Fisetin supplement
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Fisetin

David Tomen
Author:
David Tomen
9 minute read
Fisetin is anti-aging, has been shown to boost learning and memory, improve mood, reduce back & arthritic pain, reduce inflammation, improve cognition in Alzheimer’s, and reduce allergies

Fisetin (3,3′,4′,7-tetrahydroxyflavone), is a flavanol and yellow plant pigment that gives color to a variety of fruits and vegetables.[i] 

Recent anti-aging research has shown Fisetin to be the most potent senolytic compound compared to all other flavonoids. Senolytic means destroying dysfunctional cells that refuse to die.

As a nootropic, Fisetin has been found to be anti-aging, and is a powerful anti-inflammatory, antioxidant, and supports your immune system. [ii]

Fisetin helps:

  • Memory: Fisetin has been shown to increase long-term potentiation needed for encoding long-term memory.[iii]
  • Neurogenesis: Studies have demonstrated Fisetin to be the most effective flavonoid to promote dendrite outgrowth. Dendrites are the equivalent to ‘receiving antenna” on neurons and used in brain cell signaling.[iv]
  • Inflammation: Fisetin protects neurons from damage due to oxidative stress. It boosts glutathione which is your main antioxidant protecting against inflammation. And it suppresses gene expression of tumor-necrosis factor – alpha (TNF-α), interleukin (IL)-1β, COX-2, and inducible nitric oxide synthase which provides potent anti-inflammatory activity in brain microglia.[v]

Overview

Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a flavanol found in fruits and vegetables such as strawberries, apples, persimmons, grapes, onions, and cucumbers.[vi]

Fisetin supplementThe highest concentration of Fisetin is found in strawberries followed by apple and persimmon.

Fisetin has been found to be anti-tumor, antioxidant, neurotrophic and anti-inflammatory. Fisetin also helps your body and brain to produce glutathione which is your master antioxidant.[vii] [viii]

Fisetin is currently being studied for boosting memory performance in Alzheimer’s.

It is mainly being explored for its ability to slow down aging through its senolytic effects. It works to eliminate senescent (rogue) cells throughout your body.[ix]

Studies show that this polyphenol may help to reduce markers of senescence and aging.

Fisetin benefitsHow does Fisetin work in the brain?

Fisetin boosts brain health and function in several ways. But two in particular stand out.

  1. Fisetin is Anti-Aging. The most promising research and what has gained the most attention is Fisetin and its potential ability to extend lifespan.

Here is how it works. Senescent cells, which are cells that have become dysfunctional are not eliminated from your system as you age. They just hang around in your body and release toxins that injure nearby healthy cells.[x] [xi]

The accumulation of senescent cells causes inflammation which results in age-related diseases such as osteoporosis, cancer, heart disease and cognitive dysfunction.

An animal study published in 2018 showed Fisetin effectively removes senescent cells. In aging mice, Fisetin helped increase their lifespan by 10 percent.[xii] [xiii]

The Mayo Clinic are currently conducting a clinical trial with older postmenopausal women to find out if Fisetin is as effective at removing senescent cells in aging humans. And potentially extending lifespan.[xiv]

  1. Fisetin may help prevent Alzheimer’s. As you age, learning and memory decline partly because of increases in oxidative stress, inflammation, cerebral blood flow decline, Aβ accumulation, and tau tangles.

A study conducted at the Salk Institute using animal models of Alzheimer’s disease and dementia found that Fisetin helped reduce cognitive deficit in aging mice while restoring markers associated with impaired synaptic function, oxidative stress, and inflammation.[xv]

Another study showed that Fisetin helped reduce Alzheimer’s symptoms by reducing the accumulation of β-amyloid proteins which reversed synaptic dysfunction resulting in improved learning and memory.[xvi]

How things go bad

As you get older, the chemistry in your brain and energy metabolism changes.

