Vitamin B5 (Pantothenic Acid)

Vitamin B₅ (Pantothenic Acid) is one of 8 B-vitamins. B₅ is water-soluble and found in every single cell in your body.

Vitamin B₅ is essential for the synthesis of acetylcholine (ACh). Adequate levels of ACh can boost focus, memory, learning, and reduce brain fog.

Vitamin B₅ is critical for converting nutrients from food into energy, balancing blood sugar, reducing LDL-(bad) cholesterol, lowering blood pressure, preventing nerve damage and pain, and preventing heart failure.

Vitamin B₅ plays a part in the synthesis and metabolism of proteins, carbohydrates and fats. Turning them into energy that your brain uses to fire neurotransmitters in your brain.

Vitamin B₅ is required for the manufacture of red blood cells, and the stress and sex hormones produced in your adrenal glands.

As a nootropic, Vitamin B₅ is crucial for converting the choline in your nootropic stack into acetylcholine (ACh). Without adequate levels of B₅ you will not experience the benefits of using precursors to ACh like Alpha GPC and CDP-Choline.

Vitamin B₅ (Pantothenic Acid) helps:

• Brain Optimization: Pantothenic acid is at the heart of the KREBs cycle and electron transport chain which helps convert nutrients from food into energy which is used to make adenosine triphosphate (ATP). ATP is the fuel source within each of your cells. More energy increases mental clarity, alertness, memory and mood.
• Neurotransmitters: Pantothenic acid as part of Coenzyme-A (CoA) is involved in the synthesis of the neurotransmitters acetylcholine, epinephrine, and serotonin. Affecting alertness, cognition, memory and mood.
• Mood: Pantothenic acid is often referred to as the “anti-stress vitamin”. Your adrenal glands use CoA (made partly from pantothenic acid) along with cholesterol and Vitamin C to manufacture cortisol and epinephrine. Vitamin B₅ has a reputation for reducing stress, anxiety and depression.

Overview

Vitamin B₅ (Pantothenic Acid) is one of 8 water-soluble B-vitamins that are absolutely vital to the highly optimized brain. And is essential to all forms of life.

Vitamin B₅ is found in every cell in your body including your brain. The name Pantothenic is derived from the Greek word pantothen, meaning “from everywhere”. Reflecting the idea that small amounts of pantothenic acid can be found in nearly every food.

Foods rich in pantothenic acid include animal organs (liver and kidney), fish, shellfish, milk products, eggs, avocados, legumes, mushrooms, and sweet potatoes. Avocados contain the highest amount of pantothenic acid among commonly consumed foods, with one avocado containing about 2 mg.

Pantothenic Acid is a precursor in the biosynthesis of Coenzyme-A (CoA). CoA is an essential enzyme in a variety of chemical reactions that sustain life.

CoA as Acetyl-CoA is required for generating energy from fat, carbohydrates and proteins. This energy in the form of glucose is the fuel source for each cell.

Acetyl-CoA is also involved in the citric acid cycle (KREBs), in the synthesis of essential fats, cholesterol, steroid hormones, vitamins A and D, and the neurotransmitters acetylcholine (ACh) and serotonin.

Coenzyme A derivatives are also required for the synthesis of melatonin which controls your circadian rhythm and sleep/awake cycle. And for the metabolism of drugs and toxins in your liver.

How does Vitamin B₅ (Pantothenic Acid) work in the Brain?

Vitamin B₅ (Pantothenic Acid) boosts brain health and function in several ways. But two in particular stand out.

1. Vitamin B₅ increases energy. Pantothenic acid is an essential coenzyme involved in mitochondrial aerobic respiration. Vitamin B₅’s role in the citric acid cycle (KREBs) and electron transport chain helps convert nutrients from food into energy which is used to make adenosine triphosphate (ATP). ATP is the fuel source within each of your cells.

Pantothenic acid takes part in the synthesis of Acetyl-CoA which is at the heart of the KREBs cycle. Acetyl-CoA in your brain is also involved in the synthesis of cholesterol, amino acids, phospholipids, and fatty acids.

CoA is also involved in the synthesis of the neurotransmitters acetylcholine and serotonin, and steroid hormones. User reviews of those supplementing with pantothenic acid claim to having more energy. This boost in energy comes from this long series of events stemming from supplementing with pantothenic acid.[i]

2. Vitamin B₅ helps reduces stress. Pantothenic acid is often referred to as the “anti-stress vitamin”. Your adrenal glands use CoA (made partly from pantothenic acid) along with cholesterol and Vitamin C to manufacture cortisol and epinephrine.

When cortisol levels are low, your ability to cope and respond to stress is compromised. And if your cortisol levels are abnormally high (a common problem), your body’s reserve of pantethine (the active form of pantothenic acid) needs to be replenished in order to sustain good adrenal function.[ii]

Vitamin B₅ has a reputation for reducing stress, anxiety and depression.

