Lion's Mane boosts nerve growth factor in the brain

Lion’s Mane

David Tomen
Author:
David Tomen
12 minute read
Lion’s Mane Mushroom is known for stimulating Nerve Growth Factor, improving cognition and memory, and relieving depression.

Lion’s Mane (Hericium erinaceus) is unique in the mushroom family both in appearance and function. Lion’s Mane Mushroom is extremely effective at stimulating Nerve Growth Factor (NGF) in the brain.

Known for its powerful effects as a “brain tonic”, Lion’s Mane is said to have been used as a tea for thousands of years by Buddhist monks. To enhance brain power, and heighten their ability to focus during meditation.

Lion’s Mane as a nootropic, is a powerful catalyst for brain cell regeneration helping improve memory and cognition.

The primary active compounds in Lion’s Mane are hericenones and erinacines. Erinacines help your brain produce more Nerve Growth Factor. Erinacines easily cross the blood-brain barrier to boost the production of neurons.

Lion’s Mane helps:

  • Nerve Growth Factor. Lion’s Mane Mushroom prevents and treats nerve damage in the brain. Once past the blood-brain barrier, Lion’s Mane stimulates enzyme production that release Nerve Growth Factor (NGF). Nerve regeneration helps relieve neurodegenerative disease symptoms such as Alzheimer’s, dementia, and Parkinson’s Disease.
  • Neurogenesis. Lion’s Mane stimulates the repair and creation of neurons. Boosting neurotransmitters and signaling that effects memory, learning, recall, and mood.
  • Brain Optimization. Lion’s Mane helps eliminate brain fog. Restoring memory and mental alertness. And improves anxiety and depression symptoms.

Overview

Lion’s Mane (Hericium erinaceus) is a medicinal mushroom proven to benefit the brain, nerves and immune system.

Unlike other mushrooms sporting a cap and stem, Lion’s Mane has long, flowing, white tendrils. Resembling a lion’s mane. Other names include Monkey’s Head, Bearded Tooth, Pom Pom Blanc, Hedgehog Mushroom and Satyr’s Beard.

Lion's Mane Mushroom grows on trees
Lion’s Mane mushroom (Hericium erinaceus)

This parasitic fungus grows hanging off logs and trees. And is native to North American, Europe and Southeast Asia. In Japan, it’s called yamabushitake or “those who sleep in mountains”. Referring to the Shugendo sect of hermit monks and their long, flowing robes.

As a nootropic, Lion’s Mane has been shown to be particularly effective in stimulating Nerve Growth Factor (NGF) in the brain.

NGF is produced in the hippocampus throughout life. Modulating cholinergic receptors and neuroplasticity.[i] And is essential for learning.

Nerve Growth Factor are special proteins that function to regenerate neurons. Lion’s Mane contains two unique classes of NGF’shericenones and erinacines which easily cross the blood-brain barrier.

Lion’s Mane, like other medicinal mushrooms, contain high amounts of the antioxidant beta-glucoxylan and four other polysaccharides and polypeptides. Having a significant impact on enhancing your immune system. And decreasing tumor growth.

Lion’s Mane has also been studied in reducing amyloid plaques. These clumps of beta-amyloid proteins block signals between neurons. And are implicated in Alzheimer’s and other neurodegenerative diseases.

Lions’ Mane is also used to treat Lyme’s Disease, and digestive tract issues.

Here we’re talking about Lion’s Mane Mushroom and its effects on brain health and chemistry.

Lion's Mane boosts nerve growth factor in the brain

How does Lion’s Mane Work in the Brain?

Lion’s Mane boosts brain health and function in several ways. But two in particular stand out.

  1. Lion’s Mane Mushroom stimulates the synthesis of Nerve Growth Factor (NGF). NGF is a protein that plays a major role in the maintenance, survival and regeneration of neurons.

NGF is required by your brain to keep neurons strong and healthy. When various neurological disorders occur, your brain is unable to produce its own internal source of NGF.

In a study done in Kuala Lumpur in 2013, scientists showed that Lion’s Mane extract induced NGF synthesis and promoted neurite outgrowth.[ii]

  1. Lion’s Mane is effective in reducing anxiety and depression. Some even call it the “smart mushroom” for its ability to improve cognition, memory and work as an anti-depressant.

A study by researchers in Japan worked with 30 women. The female subjects had been complaining about menopause, depression, sleep quality and other issues.

The women randomly received Lion’s Mane-laced cookies or a placebo for 4 weeks. The researchers found that Lion’s Mane “has the possibility to reduce depression and anxiety, and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus”. [iii]

How things go bad

Science once believed that the brain could not grow new brain cells. That once our brain developed during childhood, and we reached adulthood, we had all the brain cells we’d ever have.

