Gotu Kola boosts brain energy

Gotu Kola

David Tomen
Author:
David Tomen
12 minute read
Gotu kola has been shown to increase memory and cognition, repair and reverse damage to brain cells, reduces anxiety, and boosts acetylcholine and 
GABA.

Gotu Kola (Centella asiatica) is often called “the student herb” in Bali. Because it sharpens the mind. Gotu Kola extract increases dendrite and axon growth in brain cells which helps memory.

Native to the wetlands of Asia, the ancient Ayurvedic medical system used Gotu Kola like a first-aid kit. It was used to treat mental fatigue, anxiety, depression, memory loss, insomnia, fever, syphilis, hepatitis, epilepsy, diarrhea and asthma.

Gotu kola even has a link to longevity. The ancients believed that elephants who ate Gotu Kola leaves lived longer than those that didn’t. Turns out they were onto something that was only revealed by scientists in late 2019. More on this in the next section.

In the U.S. and Europe Gotu Kola is typically used for varicose veins, poor blood circulation in the legs, to treat psoriasis and help heal minor skin wounds.

Gotu kola is rich in triterpene saponosides. A study in Japan showed that one of these triterpenoids called asiatic acid was able to stop the growth of cancer cells.[i]

And some of the most exciting new research on Gotu Kola shows it can spur growth in brain cells. Here we explore all the ways gotu kola can help your brain.

Gotu Kola helps:

  • Neurogenesis. Gotu Kola stimulates the growth of brain cells. It encourages dendrite branching which boosts brain plasticity and communication between neurons.
  • Neuroprotection. Gotu Kola protects your brain from toxins and oxidative stress. Studies show it helps protect against heavy metals and food additives which cause brain fog, mood swings and migraines. And it reduces oxidative stress by reducing free radicals in brain cells.
  • Neurotransmitters. Gotu Kola helps prevent the breakdown of acetylcholine. Enhancing mood, cognition, memory and learning. And preventing degenerative brain diseases like Alzheimer’s. And Gotu Kola boosts glutamic acid decarboxylase (GAD) which converts glutamate into GABA which also affects mood.

Overview

Gotu Kola (Centella asiatica) is one of the most important herbs in the ancient tradition of Ayurvedic medicine. It’s a low, ground-hugging vine found throughout the wetlands of Southeast Asia. You’ll recognize gotu kola by its bright green kidney-shaped leaves growing from a reddish stem. In season, it blooms with small white flowers.

Gotu Kola (Centella Asiatica)
Gotu Kola (Centella Asiatica)

In Bali, Gotu Kola is called “the student herb” because it sharpens the mind. The Balinese also use it to combat senility.

It’s famous in southeast Asia as a longevity herb. The ancients were convinced that when elephants ate gotu kola, they lived longer than those that didn’t.

And we now know why these elephants lived longer. A study published in October 2019 showed that Gotu Kola extract provides an 8.8 fold increase in telomerase activity

Other recent research shows shortened telomeres impairs DNA repair which shortens lifespan. And studies report reduced telomere length in patients suffering from mental disorders such as depression and anxiety.  

The leaves of Gotu Kola have been used for thousands of years to boost cognition, improve cerebral circulation, and overall brain function.

As a nootropic, Gotu Kola has been shown to be particularly effective in elderly memory loss, slow thinking and reasoning. One study shows significant improvement in Alzheimer’s patients.[ii]

Gotu kola improves memory and repairs neurons

How does Gotu Kola Work in the Brain?

Gotu kola boosts brain health and function in several ways. But two in particular stand out.

  1. Neural dendrite and axon growth. Gotu kola helps increase the length and branches of neuron dendrites. And boosts axon growth.

Dendrites are tree-like branches extending out from neurons in the brain. They receive incoming signals from other neurons. Those signals are transmitted from axons extending out from neighboring neurons.

Dendrites and axons can change over time, and in response to environmental cues. Learning something new for example cause dendrites to lengthen.

But this natural signaling mechanism in your brain’s neurons degrade over time. And several studies have shown how Gotu kola can reverse this damage.

Scientists at the Oregon Health & Science University in Portland, Oregon did their research with Sprague-Dawley rats. They put Centella ethaniloc extract, a compound in Gotu kola, in the rat’s drinking water.

