Alpha GPC and athletic performance

Alpha GPC

David Tomen
Author:
David Tomen
10 minute read
Alpha GPC has been shown to reverse age-related cognitive impairment, improve memory and learning, and boost athletic workouts.

Key Takeaways

  1. Alpha GPC (L-Alpha Glycerylphosphorylcholine) is a choline source derived from soy or sunflower lecithin and is naturally present in the body.
  2. It is highly bioavailable and can easily cross the blood-brain barrier, making it a preferred choline source for brain benefits in nootropic users.
  3. As a precursor to acetylcholine, it enhances brain energy, mood, mental clarity, and memory.
  4. Alpha GPC supports brain health by boosting acetylcholine levels, aiding brain cell membrane development, and increasing dopamine release.
  5. Recommended dosage for cognitive benefits ranges from 300 to 1,200 mg per day, and while generally safe, potential side effects include fatigue, headaches, and gastrointestinal issues.

Alpha GPC (L-Alpha Glycerylphosphorylcholine, choline alfoscerate) is a choline source derived from soy or sunflower lecithin. It is also naturally present in small amounts in your body.

Alpha GPC is more bioavailable than other sources of choline for brain benefits. Unlike choline citrate or choline bitartrate, it easily crosses the blood-brain barrier. This makes Alpha GPC a preferred choline source with experienced nootropic users.

Alpha GPC is a precursor to the essential neurotransmitter acetylcholine.

Alpha GPC helps:

  • Brain Energy. Alpha GPC improves mood, and boosts mental energy. The extra choline can increase alertness and clarity of thought.
  • Neurotransmitters. Alpha GPC is prized for its ability to improve memory. Its high bioavailability makes it a great source of choline for producing the neurotransmitter acetylcholine.
  • Brain Optimization. Alpha GPC boosts the development of new brain cells. And enhances your brain’s ability to repair damaged cell membranes.

Overview

Alpha-GPC chemical structure
Alpha GPC

Alpha GPC is a type of choline that’s produced in small amounts in your body. You can also get it from eating organ meats, dairy and wheat germ.

Choline is considered an essential nutrient because when your body uses it faster than it can produce it, you need supplemental choline either from food or a supplement.

You need choline for the production of the neurotransmitter acetylcholine. And to form phosphatidylcholine (PC), used in building cell membranes.

In fact, choline is so vital to cognition and nerve function that, without it, we couldn’t move, think, sleep or remember anything.

Alpha GPC is used throughout your body. It even helps the production of human growth hormone. Athletes use it for peak performance, and to help build lean muscle mass. It provides more energy for a workout and quicker recovery.[i]

Alpha GPC can boost athletic performance

Here we’re talking about how Alpha GPC affects your brain health and chemistry.

Alpha GPC vs. CDP-Choline vs. Choline Bitartrate: What’s the Difference?

Choline is a water-soluble nutrient and its composition is similar to B-vitamins. Alpha GPC, CDP-Choline, Choline Citrate and Choline Bitartrate are all sources of choline.

CDP-Choline (cytidine 5′-diphosphocholine): Is only about 18% choline by weight. Your body naturally synthesizes choline into CDP-Choline (Citicoline). It’s then converted to phosphatidylcholine (PC) which assists cell membranes, and helps create acetylcholine.

Alpha GPC vs CDP-CholineCholine Bitartrate: An economical form of choline, and about 40% choline by weight. So 1 gram of Choline Bitartrate offers 400 mg of actual choline. It does not easily cross the blood-brain barrier. So you won’t experience the same level of nootropic benefits as with Alpha GPC or CDP-Choline.

Alpha GPC: About 40% choline by weight and easily crosses the blood-brain barrier. Alpha GPC naturally occurs in your brain as a byproduct of phosphatidylcholine (PC). When your brain needs more choline, and the choline floating around in your brain is running low, it breaks down PC from cell membranes. And turns it into Alpha GPC.

Your body and brain loves it when you use Alpha GPC. Because it doesn’t have to cannibalize its own cells to get more choline.

How does Alpha GPC Work in the Brain?

Alpha GPC boosts brain health and function in several ways. But two in particular stand out.

  1. Alpha GPC boosts acetylcholine, a neurotransmitter tied to memory and overall brain function. Alpha GPC is a precursor to acetylcholine. Improving the efficiency of communications between neurons in your brain. This increase in neural signaling boosts memory, learning, cognitive processing and mental clarity.

