Oat Straw (avena sativa) is green oat grass. The tops of the oat plant in the milky stage before mature oat grains form a head.
Avena sativa, or the common oat plant is a popular cereal grain that has been used by humans as nutrition for at least 3,000 years.
In 1987, the German Commission E declared oat straw be used as a “nervine herb”. The Commission determined that oat straw extract was an effective herbal remedy for anxiety and stress (i.e. nerves).[i]
Oat straw has a reputation in men’s health as a sexual performance enhancer. More recent studies have shown oat straw can improve cognitive performance as well.
The nootropic benefits of Oat Straw were first revealed in the Middle Ages in Europe. In was recommended for boosting mental health, and as a restorative to the nervous system.[ii]
Saint Hildegard of Bingen, a nun and herbalist born in 1098 in what is now present-day Germany, considered oats to be a favorite ‘happiness’ herb.[iii]
Here we investigate using oat straw extract as a nootropic.
Oat Straw helps:
- Inflammation. Bioactive compounds unique to oat straw are anti-inflammatory protecting against neurodegeneration, heart disease, colon cancer and skin irritation.
- Cerebral Circulation. Oat straw helps boost nitric oxide and inhibits PDE4 which help dilate blood vessels. Increased blood flow increases delivery of vital nutrients and oxygen needed for a fully optimized brain.
- Anxiety and stress. Oat straw helps boost Alpha brain waves associated with super-learning, flow states and joy. And helps increase dopamine levels in your brain which increases feelings of pleasure, libido and sexual pleasure. Even cognition gets a boost.
Table of Contents
Oat Straw (avena sativa) as a nootropic is an extract produced from the common oat plant while still in its milky stage.
Oats are a cereal grain grown in temperate climates world-wide as food for humans and livestock. And as an ingredient used in cosmetics.
The oat plant is descended from avena sterilis, a wild oat that originated in the ‘Fertile Crescent’ that spanned from Israel to western Iran to Europe. It was domesticated about 3,000 years ago in Europe.
Tea brewed from oats has traditionally been used as a sedative. And as an herbal treatment for insomnia and nervous disorders.
Avenanthramides (bioactive compounds unique in oats) have been shown to enhance nitric oxide (NO) production in human smooth muscle cells.[iv] And have anti-inflammatory, anti-proliferative, and anti-itching activity. Protecting against heart disease, colon cancer and skin irritation.[v]
Oat straw extract inhibits phosphodiesterase type 4 (PDE4). PDE4 is a component of signaling pathways involved in the mediation of antidepressant activity.[vi]
PDE4 inhibitors can prolong the effects of cAMP in the brain which can improve long-term memory, wakefulness, is neuroprotective, works as an anti-inflammatory and antidepressant.
Oat straw extract inhibits monoamine oxidase B (MAO-B) which increases dopamine levels in the brain. Helping brain disorders like ADHD and Parkinson’s Disease.[vii]
Oat straw extract suppresses inflammatory cytokines by inhibiting nuclear factor κB (NF-κB) activation[viii] Cytokines are implicated in a number of brain disorders including major depression, schizophrenia and Alzheimer’s Disease.[ix]
How does Oat Straw work in the Brain?
Oat Straw boosts brain health and function in several ways. But two in particular stand out.
- Oat Straw boosts cerebral circulation. Oat straw extract increases blood flow to and within the brain through several mechanisms of action. Oat straw contains the amino acid arginine which synthesizes to create nitric oxide (NO). NO dilates blood vessels allowing more blood to flow.
Avenanthramides (bioactive compounds unique in oats) have been shown to enhance nitric oxide (NO) production in human smooth muscle cells. And the suppression of inflammatory cytokines in combination with increased nitric oxide increases blood flow.
A study with 37 healthy older adults (60+ years) participated in a 24-week randomized, double-blind, placebo-controlled trial. Participants received 1500 mg per day of oat straw extract or a placebo.
The study showed that cerebral vascular responsiveness increased by 42%. This indicates that the middle cerebral artery was able to dilate in response to stress.[x] And more blood flow to the brain increases oxygen and nutrient delivery to brain cells.