↓ Neurons and synapses degenerate

↓ Recall, reaction time, memory, and mood diminish

↓ Cerebral circulation decreases

↓ Learning and memory decline

↑ Increased free radicals damage cells

↑ Inflammatory and oxidative stress damages brain cells

All these age-related changes are contributing factors to the neurodegenerative diseases of aging including Alzheimer’s, Parkinson’s, and dementia.

But even if things have not degenerated to such a debilitating level, Fisetin can help.

fisetin vs quercetinFisetin Benefits

Fisetin is an antioxidant polyphenol which is present in foods such as strawberries, apples, persimmons, grapes, onions, and cucumbers.

Polyphenols are among the most effective natural ways to combat aging. And to prevent the health issues that often lead to cardiovascular and neurodegenerative diseases.

Fisetin has the unique ability to increase cell apoptosis. And promotes cell death which gives way for healthy new cells to thrive.

Studies conducted using Fisetin show increased brain antioxidant levels, which helps prevent microglia from releasing inflammatory compounds.[xvii] [xviii]

Fisetin has been shown in animal studies to help prevent cancer by reducing the formation of new blood vessels in various forms of cancer which starves tumor cells of oxygen and glucose.[xix]

In other animal studies Fisetin was shown to improve memory, reduce inflammation, and prevent the loss of brain cell function. And Fisetin has been shown to reduce β-amyloid plaque buildup and prevent the loss of healthy brain cells.[xx]

And Fisetin helps your body produce Glutathione which is your master antioxidant supporting healthy immune function.[xxi]

How does Fisetin feel?

Fisetin side effectsNeurohackers who supplement with Fisetin report better focus, memory, and mood. Some say they are more alert even when they haven’t had sufficient sleep the night before.

Several Fisetin users report less back pain and less arthritic pain.

Some Fisetin users report an increase in mental clarity and overall sense of well-being.

And some say Fisetin helped reduce their allergies.

Fisetin Clinical Research

Note that nearly all clinical studies conducted with Fisetin so far have been animal studies or with cells in a petri dish.

Fisetin for depression

Anyone who suffers from depression knows the negative effects on quality of life.

Recent animal studies demonstrated the anti-depressant effects of supplementing with Fisetin.

In this study, Fisetin provided its antidepressant effects by modulation of the serotonin pathway by inhibition of monoamine oxidase-A.

Fisetin also modulates norepinephrine which may also contribute to its anti-depressive effects.[xxii]

Fisetin for memory and cognition

When aging rats were given Fisetin, they experienced an improvement in learning and memory. Studies revealed that Fisetin activates pathways in the brain involved in encoding and storing memories.

The study also showed that Fisetin prevented memory loss in mice exposed to toxins.[xxiii] [xxiv]

Fisetin for neurodegenerative disease

In one study, Fisetin improved brain antioxidant levels and prevented microglia from releasing inflammatory compounds in response to bacterial toxins.[xxv] [xxvi]

In mice with β-amyloid plaque accumulation, Fisetin improved memory, reduced inflammation, and prevented the loss of brain cell function. In mice with Alzheimer’s, it reduced β-amyloid plaque buildup and loss of brain cells. [xxvii]

Fisetin protects against stroke

Fisetin protects brain cells and reduces inflammation and damage due to stroke in mice and rats.[xxviii] [xxix] [xxx]

In a 2008 study conducted with rabbits, Fisetin prevented loss of balance, lack of energy, and uncontrolled eye movements caused by stroke. [xxxi]

Fisetin does this by reducing inflammation and brain damage after a stroke.

Another study was conducted with mice suffering from inflammation and oxidative stress caused by aluminum. Aluminum toxicity has been linked to Alzheimer’s disease. Fisetin reduced inflammation and oxidative stress in the brain caused by aluminum.[xxxii] [xxxiii]

Fisetin supports the survival of brain cells by eliminating damaged or unneeded proteins.[xxxiv]

best Fisetin supplement

Fisetin Recommended Dosage

Since all clinical studies with Fisetin were conducted with animals and not humans which means there is no established recommended dosage.

