Are you stuck in a career that doesn’t inspire you? Or a relationship that doesn’t excite you? Or a lifestyle that doesn’t fulfill you?
Of the many excuses and issues for this complacency, one problem that surfaces the most is lack of motivation.
To make matters even worse – lack of motivation to change things that could make your life better often end up making you feel guilty and depressed.
And if left unchecked, a slow but steady spiral into long-term guilt, poor self-esteem and ongoing depression.
So what can you do to boost motivation? And where does that energy come from? That’s what we’re going to explore in this post.
We each have a limited amount of time on this planet. And no matter what stage you are in life. Realize this body will not live forever. It’s time to take back control. And learn how to change up the things you can change to create the life that you want to live.
This is where nootropics may be able to step in. And provide the brain food you need to steer you on a new path. Toward the things you want to achieve.
Table of Contents
The Neuroscience of Motivation
Dopamine and Motivation
Researchers have long known that the neurotransmitter dopamine is involved in pleasure and reward. More dopamine in your brain results in feelings of greater pleasure. And the presence of dopamine in your brain pushes you to seek this ‘reward’ of pleasure.
But researchers have recently discovered that dopamine also regulates motivation.
Dopamine provides the initiative and perseverance
needed to go after what is important to you.
In 2012, a team at Universitat Jaume I of Castellón changed the thinking and prevailing theory on dopamine. Mercè Correa said, “It was believed that dopamine regulated pleasure and reward and that we release it when we obtain something that satisfies us.
But in fact, the latest scientific evidence shows that this neurotransmitter acts before that. It actually encourages us to act. In other words, dopamine is released in order to achieve something good or to avoid something evil.”[i]
Dopamine levels vary by individual. Some people are more persistent than others when going after goals. Which you’ve likely noticed in the people around you when it comes to athletics, school and work.
Those with higher dopamine levels get more done.
Dopamine helps you to maintain the level of activity needed for what you intend. Whether it’s positive or negative. Depending on what you’re after. The goal to be a good student, or to abuse drugs.
High levels of dopamine could also explain the behavior of sensation-seekers because they are motivated to act. You see this in extreme sports. Or wildly successful musical performances.
Correa went on to say, “Depressed people do not feel like doing anything and that’s because of low dopamine levels”.
This lack of energy and motivation is also related to several debilitating health problems. Often associated with mental fatigue. Diseases like Parkinson’s, multiple sclerosis and fibromyalgia.
Slacker or Go-Getter
Another study by a team at Vanderbilt University used a PET scan to map the brains of go-getters and slackers. And they found that those willing to work for rewards had higher levels of dopamine in the two areas of the brain known to be involved in motivation and reward (striatum and ventromedial prefrontal cortex).
On the other hand, slackers had higher dopamine levels in an area of the brain called the anterior insula. This area is involved in emotion and risk perception.
This last observation came as a complete surprise to researchers. Because more dopamine in the insula is associated with a reduced desire to work. Even if it means earning less money.[ii]
Glutamate AMPA-Receptors and Motivation
Turns out that dopamine is not the only neurotransmitter involved in motivation. In 2014, researchers discovered that glutamate neurons in a specific region of your brain (dorsal raphe nucleus) activate dopamine neurons in the dopamine-reward pathway.
Glutamate receptors are associated with neural communication, memory formation and learning. When glutamate AMPA-receptors in this area of the brain (dorsal raphe nucleus) are stimulated. It ends up activating the dopamine reward system.[iii]
The researchers followed this pathway all the way through using special tracers and labeling compounds.
The reward (or motivation) pathway starts with stimulation of glutamate AMPA-receptors that connect to dopamine neurons. Which in turn follows the pathway to the nucleus accumbens. The brain structure linked to motivation, pleasure and reward.
The Motivation Missing Link in Nootropics
Common wisdom in nootropic circles (so far) advise us to boost dopamine to hack motivation. It is true that as dopamine levels rise in the nucleus accumbens (reward pathway), motivation, pleasure and reward are all affected.
But this same common wisdom would have you believe that if you boost overall dopamine levels in your brain, you’ll increase motivation. And it’s just not true.
In fact, if you increase dopamine levels too much, excess dopamine converts to norepinephrine. You get irritable and can’t sleep.
The missing link in this dopamine → reward → motivation pathway are glutamate AMPA-receptors.
Rather than boosting overall dopamine levels and hoping for the best. We need to encourage stimulation of glutamate AMPA-receptors to in turn, fire up dopamine neurons. And send dopamine on its way to the nucleus accumbens.
Best Nootropics for Motivation
We know that dopamine is critical to motivation. In the lab, researchers have demonstrated that without enough dopamine, rats starve themselves to death. Despite having access to food.[iv]
But in our world it’s doubtful that you have problems with motivation to eat. Or drag yourself out of bed in the morning. So basic dopamine levels are likely not an issue.
But what about changing course in an unfulfilling career? Or getting started on that book you want to write? Or plowing through boring and tedious work that’s just part of the job?
To successfully tweak and boost motivation, you need to address the efficiency of the dopamine – motivation pathway. And this is where many of the racetam nootropics come to the rescue.
Here’s a brief list of the most potent nootropics that we’ve discovered so far that will boost motivation. First on this list is ensuring we have enough dopamine available because it’s an integral part of the dopamine – motivation system. The rest of this list of nootropics are supplements that can influence your glutamate AMPA-receptors. And modulate the effectiveness of the main neurotransmitters that affect the motivation pathway in your brain.
- L-Tyrosine – Your brain converts L-Tyrosine to L-DOPA which then produces the neurotransmitter dopamine. The unused dopamine is then further converted into the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). This triad of neurotransmitters are collectively referred to as “catecholamines”.
L-Tyrosine enhances working memory and executive function in the prefrontal cortex. It helps with creative flow states, is fuel for inspiration, motivation, cognitive flexibility, and the kind of “convergent thinking” you do in multiple choice exams.
- Aniracetam – This member of the racetam-family of nootropics is very well known for helping anxiety and depression. And one of my favorites.
This fat-soluble ampakine nootropic affects acetylcholine levels in the brain. It activates D2 and D3 dopamine And Aniracetam modulates AMPA receptors.[v] Leading to better cognition, memory and motivation.
- Iodine – This essential trace element combines with tyrosine to form thyroid hormones T4 and T3. Thyroid hormones affect every cell in your brain and body. Within your brain, T4 is converted to T3 by selenium which then affects gene expression controlling metabolism within cells. And activates dopamine, norepinephrine and epinephrine.[vi]
It’s highly unlikely that you’ll see Iodine on any nootropic list to boost motivation. But a malfunctioning thyroid which is often caused by not enough iodine results in poor cognition, difficulty learning, problems with recall, depression, anxiety and certainly a lack of motivation.
