5-HTP helps fibromyalgia

5-HTP

David Tomen
Author:
David Tomen
13 minute read
5-HTP is known for relieving depression and anxiety, fibromyalgia, insomnia, migraines, obesity, and symptoms of Parkinson’s Disease

5-HTP (5-Hydroxytryptophan or oxitriptan) is an amino acid that is naturally produced in your body. 5-HTP is synthesized from the amino acid tryptophan which we get from food.

5-HTP is the immediate precursor of serotonin. And as a nootropic and dietary supplement, 5-HTP is popular with those who advocate its effectiveness in treating depression. Along with a number of other serotonin-related diseases.

But using 5-HTP for treating depression and anxiety is not supported by science. The research is contrary to how 5-HTP is viewed by many, including medical doctors.

When we dig into the research, we find that 5-HTP may be contraindicated for depression in those whom marketers advocate its use.[i]

We’re all for boosting neurotransmitter levels and optimizing cognitive performance here at Nootropics Expert®. But now and again I run into a nootropic or dietary supplement that may be popular. But also may be a particularly bad idea.

We’re going to get to the bottom of how 5-HTP works in your brain in this review. We’ll examine why it’s critical for brain health. And reasons why you may want to find another way to boost serotonin levels in your brain.

5-HTP helps:

  • Anxiety & Depression. 5-HTP is synthesized into serotonin in brain cells. Elevating levels of serotonin can help relieve the symptoms of anxiety and depression.
  • Neurotransmitters. 5-HTP is a necessary ingredient for serotonin synthesis which boosts mood and social behavior, improves memory, regulates appetite and digestion, sleep, sexual desire and function.
  • Brain Optimization. A critical balance of the primary neurotransmitters serotonin and dopamine are needed for the highly optimized brain. When these neurotransmitters are not in balance it affects mood, memory, cognition, decision-making, sexual desire, and a host of other critical life functions.

Overview

5-HTP (5-Hydroxytryptophan or oxitriptan) is an amino acid that’s synthesized from the essential amino acid tryptophan.

5-HTP
5-HTP

Tryptophan is hydroxylated by tryptophan hydroxylase to 5-HTP (5-hydroxytryptophan), then decarboxylated to serotonin (5-hydroxytryptamine or 5-HT).[ii]

Tryptophan → 5-HTP → serotonin

80-90% of your body’s serotonin is made in your intestines. But serotonin cannot cross the blood-brain barrier. So all the serotonin that your brain needs has to be made within the brain. This is where 5-HTP comes in…

5-HTP crosses the blood-brain barrier more readily than tryptophan. And gets synthesized into serotonin at a faster rate than from tryptophan.[iii]

As a neurotransmitter, serotonin influences directly and indirectly, the majority of brain cells. So if you want to boost serotonin in your brain, some find that supplementing with 5-HTP is better than taking tryptophan.

Tryptophan, which your body uses to make 5-HTP, can be found in turkey, chicken, milk, potatoes, pumpkin, sunflower seeds, turnip and collard greens, and seaweed.

5-HTP as a nootropic supplement is a naturally occurring amino acid derived from seed pods of Griffonia simplicifolia, found in West and Central Africa. 5-HTP content in extracts of this plant vary from 2 – 20.83% (from seeds obtained in Ghana).[iv]

5-HTP nootropic for depression

How does 5-HTP work in the Brain?

5-HTP is a precursor to serotonin. The neurotransmitter serotonin plays a role in sleep, appetite, learning & memory, mood, and sexual function.

When tryptophan’s role in converting to 5-HTP for boosting serotonin doesn’t work efficiently, the result is often depression, chronic headache and insomnia.

An open-label trial was conducted in Italy to determine the efficacy of using 5-HTP in young subjects with high levels of “romantic stress”.

Serotonin has been linked to human romantic attachment. So researchers in this study set out to determine brain levels of Brain-Derived Neurotrophic Factor (BDNF) and serotonin in relation to changes in romantic stress during the study.

15 healthy subjects (mean age 23.3 years) who had a “romantic breakup” took part in the study. Participants received 60 mg of Griffonia simplicifolia extract containing 12.8 mg 5-HTP daily for 6 weeks.