- Oat Straw increases Alpha Brain Waves. You experience alpha brain wave patterns as you become more relaxed. And is associated with super-learning, flow states and joy.
German researchers conducted a double-blind, randomized, placebo-controlled crossover study using 1,250 or 2,500 mg of oat straw extract compared to placebo. An EEG was used to measure brain wave frequencies in this trial.
The researchers noted that oat straw extract affected brain wave patterns in an area of the brain associated with cognition. The subjects performed better in arithmetic with fewer errors.[xi]
How things go bad
Ever noticed how older people seem more frail? They suffer from cognitive dysfunction and an overall decline in well-being. Research show these conditions are associated with a drop in dopamine levels as we age.[xii]
↓ Dopamine levels decrease
↑ Monoamine oxidase B (MAO-B) increases
↓ Mood, cognition and bodily function decline
Dopamine levels begin to decline by 13% per decade after age 45.[xiii] Cognition, mood and sexual function all suffer as a result. And gradually progress into diseases such as Alzheimer’s and Parkinson’s.
Oat Straw benefits
Researchers have found that this age-related decrease in dopamine is caused by an enzyme called monoamine oxidase-B (MAO-B).
In our youth, MAO-B regulates the exact amount of dopamine we need in our brain. But as we age, MAO-B levels get out of hand and increase too much.[xiv] As MAO-B levels rise, dopamine levels fall.
Research has shown that inhibition of MAO-B preserves brain function by protecting dopamine. And extends cognition, sexual function and life span.[xv]
Oat Straw extract has been found to inhibit MAO-B, and enhance dopamine that normally declines with age.[xvi]
Oat straw extract can:
- Work as an antidepressant
- Help you cope with stress
- Reduce anxiety
- Control inflammation
- Relieve skin irritation
- Increase libido and sexual performance
How does Oat Straw feel?
Most neurohackers report that supplementing with oat straw extract increases energy levels and libido.
Others report more mental clarity, less anxiety, and an overall sense of well-being.
Men say it increases libido and morning wood.
Oat Straw Clinical Research
Oat Straw Improves Memory
An Australian study was conducted with a group of elderly people. Some showed signs of mild cognitive impairment while others showed no impairment. Researchers wanted to measure cognitive performance after taking oat straw extract.
Subjects were randomly assigned to receive a single dose of oat straw extract once a week. The study used 0 mg, 1,600 mg or 2,400 mg of oat straw extract.
This was a “crossover” trial which means each subject was rotated through all 3 doses. So each participant functioned as a “control” during the trial.
Researchers used the Stroop Color-Word Test which measures memory, executive function, catching errors, appropriate responses and attention.
In this study, those who did not use oat straw extract had an average of 3.39 errors on the test. Those receiving 1,600 mg made only 1.2 errors (a 65% improvement).
The subjects who reported no cognitive impairment did even better with an average of 0.55 errors compared to placebo who averaged 2.13 errors (a 74% improvement). The 2,400 mg subjects performed about as well as those taking a placebo.
The 2,400 mg dose of oat straw extract is significant because it shows that suppressing MAO-B too much will not improve cognition.[xvii]
Oat Straw for Improved Cognition
A study using oat straw extract (Neuravena®) assessed the effects of a single dose with healthy adults aged 40 – 65 years with self-declared memory decline.
Participants received a single dose of 800 or 1,600 mg of oat straw extract. Cognitive function was assessed measuring attention, spatial-working-episodic memory and executive function before dosing. Testing was done 1, 2.5, 4 and 6 hours after dosing.
The results showed that 800 mg of oat straw extract increased speed of performance. Participants experienced improved performance of delayed word recall in terms of errors. And executive function in terms of decreased thinking time and overall completion time.
The researchers concluded that acute (one-time) dosage of oat straw extract produced optimal effects on cognition at or below 800 mg. Once again showing that when inhibiting MOA-B, too much inhibiting does more harm than good.[xviii]
Oat straw extract enhances attention and concentration without the side effects of insomnia, nervousness, or anxiety.