- Nefiracetam – This fat-soluble racetam nootropic is structurally similar to Aniracetam. Nefiracetam increases the amount of time calcium channels in neurons remain open. Enhancing signaling in the pathway critical for long-term potentiation and forming long-term memories.
Nefiracetam also potentiates protein kinase C alpha (PKCα) which is involved in long-term potentiation (LTP).[vii] PKCα is dependent on glutamate signaling. And Nefiracetam activates Ca2+/calmodulin-dependent protein kinase II (CaMKII) which is critical in memory formation.[viii] Again dependent on glutamate signaling. Remember, glutamate signaling fires dopamine neurons which leads to a boost in motivation.
- Noopept – This peptide-derived nootropic related to the racetam-family, Noopept increases BDNF, stimulates dopamine, nicotinic and serotonin receptors.[ix] Boosting energy, cognition, memory, logical thinking, mood and motivation.
Noopept also boosts Alpha and Beta brain wave You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.
- Oxiracetam – This water-soluble ampakine nootropic in the racetam-class of compounds modulates AMPA receptors.[x] Oxiracetam increases acetylcholine And boosts ATP synthesis in brain cells.
Oxiracetam significantly improves cognition, memory, sensory perception, reflexes and motivation.
- Phenylpiracetam – This water-soluble nootropic in the racetam-class of compounds is known for its stimulatory effects. It increases the density of acetylcholine (ACh), NMDA, GABA and dopamine receptors in the brain.[xi] More receptors mean more binding sites for neurotransmitters that affect memory formation, cognition, sleep, mood and motivation.
Similar to Noopept, Phenylpiracetam has been shown in clinical studies to affect Alpha and Beta brain waves. And like Ritalin or Adderall, this nootropic increases the effectiveness of dopamine in your brain. Increasing alertness, decision-making capability, cognition and motivation.
- Piracetam – The first racetam ever developed, this nootropic modulates AMPA and NMDA receptors.[xii] And boosts the flow of acetylcholine (ACh), sensitivity and density of ACh receptors in your brain.
Piracetam also boosts cerebral blood flow. Delivering more oxygen and nutrients to neurons. Improving neural signaling, cognition, memory, focus and motivation.
- Pramiracetam – A derivative of and more potent than Piracetam, Pramiracetam stimulates choline uptake in your brain. And has a profound effect on the synthesis of the neurotransmitter acetylcholine (ACh).[xiii] Boosting energy levels, providing focused stimulation for better mental drive and motivation.
- Resveratrol – Resveratrol is a polyphenol that some plants produce in response to stress, such as injury or fungal infection. Recent research shows this polyphenol works like an ampakine nootropic in the brain.
Resveratrol is an inhibitor of enzyme PDE4 (Phosphodiesterase-4).[xiv] Studies demonstrate that when you inhibit PDE4, you raise levels of cAMP in the brain. cAMP-dependent pathways in the brain activate AMPK (AMP-activated protein kinase).
Inhibiting PDE4 and boosting cAMP also makes the effect of normal dopamine production more effective. Boosting processes in this stream of chemical pathways in the brain increases learning, memory and motivation.
- Rhodiola Rosea – In Russia, Rhodiola Rosea is widely used as a remedy for fatigue, poor concentration, and decreased memory. It’s also believed to make workers more productive. Research shows Rhodiola can increase attention to detail-oriented tasks by improving concentration over a prolonged period. The ideal study nootropic.
Rhodiola Rosea stimulates your nervous system to fight fatigue that stifles mental clarity. And studies show it even saves injured neurons. And encourages the growth and development of brain cells (neurogenesis).[xv]
Any kind of fatigue you experience – regardless of source – Rhodiola Rosea is like your “magic bullet”. Mood, energy, stamina, concentration and motivation can all increase with a dose of this herb.
- Sulbutiamine – Synthesized in the lab from Vitamin B1 (thiamine), Sulbutiamine is another favorite of mine because it boosts memory, motivation and is a heck of an antidepressant.
Thiamine is essential for producing the neurotransmitter acetylcholine (ACh).[xvi] ACh is used to relay messages between neurons in your brain. And is critical for cognition, learning, memory and motivation.
Final Notes on Motivation
If you’ve ever felt mentally drained after writing an exam, an intense study session, a misunderstanding with your partner, or working out a business problem – select 2 – 3 nootropics from the list above for your nootropic stack.
Or save some time and money and get a bottle of Mind Lab Pro® which contains an effective dose of N-Acetyl L-Tyrosine to raise dopamine levels in your brain. As well as Rhodiola Rosea which is widely used as a remedy for a lack of motivation, fatigue, poor concentration, and decreased memory.
And if a lack of energy is holding you back, try a bottle of Performance Lab® Energy which helps your brain produce the fuel it needs for better motivation.
Energy and motivation go hand-in-hand.
When I’m energized, it usually translates into motivation to get things done. When energy stores are depleted in my brain and body, I’m burned out and nothing much is going to happen.
Mental fatigue has a variety of causes. Depleted neurotransmitters can cause fatigue as well as a host of other issues. A lack of Adenosine Triphosphate (ATP) which is the energy source for brain cells is another cause of mental fatigue. And leads to neurodegenerative disease.
Hormones that are out of balance can cause fatigue. And poor cerebral circulation which provides oxygen and nutrients to brain cells can result in fatigue.
The amount of available mental energy in your brain has a direct influence on your cognitive performance.
So now that you know how the motivation pathway works in your brain. Add two or three of the nootropics suggested in this post. Or just get some Mind Lab Pro® and Performance Lab® Energy. And instead of feeling guilty for being a slacker, join the go-getters who are living life to the fullest.