Most Fisetin supplements range from 100-500 mg a day. In clinical trials, the equivalent human daily doses of 100-1400 mg of Fisetin were used.

Fisetin easily crosses the blood-brain barrier and appears to promote cell communication in the hippocampus. A part of your brain associated with long-term memory.[xxxv]

Fisetin is fat-soluble and must be taken with a healthy fat like unrefined coconut oil to ensure absorption.

Fisetin Side Effects

Fisetin senolyticFisetin is non-toxic and supplementation is well-tolerated by most people. We do not have any human studies on Fisetin and must rely on user reviews.

And because we do not have any human studies to verify its safety, you may want to avoid using Fisetin if you are pregnant or breastfeeding.

Type of Fisetin to Buy

Fisetin supplements are available in tablets, softgels, and capsules. Capsules are typically 100-500 mg each.

Fisetin is a natural bioflavonoid and polyphenol similar to Luteolin and Quercetin.

You naturally get very small amounts of Fisetin by eating strawberries, apples, persimmons, grapes, onions, and cucumbers with the highest concentration found in strawberries.

The Salk Institute for Biological Studies who have been researching Fisetin for years own a patent for Fisetin as a memory enhancer.[xxxvi]

Fisetin is poorly absorbed by your digestive system so dietary supplement companies offer various unique solutions for enhancing absorption.

Novusetin® – by Bioriginal Food & Science Corp. located in Saskatoon, Canada – is a patented form of Fisetin sourced from the Japanese fruit wax tree and licensed to supplement companies like Doctor’s Best and Swanson.

Liposomal Fisetin is another attempt to improve absorption by encasing the Fisetin molecule in a phospholipid. And is often combined with another polyphenol Quercetin which is also thought to boost absorption.

Fisetin is fat-soluble, so consuming it with a healthy fat promotes better absorption no matter what the supplement label states.

Nootropics Expert® Recommendation

Nootropics Expert Tested and ApprovedFisetin 100-500 mg a day

I recommend supplementing with Fisetin as a nootropic supplement.

Your body does not make Fisetin on its own. So, to get its benefits you must take it as a supplement. Or rely on the tiny amount you get from strawberries.

Fisetin is especially helpful for those suffering from allergies, arthritic pain, muscle soreness after a workout, or a cold.

Fisetin is gaining a reputation as an anti-aging supplement because it helps remove senescent cells which are dysfunctional cells that if left unchecked cause inflammation, oxidative stress, and eventually neurodegenerative disease such as Alzheimer’s.

Fisetin is reported by aging neurohackers as helping with long-term memory.

Fisetin also shows promise in animal studies for helping reduce some of the symptoms associated with Alzheimer’s. So, if you or a loved one are dealing with Alzheimer’s I highly recommend trying Fisetin and see if it helps.

Fisetin is fat-soluble so must be taken with a healthy fat like unrefined coconut oil to ensure absorption.

Fisetin is also not very bioavailable so consider trying Liposomal Fisetin or a supplement containing the patented form called Novusetin®.

Fisetin as a nootropic seems to be effective starting at 100 mg up to 500 mg per day.

Dosages above 1,000 mg per day are used by some. But remember all we have are animal studies to rely on and do not have any information regarding the safety of long-term use.