The study concluded that axons grew at a faster rate. And the researchers stated that gotu kola extract was useful for accelerating repair of damaged neurons.[iii]

Another study showed rats given gotu kola leaf extract had an increase of 105% in dendrite growth.[iv]

A very recent study published at Northwestern University and published in Nature showed how dendrites are critical in memory formation.[v]

  1. Increase in memory and learning. Gotu kola has been revered for thousands of years for boosting memory. We know that Gotu kola extract can increase the availability of acetylcholine (ACh) in the brain. It does it by preventing ACh from breaking down.

This boost in memory may also benefit from Gotu kola’s ability to boost the growth of neuron dendrites and axons.

In one randomized, placebo-controlled, double-blind study done in Thailand, researchers gave 28 people Gotu kola extract for 2 months. Daily doses ranged from 250, 500 to 750 mg per day. Cognition in these subjects increased, and they experienced a boost in working memory.[vi]

How things go bad

Over the course of your life, your brain will lose 5 – 10% of its weight. It starts in your early 20’s.[vii]

The Framingham Offspring Cohort Study included 1,352 adults who did not have dementia. 7 years after the start of the study they used an MRI to measure participants brain size. And gave them tests to gauge executive function, planning, and organizational skills.Your brain shrinks with age

The researchers found that people with high blood pressure, diabetes, were overweight or smoked had faster brain shrinkage. They showed declines in ability to make decisions, plan, organize and remember details.[viii]

↓ Memory, cognition, learning and recall decline

↓ Neuronal cell death results in shrinking gray matter

Neuroplasticity declines degrading long-term potentiation[ix]

Your brain will shrink regardless of lifestyle. But you can reduce the speed of this shrinkage by using Gotu kola.

Gotu Kola benefits

Research from hundreds of studies have shown that Gotu kola will:

  • Improve memory and cognition
  • Restore the availability of acetylcholine
  • Improve cerebral blood flow
  • Reduce anxiety and stress
  • Help repair brain cells
  • Eliminate free radicals from within brain cells

How does Gotu Kola feel?

Gotu kola improves acetylcholine levels in your brain. It increases blood flow and helps reduce oxidative damage and toxins in brain cells. As a result, you may feel a boost in mental activity.

Many say that taking Gotu Kola is like “energizing of the brain”. Particularly during a period of high mental demand. Mental blocks or mental fatigue feel like they’re swept away.Gotu Kola boosts brain energy

Others report dreams seem more vivid and intense. And Gotu kola provides an anxiolytic (anti-anxiety) effect as well.

Gotu Kola Clinical Studies

Ever been on your way to a party with the thought, “I hope I don’t kill too many brain cells”. Science once believed that the adult human brain could not grow new brain cells. We were born with all the brain cells we’ll ever have. Once those cells were gone, they’re gone for good.

Not too long ago a study was published in the Journal of Science. It detailed a discovery by scientists of the daily growth of new brain cells in the macaque monkey. And because of this study, we now know your brain can grow new cells.

But the reality is, your brain will lose 5 – 10% of its weight. This shrinkage starts right around your 20th birthday.

The good news is you can prevent that shrinkage. And you can do it with Gotu kola.

Gotu Kola Improves Memory

Neurons connect to other neurons at a point called a synapse. Electrical pulses carry chemical messages across this gap. These chemical messengers are neurotransmitters. Each neuron in your brain can form thousands of these links.

Dendrites extend out from each neuron to neighboring neurons to receive these messages. Your brain uses these neurons in a type of network. And as one neuron sends signals to another, the synapse between the two gets stronger.

The more signals sent between these neurons, the stronger the connection grows. With each new experience, your brain slightly rewires this physical structure. This neuroplasticity determines how your brain is organized. And how memories are formed.

Gotu kola extends these neuron dendrites. And helps improve brain neuroplasticity. A study in animal models demonstrated neurite growth using a compound from gotu kola extract.[x] And clearly showed how gotu kola works to boost memory.

Gotu Kola Improves Mood and Cognition

Gotu kola has been revered for thousands of years for its ability to enhance cognition. So researchers in Thailand worked with 28 people in a placebo-controlled, double-blind trial to put some science behind this reputation.

Each participant in this study received an extract of Gotu kola at various doses ranging 250, 500, and 750 mg once per day for 2 months. The study showed the higher dose of Gotu kola enhanced working memory and mood.[xi]

Researchers in India set out evaluate the nootropic value of Gotu kola. Three-month old Swiss albino mice were given doses of Gotu kola extract for 15 and 30 days.