Now we know that neurons can regenerate. But that doesn’t mean they will regenerate. A number of health issues can contribute to neurodegeneration.declining nerve growth factor

↓ Decrease in Nerve Growth Factor = Decrease in Long-Term Potentiation affecting long-term memory[iv]

↓ Brain cells die and are not replaced

Neuroplasticity declines resulting in poor memory

Neurotransmitters decline resulting in anxiety, poor mood and depression

All of these age-related changes are contributing factors to neurodegenerative diseases like Alzheimer’s, Parkinson’s and others. And anxiety, depression and mood disorders that affect quality of life.

Lion’s Mane benefits

At least a dozen peer-reviewed studies have been published on Lion’s Mane benefits to brain health since 1991. Dr. Kawagishi of Japan was first to identify Nerve Growth Factor properties in Lion’s Mane Mushroom.[v]

In one double-blind, placebo-controlled trial, researchers in Japan worked with 50 – 80 year old men and women. All suffered from mild cognitive impairment.

The trial subjects received four 250 mg tablets containing 96% of Yamabushitake (Lion’s Mane) dry powder three times a day for 16 weeks. The men and women were tested at 4, 8, 12 and 16 weeks.

At each of the testing periods, the subjects who had used Lion’s Mane showed a significant improvement in cognitive scores. And their scores were increasing while on Lion’s Mane supplementation. But 4 weeks after stopping Lion’s mane supplementation, their cognitive scores decreased significantly.

The researchers concluded that Lion’s Mane Mushroom is effective in improving mild cognitive impairment.[vi]

How does Lion’s Mane feel?

You may not experience the effects of supplementing with Lion’s Mane Mushroom immediately. But many users report with continued use of Lion’s Mane, a boost in mood and mental energy.

Lion's Mane boosts moodSome report it increases depth perception. And an improvement in sense of smell.

Others testify to improved decision-making, the ability to solve problems and learning. Likely due to Lion’s Mane ability to improve neuroplasticity.

The overall consensus is Lion’s Mane Mushroom’s ability to lessen anxiety, reduce depression, and improve concentration.

Lion’s Mane Clinical Research

Lion’s Mane Mushroom has been used as a food and herbal medicine since ancient times in East Asia. And it has been reported in scientific research that Lion’s Mane promotes Nerve Growth Factor both in the petri dish as well as in animal and human test subjects.

Lion’s Mane Prevents Cognitive Dysfunction

In this study, researchers examined the effects of Lion’s Mane on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Amyloid β(25-35) peptide is implicated in diseases like Alzheimer’s.

Mice were injected with the peptide on days 7 and 14 of the trial. And they were fed a diet containing Lion’s Mane over 23-days of the experiment. The results showed that Lion’s Mane prevented short-term and visual recognition memory reduction normally induced by amyloid β(25-35) peptide.

They concluded that Lion’s Mane Mushroom “may be useful in the prevention of cognitive dysfunction”.[vii]

Lion’s Mane Induces Nerve Growth Factor

In this trial, mice were fed Lion’s Mane 5% freeze-dried powdered extract for 7 days. Researchers found an increase in the level of Nerve Growth Factor (NGF) in the hippocampus of the mice. Concluding that Lion’s Mane “contains active compounds that stimulate NGF synthesis”.[viii]

Lion’s Mane Repairs Nerves

In this study done with rats, Lion’s Mane extract was able to promote neuron regrowth after injury. Rats with gluteal nerve damage were able to walk again after consuming water containing Lion’s Mane extract.

The researchers concluded that Lion’s Mane regenerates damaged nerve cells. In this case, the reversal was so profound, the rats went from being totally disabled to walking again.[ix]

Lion's Mane prevents cognitive dysfunction

Lion’s Mane Dosage

Wondering how much Lion’s Mane to take? Dosing of Lion’s Mane Mushroom depends on the strength of the extract.

For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day. This means that if you choose a daily dose of 1,000 mg of Lion’s Mane extract, you should take 500 mg in the morning, and another 500 mg at noon.

Other retail extract dosage of Lion’s Mane ranges from 300 mg to 3000 mg dosed 1 – 3 times per day. Check the label and see what the manufacturer recommends. And when first using the supplement, start with the lowest dose and see how your body reacts.

Lion’s Mane Side Effects

Lion’s Mane Mushroom is non-toxic and considered very safe. So there are very few side effects reported.

Some neurohackers report itchy skin from higher doses. Likely attributable to a boost in Nerve Growth Factor.