In one study, 32 healthy volunteers received either Alpha GPC or a placebo as a pretreatment. Ten days later they were injected with scopolamine to induce amnesia. The researchers found Alpha GPC was able to prevent the impairment of attention and memory normally caused by scopolamine.[ii]

These researchers showed that memory function in young healthy people could be racked up a notch. Simply by taking Alpha GPC as a supplement.

  1. Alpha GPC directly impacts development of cell membranes in the cerebral cortex. This outer layer of neural tissues or “gray matter” is the information processing center of your brain. It controls intelligence, motor function, organization, personality, planning and touch.[iii]

Published in Clinical Therapeutics, researchers conducted a double-blind, placebo-controlled trial with mild to moderate Alzheimer’s patients. 400 mg capsules were administered 3- times per day for 180 days. The conclusion of this trial showed consistent improvement in dementia patients given Alpha GPC.[iv]

Alpha GPC increases brain cell signaling

How things go bad

As we get older, our brain chemistry and energy metabolism changes.

↓ Recall, reaction time and mood diminish

↓ Brain cell membranes degenerate

↓ Acetylcholine levels decline[v]

Nerve growth factor in the brain declines

All of these age-related changes are contributing factors to the neurodegenerative diseases of aging, including Alzheimer’s and dementia.

But even if you’re not concerned with the effects of aging, Alpha GPC can help.Alpha GPC supports optimal brain cognitive function in all age and gender groups

Alpha GPC benefits

There are many benefits of Alpha GPC. Research from hundreds of studies have shown that Alpha GPC will:

  • Improve memory and learning ability[vi]
  • Restore the bioavailability of acetylcholine[vii]
  • Restore and boost nerve growth factor receptors in the brain[viii]
  • Increase growth hormones in all age groups[ix]
  • Boost cognitive performance and memory in Alzheimer’s patients[x]

Alpha GPC is water-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.

Alpha GPC improves your brain function and learning processes by directly increasing synthesis and secretion of acetylcholine. As your body calls for it.

This form of choline is not a precursor to phosphatidylcholine (PC), but is a metabolite of PC. This means once PC is metabolized and stripped of its fatty acids – all that remains is Alpha GPC.

Instead of scavenging your brain’s own membranes for Alpha GPC, you give it exactly the type of choline its looking for.

How does Alpha GPC feel?

If you have trouble getting started in the morning, try coffee and 400 mg of Alpha GPC. Instead of your usual high sugar, high carbohydrate breakfast.

Alpha GPC can be a great way to boost your energy. Take it 45 minutes before you work out.Alpha GPC helps boost memory, mood, mental performance and energy

Alpha GPC helps with memory, mood, mental performance and energy. Its brain support and ability to fuel the acetylcholine in your brain cells should boost cognition in all age and gender groups.

Alpha GPC Clinical Research

In one study, researchers showed that Alpha GPC had positive effects for increasing human growth hormone.[xi]

Alpha GPC Increases the Release of Dopamine

Another trial demonstrated the increase in the release of dopamine.[xii] This is particularly significant in showing Alpha GPC can help those suffering from dopamine deficiencies. And alleviating the symptoms of diseases like depressive disorders and Parkinson’s Disease.

Alpha GPC Facilitates Learning and Memory

Alpha GPC boosts focus and memoryAn ongoing trial demonstrates Alpha GPC improving memory and attention. This research shows Alpha GPC increasing the effectiveness of pairing it with donepezil (acetylcholinesterase inhibitor). Far better than using donepezil on its own.

And in rats, Alpha GPC boosted learning and memory. It increased brain energy mechanisms and decreased age-related structural changes in the brain.[xiii][xiv]

Alpha GPC Relieves Cognitive Decline and Impairment in Alzheimer’s

Thirteen published clinical trials, involving a total of 4,054 Alzheimer’s patients consistently showed Alpha GPC:[xv]

  • Improved cognitive function, memory, and attention
  • Promoted recovery in stroke patients
  • Reversed the symptoms of acute cerebrovascular disease
  • Is far more effective than using choline or lecithin in treating disease

Recommended Alpha GPC  Dosage

Alpha GPC is about 40% choline by weight. So 1,000 mg of Alpha GPC provides approximately 400 mg of choline.