Oat Straw Recommended Dosage
Oat straw extract recommended dosage:
- Oat straw powder in a capsule is 350 mg up to 3-times daily
- Oat straw tincture ½ to 1 teaspoon up to 3-times daily
- Oat straw tea up to 3 cups per day
Most clinical studies showed the most effective dose to be between 800 – 1,600 mg per day.
You should not exceed the recommended dosage because studies show that inhibiting MOA-B in excess will not provide the benefits normally associated with oat straw supplementation.
Oat Straw Side Effects
Oat straw is natural, non-toxic and considered very safe.
Exceeding recommended doses however can inhibit MAO-B too much and you will not get the cognitive benefit you’re looking for with oat straw.
Best type of Oat Straw to Buy
Oat straw is available as powdered leaves and stems in capsule form, oat straw extract standardized 10:1 or 20:1, and alcohol extract tinctures.
NOTE: This review contains affiliate links, and I will be compensated if you make a purchase after clicking on my links.
Neuravena® (EFLA®955) is a patented oat straw extract made by Frutarom Health and licensed to some supplement manufacturers such as Life Extension – Dopa-Mind.
Nootropics Expert Recommendation
Oat Straw extract 800 – 1,600 mg per day
I recommend using Oat Straw as a nootropic supplement.
Your body does not make Oat Straw on its own. So you must take it as a supplement.
Oat Straw is especially helpful for those dealing with dopamine decline due to aging. As we age and particularly past age 40, MOA-B is produced in excess in our brains which causes dopamine to decline.
Declining dopamine levels affect cognition, sexual function, mood and longevity. Oat straw extract is a natural inhibitor of MAO-B and will help restore dopamine to youthful levels.
Oat Straw is also helpful for those suffering from Parkinson’s or Alzheimer’s disease. Increased MOA-B, loss of dopamine receptors, and declining dopamine levels all contribute to neurodegenerative disease. Studies have found that using oat straw extract early in the diagnosis of disease can help alleviate symptoms of these diseases.
You can safely take up to 1,600 mg of Oat Straw extract daily if needed. Half the dose first thing in the morning. And the other half early afternoon. Oat straw extract acts as a stimulant so avoid taking it too late in the day or it may affect sleep.
Do not exceed recommended doses (more than 1,600 mg) of oat straw extract. You’ll suppress MOA-B too much which can mess with dopamine levels in your brain.
[i] “Avenae herba (oat herb)” Commission E Herbal Monograph 15.10.1987. #193. (source)
[ii] Moccetti T., Wullschleger C., Schmidt A., Aydogan C., Kreuter M.H. “Bioactivity-based development of a wild green oat (Avena sativa L.) extract in support of mental health disorders” Zeitschrift für Phytotherapie 2006; 27 - P24 (source)
[iii] Campbell-Atkinson F. Hildegard of Bingen 1098-1179 "The Sybil of the Rhine." European Journal of Herbal Medicine. 2004;6(3):28-38. (source)
[iv] Nie L., Wise M.L., Peterson D.M., Meydani M. “Avenanthramide, a polyphenol from oats, inhibits vascular smooth muscle cell proliferation and enhances nitric oxide production.” Atherosclerosis. 2006 Jun;186(2):260-6 (source)
[v] Meydani M. “Potential health benefits of avenanthramides of oats.” Nutrition Revues. 2009 Dec;67(12):731-5 (source)
[vi] Dlaboga D., Hajjhussein H., O’Donnell J.M. “Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: Comparison with rolipram” Brain Research Volume 1096, Issue 1, 22 June 2006, Pages 104–112 (source)
[vii] Moccetti T., Wullschleger C., Schmidt A., Aydogan C., Kreuter M.H. “Bioactivity-based development of a wild green oat (Avena sativa L.) extract in support of mental health disorders” Zeitschrift für Phytotherapie 2006; 27 - P24 (source)
[viii] Guo W., Wise M.L., Collins F.W., Meydani M. “Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells.” Free Radical Biology and Medicine. 2008 Feb 1;44(3):415-29. (source)
[ix] Kronfol Z., Remick D.G. “Cytokines and the brain: implications for clinical psychiatry.” American Journal of Psychiatry 2000 May;157(5):683-94. (source)