How things go bad

Chronic stress, anxiety and lower acetylcholine levels can damage your brain. This damage can manifest in several ways including memory loss, brain fog, anxiety, depression, and even neurodegenerative diseases like Alzheimer’s and Parkinson’s.

↓ Acetylcholine synthesis declines

↓ Concentration, memory, learning, and recall decline

↑ LDL-cholesterol (bad) and triglycerides increase

↓ HDL-cholesterol (good) levels decline

↓ Wound healing takes longer

↓ Energy levels decline

↑ Numbness, tingling, burning sensations, shooting pain in the feet increase

Vitamin B₅ supplementation can help increase acetylcholine, epinephrine and serotonin levels in your brain. And help modulate cortisol levels produced in your adrenal glands. Helping you to cope with stress and lessen depression.

Vitamin B₅ (Pantothenic Acid) Benefits

When you take Vitamin B₅ as a supplement, it is converted to pantethine. Pantethine is a more stable disulfide (double bonded) form of pantothenic acid.

It is this active form of pantothenic acid that is converted into the enzyme Coenzyme-A (CoA). CoA plays a critical role in the metabolism and breakdown of the three essential micronutrients: proteins, carbohydrates and fats.

CoA is a cofactor in more than 70 enzymatic pathways including:

• Amino acid catabolism
• Acetylcholine synthesis
• Carbohydrate metabolism
• Fatty acid oxidation
• Heme synthesis
• Pyruvate degradation
• Phase II detox acetylation

CoA is also involved in the initial steps of cholesterol synthesis and all the downstream metabolites of cholesterol including steroids, Vitamin D, and bile acids.

CoA helps break down the carbon skeleton of amino acids which are metabolized to pyruvate and enter the KREBs cycle. This cycle is crucial to ATP synthesis within your mitochondria.

CoA directs acetyl groups to form ubiquinone (CoQ10), squalene and cholesterol. You also need CoA for the transport of long chain fatty acids into mitochondria where fats are converted into energy.

The bottom-line is CoA is behind the production of hemoglobin, bile, sex and adrenal hormones (steroids), cholesterol and the neurotransmitters acetylcholine and serotonin in your brain.

How does Vitamin B₅ (Pantothenic Acid) feel?

Vitamin B₅ is water-soluble, and has been shown to improve mood, energy and cognition.

Neurohackers who supplement with pantothenic acid report being wonderfully optimistic, energetic and mentally sharp.

People report Vitamin B₅ helps them focus better, they feel a profound increase in energy and concentration improves.

Many people dealing with acne find their skin looks great. Acne is cleared within a few days to a few weeks of supplementing with pantothenic acid.

Men and women find that supplementing with Vitamin B₅ helps prevent hair loss. And if taken early enough may even help avoid hair turning prematurely gray.

Some neurohackers report that pantothenic acid helps improve vision and hearing.

Vitamin B₅ Clinical Research

Vitamin B₅ (Pantothenic Acid) reduces Acne

100 people of Chinese descent (45 males and 55 females) aged 10 – 30 years with severe acne were treated with high-dose pantothenic acid. A total of 10 grams per day were given in 4 divided doses.

Participants were also asked to apply a cream to affected areas 4 – 6 times per day. The cream contained 20% pantothenic acid.

Their face became noticeably less oily within 3 days of starting therapy. Within 2 weeks, facial pore size became smaller and acne lesions began to heal. And the rate of new acne eruptions had slowed.

By 8 weeks, acne was usually controlled. Most acne lesions were gone and new eruptions occurred only occasionally. The participants with severe acne required 6 months of treatment to control acne.

The author of the study noted that in some of the severe cases, daily doses of 15 – 20 grams of pantothenic acid would produce a faster response. 35 patients were monitored for 18 months; the maintenance dose needed to control acne ranged from 1 – 5 grams per day of pantothenic acid.[iii]

Vitamin B₅ (Pantethine) to decrease LDL-Cholesterol

User reviews consistently show success with lowering LDL-cholesterol and triglycerides, and raising HDL-cholesterol by supplementing with Vitamin B₅ (Pantethine).

The National University of Health Sciences in Illinois conducted an evaluation of clinical trials from 1966 to 2002 for studies using the pantethine version of Vitamin B₅ to improve cholesterol.

28 clinical trials with a pooled population of 646 ‘hyperlipidemic’ subjects were evaluated. Mean age of participants were 52.8 years. Average study length was 12.7 weeks with an average dosage of 900 mg per day of pantethine.

The mean decrease of LDL-cholesterol (bad cholesterol) was 10 – 20%. The mean decrease of triglycerides was 14 – 33%. And the mean increase of HDL-cholesterol (good cholesterol) was 4 – 11%.