Lion’s Mane has been tested in animals showing no side effects or toxicity even up to 5 grams per kilogram.

Best type of Lion’s Mane to buy

Lion’s Mane Mushroom (Hericium erinaceus) as a nootropic supplement is usually offered as an extract. In powdered form, or in a capsule.

MindLab Pro with Lion's ManeLion’s Mane Mushroom can be found in some of higher quality pre-formulated nootropic stacks. For example, Mind Lab Pro® contains 11 brain enhancing nootropic compounds including Lion’s Mane with the full fruit spectrum including hericenones and erinacines.

I recommend Mind Lab Pro® because it addresses all aspects of anxiety resistance, memory and cognitive enhancement, stabilizes mood, brain repair, and maintenance.

This premium nootropic stack is designed to affect neurotransmitters, cognitive energy, brain waves, neuroprotection, and regeneration. See my Mind Lab Pro review for a detailed report.

When choosing a Lion’s Mane supplement, there’s debate over the best form of extraction to achieve the mushroom’s full medicinal benefit. Some say your best option is a hot water extraction. Another says alcohol extraction. Another claims both are necessary.

But when it comes to mushrooms, saying that one is “more potent” than another is just too simplified to be true. This is as much an art as it is science.

Much more important is choosing a supplement that includes the mycelium of Lion’s Mane Mushroom. In this mushroom, the fruiting body does not contain erinacines which is the compound that boosts Nerve Growth Factor (NGF).

The nootropic benefits of hericenones only found in the fruiting body or top of the mushroom help support your immune system and get rid of Amyloid β(25-35) peptide implicated in diseases like Alzheimer’s.

The challenge is getting a Lion’s Mane Mushroom extract that contains the full spectrum found in both the mycelium and fruiting body. But the mushroom must be grown in liquid and not a solid substrate like grain. Otherwise you’ll get ground up grain without the important erinacines needed for increased NGF.

Look at the manufacturer’s literature and marketing material and find out how their Lion’s Mane is grown. And read the reviews on shopping sites as well as forums.

Types of Lion’s Mane available:

  • Plain Lion’s Mane: Pure, powdered mushroom. Often freeze-dried, and the cheapest form available. Can be added to water, juice or smoothies.
  • Lion’s Mane Extracts: A more potent form of mushroom. Often presented as 14:1 or 10:1 extracts (14 pounds or 10 pounds reduced to 1 pound of extract).

You will get 500 mg Lion’s Mane full spectrum extract in Mind Lab Pro®.

If you want a standalone Lion’s Mane Extract, I recommend Real Mushrooms organic Lion’s Mane Extract

  • Standardized Lion’s Mane: Processed to provide exact levels of active ingredients. You can get Lion’s Mane standardized to 30% and 50% polysaccharides (including the active secondary metabolites hericenones and erinacines).
  • Lion’s Mane tea: Since this is a popular mushroom in the kitchen, the taste is acceptable. But it’s hard to get a handle on how much actual active ingredient you’re getting.
  • Amycenone®/PLM-Fraction: This “branded” product is standardized to Hericenones 0.5%, Amyloban 6%. It seems to target a lesser-known Lion’s Mane active ingredient–Amyloban–which is positioned as a mushroom compound that fights beta-amyloid proteins. Originating in Japan, it is extremely expensive, and may be found in a supplement called Amyloban®3399.

And if you decide to pick your own, before consuming any wild mushroom, make sure that it is accurately identified. Mushroom poisoning is a real problem if you pick the wrong one.

For a full list of Mycology societies that may be able to help you, go to the North American Mycological Association website (www.namyco.org).

Nootropics Expert Recommendation

Lion’s Mane 500 – 2,000 mg per day

Nootropics Expert Tested and ApprovedI recommend using Lion’s Mane as a nootropic supplement.

Your body does not make Lion’s Mane on its own. So you need to take it as a supplement.

Lion’s Mane is especially helpful for regenerating brain cells. It prevents neurodegenerative diseases like Alzheimer’s and Parkinson’s.

And it boosts long-term potentiation for memory and mental sharpness. By stimulating Nerve Growth Factor.

Lion’s Mane also helps boost mood, tame anxiety and relieve depression. For a better quality of life.

We suggest starting with a dose of 500 mg daily. The best human study used 3000 mg per day. But another researcher found lower concentrations may stimulate NGF better than higher concentrations.[x]

Start at 500 mg per day and see how it works for you. If you don’t experience a benefit, boost Lion’s Mane in small increments of 250 mg per day until you notice an improvement. And make sure you are using a supplement containing the mycelium and fruiting body that is grown in a liquid medium.