[i] Correa M., Salamone J.D. “THE MYSTERIOUS MOTIVATIONAL FUNCTIONS OF MESOLIMBIC DOPAMINE” Neuron 2012 Nov 8; 76(3): 470–485. (source)
[ii] Treadway T.T. et. Al. “Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making” The Journal of Neuroscience, 2 May 2012, 32(18):6170-6176 (source)
[iii] Qi J., Zhang S., Wang H.L., Wang H., de Jesus Aceves Buendia J., Hoffman A.F., Lupica C.R., Seal R.P., Morales M. “A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons.” Nature Communications. 2014 Nov 12;5:5390. (source)
[iv] Berridge K.C., Robinson T.E. “What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?” Brain Research; Brain Research Reviews. 1998 Dec;28(3):309-69. (source)
[v] Testa B., Mayer J.M. (1 August 2003). Hydrolysis in Drug and Prodrug Metabolism. John Wiley & Sons. pp. 109–. ISBN 978-3-906390-25-3. (source)
[vi] Peterson A.L., Gilman T.L., Banks M.L., Sprague J.E. “Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).” Synapse. 2006 Apr;59(5):317-9. (source)
[vii] Malenka R.C., Kauer J.A., Perkel D.J., Nicoll R.A. “The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation” Trends in Neurosciences Volume 12, Issue 11, p444–450, 1989 (source)
[viii] Moriguchi S., Han F., Shioda N., Yamamoto Y., Nakajima T., Nakagawasai O., Tadano T., Yeh JZ, Narahashi T., Fukunaga K. “Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice.” Journal of Neurochemistry. 2009 Jul;110(1):170-81 (source)
[ix] Ostrovskaya R.U., Gudasheva T.A., Zaplina A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., Seredenin S.B. “Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bulletin of Experimental Biology and Medicine. 2008 Sep;146(3):334-7. (source)
[x] Copani A., Genazzani A.A., Aleppo G., Casabona G., Canonico P.L., Scapagnini U., Nicoletti F. “Nootropic drugs positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors in neuronal cultures.” Journal of Neurochemistry. 1992 Apr;58(4):1199-204. (source)
[xi] Firstova Y.Y., Abaimov D.A., Kapitsa I.G., Voronina T.A., Kovalev G.I. “The effects of scopolamine and the nootropic drug phenotropil on rat brain neurotransmitter receptors during testing of the conditioned passive avoidance task” Neurochemical Journal June 2011, Volume 5, Issue 2, pp 115-125 (source)
[xii] Stoll L., Schubert T., Müller W.E. “Age-related deficits of central muscarinic cholinergic receptor function in the mouse: partial restoration by chronic piracetam treatment.” Neurobiology of Aging. 1992 Jan-Feb;13(1):39-44. (source)
[xiii] Brust P. “Reversal of scopolamine-induced alterations of choline transport across the blood-brain barrier by the nootropics piracetam and pramiracetam.” Arzneimittelforschung. 1989 Oct;39(10):1220-2. (source)
[xiv] Li Y.F., Cheng Y.F., Huang Y., Conti M., Wilson S.P., O’Donnell J.M., Zhang H.T. “Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.” Journal of Neuroscience. 2011 Jan 5;31(1):172-83 (source)
[xv] Panossian A., Wikman G., Sarris J. “Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.” Phytomedicine. 2010 Jun;17(7):481-93. (source)
[xvi] Martin P.R., Singleton C.K., Hiller-Sturmhofel S. “The Role of Thiamine Deficiency in Alcoholic Brain Disease” National Institute on Alcohol Abuse and Alcoholism nih.gov Retrieved April 7, 2016 (source)
As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.
Dear David, I wrote you a long comment (sorry for that) asking for help, it was a few weeks back & would appreciate your input on it.
David Tomen says
Fred, I must have missed your comment. If it was too long the system likely just deleted it. That’s not really what this comments section is for. Keep it as brief as you can and I’ll try to answer.
Kevin Dean says
I’m 48, nearly 49, and my life has spiralled out of control. Xmas is upon me and I’m sat at home alone surrounded by boxes and I’m knee deep in trash. I’ve had days in my kitchen. I eat little other than processed sugary food for a hit.
I’ve pleaded with my doctor for help. I’m ADHD (combined, UK Psych speak for pure, old skool, ADHD), I’ve suffered depression anxiety all my days, have chronic sleep problems and no routine in life. I’m prescribed 70mg Lisdexamphetamine daily, with 40mg Duloxetine and a stack of vitamins and minerals etc. I’m now suspected autistic/absorbers due to high IQ.
I can no longer move for fear of not doing whatever perfectly. I crashed last summer when I just wanted the world to leave me alone, but there’s no getting away.
Social services have supposed to be helping me but nothing forthcoming. I’m now presently losing the will to finish this message so I’ll be quick. I’ve no motivation, no clarity and feel like dirt both to myself and to how I’ve behaved toward others. I hold myself to extreme standards, but these are no longer enough.
The few people I knew and loved have gone. Social Services are not here unless you are over 80. I’ve just began looking at Ashwagandra, Curcumin, CBD etc for an answer, but the endless possibilities I could handle cognitively even 2 years ago now turn my head to putty.
I’m desperate for some clarity, to stop my kinds endless jabber sending my ideas in circles until I’m out of mental energy.
I need an intervention by someone/something. Nootrpic? Can I buy it herein the Uk?
David Tomen says
Kevin, I hear you and yes, nootropics likely could help you. But first, you need to find out the source of the problem. Otherwise, you’re guessing and hoping for the best. Nothing works that way.
If I was in your situation and could not figure it out on my own I would look for a naturopathic doctor who was willing to work with me. Until we found out what was wrong physically. And then make recommendations on what to start with.
The key to success with nootropics is trial and error. That is trying something to see if it works. If not then try the next supplement. And then the next, etc. Until you find something that makes you feel a little bit better.
Then you find out everything you can about that one thing that made you feel a little bit better. Find out exactly how it works. And find other supplements that do a similar thing in your brain and body.
If you are truly ADHD then follow the protocol described in this article exactly and see if you feel better: https://nootropicsexpert.com/best-nootropics-for-adhd-add/
Depression and anxiety are two very different things. Here’s information about depression: https://nootropicsexpert.com/best-nootropics-for-depression/
And here is information on anxiety: https://nootropicsexpert.com/best-nootropics-for-anxiety/
But I suggest you pick one problem first and work on that. Otherwise, you’ll be overwhelmed and not get anything done. Do this while you are looking for a new doctor or medical professional who is willing to listen to you.
Is there any way nootropics can help everyone who’s feeling lethargic all the time?
I’ve used several nootropics, from Rhodiola to L-Dopa. Those all work for 2 hours maximum then I feel lethargic again.
Seems like I’m about to or already developed Serotonin Syndrome or something similar. Bromocriptine works for maximum 4 hours.
Is there any fix at all?
(I’m not feeling low in energy, but just not getting the will power or motivation to work or do anything. If a tiger chases me for example, then I would suddenly get into F&F mode and do whatever is necessary).