  • Alpha GPC suggested dosage for cognitive benefits is 300 – 1,200 mg per day.
  • Athletic training suggested dosage of Alpha GPC is 300 mg first thing in the morning, and another 400 mg dose 15 – 30 minutes before working out.
  • Clinical treatment of Alzheimer’s Disease, dementia and other cognitive disorders dosage of up to 1,200 mg per day.

For higher dosages, split the daily Alpha GPC total into 2 or 3 doses per day. For example, 1,200 mg would be taken 400 mg at a time.

Alpha GPC Side Effects

Alpha GPC is produced naturally in your body. So is considered well-tolerated and safe.

Side effects are rare but can include fatigue, headaches, nervousness, nausea, diarrhea and gastrointestinal issues. This is often an indication you have too much choline in your body.

Because Alpha GPC causes an energy boost in many neurohackers, avoid dosing in the evening. Or you may have difficulty getting to sleep.

A very recent study published in 2021 including more than 12 million individuals aged 50 years or older who used Alpha GPC for at least 10 years had a 46% increased chance of stroke. So for short-term use Alpha GPC is safe. But if you need a choline supplement for long-term use you may want to consider switching to CDP-Choline (Citicoline) like I did once I read that study.

Type of Alpha GPC Supplement to buy

Because Alpha GPC tends to liquefy at 99-100%, many suppliers offer 50% Alpha GPC powder combined with 50% of a filler like silicon dioxide. Adjust your dosage accordingly.

AlphaSize® and CholineAid® are a Kosher Certified, Halal Certified, USP grade, NDI, GRAS-affirmed, patented forms of Alpha GPC manufactured by Chemi Nutra. Which is the U.S. business unit of parent company Chemi S.p.A., a privately held pharmaceutical and nutraceutical company based in Milan, Italy. The company has cGMP certified manufacturing facilities in Italy and Brazil.

Nootropics Expert Recommendation

Alpha GPC 300 – 1,200 mg per day

Nootropics Expert Tested and ApprovedI recommend using Alpha GPC as a nootropic dietary supplement.

Your body does make some Alpha GPC on its own. And from the food you eat. But studies have shown we don’t get an adequate supply of dietary choline from food sources in our modern diet.

Alpha GPC is especially helpful for those suffering from age-related cognitive decline. Studies show it helps stop or reverse brain degeneration like Alzheimer’s Disease, and other cognitive disorders. Particularly in the early to mid-stages of the disease.

I suggest starting with a dose of 400 mg daily. And Alpha GPC is a great compliment to a stack including any nootropic from the racetam-family. Anything that causes an increase in uptake of acetylcholine in your brain.

You need to provide your brain with the choline it is demanding. Or it starts cannibalizing your own brain cells for more acetylcholine. Signs that you’re lacking adequate choline are headaches.

Take Alpha GPC at a ratio of 1:4. For example, 400 mg of Alpha GPC dose to 1,600 mg of a racetam like Piracetam.

How much Alpha GPC you should take will depend on your situation.

Age-related cognitive disorders like Alzheimer’s may want to up the dose to 1,200 mg of Alpha GPC per day.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Ziegenfuss T., Landis J. Hofheins J. “Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise” Journal of the International Society of Sports Nutrition 20085(Suppl 1):P15 (source)

[ii] Canal N., Franceschi M., Alberoni M., Castiglioni C., De Moliner P., Longoni A. “Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.” International Journal of Clinical Pharmacology, Therapy, Toxicology. 1991 Mar;29(3):103-7. (source)

[iii] Kidd P.M. “Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management.” Alternative Medicine Review 2005 Dec;10(4):268-93. (source)

[iv] De Jesus Moreno Moreno M. “Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.” Clinical Therapeutics 2003 Jan;25(1):178-93. (source)

[v] Cohen B.M., Renshaw P.F., Stoll A.L., Wurtman R.J., Yurgelun-Todd D., Babb S.M. “Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.” JAMA 1995 Sep 20;274(11):902-7. (source)

[vi] Drago F., Mauceri F., Nardo L., Valerio C., Lauria N., Rampello L., Guidi G. “Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat.” Pharmacology, Biochemistry and Behavior 1992 Feb;41(2):445-8. (source)

