7 Best Nootropics for Anxiety

Key Takeaways

1. Understanding the root causes of anxiety, often associated with neurotransmitter imbalances, is crucial.
2. Certain nootropics can be effective in alleviating anxiety symptoms by targeting specific neurotransmitters.
3. Acetylcholine, dopamine, and GABA are some neurotransmitters related to anxiety, and supplements like Alpha GPC, CDP-Choline, and L-Tyrosine can help modulate their levels.
4. A trial-and-error approach may be necessary to find the most effective nootropic for individual anxiety relief.
5. Nootropics offer a natural alternative to traditional anti-anxiety medications, with the potential for fewer side effects​1​.

This post is for you if tried anti-anxiety meds, Cognitive Behavioral Therapy, counseling, or psychotherapy. And are looking for a natural nootropic alternative to reduce anxiety.

Or maybe you tried talking to your doctor about how you feel and didn’t get the help you need.

It may be of little comfort, but did you know there is a 77% chance that your anxiety has been misdiagnosed as some physical problem instead?[i]

Because anxiety often manifests as sweating, trembling, nausea, abdominal problems, dizziness, insomnia, heart palpitations, accelerated heart rate, chest pain, shortness of breath, pins and needles, feeling like your losing control and/or feelings of impending doom.

Instead of dealing with the real cause, maybe you were sent down the wrong path. And are still looking for answers.

Nootropic supplements may help if you’re dealing with a genuine anxiety disorder. The kind of anxiety that has you feeling constantly on-edge and an overwhelming sense of dread.

The type of anxiety where you have difficulty concentrating, you’re irritable or restless to the point you’re avoiding family and friends just to numb yourself from feelings of worry and unrelenting doom. Stress hormones go nuts.

You know, it’s that very type of stress that makes your blood pressure rise from doing too much, or being stretched thin and depression symptoms start to peak through your window and you may even begin to manifest this unresolved energy into panic attacks? Yeah, we’re talking about that kind.

Here you’ll discover the real cause of your anxiety symptoms. And get some help dealing with how you feel. Concrete steps to take that doesn’t include meditation, yoga, Cognitive Behavioral Therapy, or psychoanalysis.

The Root Cause of Generalized Anxiety Disorder

Something may have happened that triggered the anxiety that has turned your life upside down. But if your feelings of anxiety are hanging on and won’t let go, it’s likely because of the dysfunction of neurochemicals in your brain.[ii]

It could be problems with acetylcholine, dopamine, GABA, glutamate, norepinephrine, or serotonin.

But the challenge is figuring out which neurotransmitter is causing the problem. And why drugs like benzodiazepines, SSRIs, SNRIs, TCAs, and MAOIs are often prescribed for treating anxiety.

How to Find the Root Cause of Your Anxiety Symptoms

If you have been using an anti-anxiety drug and experienced some relief in your symptoms, you have a head-start.

Because now you have a clue what could be causing your problem. And it may be easier for you to decide which nootropics to try to help you get better and reduce your anxiety.

First, become familiar with the mechanism of action (or pharmacology) of the med you are using. Find out how the drug works in your brain. Wikipedia.org is a good resource for this information.

Simply do a search of Wikipedia for your drug’s generic name. And scroll down to the section “Pharmacology”. Sometimes called the “mechanism of action”.

Once you understand how the drug works in your brain. And which neurotransmitter system it affects. Scroll down the list of nootropic supplements below.

And choose one of the anti anxiety nootropics that has a similar mechanism of action to the drug you were using. Then follow the dosage recommendations for that supplement and try it to see if you feel any anxiety relief.

Typical signs of relief can include positive cognitive performance like reduced brain fog and mental fatigue, less emotional stress, and lowered blood pressure.

Anxiety Caused by Neurotransmitter Dysfunction

Anti-anxiety meds are usually some type of benzodiazepine. Benzos work on GABA receptors. So, a nootropic that boosts GABA may help relieve your anxiety.

But if you’ve never tried using an anti-anxiety med to treat your anxiety, or have used one that didn’t work, you’re anxiety may be caused by something other than GABA.

This is where trial and error and the willingness to experiment comes into play. And this is how it works.

Start at the beginning of the list below and try the first nootropic supplement for 1 or 2 days. And see how you feel. If you experience relief from your anxiety symptoms and improved mental health, success!

Now you know which neurotransmitter to work with. You can continue using that nootropic as recommended. And look for other natural nootropic adaptogens that work on the same system.

For example, if L-Tyrosine helps relieve your anxiety symptoms then you know that dopamine is your problem. But if L-Tyrosine is not enough and only provides some relief, then look for other nootropic supplements that also affect dopamine.

Other supplements that affect how dopamine works in your brain include Oat Straw extract, Polygala Tenuifolia, L-Theanine, St. John’s wort, and Ginkgo Biloba.

But if L-Tyrosine doesn’t provide any comfort for lowering your anxiety, put it aside. And try the next nootropic on the list below for a couple of days again following dosage recommendations.