 

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). “Fisetin: a dietary antioxidant for health promotion.” Antioxidants & redox signaling, 19(2), 151–162.(Source)

[ii] Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). “Fisetin is a senotherapeutic that extends health and lifespan.” EBioMedicine, 36, 18–28. (Source)

[iii] Maher P. Akaishi T. Abe K. “Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory.” Proceeding of the National Academy of Sciences U S A. 2006;103:16568–16573 (source)

[iv] Sagara, Y., Vanhnasy, J., & Maher, P. (2004). “Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation.“ Journal of neurochemistry, 90(5), 1144–1155 (source)

[v] Zheng LT. Ock J. Kwon BM. Suk K. “Suppressive effects of flavonoid Fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.” International Immunopharmacology.” 2008;8:484–494. (source)

[vi] Kimira, M., Arai, Y., Shimoi, K., & Watanabe, S. (1998). “Japanese intake of flavonoids and isoflavonoids from foods.” Journal of epidemiology, 8(3), 168–175. (Source)

[vii] Maher P. (2015). “How fisetin reduces the impact of age and disease on CNS function.” Frontiers in bioscience (Scholar edition), 7, 58–82. (Source)

[viii] Firuzi, O., Lacanna, A., Petrucci, R., Marrosu, G., & Saso, L. (2005). “Evaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetry.” Biochimica et biophysica acta, 1721(1-3), 174–184. (Source)

[ix] Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). “Fisetin is a senotherapeutic that extends health and lifespan.” EBioMedicine, 36, 18–28. (Source)

[x] LeBrasseur, N. K., Tchkonia, T., & Kirkland, J. L. (2015). “Cellular Senescence and the Biology of Aging, Disease, and Frailty.” Nestle Nutrition Institute workshop series, 83, 11–18. (Source)

[xi] Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J., … Kirkland, J. L. (2018). “Senolytics improve physical function and increase lifespan in old age.” Nature medicine, 24(8), 1246–1256. (Source)

[xii] Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’Hara, S. P., LaRusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B., … Kirkland, J. L. (2015). “The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs.”Aging cell, 14(4), 644–658. (Source)

[xiii] Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L., … Niedernhofer, L. J. (2018). “Fisetin is a senotherapeutic that extends health and lifespan.” EBioMedicine, 36, 18–28. (Source)

[xiv] “Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women (AFFIRM)” U.S. National Library of Medicine clinicaltrials.gov (source)

[xv] Currais, A., Farrokhi, C., Dargusch, R., Armando, A., Quehenberger, O., Schubert, D., & Maher, P. (2018). “

.(Source)th amyloid plaques, FFFisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse.” The journals of gerontology. Series A, Biological sciences and medical sciences, 73(3), 299–307.(Source)

[xvi] Ahmad, A., Ali, T., Park, H. Y., Badshah, H., Rehman, S. U., & Kim, M. O. (2017). “Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice.” Molecular neurobiology, 54(3), 2269–2285. (Source)

[xvii] Zheng, L. T., Ock, J., Kwon, B. M., & Suk, K. (2008). “Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.” International immunopharmacology, 8(3), 484–494. (Source)

[xviii] Cho, N., Choi, J. H., Yang, H., Jeong, E. J., Lee, K. Y., Kim, Y. C., & Sung, S. H. (2012). “Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.” Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(6), 1940–1945. (Source)

[xix] Bhat, T. A., Nambiar, D., Pal, A., Agarwal, R., & Singh, R. P. (2012). “Fisetin inhibits various attributes of angiogenesis in vitro and in vivo–implications for angioprevention.” Carcinogenesis, 33(2), 385–393 (Source)

[xx] Ahmad, A., Ali, T., Park, H. Y., Badshah, H., Rehman, S. U., & Kim, M. O. (2017). “Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice.” Molecular neurobiology, 54(3), 2269–2285. (Source)

[xxi] Ishige, K., Schubert, D., & Sagara, Y. (2001). “Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms.” Free radical biology & medicine, 30(4), 433–446 (source)

[xxii] Zhen, L., Zhu, J., Zhao, X., Huang, W., An, Y., Li, S., Du, X., Lin, M., Wang, Q., Xu, Y., & Pan, J. (2012). “The antidepressant-like effect of Fisetin involves the serotonergic and noradrenergic system”. Behavioural brain research, 228(2), 359–366 (source)