The subjects were evaluated for BDNF and serotonin levels at the beginning of the study, at 3 weeks and then again at the end of the 6-week trial.

The scientists observed significant improvements in romantic stress scores from weeks 0 through 3. So far, 5-HTP seems to be working. But no further improvement was seen from weeks 3 through 6. Even though the young people had significantly higher levels of BDNF and serotonin.[v]

More Involved in Depression and Stress than Serotonin

This “romantic breakup” study is a classic illustration of why using 5-HTP alone to treat depression and stress may not work. And if it does work, why it may not work for long.

5-HTP for romantic stress

Depression is often more than simple serotonin dysfunction. Depression can also be associated with catecholamine dysfunction, including dopamine and/or norepinephrine. Or a combination of serotonin and catecholamine dysfunction.

When you take 5-HTP alone, you are also depleting dopamine, norepinephrine, and epinephrine. Synthesis of serotonin from 5-HTP, and dopamine from L-DOPA is catalyzed by the same enzyme, L-aromatic amino acid decarboxylase (AAAD).

Dopamine and serotonin precursor supplementation must be taken in proper balance. Because when you use only 5-HTP, it dominates dopamine at the AAAD enzyme synthesis level.

Blocking dopamine synthesis at the AAAD enzyme through competitive inhibition will lead to depletion of dopamine and the rest of the catecholamines.[vi]

Going back to our Italian study of young people dealing with “romantic stress”, the subjects stopped responding to 5-HTP in the 2nd half of the study. Likely because their catecholamines became depleted through continuous 5-HTP supplementation.

Studies have found that when dopamine is depleted enough, 5-HTP will no longer function.[vii]

Catecholamine Dysfunction Affects More Than Just Depression

When catecholamine neurotransmitter levels (dopamine and/or norepinephrine) influence depression, supplementing with 5-HTP alone is not the way to go. Because you may deplete dopamine and norepinephrine, worsening the disease and its underlying cause.

But this contraindication is not exclusive to depression. It extends to all other diseases where catecholamine dysfunction has been implicated. Including ADHD[viii], obesity, anxiety, seasonal affective disorder  (SAD), and Parkinson’s Disease.[ix]

How things go bad

5-HTP boosts serotonin levelsAmino acid precursors of serotonin (i.e. 5-HTP) and dopamine (i.e. L-Tyrosine) work together during synthesis, metabolism and transport to the point that they function as one system.

When serotonin and dopamine are properly balanced, functions that are regulated only by serotonin, can be regulated by manipulating dopamine levels. And functions regulated only by dopamine in this balanced state can be regulated by manipulating serotonin.[x]

When you mess with this balance and improperly supplement with serotonin or dopamine precursors, you don’t get the desired effect of using that nootropic. And you increase the possibility of side effects with too much serotonin.

If you supplement with only one precursor (i.e. 5-HTP to boost serotonin) that dominates the other system (i.e. dopamine synthesis), depletion of the dominated system will occur (i.e. depleted dopamine).

And if this effect is pronounced enough, you will not get the benefit you were aiming for when supplementing with the original precursor (i.e. 5-HTP).

A powerful example of this effect is in the management of Parkinson’s Disease where the effects of L-DOPA are no longer observed over time due to serotonin depletion.[xi]

Since serotonin and dopamine cannot cross the blood-brain barrier, the number of serotonin and dopamine molecules in the brain is a function of the amount of nutrients (amino acid precursors) that are available to be synthesized into new neurotransmitter molecules.

Optimizing brain function with minimal side effects is NOT a function of supplementing until you get sufficiently high amino acid levels. It’s a function of achieving the proper balance between serotonin and dopamine.

5-HTP improves mood

5-HTP benefits

5-HTP is absolutely critical for synthesis of serotonin in your brain. But supplementing with 5-HTP to boost serotonin does not work well.

Using 5-HTP to treat depression has had very little success over the last few decades of clinical trials and biohacking.

Integrating 5-HTP into your nootropic stack is much more complicated than simply adding some 5-HTP in order to boost serotonin.

5-HTP alone will not work for depression, or any other issue you’re dealing with involving the catecholamines (dopamine, norepinephrine, epinephrine) because of 5-HTP’s tendency to deplete those neurotransmitters.

