Therapeutics. 1982 Oct;223(1):190-6. (source)

[vi] Sabelli H.C., Javaid J.I. “Phenylethylamine modulation of affect: therapeutic and diagnostic implications.” Journal of Neuropsychiatry and Clinical Neuroscience. 1995 Winter;7(1):6-14. (source)

[vii] Sabelli H., Fink P., Fawcett J., Tom C. “Sustained antidepressant effect of PEA replacement.” Journal of Neuropsychiatry and Clinical Neuroscience. 1996 Spring;8(2):168-71. (source)

[viii] Shimazu S., Miklya I. “Pharmacological studies with endogenous enhancer substances: beta-phenylethylamine, tryptamine, and their synthetic derivatives.” Progress in Neuropsychopharmacological and Biological Psychiatry. 2004 May;28(3):421-7. (source)

[ix] Xie Z., Miller.GM. “Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain.” Journal of Pharmacology & Experimental Therapeutics 2008 May;325(2):617-28. doi: 10.1124/jpet.107.134247. (source)

[x] Benzenhöfer U., Passie T. “Rediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin.” Addiction. 2010 Aug;105(8):1355-61. (source)

[xi] Bunzow J.R. et. al. “Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.” Molecular Pharmacology. 2001 Dec;60(6):1181-8. (source)

[xii] World Health Association WHO. “The global burden of disease: 2004 update.” WHO Library Cataloguing-in-Publication Data; 2008. ISBN 978 92 4 156371 0.

[xiii] Xie Z., Miller G.M. “Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain” Journal of Pharmacology & Experimental Therapeutics 2008 May;325(2):617-28. (source)

[xiv] Scassellati C., Bonvicini C., Faraone S.V., Gennarelli M. “Biomarkers and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses.” Journal of the American Academy of Child Adolescent Psychiatry. 2012 Oct; 51(10):1003-1019. (source)

[xv] Kusaga A., Yamashita Y., Koeda T., Hiratani M., Kaneko M., Yamada S., Matsuishi T. “Increased urine phenylethylamine after methylphenidate treatment in children with ADHD.” Annals of Neurology. 2002 Sep; 52(3):372-4. (source)

[xvi] Xie Z., Miller G.M. “Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain.” Journal of Pharmacology & Experimental Therapeutics. 2008 May; 325(2):617-28. (source)

[xvii] Shannon H.E., Cone E.J., Yousefnejad D. “Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog.” Journal of Pharmacology & Experimental Therapeutics. 1982 Oct; 223(1):190-6. (source)

[xviii] Cashin C.H. “Effect of sympathomimetic drugs in eliciting hypertensive responses to reserpine in the rat, after pretreatment with monoamineoxidase inhibitors.” British Journal of Pharmacology. 1972 Feb;44(2):203-9. (source)

[xix] Finberg J.P., Gillman K. “Selective inhibitors of monoamine oxidase type B and the “cheese effect”.” International Review of Neurobiology. 2011;100:169-90. (source)

[xx] Zarmouth N.O., et. al. “Natural Products Screening for the Identification of Selective Monoamine Oxidase-B Inhibitors” European Journal of Medicinal Plants 2016 May; 15(1): 14802. (source)

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Join The Discussion - 158 comments

Greg hodes
October 20, 2019

David,

I understand l-phenylalanine produces PEA. Would l-phenyalanine generate
PEA continuously over longer periods, thus solving the short half-live problem with PEA/

    David Tomen
    October 21, 2019

    Greg, it will not and the best explanation I can offer is the first 3-4 paragraphs under the “Overview” section of this review.

Brandon White
October 9, 2019

David,

I commented on your NADH article where you suggested I take a look at other supplements that could help me lower my adderall dose (I have been prescribed since I was 13 years old). I came across this article and the supplement looks very promising. Would PEA be a good supplement to take with adderall? Thank you for your help.

    David Tomen
    October 10, 2019

    Brandon, not particularly because the half-life of PEA taken as a nootropic supplement is only 5 – 10 minutes. You’ll have more success supporting Adderall with L-Tyrosine, NALT or Mucuna Pruriens (L-DOPA).

    I personally use 750 mg L-Tyrosine or NALT 3-times per day. The last dose is around 4 PM and used to prevent a stimulant crash. And depending on your age you may find that additional dopamine is needed. In that case you’d add Mucuna when dosing L-Tyrosine.

Tiffany
June 29, 2019

Can I ask exactly why, this CANNOT be used with Parnate? But Selegeline is OK? What would happen?