You can buy individual Lion’s Mane supplements. Or you could try my favorite pre-formulated nootropic stack Mind Lab Pro® which includes the full spectrum including hericenones and erinacines found in Lion’s Mane Mushroom.

Mind Lab Pro contains a synergistic blend of 11 brain enhancing nootropics covering all aspects of cognition and brain health. See my full Mind Lab Pro review for more.

Lion’s Mane is a great compliment to a nootropic stack including Aniracetam, Alpha GPC and Omega-3’s for an immediate cognitive boost.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Conner J.M. et. Al. “NGF Is Essential for Hippocampal Plasticity and Learning” The Journal of Neuroscience 2 September 2009, 29(35): 10883-10889 (source)

[ii] Lai P.L., Naidu M., Sabaratnam V., Wong K.H., David R.P., Kuppusamy U.R., Abdullah N., Malek S.N. “Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.” International Journal of Medicinal Mushrooms. 2013;15(6):539-54. (source)

[iii] Nagano M., Shimizu K., Kondo R., Hayashi C., Sato D., Kitagawa K., Ohnuki K. “Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.” Biomedical Research. 2010 Aug;31(4):231-7. (source)

[iv] Kelly A., Conroy S., Lynch M.A. “Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus.”Neuropharmacology. 1998 Apr-May;37(4-5):561-70. (source)

[v] Kawagishi H., et. Al. “Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum” Tetrahedron Letters Volume 35, Issue 10, 7 March 1994, Pages 1569–1572 (source)

[vi] Mori K., Inatomi S., Ouchi K., Azumi Y., Tuchida T. “Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.”Phytotherapy Research. 2009 Mar;23(3):367-72. (source)

[vii] Mori K., Obara Y., Moriya T., Inatomi S., Nakahata N. “Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.” Biomedical Research. 2011 Feb;32(1):67-72. (source)

[viii] Mori K., et. Al. “Nerve Growth Factor-Inducing Activity of Hericium erinaceus in 1321N1 Human Astrocytoma Cells” Biology Pharmaceutical Bulletin September 2008 31(9) 1727—1732 (2008) (source)

[ix] Wong K.H., Naidu M., David P., Abdulla M.A., Abdullah N., Kuppusamy U.R., Sabaratnam V. “Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae).” Evidence-Based Complementary and Alternative Medicine. 2011;2011:580752. (source)

[x] Sabaratnam V., Kah-Hui W., Naidu M., David P.R. “Neuronal Health – Can Culinary and Medicinal Mushrooms Help?” Journal of Traditional and Complimentary Medicine 2013 Jan-Mar; 3(1): 62–68. (source)

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Join The Discussion - 384 comments

Joe
November 3, 2020

Considering taking Lion’s Mane and I was doing some research. My biggest concern is does it have any side-effects on males? Particularly related to sex health, ie sperm cell and etc. I’m a male in my early 30s and no kids yet, but planning on it in the near future, so would not want anything to potentially risk that.

    David Tomen
    November 4, 2020

    Joe, I am not aware of any negative consequences for human males using Lion’s Mane. Have you seen some research that I may have missed? I’m not talking about hearsay from some blogger. I mean real, peer-reviewed science published in a journal.

Vadim
October 29, 2020

Hello
Relatively recently, I learned about the fact that the lion’s mane, combined with niacin, can help restore the peripheral nervous system (I need this because of the Charcot Mari tut disease) and of course I immediately started taking it. Later, I thought it was a cool idea to start another methylene blue, at that time I already took about 1.5 months a lion’s mane. It seemed to me that they should work cool in combination. I already had experience taking methylene blue, about 500 mcg per day may 1 mg. But despite this, I decided to try a very small dosage, I diluted with water such a small part of methylene blue that it was transparent, and after that I tried with the tip of my tongue. I don’t know what dosage I received, but as you know, it was very small.
Five minutes later, my pulse rose sharply to 150 beats. My pressure then rose too much (I don’t remember the exact numbers anymore). My mouth was dry and I constantly wanted to drink a strong odor of acetone in my mouth. This evening I drank incredibly a lot of water and at about 23:00 the pulse began to decline and returned to normal, and at about 24:00 I might fall asleep later.
Waking up in the morning, I felt good about yesterday. However, by 3-4 o’clock in the evening I felt sick I felt cold I felt weak. After an hour and a half, the sensation began to pass and it became easier for me. Later I checked my heart rate (130) and blood pressure (150 to 90). Also, I could not eat anything because I immediately began to feel sick and a ringing appeared in my head.
The next day I felt better again but was still ill. In the evening my kidneys started to hurt.
I don’t know why why I got so many negative effects, but I decided to write this post to warn against experiments with such a combination. I have a feeling that if I received a dosage of at least 2 times that I could die.