[x] Wong R.H., Howe P.R., Coates A.M., Buckley J.D., Berry N.M. “Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults.” Journal of Hypertension. 2013 Jan;31(1):192-200 (source)
[xi] Dimpfel W., Storni C., Verbruggen M. “Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects.” Journal of Alternative and Complementary Medicine. 2011 May;17(5):427-34. (source)
[xii] Arnsten A.F., Cai J.X., Steere J.C., Goldman-Rakic P.S. “Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys.” Journal of Neuroscience. 1995 May;15(5 Pt 1):3429-39. (source)
[xiii] Knoll J. “Deprenyl (selegiline): the history of its development and pharmacological action.” Acta Neurologica Scandinavia: Supplements. 1983;95:57-80. (source)
[xiv] Mazzio E., Deiab S., Park K., Soliman K.F. “High throughput screening to identify natural human monoamine oxidase B inhibitors.” Phytotherapy Research. 2013 Jun;27(6):818-28 (source)
[xv] Knoll J., Dallo J., Yen T.T. “Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-) deprenyl.” Life Sciences. 1989;45(6):525-31. (source)
[xvi] Wong R.H.X. et. Al “ Chronic Effects of a Wild Green Oat Extract Supplementation on Cognitive Performance in Older Adults: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial” Nutrients. 2012 May; 4(5): 331–342. (source)
[xvii] Berry N.M., Robinson M.J., Bryan J., Buckley J.D., Murphy K.J., Howe P.R. “Acute effects of an Avena sativa herb extract on responses to the Stroop Color-Word test.” Journal of Alternative and Complementary Medicine. 2011 Jul;17(7):635-7. (source)
[xviii] Kennedy D.O., Jackson P.A., Forster J., Khan J., Grothe T., Moccetti T., Haskell-Ramsey C.F. “Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial” Nutritional Neuroscience 30 Nov 2015 pages 1 – 17 (source)
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What is Oat Straw extract eliminate half-life?
David Tomen says
Petrus, not sure because I have not been able to locate a study that included the half-life of this compound.
William Phelan says
I have often seen the 1600 mg dose recommended, yet no one specifies whether this is for a 10:1 or 4:1 or other ratio of extract. This seems like an important thing to know.
David Tomen says
William, it is and I suggest you contact the manufacturer and ask them.
Life Extension has both silica and vegetable strategists in it. Is there another brand that does not? Thank you.
Auto correct,lol. Sterate.
David Tomen says
Angela, the only other one that I trust but is not the patented form is in powder form here: https://geni.us/Xnkr
First thanks for sharing your knowledge.
1) I was wondering if you knew about anything more one can do to increase their level of nitrite oxyde? The thing is that I can’t use anything having to do with serotonin (I get serotonin syndrom very easily, apparently I’ve got no problem there).
2) I was also wondering if you knew if L-arginine is a MAOI-B like oat straws?
Background : B Thalassemia minor decreases a lot nitric oxyde
I have beta thalassemia minor, which is genetical blood disease which has been found to be linked to a deficiency in nitrite oxyde. (“Plasma direct nitrite, total nitrite and nitrate levels were 7.561±6.19, 42.548±7.37 and 34.84±6.24 in beta-thalassemia minor patients versus 36.9±19.8, 85.9±35.3 and 48.61±17.35 Ìmol/dl in controls, respectively.” [Source : “The levels of nitric oxide in beta-thalassemia minor”, https://pubmed.ncbi.nlm.nih.gov/27264921/ ]).
Some values were found to be more than three times lower than controls, most of them at least 2 times less…
No need to make the link with anxiety/stress/fear related to that, it’s what you’ve written about in the article about the “flow state”. I need to “flush out” !
Please, change whatever I wrote to “nitric oxide”, of course.
David Tomen says
Ava, Maritime Pine Bark Extract helps increase nitric oxide in the brain. And L-Arginine does NOT act like a MAOI-B.
Thanks a lot !
PS for any “sufferer” of that condition or something similar : weight lifting/resistance training might help, but the effects are not lasting long enough so the amount of training needed wouldn’t be a sustainable strategy alone.
Anyway. Have a nice life all. Thank you again David.