[xxiii] Maher, P., Akaishi, T., & Abe, K. (2006). “Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory.” Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16568–16573. (Source)

[xxiv] Cho, N., Lee, K. Y., Huh, J., Choi, J. H., Yang, H., Jeong, E. J., Kim, H. P., & Sung, S. H. (2013). “Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities.” Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 58, 355–361. (Source)

[xxv] Zheng, L. T., Ock, J., Kwon, B. M., & Suk, K. (2008). “Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.” International immunopharmacology, 8(3), 484–494. (Source)

[xxvi] Cho, N., Choi, J. H., Yang, H., Jeong, E. J., Lee, K. Y., Kim, Y. C., & Sung, S. H. (2012).” Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.” Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(6), 1940–1945. (Source)

[xxvii] Ahmad, A., Ali, T., Park, H. Y., Badshah, H., Rehman, S. U., & Kim, M. O. (2017). “Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice.” Molecular neurobiology, 54(3), 2269–2285. (Source)

[xxviii] Gelderblom, M., Leypoldt, F., Lewerenz, J., Birkenmayer, G., Orozco, D., Ludewig, P., Thundyil, J., Arumugam, T. V., Gerloff, C., Tolosa, E., Maher, P., & Magnus, T. (2012). “The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.” Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(5), 835–843. (Source)

[xxix] Rivera, F., Urbanavicius, J., Gervaz, E., Morquio, A., & Dajas, F. (2004). “Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship.” Neurotoxicity research, 6(7-8), 543–553. (Source)

[xxx] Zhou, C. H., Wang, C. X., Xie, G. B., Wu, L. Y., Wei, Y. X., Wang, Q., Zhang, H. S., Hang, C. H., Zhou, M. L., & Shi, J. X. (2015). “Fisetin alleviates early brain injury following experimental subarachnoid hemorrhage in rats possibly by suppressing TLR 4/NF-κB signaling pathway.” Brain research, 1629, 250–259. (Source)

[xxxi] Maher, P., Salgado, K. F., Zivin, J. A., & Lapchak, P. A. (2007). “A novel approach to screening for new neuroprotective compounds for the treatment of stroke.” Brain research, 1173, 117–125. (Source)

[xxxii] Tomljenovic L. (2011). “Aluminum and Alzheimer’s disease: after a century of controversy, is there a plausible link?”. Journal of Alzheimer’s disease: JAD, 23(4), 567–598. (Source)

[xxxiii] Prakash, D., Gopinath, K., & Sudhandiran, G. (2013). “Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity.” Neuromolecular medicine, 15(1), 192–208. (Source)

[xxxiv] Maher P. (2008). “The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity.” Archives of biochemistry and biophysics, 476(2), 139–144. (Source)

[xxxv] He, W. B., Abe, K., & Akaishi, T. (2018). “Oral administration of Fisetin promotes the induction of hippocampal long-term potentiation in vivo.” Journal of pharmacological sciences, 136(1), 42–45 (source)

[xxxvi] U.S. Patent 7897637 B2 (source)

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Join The Discussion - 45 comments

Marcie Webber
June 25, 2022

Can you take senolytic activator by itself in place of Fisetin?
Is Fisetin long term or need to be recycled?

How about the Actvator, same question, long term or recycle?
Thanks.

Reply

    David Tomen
    June 27, 2022

    Marcie, the best senolytic activators I know of are Fisetin and Quercetin. They do not need to be cycled.

    As for long-term, there are only user reports to rely on because no one is willing to pay for long-term clinical studies on natural supplements. If you use them long-term it’s best to get your labs done now and again and check your kidney and liver numbers. Just to make sure they are healthy and continue to be so.

    Reply

      Todd Beal
      December 31, 2022

      NAC detoxifies both the liver and kidneys. My mother receives chemotherapy injections every 6 weeks to reduce her rheumatoid inflammation. After failing her blood test 3 months ago for elevated liver and kidney toxins, I increased her NAC dosage (with her rheumatologist’s blessing) from 1200 mg, once daily, to 1200 mg twice daily. She passed the next blood test and has passed each subsequent test.