[vii] Bronzetti E., Felici L., Amenta F. “Effect of ipsilateral lesioning of the nucleus basalis magnocellularis and of L-alpha-glyceryl phosphorylcholine treatment on choline acetyltransferase and acetylcholinesterase in the rat fronto-parietal cortex.” Neuroscience Letters 1993 Dec 24;164(1-2):47-50 (source)

[viii] Vega J.A., Cavallotti C., del Valle M.E., Mancini M., Amenta F. “Nerve growth factor receptor immunoreactivity in the cerebellar cortex of aged rats: effect of choline alfoscerate treatment.” Mechanisms of Ageing and Development 1993 Jun;69(1-2):119-27. (source)

[ix] Ceda G.P., Ceresini G., Denti L., Marzani G., Piovani E., Banchini A., Tarditi E., Valenti G. “alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.”Hormone and Metabolic Research 1992 Mar;24(3):119-21 (source)

[x] Parnetti L., Abate G., Bartorelli L., Cucinotta D., Cuzzupoli M., Maggioni M., Villardita C., Senin U. “Multicentre study of l-alpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer’s type.” Drugs Aging 1993 Mar-Apr;3(2):159-64 (source)

[xi] Ceda G.P., Ceresini G., Denti L., Magnani D., Marchini L, Valenti G., Hoffman A.R. “Effects of cytidine 5′-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects.” Acta Endocrinologica (Copenhagen).1991;124(5):516-20. (source)

[xii] Trabucchi M., Govoni S., Battaini F.  “Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drug.” Farmaco Sci.1986 Apr;41(4):325-34. (source)

[xiii] Traini E., Bramanti V., Amenta F. “Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent.” Current Alzheimer’s Research 2013 Dec;10(10):1070-9. (source)

[xiv] Florio T., Bajetto A., Thellung S., Arena S., Corsaro A., Bonavia R., Merlino M., Schettini G. “Prolonged treatment with α-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats” Aging Clinical and Experimental Research October 1999, Volume 11, Issue 5, pp 335-342 (source)

[xv] Parnetti L., Amenta F., Gallai V. “Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data.” Mechanisms of Ageing and Development 2001 Nov;122(16):2041-55. (source)

Subscribe to the Nootropics Expert newsletter

Keep up to date with the latest developments in the nootropics space.

Head First 2nd Editon

The Award Winning Guide to Healing & Optimizing Your Brain with Nootropic Supplements.

Head First 2nd Edition

NEW! Eliminate Brain Fog, Low Energy, Moodiness, Difficulty Sleeping, Memory Loss or Anxiety. Available on Amazon, Barnes & Noble, Apple Books, Walmart and more...



Where to Buy Nootropics

Wondering where to buy nootropics? Well, you’re in the right place. Because here you will find the nootropic supplements that I personally use and recommend. Each supplement has a link to the company store and product that I use. I also include a link to my full review for each supplement here on Nootropics Expert® […]

The Definitive Guide to Nootropics

Nootropics can help increase your memory, boost learning ability, improve your mood and assist overall brain function. If you’re new to nootropics, or wonder about the difference between a nootropic and a smart drug, then this page is for you. Here you’ll find the definition of a nootropic, how to pronounce the word “nootropic”, the […]

The Most Comprehensive Nootropics List

This is our big list of the most popular Nootropics in use today. Here you’ll learn what each nootropic is, what it does and suggested dosages. What is this List of Nootropics About? Nootropic supplements are cognitive enhancers aiming to improve brain function. Whether you are looking to treat mild cognitive impairment, improve mental focus, or biohack […]



Free Secrets of the Brain 3rd Edition

Get “Secrets of the Optimized Brain,” 92 nootropics to help you plan your Nootropic Stack when you sign up for my newsletter:

Join The Discussion - 212 comments

Jeff D
September 9, 2018

Would taking CDP-Choline together with Alpha GPC on the same day be a good idea? Like 250mg CDP choline at the same time as 400mg Alpha GPC, or better to split them by taking one in the morning and the other in the afternoon , or is it even better to alternate by taking one of them one day and the other the next day (and keep alternating like that)

    David Tomen
    September 9, 2018

    Jeff, it depends … I use both and my brain loves it. I suggest trying them together then separated by a few hours and see if you notice any difference.

Sarah Cloud
August 16, 2018

Sorry for so many questions!! I think what I’m reading is… I can take Alpha GPC and this will suffice for a choline supplement since it contains choline. Is this correct?