Go through the list one-by-one until you find a nootropic that helps you and relieves at least some of your anxiety symptoms.

Most of the nootropics on the list below are precursors. Which means it provides the chemical or molecule needed to make or increase levels of a specific neurotransmitter.

Let’s get started …

Neurotransmitter imbalances

Acetylcholine

Acetylcholine is your major signaling neurotransmitter and plays a critical role in learning and memory. And acetylcholine levels are modulated by levels of stress in several regions of your brain.

Acetylcholine levels also decline as you get older. You need choline for the production of acetylcholine. Not eating enough foods high in choline can also result in insufficient acetylcholine.

In fact, choline is so vital to cognition and nerve function that, without it, we couldn’t move, think, sleep or remember anything.

Studies show that acetylcholine signaling in your hippocampus regulates social stress resilience and anxiety.[iii]

The only two nootropic supplements that can effectively increase acetylcholine levels in your brain are Alpha GPC or CDP-Choline (Citicoline) used with the cofactors Acetyl L-Carnitine (ALCAR) along with Vitamins B₁ & B₅, magnesium and Vitamin D.

Alpha GPC

Alpha GPC is a precursor to the neurotransmitter acetylcholine. Alpha GPC naturally occurs in your brain as a byproduct of phosphatidylcholine (PC).

When your brain needs more choline, and the choline floating around in your brain is running low, it breaks down PC from cell membranes. And turns it into Alpha GPC.

Alpha GPC, acetyl L-carnitine (ALCAR), and phosphatidylserine (PS) provide mitochondrial support and conserve growth factor receptors.

DHA (Omega-3) combines with phosphatidylcholine (PC) and phosphatidylserine (PS) to form brain cell membranes critical for neuron generation and regeneration.[iv]

Recommended dosage of Alpha GPC is 300 mg 3-times per day.

And I use and recommend: Performance Lab^® Omega-3 which provides your brain with DHA. And Mind Lab Pro^® which provides Phosphatidylserine (PS) along with 10 other effective nootropic ingredients.

CDP-Choline (Citicoline)

CDP-Choline is a type of choline that is present in every cell in your body.

Taken as a supplement, it’s then converted to cytidine and choline in your gut. Once it crosses the blood-brain barrier it’s converted back to CDP-Choline.[v] The choline then assists cell membranes and helps create acetylcholine.

CDP-Choline is involved in memory and cognitive functions. And provides energy for the brain to conduct sustained mental effort.

Recommended CDP-Choline dosage is 250 – 300 mg twice per day. I use and recommend Mind Lab Pro^® which contains 250 mg Citicoline.

And by the way, you only need to use one to test your acetylcholine levels. Use either Alpha GPC or CDP-Choline with Acetyl L-Carnitine (ALCAR). There is no need to use both. Either one will work.

Dopamine

L-Tyrosine taken as a nootropic supplement converts into the neurotransmitter dopamine. The cofactors in dopamine synthesis include Vitamin B₆, B₉, & B₁₂, magnesium and Vitamin D.

Dopamine helps control muscle movement in your body, is fundamental to memory, attention and problem solving.

The unused dopamine can then convert into the catecholamine neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

Norepinephrine is important for attentiveness, emotions, sleeping, dreaming, and learning.

Epinephrine drives your ‘flight-or-flight’ response. It’s what prompts your reaction to dangerous circumstances, emergency situations, or in stressful situations or environments.

Sleep deprivation and extreme stressors like heat and cold can deplete catecholamine levels. L-Tyrosine restores them to preserve optimal cognition and reduce anxiety.[vi]

Recommended dosage of L-Tyrosine is 500 mg twice per day.

I use and recommend  Mind Lab Pro^® which contains 175 mg N-Acetyl L-Tyrosine along with 10 other potent and effective nootropic ingredients.

GABA

GABA (Gamma-amino butyric acid) is the most abundant inhibitory neurotransmitter in your brain. And known to counterbalance the action of the excitatory neurotransmitter glutamate.

GABA has long been recognized as the main regulator of anxiety. And the GABA neurotransmitter system is the main target of benzodiazepines and other anxiety related drugs used to treat anxiety disorders.[vii]

When GABA is taken as a nootropic supplement, and contrary to what you may have read elsewhere, crosses your blood-brain barrier, it binds with the GABA_A receptor protein complex, and acts as an agonist: inducing changes in which the permeability of the central pore to chloride ions gets increased.

The resulting chloride flux hyperpolarizes the neuron, leading to a reduction in its excitability. And producing a general inhibitory effect on neuronal activity.[viii]

Recommended dosage of GABA is 250 – 500 mg per day. I use and recommend PharmaGABA^® (Amazon) which is a natural form of GABA grown on lactobacillus hilgardii bacteria.

Glutamate

L-glutamine is a ‘conditionally’ essential amino acid and main precursor for the production of glutamate and GABA in your brain.

(NOTE: Don’t confuse glutamine with glutamate!)