5-HTP will boost serotonin in your brain.[xii] But 5-HTP must be carefully stacked with precursors for dopamine and norepinephrine or you risk making the situation worse.

You must avoid supplementing with only one of the serotonin or dopamine amino acid precursors. When amino acid precursors are not in balance, you end up with decreased effectiveness of that nootropic, increased side effects, and depletion of the non-dominant system.

How does 5-HTP feel?

Reactions to supplementing with 5-HTP vary considerably but the one consistent theme is initial feelings of well-being, better sleep, less need for sleep, improved mood, less social anxiety, lower appetite, improved tolerance for stress and improved cognitive function.5-HTP helps fibromyalgia

And after a couple of weeks of dosing 5-HTP  – side effects begin. Serotonin overload results in dopamine and norepinephrine depletion.

Side effects include feelings of lethargy, depression, brain fog, stomach pain, and possibly a chronic tension type of headache. Worst case scenario is nausea, vomiting and even blacking out.

Neurohackers who report consistent success supplementing with 5-HTP stack it with B-Vitamins, a dopamine precursor like L-Tyrosine, and only use 5-HTP as needed.

Those who have a bad experience with 5-HTP from the start often have no idea why they’ve reacted badly. But an educated guess is their depression was catecholamine (dopamine, norepinephrine, epinephrine)-related. And boosting serotonin made their dopamine-related issues worse. Very quickly.

One huge word of WARNING: Do NOT take 5-HTP with any antidepressant medication. You put yourself in the very real danger of Serotonin Syndrome which can ultimately kill you.

does 5-htp work for depression?

5-HTP Clinical Research

5-HTP supplements are heavily marketed as a natural remedy for depression. But the science does not support using 5-HTP for depression. We have decades of clinical trials available. And there is no evidence of the efficacy in using 5-HTP for depression.

5-HTP instead of selective serotonin reuptake inhibitors

The Department of Public Health at the University of Queensland Medical School in Australia did a systematic review of literature dating from 1966 – 2000 for “5-HTP” and “depression”.

The researchers found 108 clinical studies of which only 2 studies, one with serotonin (5-HT) and one with L-Tryptophan for a total of 64 patients met sufficient quality criteria to be included. These studies suggest serotonin (5-HT) and L-Tryptophan are better than placebo at alleviating depression.

But the researchers noted “the small size of the studies, and the large number of inadmissible, poorly executed studies, cast doubt on the results from potential publication bias, and suggests that they are insufficiently evaluated to assess their effectiveness.”[xiii]

5-HTP for Fibromyalgia

A double blind controlled study in Italy studied the efficacy of using 5-HTP in treating fibromyalgia symptoms.

50 patients with primary fibromyalgia syndrome were selected for this study. This 1990 study did not publish the amount of 5-HTP used. But the researchers found a significant improvement in fibromyalgia symptoms with only mild and transient side effects.[xiv]

5-HTP for Treatment of Depression

Insufficient activity of the neurotransmitters serotonin and norepinephrine is a central element of the model of depression most widely held by neurobiologists today.

In the late 1970’s and 1980’s, numerous studies were performed in which depressed patients were treated with the serotonin precursors L-Tryptophan and 5-Hydroxytryptophan (5-HTP), and the dopamine and norepinephrine precursors Tyrosine and L-Phenylalanine.

A summary published in the Alternative Medicine Revue looked at the data from all these studies. The author noted that the nature of the studies makes it difficult to draw firm conclusions regarding the efficacy of neurotransmitter precursors for treating depression.

While there is evidence that precursor loading could work, particularly for serotonin precursor 5-HTP, more studies of suitable design and size “might lead to more conclusive results”.[xv]

Those studies have not materialized since that report was published 22 years ago.

5-HTP Recommended Dosage

Recommended dosage of 5-HTP if you’re going to try it is 50 mg 1 – 3 times per day.5-HTP nootropic dosage

Some studies have used higher doses than the recommended dose, but 5-HTP can be toxic for your central nervous system at high doses.

For anxiety or depression, 5-HTP is dosed at 150 – 300 mg per day total.