I’m bipolar type 1, in this 2 types of moods are present, extremely low mood and extremely up mood. In my case, I get extremely lethargic and extremely energetic time to time. The problem is, nowadays the extremely energetic mood is coming very less often.
Putting 10mg of Camphor under my tongue works, it gives me the extreme energy that I need, but soon after using it, like 4 hours after being in a high energy state, I start to feel anxious and depressed at the same time. Terrible thoughts come in my mind, I start to worry about small things which no-one does. That’s why I don’t use Camphor unless it’s very necessary.
David Tomen says
Troy, try something like Noopept with Alpha GPC which should boost your productivity. Nothing is going to work for any more than 2 – 4 hours no matter what you try. Other racetams may help as well. Aniracetam, Oxiracetam etc. https://nootropicsexpert.com/the-top-7-racetams-which-one-is-best/
But your most fundamental source of energy comes from your mitochondria. If your mitochondria are not producing ATP like they should nothing else will work. See one of my posts on “energy” like this one for example: https://nootropicsexpert.com/best-energy-supplements-to-buy-in-2020/
And Camphor is made from turpentine. It should NOT be used internally. It’s been shown to cause liver damage even when used topically.
I have a question, what do you think about adrenal fatigue or chronic fatigue? I talked with a few good doctors about using nootropics in order to cope with my lack of energy, motivation, concentration, verbal fluency and with my anxiety, but all of them told me that medium and long term use of nootropics can back fire, especially when taking in consideration the function of hypothalamic–pituitary–adrenal axis, because all these nootropics also stimulate the use of the bodies naturally produced endorphins, and have similar effects like illegal drogs do, that make you even more tired and fatigued after you used them, especially when you are suspected of adrenal fatigue. So what’s your angle on this? Thanks a lot!
David Tomen says
Silviu, it’s BS and they have no idea what they’re talking about. I’ve been using nootropics daily for the last 13 years and they saved my life. We have tens of thousands in the Nootropics Expert community who will tell you the same thing.
OMG! Lack of motivation seems so much more on point than other considerations such as 1. lack of focus or 2. brain fog/ fatigue or any of a houndred terms I and others have labeled me with.
I can understand why my Anterior Insula is a cave to which I retreat for comfort even as my deficiencies lead to the rest of the world falling down around me.
This article on motivation is another point of possible salvation.
I am in the process of purchasing some of the items referenced in your article.
I have a jug (500 G) of L-Glutamine. Can I use it as a Glutamate source?
David Tomen says
Howard, happy to hear that this hit home for you. Remember, the key here is to activate AMPA receptors which in turn activates the dopamine/reward/motivation pathway in your brain. Miss the first part and no motivation.
L-Glutamine is the main precursor for the production of the neurotransmitters glutamate and GABA (γ-aminobutyric acid) in your brain. So yes, you can use L-Glutamine to raise glutamate.
Howard Walters says
Thank you David.
I have started 5g of L-Glutamine with 800 NALT two times per day. waiting for results and the delivery of some of the Motivation nootropics you mentiones in the article.
Do we wait days for nootropics to produce effects or are their intended effects relatively immediate.? In other words, are we waiting for the nootropics to reach a certain concentration or should we see relatively immediate effects once the nootropics are in the blood and engaged with the relevant chemical pathways?
David Tomen says
Howard, good question and some of the amino acids like NALT begin to work within 15 minutes. But continued daily use does help your brain eventually stabilize into a new, healthier ‘normal’.
So some of the effects you should feel right away. And it gets better the longer you use these supplements.
I take 1500 mg of Berberine and 1200 mg of Quercetin devided in 2 doses ( early morning and mid afternoon). These effectively help my desire to avoid hunger and eat only one meal per day. I have not measured it lately but I believe they keep me in ketosis until my feeding window at 4 to 8 pm.
My question is how might Berberine and Quercetin affect the motivation nootropics mentioned in the article above?
David Tomen says
Howard, Berberine has been shown to activate AMPA receptors and which I didn’t include in the suggested nootropics above because I wrote this post before I reviewed Berberine. I should add it to the options and thanks for the reminder.
I haven’t done the research on Quercetin yet. But a quick search hinted that it may be effective as well.
First of all thank you for such a great, detailed nootropic site with your own experiences.
I am currently using modafinil and it seems to work. Also i am planning to use rhodiola rosea for chronic fatigue, depression and motivation.
Should i add ginseng besides these? Should i use all of them together?
What would you suggest with rhodiola rosea to use for motivation and energy?
I can’t find all the substances in my country as some of them are forbidden. So i can find ALCAR, L-tyrosine, ginseng, rhodiola rosea, modafinil, piracetam etc.
David Tomen says
Hakan, the only things missing from your stack to support Modafinil use is a good choline supplement like CDP-Choline (Citicoline), a high quality B-Complex supplement and DHA (Omega-3).
Please see the individual reviews for each of those to understand why I’m recommending them. And yes, you can use this stack together but be careful with the dosage of each. Use the lowest recommended dose to start and be aware that some of these nootropics need to be used at least twice or 3-times per day. Especially if stacked with Modafinil.
Thank you for the fast reply David.
So my stack will be like this:
Modafinil, rhodiola rosea, ginseng, DHA, CDP-Citicoline, B-complex
So using all of them together won’t cause any trouble right?
Also didn’t understand this:
“be aware that some of these nootropics need to be used at least twice or 3-times per day. Especially if stacked with Modafinil.”
So should i use more dosage like twice or 3-times per day? or should i split the dosage to 2-3?
David Tomen says
Hakan, see my response to your first question in the Rhodiola Rosea thread please before you use Rhodiola.
DHA 1,000 mg is dosed in the morning, Ginseng 1 or 2-times per day, B-Complex in the morning and CDP-Choline 300 mg 2 or 3-times a day.
Thank you David.
I think i can’t find CDP-Choline in my country, is there a substitute for it?
David Tomen says
Hakan, you do have other options. See my post on choline here: https://nootropicsexpert.com/advanced-guide-to-choline-in-nootropic-stacks/.
A direct substitute is Alpha GPC. And if that’s not available you can use Choline Bitartrate or Choline Citrate but at much higher doses.
Thanks again, i bought ginseng, rhodiola rosea and can buy alpha gpc options in powder form.
How should i use them? should i mix and diffuse them with fruit juice or water? Or can i put them in mouth first with a teaspoon then drink water over it?
David Tomen says
Hakan, I suggest putting it in yogurt, a smoothie or juice and NOT trying to wash it down with just water. It helps to have some ‘fat’ with it so yogurt would be your best option. Unless you had the capacity to make your own capsules which is what I do.