The researchers found that Gotu kola increases acetylcholine activity. And increased dendrites in the mice hippocampus. Showing that Gotu kola can promote higher brain function.[xii]

Gotu Kola Recommended Dosage

Recommended dose of Gotu kola standardized extract is 50 – 250 mg taken 2 or 3 times daily. Gotu Kola powder in capsules recommended dosage is 400 – 450 mg per day.

Standardized extracts should contain 40% asiaticoside, 29 to 30% asiatic acid, 29 to 30 % madecassic acid, and 1 to 2% madecassoside. But most Gotu Kola supplements sold in the USA are capsules of dried powder and not a standardized extract. The few extracts available contain only 10% Triterpenes. 

Gotu Kola (Indian Pennywort)

In human studies in people with venous insufficiency (poor blood circulation in the legs), 90 – 180 mg daily worked well for these patients.

As a tincture (1:2 w/v, 30% alcohol): 30 to 60 drops (equivalent to 1.5 to 3 mL, there are 5 mL in a tsp.), 3 times daily.

Gotu Kola Side Effects

Side effects are rare with Gotu kola. But may include skin allergy and burning sensations if you’re applying it on your skin. Taken internally, side effects could include headache, upset stomach, nausea, dizziness and drowsiness.

Gotu kola has been used in some studies that lasted up to one year. But please note that Gotu kola has the potential to be harmful to the liver. Some medical authorities caution that it is best not to use Gotu kola for more than 6 weeks without talking to your doctor.

Asiaticoside, a major part of Gotu kola, has also been linked with tumor growth in mice. If you have a history of precancerous or cancerous skin lesions, such as squamous cell, basal cell skin cancer, or melanoma, you should not use Gotu kola.

Some men have reported that Gotu Kola reduced libido. Animal studies show that supplementing with Gotu Kola may reduce sperm count in men, and reduce levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).

And if you have liver disease, or take medications that affect the liver, you should not take Gotu kola. Again, check with your doctor if you take any prescription medications, or often take over-the-counter pain relievers that could affect your liver.

Type of Gotu Kola to Buy

Gotu kola is available in teas, dried leaf in powder form, tinctures, capsule, tablets and ointments.

Most of the clinical studies used in this review were using Gotu Kola extracts. In the USA, most Gotu Kola supplements are not extracts but dried powder in capsules. And the few Gotu Kola extracts that are available contain at most 10% triterpenes.

You will get the most nootropic value from a standardized extract of Gotu Kola. Checking the user reviews will help narrow your choice.

Check to ensure the supplement company has a robust testing program in place. They should have a Certificate of Analysis available for the Gotu Kola supplement you are considering to verify the purity and quality of their supplement. If not, move on the next Gotu Kola supplement and run it through your verification process.

Nootropics Expert Recommendation

Gotu Kola extract up to 500 mg per day

Nootropics Expert Tested and ApprovedI recommend using Gotu Kola as a nootropic supplement.

Your body does not make Gotu Kola. So you must take it as a supplement to get its effects.

This ancient herb has a long history of safe use as both an herbal remedy, and food throughout much of southeast Asia.

Here in the West, Gotu Kola is mostly used for healing varicose veins and skin conditions. But its overlooked as a nootropic.

Gotu Kola can improve your mood and memory. And protect your brain from free radicals and the toxins you’re exposed to everyday.

Gotu Kola as a nootropic has the potential to keep you mentally sharp for life. And if the ancients were right, may even help you live longer.

You can even out the stress and anxiety of your day by sipping Gotu Kola tea. Or use a supplement as a cognitive enhancer.

If you’re using Gotu Kola extract the recommend dosage is up to 500 mg per day which is 250 mg twice per day.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Wang L., Xu J., Zhao C., Zhao L., Feng B. “Antiproliferative, cell-cycle dysregulation effects of novel asiatic acid derivatives on human non-small cell lung cancer cells.” Chemical and Pharmaceutical Bulletin (Tokyo). 2013;61(10):1015-23 (source)

[ii] Orhan G., orhan I., Sener B. “Recent Developments in Natural and Synthetic Drug Research forAlzheimer’s Disease” Letter in Drug Design & Discovery 2006 (source)

[iii] Soumyanath A., Zhong Y.P., Gold S.A., Yu X., Koop D.R., Bourdette D., Gold B.G. “Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.” Journal of Pharmacy & Pharmacology. 2005 Sep;57(9):1221-9. (source)