    David Tomen
    October 29, 2020

    Vadim, a couple of things. Are you using the same Methylene Blue as you were before? Because it could be a toxic batch. MG is known for being high in heavy metals to begin with.

    The other thing is Methylene Blue is a monoamine oxidase inhibitor (MAOI) which means it boosts all of the catecholamines and even serotonin to certain extent. That could upset the balance of what you had going on in your brain.

      Vadim
      November 22, 2020

      It was the same methylene blue and from the same bottle.

      With my message I would like to warn about such a potentially dangerous combination. I don’t know, maybe it’s just for me she’s dangerous.

      And of course it would be great if you could guess why it worked this way at all.

        David Tomen
        November 23, 2020

        Vadim, Lion’s Mane modulates choline receptors. And Methylene Blue is an acetylcholinesterase inhibitor. Your acetylcholine levels must have spiked.

        That is the only thing I can think of that may have caused this reaction in you.

        Vadim
        November 29, 2020

        Thanks for the answer! Initially, I suspected that this was due to the fact that they are both MAO inhibitors, but now I think you are right with the assumption about acetylcholine.

Denise Kimberly
October 23, 2020

I purchased today and the recommended dosage is 1 tablet a day containing 300mg of Lion’s Mane.

    David Tomen
    October 23, 2020

    Denise, don’t pay attention to dosage recommended on bottles from the manufacturer. Use the dosage recommended here because these were taken from clinical studies on what actually works.

    300 mg of Lion’s Mane is such a low dose it would take a long time before you experienced any benefit.

Alex
October 20, 2020

Hello David, Ive started taking the 8:1 powdered extract from Nootropicdepot and I started having insufferable headaches from it. I really dont want to stop taking it, what should I do?

    David Tomen
    October 20, 2020

    Alex, switch brands. There is no reason Lion’s Mane should cause headaches.

      Servo
      December 25, 2020

      Apparently, for some people, potentially high AcH levels cause migraine type symptoms, including tension headaches.

        David Tomen
        December 26, 2020

        Servo, too much acetylcholine will cause issues possibly including headaches. But Lion’s Mane does not increase acetylcholine levels. So that’s that the problem here.

    Ron
    December 18, 2020

    Alex, have you tried another brand ye? I am taking the same brand 8:1 and have experienced terrible headaches. I want to know if it’s worth spending money on another brand of powder.

Karen Story
October 10, 2020

Lions mane can be dangerous. I had an experience where on the first night of taking it, I had a bit of A-fib (the first ever). The second day, I took less but again my heart rate went all over the place and I was hospitalized and had to do cardio-conversion. I have read others have experienced very rapid heart rates and heart rhythm issues using lions mane. Please be careful

    David Tomen
    October 11, 2020

    Karen, I don’t doubt what you are saying. But in all of my research into Lion’s Mane I never came across anything like what you describe. And looking at the mechanism of action for Lion’s Mane I still don’t see how it can cause what happened to you. This sounds more like an adulterated supplement. And not pure Lion’s Mane.

Sarah
September 28, 2020

Hi! I have been searching for so long for an answer to this question… Using the alcohol jar method of extraction, If I left my lion’s mane in the alcohol for a year, is it ok to use and continue to the water extraction method? What happens to the mushrooms and the alcohol it if it sits that long? The only thing about it i can find says to let sit up to a month. one site said 3 months is ok. But i can’t find a site that tells me why only that long and what happens if its forgotten. I can’t imagine im the only person who has forgotten about something like this, right? or maybe i am. who knows. I would love to gain some insight on this! much appreciated!

    David Tomen
    September 29, 2020

    Sarah, anything left in alcohol for a year is likely safe to use but I can’t imagine any benefit to doing it. And I’ve never seen any value in trying to create my own extract from something like Lion’s Mane when it is so readily available to buy.

    The sites that you mention are likely bloggers doing their own experiments. So please be careful what you use from sites like that. Safer to leave it to the professionals who have figured extracts out and sell it as a supplement.

Sonya Bartley
September 16, 2020

I am desperately looking for a supplement that will help with focus and concentration, without the caffeine jitters! I love to read, but cannot stay focused without my mind wondering away! Please, please any recommendations?

dave
August 14, 2020

Is it possible and effective to sublingual administer lion’s mane extract?

    David Tomen
    August 15, 2020

    Dave, that’s not the way Lion’s Mane works. The minimum dose of Lion’s Mane is 500 mg and your body needs to digest it to extract the active compounds. That would be impossible if you injected it directly into your bloodstream.

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