Thanks again for your detailed replies. I am trying to find the substances you recommended for my stack.
So adding any of these supplements below would be beneficial or useless for my stack?
L-Theanine, Pine Bark Extract, Bacopa Monnieri, Lions’ Mane.
David Tomen says
Hakan, all would be beneficial. Depending on your cognitive goals I’d put them in order of priority from highest to not as high: Pine Bark Extract, Lion’s Mane, L-Theanine, and Bacopa Monnieri.
I am using rhodiola, ginseng both powder forms with a 1/3 teaspoon for each a week so far no issues. (approximately 600 mg) But i couldn’t get much energy sometime i fall asleep.
I am trying to order DHA, b complex, alpha gpc to complete the stack from amazon or iherb.
I have to re-read sentences 2-3 times to understand exactly nowadays.
Should i add ALCAR and PS to the stack or above is enough?
Also someone told that, i should have tolerance to dopamine, noradrenaline because of stimulants like modafinil and memantine could reset them. Do you have any knowledge about memantine?
David Tomen says
Hakan, if you think your receptors have become desensitized from using stimulants it’s possible to ‘re-sensitize’ them. DHA, rhodiola, ginseng and the B-Vitamins will help.
L-Tyrosine and N-Acetyl L-Cysteine (NAC) will also help. Mind Lab Pro is also a good choice because it contains L-Tyrosine, Phosphatidylserine (PS), and Lion’s Mane Mushroom (https://nootropicsexpert.com/mind-lab-pro-review/). If you do MLP then I’d just add NAC.
ALCAR is also a great choice because you need the Alpha GPC, ALCAR and the B-Vitamins to synthesize acetylcholine. Adding ALCAR will also help with energy. And this entire stack should eventually help you to avoid having to re-read sentences because it supports short-term memory and brain cell signaling.
I have read that most amino acids should be taken with empty stomach to get better benefits.
So should I get ALCAR, glycine, creatine, l-theanine on empty stomach? Also can I get ginseng and rhodiola with them before meal?
David Tomen says
Hakan, it’s better to take amino acids an hour before food. Because otherwise, they’ll be competing for the same amino acid transporters as the amino acids in your food. And someone will loose out. Either you won’t get the full benefit of the supplement. Or you won’t get the nutrition you need from the meal.
Ginseng and Rhodiola Rosea are likely better if used with a healthy fat. Like unrefined coconut oil or MCT Oil. Because there are compounds in those supplements that are fat-soluble.
Hello David, I was comparing this article to your “Best Nootropics 2020” article, which recommended ALCAR, Alpha Lipoic Acid, Caffeine, CDP-Choline, Rhodiola, CoQ10, and PQQ for energy and motivation. There seem to be differences in the recommendations. Which ones would you most highly recommend to try and in what combination?
Also, are there any pre-made stacks for motivation that you’d recommend?
Thank you very much for any insights on this.
David Tomen says
Daniel, the recommendations on the Best Nootropics page were meant to provide choices. Energy and Motivation are two separate subjects as you can tell by reading the above post.
The best pre-made stack for energy in my opinion is the Performance Lab Energy stack which includes the right dosages of ALCAR, R-Lipoic Acid, CoQ10 and PQQ.
The key to motivation is activating the dopamine-reward pathway via stimulation of glutamate AMPA-receptors. Options for doing that are included in this post.
Very excited about finding your work. Would like your suggestions regarding the Nootropics to try. I would like to try Iodine then one of the following –
I have a lot of PTSD throughout my life. A concussion back in 2001 which I haven’t fully recovered from. Can’t handle stress, have trouble socializing. No recall of my childhood or the movie I saw last year or last week. Have lost all desire as an artist. I do not have low energy, but do have low motivation, low self esteem. Do not feel depressed but do not feel joyful either. I cannot eat turkey-get cramps and complete loss of energy and sleep long hours(I figure it is the tryptophan)
David Tomen says
I suggest first checking out my post on PTSD here: https://nootropicsexpert.com/treating-post-hurricane-ptsd-with-nootropic-supplements/
The symptoms you are describing include what’s often called “anhedonia”. Do a search here on Nootropic Expert and you likely find reference to it in at least a couple of places. It’s kind of a sub-category of lack of motivation.
One of the best nootropics I’ve found for “getting things done” is Noopept. It is often included in the list of racetams but is not a true racetam. But boy does it work if dosed properly including using it with Alpha GPC or CDP-Choline.
Some of your symptoms could be low levels of dopamine, GABA and/or serotonin. I’d try a precursor as well for each of those but one at a time and see if you get any positive effect. For example; L-Tyrosine for dopamine, GABA for GABA (duh), and L-Tryptophan for serotonin.
I’ve also found the inflammation can be at the root of a lot of the symptoms you are describing as well. Esp. if you are truly dealing with PTSD. I suggest choosing a couple of nootropics to get inflammation under control as well. Lots of options here but you could start with Pine Bark Extract and Curcumin.
First of all, I would like to thank you David for the so helpful information that you provide on your website!
I am an adult ADD with depression tendencies (used to have chronic heavy depression), social anxiety, several addictions (such as porn and internet addiction), and honestly, who knows what else. I used to live most of my life in a country where you can’t get much of a professional help in these areas, so I am mostly self-educated. I tried several ways to deal with all that, including motivational techniques, then (when I discovered my ADD) I went to Neurofeedback practitioner. That actually helped a lot, but it was very expensive to say the least and after several years under some serious stress I realized that some of the symptoms have resurfaced.
Then I started to delve into life hacking which brought me to the nootropics. Now, it’s been a bit more than half a year and my stack is something like this:
– NAC (x2/day)
– Curcumin with BioPerine
– Chelated Magnesium
– DHA 1000mg
– Coconut Oil
– Performance Lab Whole-Food Multi
– Mind Lab Pro
– Performance Lab Energy
– Performance Lab Prebiotic
I have tried Forskolin/Artichoke (LifeExtension), but it didn’t do much, so I consider stopping it. Dopa Mucuna (Now) had some interesting effects, but it was horrible for my porn addiction. I continuously relapsed during my time taking it and couldn’t recover for a long time. Now I am very reluctant if I should even give it another chance.
Basically, I have improved a lot when it comes to concentration, memory, attention, energy. My brain fog disappeared completely (well, unless I am relapsing with my porn addiction) and I can work for hours heavy physical work.
My biggest worry is motivation. I still have problems with organizing myself and get things done. Having future goals is pretty much beyond me and that is devastating for my daily life.