      Mom has severe pain from rheumatoid. In addition to the 6-week chemotherapy injections, she also takes methotrexate (oral chemotherapy drug) and 1200 mg acetaminophen 2-3 times daily. 1200 mg NAC twice daily adequately detoxifies her kidneys and liver enough to pass each toxicity blood test.

      Thanks to your NAC research, David, mom uses NAC to keep her liver and kidneys healthy. I take NAC now too, and I’ve discovered that I gain weight when I run out for an extended period of time.

      Thank you, David, for your hard work and willingness to share, explain, and instruct.

      Reply

        David Tomen
        January 13, 2023

        Thank you Todd. And my apologies for the late response. The holidays turned everything upside down on this end.

        Reply

Debbie
May 30, 2022

Hi David, where I live I can only find Fisetin made from Cotinus Coggygria and not from Rhus Succandanea. Is that an acceptable form of Fisetin?
Thanks

Reply

    David Tomen
    May 30, 2022

    Debbie, Fisetin is found in a variety of fruits and vegetables. Doesn’t matter where it comes from as long as its pure Fisetin.

    Reply

      Debbie
      June 1, 2022

      Thanks

      Reply

Steve
April 8, 2022

In terms of bioavailability, if you had to choose, Would you recommend a Liposomal Fisetin supplement over doctors best Novusetin ?
I ask because i’ve seen several Liposomal Fisetin supplements of the kind you mention in your article, and indeed they include quercetin like you say, and normally around 1000mg Fisetin (standardised to 98% pure fisetin from rhus succandanea stem).
This is in comparison to Doctor’s Best 100mg Novusetin.
This seems like a huge difference in dosage, especially as they’re around same price.

So in terms of bioavailability & crossing the BBB, which form would you recommend over the other, Dr. Best Novusetin or a Liposomal Fisetin?

Thanks for this great article, really appreciate your website.

Reply

    David Tomen
    April 8, 2022

    Steve, the benefit of using Novusetin® is you are getting a patented extract which is about as close of a guarantee that you are getting high quality. I do not believe however that they have done anything to improve Fisetin bioavailability with this extract.

    There is some evidence that when an ingredient is encased in a phospholipid (Liposomal) it improves cell bioavailability.

    Once you are done researching check the User Reviews for each supplement and see what others say about the benefits they experienced.

    Reply

Marcie Webber
February 20, 2022

Thanks for your email I stumbled on this Fisetin info which i learned heard from somewhere else and you do have an input on it.

David, you are really my very good source of healthy living. I am inspired and awfully grateful how Almighty God had used you in my life.

Through the comments here I ordered Senolytic and Fisetin of LE being a member and get $ back in rewards. I got the products yesterday and David I reviewed your article here once again today in my own pace.
I discovered the best Fisetin upon close scrutiny is the Liposomal you mentioned which I will be ordering in 3 months once my LE supply is consumed. No fillers folks! Too bad I discovered this late and am sharing with you guys there like me seeking a better quality of life.

David once again, thank you for being there. I just turned 80 years young 1/24/22 and wondering what this phase of life will be. My husband is forgoing surgery soon for bladder CA and guess the toll it brings anxious of the future sharing perhaps the suffering emotional, psychological pain and physical care which I needed the energy and strength as well as the spring of hope to bounce perfectly 10 everyday @ the breaking of the day to cope up with the challenges it brings in our senior years.

David, you are a blessing. You are the reason i am here. You are the reason to exist! Many thanks. Marcie

Reply

    David Tomen
    February 21, 2022

    Thank you Marcie.

    Reply

Ted
February 18, 2022

Hi David and thanks for this new article! I wanted to ask what you think of Spermidine? Might be a candidate for another of your reviews. Seems to be getting a lot of positive discussion on the internet lately. Really appreciate the work you do!