[iv] Gadahad M.R., Rao M., Rao G. “Enhancement of hippocampal CA3 neuronal dendritic arborization by Centella asiatica (Linn) fresh leaf extract treatment in adult rats.” Journal of the Chinese Medical Association. 2008 Jan;71(1):6-13. (source)

[v] Sheffield M.E.J., Dombeck D.A. “Calcium transient prevalence across the dendritic arbour predicts place field properties” Nature 517, 200–204 (08 January 2015) (source)

[vi] Wattanathorn J. et. Al. “Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.” Journal of Ethnopharmacology. 2008 Mar 5;116(2):325-32. (source)

[vii] Peters R. “Ageing and the brain” Postgrad Medical Journal 2006 Feb; 82(964): 84–88. (source)

[viii] Seshadri S., Wolf P.A., Beiser A., Elias M.F., Au R., Kase C.S., D’Agostino R.B., DeCarli C. “Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study.” Neurology. 2004 Nov 9;63(9):1591-9. (source)

[ix] Barnes C.A. “Long-term potentiation and the ageing brain.”Philosophical Transactions of the Royal Society of London Series B Biological Sciences. 2003 Apr 29;358(1432):765-72. (source)

[x] Wanakhachornkrai O., Pongrakhananon V., Chunhacha P., Wanasuntronwong A., Vattanajun A., Tantisira B., Chanvorachote P., Tantisira M.H. “Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells.” BMC Complementary and Alternative Medicine. 2013 Aug 4;13:204. (source)

[xi] Wattanathorn J., Mator L., Muchimapura S., Tongun T., Pasuriwong O., Piyawatkul N., Yimtae K., Sripanidkulchai B., Singkhoraard J. “Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica.” Journal of Ethnopharmacology. 2008 Mar 5;116(2):325-32. (source)

[xii] Rao S.B., Chetana M., Uma Devi P. “Centella asiatica treatment during postnatal period enhances learning and memory in mice.”Physiology and Behavior. 2005 Nov 15;86(4):449-57. (source)

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Join The Discussion - 61 comments

Jazmin
October 28, 2021

Hi David! You think is recommended to take Gotu Kola when taking methylphenidate? I’m taking it to treat ADHD and I don’t want to reduce its effect.

Thanks

    David Tomen
    October 30, 2021

    Jazmin, I don’t think Gotu Kola will reduce the effectiveness of methylphenidate. There is no data suggesting that it will. And I haven’t heard anything to the contrary either.

Bob
September 27, 2021

Hi David,

I have tried gotu kola and really like the effects of it, my memory increased a lot. Although, I have experienced lower libido while taking it. I am 25 years old male.
I found this research paper which made me stopped taking it. https://pubmed.ncbi.nlm.nih.gov/21870191/
What do you think about this paper? Should I be concerned?
Also, do know any other nootropic with similar effects to gotu kola but without the reduction in serum testosterone?

Thank you for your answer.
bob

    David Tomen
    September 28, 2021

    Bob, I knew that long-term use of Gotu Kola could be hard on your liver. But decreased sperm count, testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels is news to me. Looks like I need to update the Side Effects section of this review.

    Gotu Kola supports memory by increasing the availability of acetylcholine as well as dendrites and axons. You can use Alpha GPC or CDP-Choline along with ALCAR to increase acetylcholine. And you’ll get ideas for helping memory by increasing axon and dendrites from this article: https://nootropicsexpert.com/best-nootropics-for-learning-and-memory/

Anastasia
September 2, 2021

Hello, David!
I wanted to use Gotu Cola mostly for the circulation, and other benefits as l have fond here… The question is if it is just a powder, not extract, will it help in something? I mean, should l hive it a try or search extract or another herb?…
And l also scarried a little bit about side effects. Is the powder as dangerous as the extract?
And is there any problems to take it with Ashwaganda?
Thank you for your help

    David Tomen
    September 2, 2021

    Anastasia, Gotu Kola has been used for thousands of years in traditional medicine and they certainly did not have “extracts” to work with back then. Today, we are fortunate that technology allows up to use extracts. So we get more of the active compounds in these herbs at lower dosages. It if it just plain, ground up Gotu Kola you use a higher dose to get the same effect.