So, I am not really sure where to go from here on.
1. Should I concentrate on my ADD and increase NALT and ALCAR or start experimenting with racetams?
2. I am considering L-Phenylalanine and Uridine. Would that help with my current stack?
3. I am also interested in Sulbutiamine, but I am very hesitant, because I’ve read it could be problematic for people with addictions.
4. Should I add a B-complex next to the Whole-Food Multi I am currently taking?
David Tomen says
Kris, you are on the right track. One of the side effects of prescription L-DOPA which is similar to Mucuna is addiction to gambling, porn, etc. But I haven’t heard that associated with L-Tyrosine or NALT. If you are ADD then you very likely require additional dopamine. You are getting some from Mind Lab Pro but it’s likely not enough.
You’ve likely read my post on ADD here: https://nootropicsexpert.com/best-nootropics-for-adhd-add/
Motivation is associated with the dopamine pathway but just raising dopamine doesn’t solve the problem. Here’s why: https://nootropicsexpert.com/hacking-motivation-with-nootropics/
For now, please read those post until you understand exactly what you are dealing with. Then concentrate on your #1 and #4.
Naveen India says
I can give u a suggestion, use modafinil (100-200 mg) along with or without the above stack…Im not a medical professional or nootropics expert like David but moda helped me to mask ADD completely.. social insecurity along with depression too subsided.. taking caffeine along with this may cause anxiety.. nootropics i uses now is moda,ashwagandha,bacopa… to cycle moda, Im planning to use caffeine+ L theanine as a modafinil substitute for 2-3 weeks or maybe a month..and u should stop porn and masturbation with this ADD.. having real sex isnt a problem in my experience..
I’ve been diagnosed as bipolar and a recovering drug and alcoholic
I’m currently on lexipro 20mg-levetiracetam 1500mg-lamotrigune 200mg daily and on Keto diet
I’ve started using your supplement stack performance lab sleep 2 caps-vision 1 cap-prebiotic 3cap-mind 1 cap twice day-energy 1 cap twice day-men’s whole food multi 2 caps twice day -mind lab pro 1cap twice a day-bulletproof coffee in morning- L-theanine depending on jitters from caffeine
What should add or take away to this for better memory and brain health-I have a better alertness and no brain fog after my morning routine
My day starts at 4 am-9 PM -Thursday-friday 2am-9 PM-Saturday 4 am-9pm Sunday 2 am -8pm
Friday -Sunday I’m on a plane for 4 hours down and 4 hrs back on Sunday
David Tomen says
Bob, looks like you are on the right track so far. For better memory and depending on your age you may want to consider adding ALCAR, NALT, and a high quality B-Vitamin Complex (https://amzn.to/2TxlHvQ). And consider the Artichoke Extract and Forskolin stack.
Check each of the separate reviews for dosage for all of these: https://nootropicsexpert.com/nootropics-list/
And each time you take your supplements, use a tablespoon of unrefined coconut oil.
When you’re on the plane, read through the following post and hopefully it doesn’t melt your brain: https://nootropicsexpert.com/best-nootropics-for-learning-and-memory/. It’s a rather deep-dive into how memory works.
I also suggest you learn the exact mechanism of action for each of the prescription meds you are using. Wikipedia is a great source for this research. That way you keep yourself out of trouble and not be tempted to try something that is contraindicated with any of those drugs.
J. Wat says
Hi David and Nootropics Community!
I greatly appreciate your work and it’s quality.
I decided to reach out today because I am having a motivation problem that appears rare when I look over the internet. I am already a fan of Nootropics and I take them for college.
A little about me, I’m a female, engineering student, 32 years old, also working at an engineering firm.
I have a problem with oversleeping. The reason this seems rare, is that I have the trouble waking up and sleeping 9-12 hours a night like depression usually caused (I don’t want to start my day), but I had a therapist give me a full panel of psychological testing and they confirmed that I don’t have depression, I do have anxiety and an OCD related personality disorder to boot.
The internet would tell you that depression equals oversleeping and anxiety equals insomnia. Over and over I read that is the typical way it goes. So I think what I’m experiencing is uncommon, but I’ve been clinically checked by a professional and it’s definitely anxiety, not depression.
It’s not that I’m unambitious, as you can see in my lifestyle, but I have to take things slow to not get overwhelmed and the overwhelm from anxiety, overthinking, hesitation to act, and fear over beginning my day… really all hits me in the mornings.
I have noticed that the more overwhelm and conflict I feel about navigating my schedule, the more I oversleep.
I was hoping to hear your insights and maybe you someone from Nootropics expert could send me an email with tips.
Tryptophan 2-3g is something I take Sunday nights to start off the week. It helps a lot an reduced my sleep time. If I take it multiple days, I can get more daytime grogginess than I want.
Other supplements/Nootropics I already take:
*5mg B5(Calcium D-Pantothenate)
*250mg Acetyl-L-Carnitine Hydrochloride
*150mg Cognizin ™
* 60mg Phosphatidycholine
*25mg ALA Alpha Lipolic Acid
*200mg DHA omega (From Algae)
*300-400mg Bacopa Monnieri (with standardized 25% bacosides A&B).
I was a fan of Lions Mane when I took it, in the MindLabPro stack, which I do not have at home right now, but I never stopped with the oversleeping and overwhelm.
Ginko and St. John’s Wort didn’t help much.
Green Tea helps a lot with anxiety feelings.
This oversleeping and overwhelm is really holding me back from my potential an sometimes jeapordises my goals and values.
Please, PLEASE, offer ideas. Thank you.
David Tomen says
J. Wat, you are already on the right track but I suggest you check the full review for each of the nootropics you are taking now. And increase your dosage to what’s recommended in each of those reviews.
Please see this post on anxiety for other ideas: https://nootropicsexpert.com/best-nootropics-for-social-anxiety/
Reduce your dosage of L-Tryptophan to 500 mg and take it every night about 90 mins. before bed. And see this post on other suggestions for sleep (including magnesium): https://nootropicsexpert.com/best-nootropics-for-sleep/
And check out my review for CBD Oil: https://nootropicsexpert.com/cbd-oil/
First of all, thank you for the amazing and solid information you put out and keep up the great work!
Secondly, and this might seem like a stupid question, but is it wise/recommended to ingest all of the nootropics mentioned in this article all at once? or will this create some sort of negative interaction?
David Tomen says
Alex, I suggest trying one of the racetams with Alpha GPC or CDP-Choline as per the dosage instructions specific to that racetam. And add Rhodiola, Resveratrol, and possibly iodine and see how the stack works for you.