To relieve post MDMA (Ecstasy) depression, 5-HTP 100 mg on Day 3-7 after MDMA use.[xvi]

Successfully supplementing with 5-HTP requires stacking it with a dopamine precursor like L-Tyrosine or L-DOPA along with B-Vitamins (for synthesis), and one of the sulfur-containing amino acids (methionine, cysteine, homocysteine, or taurine).

And you must monitor the effects this stack is having on your body. If you start experiencing side effects of any kind, it’s a good indication that either serotonin or dopamine is out of balance.

DO NOT combine 5-HTP with any kind of antidepressant medication.

Combining SSRI’s, Tricyclics or MAOI’s with 5-HTP will cause Serotonin Syndrome. An extremely dangerous condition involving severe mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma leading to death.

Serotonin Syndrome can kill you. And I’m not kidding here.

5-HTP Side Effects

5-HTP supplementation can cause heartburn, heart palpitations, headache, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems and muscle issues.

5-HTP can also cause some pretty radical mood changes including agitation, aggressiveness, anxiety, euphoria, poor decision-making, irritability, psychosis, restlessness and insomnia.

5-HTP can make the symptoms of schizophrenia, bipolar disorder and other mental disorders worse.

Serotonin Syndrome

And I can’t emphasize this enough so I’m going to repeat it here in case you missed it…

DO NOT combine 5-HTP with any kind of antidepressant medication. Or with carbidopa. 

Combining SSRI’s, Tricyclics or MAOI’s with 5-HTP will cause Serotonin Syndrome. An extremely dangerous condition involving severe mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma.

And combining 5-HTP with carbidopa also has the potential of causing Serotonin Syndrome.

Serotonin Syndrome can kill you. And I’m not kidding here.

Type of 5-HTP to Buy

5-HTP is made from tryptophan in your body.

5-HTP as a nootropic supplement is made from extracts of the African tree Griffonia simplicifolia. 5-HTP supplements are typically in tablet or capsule form.

You’ll often find 5-HTP in many ready-made vitamin and herbal formulas.

If you are going to stack low-dose 5-HTP with L-Tyrosine I suggest: Natrol 5-HTP Fast Dissolve Tablets (Amazon). Cut the 100 mg tablet into quarters using a pill splitter and dissolve 25 mg 5-HTP under your tongue (sublingually).

Nootropics Expert Recommendation

5-HTP 50 mg up to 3-times per day

Nootropics Expert - Tested and Not ApprovedI DO NOT recommend using 5-HTP as a nootropic supplement.

Your body does synthesize 5-HTP on its own to make serotonin in your brain. And you can’t get 5-HTP from food. But you can get L-Tryptophan from food which is synthesized into 5-HTP in your body.

5-HTP may help you if you’re dealing with depression. But you must stack if with a dopamine amino acid precursor along with B-Vitamins and a sulfur-containing amino acid. See the “5-HTP Recommended Dosage” in this review above.

IF you are going to try 5-HTP, I suggest starting with a dose of more than 50 mg daily. You may want to take it in the evening because it could help sleep disorders.

Short-term dosing of 5-HTP of no more than 2 weeks seems to provide the most benefit if you’re going to benefit from this nootropic.

Or try using 5-HTP only on an “as needed” basis. For a mood boost, reduce social anxiety, and provide a short-term boost in cognition.

5-HTP supplementation on its own is NOT recommended. Nor is it recommended for long-term use.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Hinz M., Stein A., Uncini T. “5-HTP efficacy and contraindications.”Neuropsychiatric Disease and Treatment. 2012;8:323-8. (source)

[ii] Turner E.H., Loftis J.M., Blackwell A.D. “Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.”Pharmacology and Therapeutics. 2006 Mar;109(3):325-38. (source)

[iii] Birdsall T.C. “5-Hydroxytryptophan: a clinically-effective serotonin precursor.” Alternative Medicine Revue. 1998 Aug;3(4):271-80. (source)

[iv] Lemaire P.A., Adosraku R.K. “An HPLC method for the direct assay of the serotonin precursor, 5-hydroxytrophan, in seeds of Griffonia simplicifolia.” Phytochemical Analysis. 2002 Nov-Dec;13(6):333-7. (source)