Marffa
August 1, 2018

Hey David.
What brand do you take for both of yours Alpha GPC & CDP-Choline?
And if I will take 1 or the other, or both do I still need to take Phosphatidylcholine as a supplement and if so, which brand?

    David Tomen
    August 2, 2018

    Marffa, I’m currently using Alpha GPC produced by Lyfetrition. And the CDP-Choline is the Cognizin in Mind Lab Pro.

    It would be helpful to use both Phosphatidylcholine (PC) and Phosphatidylserine (PS) although I can’t recommend a particular brand at this point. Go with a reputable manufacturer and then check the user reviews.

    All four of these nootropics work together if you investigate their mechanism of action. If your budget only allows so much then I would stay with Alpha GPC or CDP-Choline. Depending on which one works best for you. If you can add PC and PS as well you should notice a difference and how you feel and how your brain works.

      Marffa
      August 3, 2018

      Thank you for the answer, it was very detailed.

      I am new to this stuff and I still wonder, they all say CHOLINE somewhere in the word. I can’t afford having all 4, so could I instead of taking either ALPHA GPC or CDP Choline with my DMAE just take Phosphatidylcholine (since, as I understand, it is also a source of Choline) and stack it with Phosphatidylserine since they go together well?

      Thanks.

        David Tomen
        August 3, 2018

        Marffa, I realize this can be confusing so stay with me here …

        Your body naturally synthesizes choline (from your diet) into CDP-Choline (Citicoline). It’s then converted to phosphatidylcholine (PC) which assists cell membranes, and helps create acetylcholine.

        Alpha GPC naturally occurs in your brain as a byproduct of phosphatidylcholine (PC). When your brain needs more choline, and the choline floating around in your brain is running low, it breaks down phosphatidylcholine from cell membranes. And turns it into Alpha GPC.

        Phosphatidylcholine (PC) is in the outer layer of brain cell membranes, and Phosphatidylserine (PS) is part of the inner layer.

        This is very simplified version of how this works. Each of these provides various benefits to your body and brain. And all are needed for you to survive.

        The problem arises when one or more of these functions does not work as designed. And it’s different in each one of us.

        You may only need to support one out of four. Or maybe more. The only way to figure this out is to try each one and see how you feel. If you don’t feel any better in any way then that means your body has already taken care of it. And you don’t need to supplement with that particular nootropic. All four are required but you may not need to use all four. Testing, testing, testing is the key to success with nootropics.

Shane
July 29, 2018

Hi David, how are ya. Thank you so much for all the invaluable information you provide on nootropics; it is profusely appreciated. I have been consistently taking ALPHA GPC for 3 months now. The recommended dosage on the bottle is 2 capsules a day with food (not to exceed 8 capsules daily) however, I have been taking 12 capsules daily (300mg per capsule) for 3 months and the results have been extraordinary. My memory has definitely improved but the truly marked difference has been in my muscular development and strength. It has been remarkable. People have asked me if I am on steroids.

I take a lot of supplements, about 95 a day. And when I take the Alpha GPC I take all 12 capsules at the same time along with maybe 30 other capsules from various supplements and vitamins.

I have 4 questions David. Is this a risk to my health?
Are there any side effects to taking this many Alpha GPC? Is it okay to take all 12 capsules at the same time along with other vitamins and supplements? And lastly, is it okay if I keep up this unusually high dosage for as long as I want to?

Again, the physical and strength results have been nothing short ofunbelievable. Thank you so much David, I truly appreciate your time. Looking forward to hearing from you.

Gratefully Yours,

Shane

    David Tomen
    July 30, 2018

    Shane, Alpha GPC is considered non-toxic. So higher dosages for extended periods shouldn’t be a problem. It sounds like your body is desperate for choline and acetylcholine. So listen to your body. If you begin feeling fatigue, headaches, nervousness, or nausea then you’ll know to cut back.

    I’m not sure what the half-life is for Alpha GPC. Most of us split our dosage into 3-times per day to maintain consistent levels of Alpha GPC in our body. But you want to avoid taking it too late in the day. Otherwise the boost in energy could interfere with sleep.

John P Morgan
June 6, 2018

Fat or water soluble,
Great Information Thanks Mr. David Tomen

    David Tomen
    June 6, 2018

    John, choline supplements are usually ‘water-soluble’.