You definitely don’t want to use all of the racetams in this list at once.
At age 4 months my son had menigacoccal meningitis, its very difficult to say as he was so young, but he slept very well and was very calm baby prior to this, from hospital he seemed unsettled and didn’t sleep very well, this has continuied throughout his life and at age 29 years, we are finally trying to get a diagnosis, as this type of disease, (we have read) can cause ABI, Associated Brain Injury. He is having tests, and they have currently diagnosed him with PTSD, psychiatrist has admitted he doesn’t know anything about ABI! We are in the UK.
Basically, the meningitis was found in the later stages, after rash had appeared, doctors at the time said he made a good recovery and appeared fine but would definately be left with something, possibly learning difficulties, he was watched closely and this didn’t appear to happen, he started walking at 9 months, talking very quickly and academically did not struggle in fact the opposite, he learns quickly and has good intelligence, however he does suffer greatly with poor sleep, which has never recovered, and has symptoms of apathy, low motivation, at times very intravert and gets frustrated easily and although he tries to manage it he is aware that being around him you get a sense that he is very agitated and this can appear quite quickly, he can be in conversation with you and will become agitated.
I am trying to keep this as brief as possible, but I am wondering if any of the nootropics could be a good place to start, or are his symptoms and lack of diagnosis to vague to suggest a starting place for supplementation.
I am happy to research further if you think I should.
David Tomen says
Deni, I have no easy answer or suggestions for you because there is no way to really know exactly what is causing these symptoms. Especially at a relatively young age.
Carefully experimenting with different nootropic supplements is the only way to find out what may work. If he is experiencing ‘agitation’ I would start with something calming like Aniracetam and Sulbutiamine. But following dosage recommendations carefully.
Agitation is often caused by excess norepinephrine so I’d stay away at least initially with any nootropic that directly boosts dopamine.
For sleep, please see my post here: https://nootropicsexpert.com/best-nootropics-for-sleep/
What do you think about this content (all these are in one product, plus solid vitamin and mineral doses, daily serving – 8 capsules)? Recommendation is to split it in two daily doses. My golas in dopamine (and less serotonin) boost, focus and motivation.
N-Acetyl L-Tyrosine – 500 mg
DMAE – 200 mg
Gotu Kola – 200 mg
Bacopa – 100 mg
Rhodiola – 100 mg
Gingko – 60 mg
NAC – 250 mg
ALA – 100 mg
Inositol – 200 mg
Choline Bitartate – 500 mg
David Tomen says
Aleksandar, this stack is OK. Wonder why they use Choline Bitartrate and not Alpha GPC or CDP-Choline. It’s likely because of cost. But the rest of the stack is fairly well-balanced.
im looking for a combination notropics for motivation!! low energy, low self esteem…..looking for a reply…to get off antidepressant meds.
David Tomen says
Ammie, you’ll have a difficult time increasing your energy levels and self esteem as long as you using antidepressants. You could try 2 or 3 supplements mentioned in this post as long as they are not contraindicated with whatever meds you’re taking. Or try a pre-made stack like Mind Lab Pro.
But it’s an uphill battle while using antidepressants because they are so powerful.
David, You’re motivation hack guide is great! but where do I start? Lifetime of low motivation…which Racetam first? I’m 60, I want to break the ‘slow steady spiral into long-term guilt, poor self-esteem and ongoing depression.’ I tried l-acetyl-cartinine seemed to make me very negative.
David Tomen says
Laura, one nootropic will not do it for boosting something like motivation. You’ll likely need a stack of several supplements to get where you want to go. But where to start …
If ALCAR didn’t work for you then it isn’t for you. And I wouldn’t suggest starting with one of the racetams either if you are just getting started. Please see this post I wrote on the “aging brain” here > https://nootropicsexpert.com/best-nootropics-for-the-aging-brain/
I suggest starting with the fundamentals. A high quality multivitamin like Performance Lab Whole-Food Multi for women. Magnesium, iodine, and a bio-identical B-Complex supplement.
Then try something to boost dopamine like L-Tyrosine and something to boost serotonin like L-Tryptophan.
Follow the dosage suggestions for each of these which you’ll find in the individual reviews on Nootropics Expert. See how you feel in a couple of weeks. Then check back and we’ll go from there.
Keep in mind that you have 60 years of wear and tear and whatever other health issues you may be dealing with. Possibly even undiagnosed issues you may not be aware of. It will take some time and dedicated effort to get your brain healthy before you should even consider boosting anything.
Hello david i was just wondering if you could point me in the right direction of a list of nootropics that can help with alcohol addiction i am trying to form a supplment that help people withdraw i have been studying nootropics for alcoholic addiction for 18 months phenibut is dangerous if you have problems with addiction
David Tomen says
James, I haven’t spent much time in research on nootropics for addiction and withdrawal. However, I just wrote a review for PEA here: https://nootropicsexpert.com/phenylethylamine/. Some neurohackers reported PEA helped them quit Phenibut and caffeine.
And I agree that Phenibut is a very bad idea. Anything that could potentially invite dependence would not work.
I suggest you do some research on exactly how and why addiction forms in the brain. Find out what it does and how it works. Then look for nootropic supplements that could help whatever that is. See how PEA works and it may give you some ideas on the direction to go.
Thank you for giving me hope again! Know will not be an overnight fix, but sharing your own story has helped me to not lose faith. Believe we’ve shared similar challenges.
And reminded me about thyroid health, lost track of for sure. Yes, Nature Throid, took for 1.5 yrs, compounded to meet my needs & worked wonders! Not with pain, I still believe 100% is nerve damage caused by mercury(47.0). Mercury disrupts NAC needed by liver for conversion process, & leads to breakdown of mylin sheath resulting in nerve damage & pain, believe is how was explained to me keeping in mind my memory is way below par. Thanks for including info about thyroid health & iodine, I lost sight of this.
The “light bulb” came on, bet I have 3 issues causing all of this; metal & toxin stores, poor thyroid health & long term affects from using strong pain meds. And now I wonder if monthly injectable for pain causing prob’s too?