    David Tomen
    June 29, 2019

    Tiffany, likely because Parnate is a monoamine oxidase-A inhibitor and Selegiline is a monoamine oxidase-B inhibitor. What may happen is severe hypertension and a heart attack.

Seth
June 12, 2019

If I was to stack PEA with a chinese liquorice root extract. What would be a recommended dose 15 min prior to dosing PEA?

    David Tomen
    June 13, 2019

    Seth, check with the Liquorice root extract manufacturer because I’ve not done any research on the supplement.

Adam
March 26, 2019

Phenylethylamine is a trace amine.

Chris D
November 16, 2018

hi, I tried PEA 3 times recently and experienced NO effects except maybe a slight nausea. I am taking 75 mg of clomipramine (a tricyclic antidepressant) which I thought would increase PEA action.
Last trial (about 500mg) was 30 min after taking 2 large caps of sumac (finely ground) as I understand it is a mild MAO inhibitor and still no effect.
I trust my source of PEA which even came with a lab report on it’s purity.
ANY FEEDBACK? Thanks

Chris

    David Tomen
    November 17, 2018

    Chris, could be at least two things going on here. First, take a look at the 2nd part of “How does Phenylethylamine work in the brain?” in this review. PEA doesn’t work like a ‘standard’ stimulant-type drug. It’s more like ‘on demand’ depending on the signals your brain is receiving.

    Second, take a look at the mechanism of action for Clomipramine here > https://en.wikipedia.org/wiki/Clomipramine#Pharmacology.

    Just trying to understand how these two would interact is enough to melt your brain. Hopefully, a pharmacology pro shows up on this comment thread and explains what’s going on here. But I’m guessing that these two just don’t mix well.

Steve
November 6, 2018

Hi,

I tried PEA (500mg) + Hordenine (70mg), and all I can say is: WOW! This beats adderall in every way. love it!

I noticed how this article mentions the recommended dose of PEA being 500mg, three times a day. Is that also true when stacking it with a MAOI-B inhibitor? I noticed that when doing the latter, the effects are felt to linger throughout most of the day (which is nice). Wouldn’t doing this 3 times a day maybe be too much and create side effects?

I am looking forward to your reply/opinion!

Steve

    David Tomen
    November 7, 2018

    Steve, the recommended dosage of PEA is a ‘suggestion’ based on clinical studies and personal experience. Every brain is different. You may need less when using with a MAOI-B. Experiment and see what works best for you.

    Mary J~
    October 24, 2019

    Thank you for this great information resource.

    What would you recommend as a starting dose for a stack of Phenylethylamine + Hordenine? I’m 130 lbs.
    Also, should they be taken together at the same time?

    Thanks so much!!

    Mary J~

      David Tomen
      October 24, 2019

      Mary, try 25 mg of Hordenine each time you dose PEA.

    Adam Phytophile
    November 16, 2019

    Agreed that repeated dosing throughout the day is not necessary with an MAO-B inhibitor. I have used it in conjunction with Selegline, and once a day can be plenty, or two lower doses. I can’t speak to Hordinine as I have not worked with it. Just my experience. Also lower doses of PEA seem to have a comparable effect. More than 100mg with a strong MAO-B inhibitor like Selegline is the maximum I could recommend, from experience.

    It is also worth noting that Selegiline has poor oral bioavailability, somewhere around 30%. It is also available as sublingual drops, usually 1mg per drop, or as a transdermal patch. When recommending about 2.5mg per day of Selegiline, this means assuming high bioavailability such as sublingually. The equivalent dosage orally would be about 7.5mg. 10mg is typical oral dose, and 3mg sublingually is comparable (with the addition of absorbing more quickly). Up to 5mg sublingual or 15mg oral per day should be the maximum, as approaching 10mg fully bioavailable Selegiline reverses its selectivity and makes it inhibit MAO-A as well, which is asking for trouble, as mentioned in the article.

    Regards.

Mary Bradley
June 21, 2018

Hi iam wondering where i can purchase those three nootropics phenylethylamine, alcar and n-acetyl l-tyrosine.

Thank you,
Mary Bradley

I really want to try this stack of nootropics.

    David Tomen
    June 22, 2018

    Mary, depends on what country you’re in. You can get PEA, ALCAR and NALT from Amazon here in the USA. Depending on the supply, sometimes they are sold by Amazon. And sometimes it’s a 3rd party vendor that sells on Amazon. All three are likely available at the major vitamin shops as well.

    But before you buy, please see my post for guidelines and ideas on choosing the best supplements here: https://nootropicsexpert.com/7-tips-for-choosing-the-highest-quality-nootropic-supplements/

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