Reply

Juck
February 14, 2022

Hi, David! Which is better overall, Fisetin or Pterostilbene? Thanks.

Reply

    David Tomen
    February 14, 2022

    They are both polyphenols but you can’t say one is better than the other because they are different polyphenols. I suggest studying the mechanism of action and benefits of each and then decide which would best for whatever you are trying to do.

    But research has shown Fisetin to be the most potent senolytic compound compared to all other flavonoids including Pterostilbene.

    Reply

      Juck
      February 15, 2022

      Thanks for the reply, David. Another question, can I take both, PTE in the morning and Fisetin in the mid afternoon? I have both of them and I hate sidelining PTE in favor of Fisetin.

      Reply

        David Tomen
        February 16, 2022

        Why would you not take Pterostilbene with Fisetin? They are two different polyphenols providing their own benefits.

        Reply

        Juck
        February 27, 2022

        Thanks, David.

        I take Fisetin with virgin coconut oil. Would it be okay if I also take Citicoline and Centrophenoxine, both of which are water-soluble? Wouldn’t there be any trouble in absorbing the latter two supplements?

        Reply

        David Tomen
        February 28, 2022

        Juck, your body should absorb those supplements just fine. You’re taking care of the fat-soluble ingredients withy unrefined coconut oil.

        The water soluble supplements will take care of themselves even while supporting absorption of fat-soluble ingredients.

        Reply

Gary Smith
February 5, 2022

Hi David, what do you think if Double Wood’s version – Double Wood Supplements = Fisetin

Reply

    David Tomen
    February 7, 2022

    Gary, I like Double Wood and this a a good supplement. But keep in mind it is fat soluble and you need a healthy fat each time to take it to make sure it is digested and used by your system. I use a tablespoon of unrefined coconut oil.

    Reply

      Gary Smith
      February 7, 2022

      Thanks. The bottle says to take on an empty stomach. I am thinking before breakfast, even though I am hoping it will help with sleep. I continue to search for antinflammatories since Advil seems to help me sleep. It’s still okay to take with coconut oil?

      Reply

        David Tomen
        February 8, 2022

        Gary, the label is wrong. If you take it before breakfast on an empty stomach the next time you go to the bathroom your body will get rid of it unused.

        One of the most potent anti-inflammatories I know of is Curcumin. But there are plenty of others I’ve reviewed as well. Use the search function top right of the top menu and search for “anti-inflammatories”.

        Reply

        Gary Smith
        February 9, 2022

        Thanks, David. I will search for anti-inflammatories now. I have tended to have issues with curcumin. Either it exacerbates the depression or makes sleep worse. I had recently tried supplementing with white willow bark and rosemary at bedtime for sleep. It helped for a couple of weeks but then stopped.

        Other than taking fisetin with coconut oil, what is the best time of day to take it? Thanks!

        Reply

        David Tomen
        February 10, 2022

        Gary, Fisetin is fat-soluble so whatever your body does not use is stored in fat cells. So, you can take it early in the day with a healthy fat and consistent daily use means the benefits should build over time.

        Reply

David K
January 27, 2022

Are you familiar with Senolytic Activator by Life Extensions? This OK for the fisetin?

Reply

    David Tomen
    January 27, 2022

    If you mean this one: https://amzn.to/32CkI3i then yes. Life Extension claims that the Fenugreek makes Fisetin more bioavailable but we have to take their word for this claim because the study it is based on is unpublished. And this supplement also contains Theaflavins from Black Tea, Quercetin, and apigenin which all target senescent cells.

    Reply

      David K
      January 28, 2022

      Does Senolytic Activator sound like it might be worth adding?

      Reply

        David Tomen
        January 28, 2022

        David it is worth trying. The ingredients in that supplement are all backed by solid science.

        Reply

        David K
        January 29, 2022

        Thanks

        Reply

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