[v] Emanuele E., Bertona M., Minoretti P., Geroldi D. “An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.” Neuro Endocrinology Letters. 2010;31(5):663-6. (source)

[vi] Hinz M., Stein A., Uncini T. “APRESS: apical regulatory super system, serotonin, and dopamine interaction.” Neuropsychiatric Disease and Treatment. 2011;7:457-63. (source)

[vii] Hinz M., Stein A., Uncini T. “Relative nutritional deficiencies associated with centrally acting monoamines.” International Journal of General Medicine. 2012;5:413-30 (source)

[viii] van Praag H.M. “n search of the mode of action of antidepressants. 5-HTP/tyrosine mixtures in depressions.”Neuropharmacology. 1983 Mar;22(3 Spec No):433-40. (source)

[ix] Hinz M., Stein A., Uncini T. “5-HTP efficacy and contraindications”Neuropsychiatric Disease and Treatment. 2012; 8: 323–328. (source)

[x] Hinz M., Stein A., Uncini T. “APRESS: apical regulatory super system, serotonin, and dopamine interaction.” Neuropsychiatric Disease and Treatment. 2011;7:457-63. (source)

[xi] Hinz M., Stein A., Uncini T. “Amino acid management of Parkinson’s disease: a case study” International Journal of General Medicine. 2011; 4: 165–174. (source)

[xii] Birdsall T.C. “5-Hydroxytryptophan: a clinically-effective serotonin precursor.” Alternative Medicine Revue. 1998 Aug;3(4):271-80. (source)

[xiii] Shaw K., Turner J., Del Mar C. “Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis.” Australia and New Zealand Journal of Psychiatry. 2002 Aug;36(4):488-91. (source)

[xiv] Caruso I., Sarzi Puttini P., Cazzola M., Azzolini V. “Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome.” Journal of International Medical Research. 1990 May-Jun;18(3):201-9. (source)

[xv] Meyers S. “Use of neurotransmitter precursors for treatment of depression.” Alternative Medicine Revue. 2000 Feb;5(1):64-71. (source)

[xvi]Wang X., Baumann M.H., Dersch C.M., Rothman R.B. “Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan.” Neuroscience. 2007 Aug 10;148(1):212-20. (source)

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Join The Discussion - 343 comments

Sonja Strazisar
February 5, 2023

Hello David,
I have anxiety/depression and I know you don’t recommend 5HTP for anyone with anxiety. Early on I thought 5HTP would be a life saver but was disappointed and used it only for sleep with 500mg Gaba
My question is should I just stop taking it altogether. And if I stop what would you recommend ? I am currently taking Rhodiola 2xper day & for sleep 400mg Mag.Glycinate w/ Theanine w/ Glycine if needed or Mag. Glycinate with 1000mg of Taurine or just starve and take Kava. Thank you!

    David Tomen
    February 9, 2023

    Sonja, you can safely use L-Tryptophan to increase 5-HTP and serotonin which goes on to assist in the production of melatonin to help you sleep. I use 500 mg L-Tryptophan about 90 minutes before bed and it works great.

      Sonja Strazisar
      February 13, 2023

      The problem for me taking the tryptophan is I must have an empty stomach for it to work and I tend to eat sweets in the evenings. I have found that taking 100mg 5htp w/500 gaba I become sleepy despite of my evening snacking. I take it about an hour after my sweets. I agree, when I do have an empty stomach before bed tryptophan works very well and if don’t have the trypt. capsules I drink 1/2 glass of kefir.
      thank you!

Mary
January 23, 2023

Hi David, thanks for the information! I’ve been taking tryptophan for a long time already and have always been happy with it. But recently I’ve heard about eosinophilia-myalgia syndrome caused by tryptophan. What do you know about that? Is there a way of being sure the tryptophan isn’t contaminated? Thanks in advance

    David Tomen
    January 25, 2023

    Mary, go to this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848710/. And read the paragraph right under “Introduction”. That issue came up when a Japanese company made a batch of Tryptophan in 1989 in a contaminated vat. It has not happened since.

Daniel Barber
January 20, 2023

5-HTP has been recommended to me as a supplement to improve dream recall (combined with an acetylcholinesterase inhibitor). I already take B5 & B6 every morning. Can I take 5-HTP regularly, and anything I should watch out for? Do I need to take anything else with 5-HTP?