Glutamine is the most abundant amino acid in your body. And is involved in many of your bodily functions. Including much of the activity in your brain.

But Glutamate is the main excitatory neurotransmitter in your brain.[ix] And the balance of glutamine and glutamate is critical for optimal brain function.

Glutamate plays various important positive roles in your brain including brain development, learning and memory.

And degenerative roles including stroke, traumatic brain injury, Huntington’s and Alzheimer’s disease, stress response, and anxiety disorders.

Glutamate mainly acts through ion channel receptors including NMDA receptors, AMPA receptors, and G protein-coupled metabotropic receptors (mGluR1-8).

Glutamate is involved in synaptic release of acetylcholine, adenosine, kappa opioid, GABA, and neuropeptides.[x]

Recent research shows that glutamate dysfunction is involved in fear conditioning, OCD, PTSD, anxiety disorder and social phobia.[xi]

Monosodium glutamate (MSG) which is used as a flavor enhancer has been linked to obesity, metabolic syndrome, and neuron toxicity that can lead to cell death causing stroke, epilepsy, schizophrenia, anxiety, depression, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS).[xii]

Eliminating your anxiety could be as simple as avoiding all foods containing MSG.

When your neurotransmitters, including L-glutamine and glutamate are in balance, you feel motivated, productive, and energetic. And you feel calm and relaxed during downtime.

When L-glutamine levels are low you feel filled with dread, you’re constantly worried, you have racing thoughts, and you’re frequently late and disorganized.

When you are in this L-glutamine slump is when you’re tempted to resort to high carbohydrate foods, and drugs or alcohol to relax.

Recommended dosage of L-Glutamine is 2 – 5 grams per day.

But remember, glutamine and glutamate must be in balance! If you suspect your glutamate levels are too high, you can get it under control by inhibiting its NMDA and AMPA receptors.

Some antidepressant drugs relieve anxiety by inhibiting NMDA receptors.[xiii]

Try the nootropics including Cat’s Claw[xiv], and L-Theanine[xv]  for inhibiting NMDA receptors. And Noopept[xvi] and many of the racetams[xvii] which inhibit AMPA receptors.

Keeping glutamate under control and helping to reduce anxiety if your condition is caused by glutamate dysfunction.

Serotonin

Serotonin plays a significant role in the development and persistence of anxiety disorders.

Several studies show that increases in serotonin increases anxiety. And when serotonin decreases you may experience a reduction in the anxiety that’s associated with OCD or PTSD[xviii].

Too much serotonin and excess serotonin signaling has been implicated in social anxiety disorders.[xix]

If you are experiencing any type of anxiety, you should avoid anything that increases serotonin. Do NOT use nootropics like L-Tryptophan or 5-HTP. Because L-Tryptophan or 5-HTP are the only nootropic supplements that can directly increase serotonin levels.

Instead, use nootropics that help modulate serotonin and bring it under control.

Bacopa Monnieri helps modulate serotonin and dopamine which produces an anxiolytic effect. Studies show that Bacopa Monnieri is as effective as the anti-anxiety drug lorazepam in reducing anxiety.[xx]

Vitamin D₃ and Omega-3s (EPA & DHA) helps control serotonin synthesis and action. EPA helps inhibit serotonin release and DHA influences serotonin receptors. While Vitamin D₃ deficiency can contribute to anxiety.

Supplementing with Omega-3s and Vitamin D₃ may help reduce anxiety.[xxi]

I use and recommend Performance Lab^® Omega-3 and Performance Lab^® (NutriGenesis^®) Vitamin D₃ + K₂

Ginkgo Biloba acts as a monoamine oxidase inhibitor (MAOI) which helps boost dopamine in your brain. Increasing dopamine can help lower serotonin levels. The result can be a reduction in anxiety.[xxii]

Rhodiola Rosea is an adaptogen that has been used in traditional medicine for thousands of years. Rhodiola Rosea enhances stress tolerance and relieves anxiety by modulating key brain neurotransmitters such as serotonin, norepinephrine and beta-endorphins (opioid neuropeptides).[xxiii]

Anxiety Disorders Eliminated

Nootropics can be a viable and potent alternative to many anti-anxiety medications.

But you first need to determine the cause of anxiety in your brain. Use the trial and error method I suggested above and work through the nootropic supplements I recommended one-by-one.

If you are not experiencing any results from taking a single nootropic, it may be that a combination of nootropics may be required to get the job done, and once the cross the blood brain barrier, have an effect.

Just remember, that the goal of experimenting is to find what works best for you is so you can determine what gets you the best results for reducing stress, improved mental energy, and reduce anxiety symptoms.

But a very strong word of caution – if you are currently using any prescription anti-anxiety or antidepressant medications. Or any medications for that matter. Research each nootropic including side effects and prescription drug interactions before using them.

You can relieve anxiety and start feeling some relief from stress, Hopefully once-and-for-all by using the right nootropic supplements.

But this will only work if you do your research. And are willing to experiment until you find the nootropic supplements that are right for you, and mental clarity will come.