    Recommended dose of Gotu kola standardized extract is 50 – 250 mg taken 2 or 3 times daily. Gotu Kola powder in capsules recommended dosage is 400 – 450 mg per day. And yes, you should be able to use it with Ashwagandha without a problem.

    Other great ways to boost cerebral blood flow are with Vinpocetine and Maritime Pine Bark Extract.

R
May 19, 2021

Hi David, these are very helpful guides, thank you. It would be even more helpful if you were to include best time of day to take, as well as if to take on an empty stomach or with food. For example I think I’ve read that gotu kola is calming, so better before bed? I always have to google “best time of day to take” and “empty stomach or food” for every supplement i’m interested in. Would be that much more helpful to have the info already in the same place. Thanks again.

    David Tomen
    May 19, 2021

    I do include timing during the day for each of the supplements I write and talk about. For example, “Recommended dose of gotu kola standardized extract is 50 – 250 mg taken 2 or 3 times daily.” Maybe I should make it clearer by adding “morning, noon and late afternoon or early evening”?

      Chris Isherwood
      June 10, 2021

      Hi Dave,

      First, thanks for being a great guide! I’m new to Gotu Kola. I had a question about dosage; the capsules I brought ( Nature’s Way) say there’s 950mg per serving, and to take two capsules daily. This seems much higher than recommended here. The brand is apparently respectable so I’m curious as to your experienced opinion; would two be too many?

      Thanks

        David Tomen
        June 10, 2021

        Chris, my recommended dosage for Gotu Kola is for an extract. Nature’s Way Gotu Kola is NOT an extract so dosage of two capsules = 950 mg. If it’s just the powder you should be able to use that dose twice per day. Start with one dose per day and see how you feel. After 2 – 3 days try increasing the dose and see how that works.

        But keep in mind that if you have any type of liver problems you should not be using Gotu Kola.

bob
November 3, 2020

Hi David,
I’ve been reading this paper on researchGate about the telomeric effects of Gotu Kola: https://www.researchgate.net/publication/335367218_Discovery_of_potent_telomerase_activators_Unfolding_new_therapeutic_and_anti-aging_perspectives

I’ve not (yet) found any online advice about whether I should simply buy raw Gotu Kola powder, or whether I should buy an ‘extract’ powder. Do you have any advice on this question? Or perhaps you have a suggestion regarding where I might find an answer?

thanks for your help, have a great day 🙂

Rob

PS. In the paper (cited above), the next most powerful telomeric stimulator was oleanolic acid (found in olive leaf extract supplements)

    David Tomen
    November 4, 2020

    Bob, the study you cited says that Gotu Kola extract produced an 8.8 fold increase in telomerase activity. It was definitely an “extract”. You can try this one: https://amzn.to/35XvNcM. Or Bulk Supplements has a Gotu Kola extract powder here: https://amzn.to/2TXu4yw

Dave
June 29, 2020

Hi Dave,

Is Gotu kola harmful when T3 and T4 are at the upper levels (not crossing the maximum levels).

I am particulary careful, as several months ago, these were elevated due to combination of Ashwagandha and L-Tyrosine.

    David Tomen
    June 29, 2020

    Dave, Gotu Kola doesn’t have any effect on thyroid hormones.

Nick
January 6, 2020

You mention that it should be taken for 6 weeks at most in order to avoid any liver damage. Can you tell us what should be the interval between usages?

    David Tomen
    January 7, 2020

    Nick, I mentioned that “some medical authorities” advise caution when using Gotu Kola long-term because it has the potential to harm your liver. Other medical literature suggest this is only a problem if you have issues with your liver.

    I think the easiest way to figure out what’s best for you is try Gotu Kola. If it works for you and you want to continue using it then have your doc include labs for your liver every few months. That’ll tell you if this nootropic is causing problems. Certain elevated enzymes in your liver could be a warning.

Jean-Philippe Raymond
December 12, 2019

Hi David I was reading your newsletter about telomere growth.

When we spoke you told me holy basil made what gotu kola does + more.

Do you still recommend holy basil first before gotu kola ?
Thanks

    David Tomen
    December 12, 2019

    Jean-Philippe, I still recommend Holy Basil for what it does including helping repair DNA. Gotu Kola has its own unique benefits including this new and substantiated claim of regrowing telomeres. Both are amazing nootropic adaptogen supplements.

    I suggest going back as carefully going through the mechanism of action for each to clarify how they each offer unique benefits.

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