If so, will deal with for now, 16 wks nearly pain free has been beyond wonderful. Will start with my thyroid, willing to bet is a contributing factor to my recent and rapid cognitive decline, thick fog, inability to get anything done, difficulty speaking & remembering words. I will begin as you recommended, not familiar with iron but will do some research. I’ve modeled my stack after yours with exception of Mind Lab Pro due to cost right now, initial investment huge & waiting on Iodoral, Sulbutiamine,
Vinpocetine, PS, B8 and B9 to arrive. I take LE B-Complex 2 x’s day, only brand works for me or get cracks corner of mouth which is classic symptom of B deficiency. But since my depression is palpable, felt extra Folate & Inositol may help to combat the blues. Had already purchased a few items and was trying different stacks a few weeks prior to stumbling upon your site. Have Alpha GPC and Citicoline which alternate. Did order CDP Choline in powder form as is more economical, 3rd party tested, GPC & 14 yrs in business. Eat super clean, make a priority & same with supplements, not worth it to scrimp end up with questionable products of poor quality. Did follow your lead, increased DHA & tbsp virgin coconut oil 3 x’s day. Had Aniracetam purchased yrs ago at LE, didn’t know was a racetam! Still have half bottle & even though expired seems to be working, it replaced Adrifinal used in prior stack. And 100 mg Phenylpiracetam, bought 7.5 grms prior to finding your site. Been taking NAT-caps, NAC in liquid
form & NAL Cysteine caps all along, 200mg LE SAMe blister packed 3 x’s day (mercury causes prob’s with SAMe). Added L-Theanine 100mg 2 x’s day & love! Added L Dopa & Bacopa, just started. And started back on 5-HTP, 100mg day. Found bottle of Adrenal Support never finished, contains Ashwaganda, Rhodiola, Basil & Macca Root – time will tell. So far, believe this will be a good stack for me along with Ritalin hope to get soon. I take 150 mg liquid magnesium in my morning juice with 100mg liquid selenium. Get rest of magnesium from food & topically from quality spray. Take extra C but do eat a lot of fruit & produce, nuts & seeds. Try to eat clean, no processed or fast food. One step and one day at a time! But know must get a thyroid panel done asap. Thanks David!
Hi David, I agree with all recommendations 100%. I will need to purchase your book when something improves financially, trying to rent out spare bedroom. In very serious trouble, procrastinated much too long but never expected to lose over 50% of my biz in such a short amount of time. May try disability, although Clinician at Henderson said no way due to the use of pain meds. I know type of Dr I need, must be member of; Acadamy of Anti-Aging Medicine, is where the functional not conventional Dr’s are found, to avoid Rockefeller Med School mentality designed to feed the drug co’s at the expense of our health as we know most often the cycle never ends & not being treated to actually correct health issues. It’s so sad how many people don’t understand most all health problems are caused by poor nutrition, imbalances and deficiencies. And exactly why I feel as though I hit the brain lotto finding your site, exactly what I needed to continue down the wellness trail! Yes, know am hypothyroid, & know better, but too many issues, $ prob’s, ran out of liquid Lugol’s but didn’t replace, shame on me. Ordered Iodoral Sat. I can get a thyroid panel done through Life Extension for $78 without seeing a Dr. When get results back can request to review with an LE Dr, they are all functional MD’s, helped me last time. But back then had insurance & life was easier, was able to get ??? same as Armour but better & can’t remember name but was compounded dessicated swine thyroid. I’m not able to do this now, am lucky to have utilities on! I wonder if iodine and N Acetyl Tyrosine will be enough for my thyroid to heal and for my T3 and T4 to readjust? I understand can’t give me health advice but your opinion on this?
It’s unreal how different I am now, as if in another person’s body, as if I’m gone! I let everything go but almost didn’t care as all crumbled around me, maybe because it was just too much at once and dealing with tolerance & true severe pain issues. I can only hope the damage caused by the mercury, lead & fluorilisic acid…bromide, cadmium, arsenic, aluminum & God knows what else, can only pray not permanent as I’ve read. I believe the body has an amazing ability to heal with proper nutrition & if address deficiencies. I learned the hard way not to chelate mercury on my own ever again! Not with such high levels, found myself in a terrible health crisis. I followed Dr Brown’s iodine detox protocol with Lugol’s 50 mg per day, but ended up with chronic fatigue so bad, slept for 20 hrs straight, many times, my Tenitus got worse & could barely formulate a sentence, scary! And prior to that was using high quality Chlorella powder to remove mercury but believe my levels are too high & unable to chelate as most others can, and should use chelators once a week to remove any toxin stores to prevent accumulation. When cross that line and body can no longer correct or keep at “bay” toxic assualt (lack of glutathione I believe but you would know better) all of a sudden you have symptoms never had prior, health begins to deteriorate. Traditional Dr’s search for a label then a drug to match, and so many are weirdly interchangeable & must wonder how that can be!
I’ve been fed so many CRAP med’s over past decade. And you are correct, these drugs over time can cause other problems, & some side affects can be
devastating. Anti depressant meds some of the worst. I’ve fired sooo many Dr’s, you must really watch your back. I went through a terrible bout with reflux for 8 Mo’s & will never forget a $300 specialist told me to get the Enterex procedure done, coat inside of esophagus with plastic to avoid heartburn, when 5 min prior said I have no heartburn, didn’t even listen to me! A few months later FDA banned procedure, ppl were dying left and right. My advice to everyone, do your homework. I was first diagnosed with Fibromyalgia. In my humble opinion just a name or label for pain when no apparent cause. Didn’t accept the label, pain happens for a reason, it’s your body telling you there’s a problem.
Glad to hear you don’t have issues filling Ritalin. I have gone without as well, not a year as you did, but I know that I need it, and eventually will find the best Dr to help me. I want to thank you again for caring, for giving back. I will be sharing your site with friends and family, no need to go anywhere else to learn about Nootropics, hands down you’re the true expert! Hope I didn’t overstep with sharing, it’s been a long haul & never know when can help another, just as you are!
David Tomen says
Debbie, thank you for sharing our story. I know many others will be able to relate. And it will give them hope.
For your thyroid, and until you can get Armour, NP Thyroid or Nature-Throid you can help your thyroid with iodine, NALT, selenium, magnesium and possibly iron.
I found fibromylagia finally went away after I got my T3 levels in check. That took about 3 years of consistent trial and error. And nature taking its course and fixing things that needed to be fixed.
Matt Rader says
Hey David which brand do you prefer for your everyday vitamins and supplements? Like omega and CoQ10 and vitamin b?
David Tomen says
Garden of Life “vitamin Code” multi-vitamin
Nature’s Way Mega DHA – because they are TRU-ID™ Certified, non-GMO and organic when they can
Nature’s Bounty Ubiquinol – because they are audited by the United States Pharmacopeia (USP)
Life Extension Bio Active Complete B-Complex – only one I can find that uses folate instead of folic acid and methylcobalamin instead of some type of “cobalamin”