The researchers concluded that “pantothenic acid was an effective therapeutic option in treating patient populations with total serum cholesterol levels greater than 200 mg/dL, and/or serum triacylglycerol levels greater than 150 mg/dL.”

The team noted that the full benefit of pantethine may not be attained until at least 4 months from beginning supplementation. And that pantethine is a well-tolerated therapeutic agent that deserves much more attention than it has recently received.[iv]

Vitamin B₅ (Pantothenic Acid) increases Longevity

Vitamin B₅ is believed to extend life span. But research in humans for obvious reasons has been difficult. Humans live longer than most mammals. And tracking human subjects for life would be prohibitively expensive.

So animal research is the next best thing. A team in Austin gave 33 young male and female mice 300 μg of calcium pantothenate daily in drinking water. Forty-one control mice did not receive the vitamin supplement.

The mean life span for mice who received calcium pantothenate was 653.1 days. And for the control mice life span was 549.8 days. The mice using Vitamin B₅ lived 19% longer.[v]

Royal jelly has long been used as a longevity supplement. And some of the science backs this up. Pantothenic acid is the primary anti-aging factor isolated from royal jelly.

The combination of pyridoxine, biotin and sodium yeast nucleate extended the lifespan of the common fruit fly. And the addition of pantothenic acid further increased life span.[vi]

Seems that supplementing with pantothenic acid (Vitamin B₅) will help you live longer.

Vitamin B₅ Recommended Dosage

If you are using an acetylcholine (ACh) precursor like Alpha GPC or CDP-Choline in your nootropic stack, you should be using Vitamin B₅. Because B₅ is needed to make Coenzyme-A (CoA). CoA and choline are needed to synthesize acetylcholine.

The recommended dosage of Vitamin B₅ (Pantothenic Acid) is a one-to-two ratio with a choline supplement. For example, 250 mg of Vitamin B₅ with 500 mg of CDP-Choline.

If you don’t get enough Vitamin B₅, you may not notice significant improvements when supplementing with your preferred choline source. If you’ve added choline to your racetam stack and still get a “choline headache” it’s likely because you don’t have adequate Vitamin B₅ in your system.

Pantothenic Acid or Pantethine is generally well tolerated in doses up to 1,200 mg/day. Some neurohackers report doses above 1,000 mg can induce gastrointestinal side effects like nausea or heartburn.

Oral contraceptives (birth control pills) containing estrogen and progestin may increase the requirement for additional pantothenic acid.

Use of Pantothenic Acid in combination with cholesterol-lowering drugs (statins) or with Vitamin B₃ (niacin or nicotinic acid) may produce additive effects on blood lipids. So be careful because you could lower LDL-cholesterol to unhealthy levels.

Vitamin B₅ Side Effects

Vitamin B₅ (Pantothenic Acid) is non-toxic. So is considered well-tolerated and safe.

Side effects are rare but very high doses can include stomach upset, nausea or diarrhea.

If you are taking the antibiotic tetracycline, you should avoid using extra Vitamin B₅ because it could negate the effects of tetracycline.

If you are on cholinesterase inhibitors used for treating Alzheimer’s, you should not be using Vitamin B₅.

Type of Vitamin B₅ to buy

When choosing a Vitamin B₅ supplement, your basic choice is between Pantethine or Pantothenic Acid.

Pantethine is by far the more active choice when it comes to producing CoA. And this is backed up by many clinical trials. Researchers have pointed out that Pantethine creates twice as much CoA compared to Pantothenic Acid.

However, Pantothenic acid does have its benefits. It enhances adrenal function and modulates inflammation. If you can, find a supplement that combines both.

Vitamin B₅ supplement labels will show pantothenic acid as “Calcium” or “sodium D-pantothenate” which is used for treating stress, migraines and allergies.

Pantethine is mainly recommended for lowering blood cholesterol levels. And pantethine is better for stacking with a choline supplement because it creates more CoA than other forms of pantothenic acid.

Pantothenol (panthenol) is a stable alcohol analog of Vitamin B₅ (pantothenic acid), which can be rapidly converted to pantothenic acid by humans.

Most multivitamins also include some form of Vitamin B₅ (Pantothenic Acid) in their formula. But many of these multis don’t contain enough for optimum health. And many have an inferior isolated or synthetic version of the nutrient.

The Performance Lab^® NutriGenesis Multi offers a nature-identical form of Vitamin B₅ (Pantothenic Acid) and is now my favorite daily multivitamin/mineral supplement.

I prefer the Performance Lab® multi because it’s more potent, it’s biologically active and I’ve found to be a far more effective multi compared to every other multivitamin supplement I’ve ever used.

Performance Lab^® uses their own priority BioGenesis^® vitamins and minerals which are grown on probiotic, plant and yeast cultures in a state-of-the-art lab.