Sparsh
March 25, 2018

Confused about the ratio of Alpha-gpc vs Piracetam. In one of your other articles, you said that one should take 1:8 ratio or 1:4 ration of Piracetam and CDP-choline. Given that alpha-gpc is more bioavailable, and more concentrated, the dosage should be less than that of CDP-choline.

So, what dose of Alpha-GPC do you use with with a total of 4.8g piracetam per day. Would 600mg alpha-gpc suffice?

    David Tomen
    March 26, 2018

    Sparsh, I realize it can be confusing because there is no solid ratio. It really depends on two things; how your body reacts, and the type of Alpha GPC you are using. Most Alpha GPC supplements are only 50% and the other half filler. Because Alpha GPC tends to liquefy when pure.

    You will not do any damage by doubling your dose of Alpha GPC. The most that will happen is you’ll get sleepy from too much choline. Start with 600 mg and see how it works. Preferably split into two doses of 300 mg each time you dose Piracetam.

David
February 23, 2018

I’m looking to use a stack of noopept and alpha gpc. I am starting with 10mg of noopept and 400mg of alpha gpc 50% (meaning 200mg of a-gpc). Am I correct in thinking, since it is 50% a-gpc, that I am getting the correct ratio of 20:1?

    David Tomen
    February 23, 2018

    David, it’s not an exact science. Try 10 mg of Noopept with 400 mg of the Alpha GPC you have and see how you feel. If you notice any fatigue then the dose of Alpha GPC is too high.

Mike Gold
January 31, 2018

I started taking 400mg Alpha GPC and 1600mg Piracetam a few days ago. I am also taking Lion’s mane and B complex. I am 5’3″ 115 lbs. Almost every day I feel sick. Two days ago I was dealing with mild depression, and yesterday I felt like I was sick all day with a headache, low energy, bad mood, and achy joints. I am almost positive it is from the nootropics, as I feel great in the morning or later in the day when I believe . Do you think the dosage is too high for my body?

    David Tomen
    January 31, 2018

    Mike, it sounds like your body is not responding well to either Alpha GPC or Piracetam or both. Try eliminating Alpha GPC with the rest of your stack and see how you feel. If that solves the problem then you may want to try CPD-Choline instead. If both choline supplements cause problems it means your body already has plenty of choline.

    If eliminating Alpha GPC doesn’t change anything then I would try using your stack without Piracetam. But the description of your symptoms sounds like too much choline or acetylcholine.

    I’ve found it takes a lot of trial and error with nootropics to see what my body and brain best respond to.

    Trevor
    April 26, 2018

    Well Mike… I am trying something similar and along with the coline and others, I am trying GOOD pro-biotics and the sickness and stomach problems have all but gone after just a few days. Worth a try??? Also as a point of note, with the new approach, I am completely changed and I am a completely new person. I was driven insane by the medication given to me by the GP and Psychiatrist and the very day I gave up the medication, the panic went and I refuse to take any medication prescribed since except Lyrica, which I believe is a wonder drug, for me anyway, and I am on a new approach of dealing with it naturally and I can honestly say that I am 90% cured from panic, anxiety, depression, headaches and mental disorders. So if you can, stick with it and if it’s giving you problems, tinker about with it to find the exact formula that works for you!! All the best, Trevor.

      laurent23
      August 10, 2019

      hello David, I m bipolar type II treated by lamictal and little dose of lithium. Since 6 months and a episode of hypomania under ssri I have many brain fog difficulty to focus and less speech ability (maybe attention deficit disorder without hyperactivity). I have seen that A-Gpc is effective for my sickness but I don t know the dosage for bipolar. I currently take 2x500mg per day since 20 days. The improvement is real but not enough unfortunately. I think about ritalin but I m little bit scared about the long term use and high anxiety. It s very controled substance in my country (france). I wanted to know your expert advise about the dosage of a-gpc for my condition and your opinion about ritalin and risk of mania under this kind of stimulant. Thank you

        David Tomen
        August 10, 2019

        Laurent, the top limit on suggested dosage for Alpha GPC is 1,200 mg per day. Divided into 2 or 3 doses.

        Ritalin in my opinion is a great solution for someone who is clinically Adult ADD. But its not for everybody. It is possible to control ADD symptoms with just nootropics which I did for one year using this nootropic stack: https://nootropicsexpert.com/best-nootropics-for-adhd-add/

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.