    David Tomen
    January 25, 2023

    Daniel, the biggest problem with 5-HTP is if used long-term it typically stops providing the intended benefit. No one has every explained why this happens. But I suspect it likely increases serotonin to the point where it suppresses dopamine. Serotonin and dopamine must be in balance.

    And using Vitamin B6 in isolation without also using B9 & B12 increases homocysteine to unhealthy levels. And could result in a heart attack. Better to use a BioActive B-Complex to get the B5 and B6 you want.

NP
January 15, 2023

Hi David,

I’ve been taking Lions Mane supplements with L-Tyrosine for about 4 months (not always consistently) for brain fog and focus for a high pressure job. I’ve heard that I could be affecting my serotonin levels with this combo, so I was considering taking 5-HTP to balance out. Should I move forward with this, and if so, how should I stack and for how long?

    David Tomen
    January 18, 2023

    Take 500 mg L-Tryptophan before bed every night to keep serotonin and dopamine in balance.

      Dan
      February 8, 2023

      are you sure this will be enough? since tyrosine is like 5-xtp only from phenylalanine, I wonder if tryptophan helps the body in some other way than the production of 5-xtp, and after serotonin? If not, then taking 5-xtp will be the same as tryptophan but more effective and give the same benefit, but yes, for long-term use is unknown.

        David Tomen
        February 9, 2023

        Dan, long-term use of 5-HTP does not work according to user reviews and clinical studies. Likely because it disrupts the balance of serotonin and dopamine. Better to use L-Tryptophan long-term.

      Dan
      February 8, 2023

      then eating l-dopa, so there is enough tryptophan to balance the difference due to taking tyrosine? And if you take phenylalanine and tryptophan, will dopamine be depleted? All the same, phenylalanine needs to go through 3 transformations, and tryptophan through 2

        David Tomen
        February 9, 2023

        Dan, I think you are over thinking this. Use L-Tyrosine 500 mg twice per day and 500 mg L-Tryptophan before bed and you should be fine.

Christine Cooney
January 10, 2023

Hello David and thanks.

Is it true you need to take L-tyrosine with 5htp so the dopamine does not get depleted?
If so, please could you advise me when to take both of these nootropics and if I need an empty stomach?
Also, could I dose once a day with each one if I need an empty stomach, as I find it takes quite a few hours for my stomach to empty.
Thank you

    David Tomen
    January 10, 2023

    Christine, too much serotonin depletes dopamine. And the opposite it true as well. I would not worry if all you using is 100 mg 5-HTP per day. But 500 mg 5-HTP per day would be in excess. In that case you would use 500 mg L-Tyrosine morning and then again at noon to balance dopamine with serotonin.

Daniel Zanier
November 12, 2022

Are you familiar with the Hinz protocol for treating Parkinson’s? It uses a natural form of l-dopa and amino acids to treat the disease. It claims that carbidopa depletes vitamin B6 – which is needed to produce dopamine – both centrally and peripherally, and that using tyrosine, mucuna pruriens as l-dopa, a sulphur amino acid and B6 is a better way to treat Parkinson’s than traditional levodopa/carbidopa. What are your feelings about this, if any?

    David Tomen
    November 16, 2022

    Daniel, I am not familiar with that protocol but we have many in our community who are dealing with Parkinson’s naturally. They are using natural L-DOPA extracted from Mucuna Pruriens instead of levodopa/carbidopa.

Ed
November 10, 2022

For my depression/dysthymia i want to try 5-HTP.But i use a small dosage of anti-epileptic, Lamotrigin. Lamotrigin is also an antidepressant, and in my case it isn’t used on/for serotonin, it ‘works’ on a different part of the brain. Is it save to use or can this combination even lead to Serotonin Syndrome?

Thanks.

Keeks
October 5, 2022

thank goodness for your knowledge on this and thank you for sharing it, I had just ordered 5-htp from amazon and then I read all the HORRIBLE comments and what happened to people and how sick they got when taking it. I cancelled the order after reading this. It takes a lot of research and you deff should not just put something in your body based on some peoples good experiences.

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