Noopept

Noopept

David Tomen
Author:
David Tomen
Robert Iafelice, MS, RDN, LDN
Fact Checked:
Robert Iafelice, MS, RDN, LDN
16 minute read
Noopept is known for boosting memory, learning, perception, logical thinking, mood, and improved cognitive function.

Key Takeaways

  1. Noopept is a potent cognitive enhancer with various benefits for memory, learning, perception, and mood.
  2. It differs from traditional racetam compounds but still produces similar effects.
  3. It is up to 1000 times more potent than Piracetam and offers additional benefits, such as lower effective doses and influencing memory consolidation and retrieval.
  4. Noopept is considered safe within the recommended dosage range of 10 – 30 mg per day.
  5. In the USA, the best place to buy Noopept is Cosmic Nootropic – Noopept or Science.bio-Noopept Powder or Science.bio-Noopept Solution


Noopept (n-phenylacetyl-l-prolylglycine ethyl ester or GVS-111)
is an ampakine nootropic similar in action to the racetam-class of compounds. Noopept is up to 1000-times more potent than the original racetam, Piracetam.

Noopept was patented by Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals in 1996. Research shows Noopept has similar effects, but works differently than other nootropics in the racetam-family.

Noopept is not considered a true “racetam” because it doesn’t have a 2-oxo-pyrrolidine core.

Noopept does not appear in blood samples when taken as a supplement. Instead it elevates concentrations of cycloprolylglycine (CPG) in the brain.[i]

CPG is a dipeptide consisting of proline and glycine which acts as a modulator of acetylcholine transmission and AMPA receptor function.

Noopept is patented in both Russia and the USA. It is sold as a prescription drug in Russia, and other countries that were part of the Soviet Union. And as a supplement in the United States.

Neurohackers use Noopept to boost cognition, memory and learning. And to improve reflexes, perception, logical thinking and mood.

Noopept helps:

  • Brain Optimization: Noopept increases Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). Critical for neuroplasticity and Long-Term Potentiation. Brain health gets a boost along with long-term memory.
  • Neuroprotection: Noopept prevents the release of excess glutamate in your brain. Glutamate is the brain’s primary excitatory neurotransmitter. When there’s a lack of oxygen in the brain, neurons can’t receive glutamate. This leads to toxic levels of glutamate within brain cells. And can result in neuron damage and death. Diminishing this neurotoxic overload with Noopept is potent neuroprotection.[ii]
  • Brain Waves: Noopept boosts Alpha and Beta brain wave activity. You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.

Overview

Noopept (nphenylacetyllprolylglycine ethyl ester or GVS-111) is often included in the racetam-family of nootropic compounds. But is not a true “racetam” because it does not have a 2-oxo-pyrrolidine nucleus.

Noopept
Noopept

Noopept was developed in Russia where it is called Ноопепт or GVS-111. Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals synthesized Noopept in 1996 based off the endogenous neuropeptide cycloprolylglycine (CPG).

Researchers in Moscow found Noopept similar to Piracetam in not only it’s nootropic effect, but also anxiolytic activity.[iii]

Noopept is a water-soluble ampakine nootropic. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic) refers to one of three glutamate receptors in your brain.[iv]

Noopept could also be considered a Cholinergic compound because it affects acetylcholine levels in the brain.

One of the newer synthetic nootropic compounds, Noopept is known as a cognitive enhancer. And is known for its anxiolytic, or anti-anxiety effects.

As a cognitive enhancer, Noopept is considered to be up to 1000-times more potent than Piracetam. As an ampakine nootropic, it helps increase attention span, alertness and boosts all three levels of memory. Memory formation, retention and recall.

Ampakines tend to have a stimulant effect. But do not produce the same stimulant side effects as Ritalin or coffee from prolonged use.

Noopept vs. Piracetam: What’s the Difference?

Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals developed Noopept in the late 1996 as a peptide analogue of the original nootropic Piracetam.[v]Both Noopept and Piracetam are able to improve learning and memory. And both are able to repair brain damage.

Noopept and Piracetam are both water-soluble. And both Noopept and Piracetam are cognitive enhancers. Both have neuroprotective and anxiolytic (anti-anxiety) qualities.[vi] Both racetams are able to improve learning and memory. And both are able to repair brain damage.

But Noopept has additional benefits not shared with Piracetam. First, the effective dose of Noopept compared to Piracetam is 1,000-times lower. A typical dose of Noopept is 10 – 30 mg while Piracetam is often dosed up to 3 or 4,000 mg.

Second, Piracetam facilitates only the early stages of the memory process. On the other hand, Noopept influences memory consolidation AND retrieval steps as well. But if someone claims “is Noopept a stimulant” it’s simply not true.

So Noopept helps you develop the memory, retain the memory, and then recall what you have stored in memory.[vii]

Noopept also has additional selective anxiolytic (anti-anxiety) action. Researchers believe this is due in part to Noopept’s antioxidant effect, anti-inflammatory action, and the ability to prevent the neurotoxic effect of too much calcium and glutamate.

Noopept can restore the harmony of glutamate and acetylcholine function which can boost cognition, memory, learning, recall, mood and relieve anxiety.

How does Noopept work in the Brain?

Noopept boosts brain health and function in several ways. But two in particular stand out.

  1. Noopept modulates AMPA and NMDA receptors and acetylcholine (ACh) transmission. Noopept boosts the level of cycloprolylglycine (CPG) in the brain. CPG is a dipeptide consisting of proline and glycine which acts as a modulator of acetylcholine transmission, and AMPA and NMDA receptors.

When brain cells are starved of oxygen, glutamate which is your brain’s primary excitatory neurotransmitter, does not work efficiently with neuroreceptors. The result can be a toxic buildup of glutamate within brain cells. Causing neuron damage and ultimately, neuron death.

Noopept modulates neuroreceptor function keeping glutamate transmission at normal levels. Protecting neurons and other brain cells from glutamate damage.

Noopept has also been shown to modulate acetylcholine flow in your brain. Restoring the harmony of glutamate and acetylcholine function not only protects your brain from damage. It can boost cognition, memory, learning, recall, mood and relieve anxiety.

  1. Noopept increases Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and mRNA. NGF and BDNF are directly related to neuroplasticity. This ability to repair and even grow new brain cells can have profound implications. Particularly with someone with neurodegenerative brain damage like Parkinson’s or Alzheimer’s. And even affecting Long-Term Potentiation needed for long-term memory development.

mRNA affects the expression of genes and intracellular communication in brain cells. This ongoing brain signaling and gene expression within brain cells is required for healthy cognition.

One study conducted in Moscow showed long-term use of Noopept boosted NGF, BDNF and mRNA. The animal subjects in this study showed no sign of tolerance. And long-term use of Noopept even potentiated the neurotrophic effect.[viii]

How things go bad

Glutamate is an excitatory relative of GABA. While GABA has a calming effect, glutamate stimulates. Glutamate is the most common neurotransmitter in the central nervous system.Noopept increases Nerve Growth Factor and BDNF which helps reduce age-related cognitive decline.

But glutamate can be toxic to neurons. And too much of it in your brain can kill brain cells. Lou Gehrig’s Disease for example, is caused by excess glutamate.

But glutamate is a pivotal neurotransmitter in the brain. It links the brain circuits involved in memory, learning and perception.

↑ Too much glutamate can kill neurons

↓ Too little glutamate can cause problems with memory, learning and perception

↓ Acetylcholine levels decline

↓ Nerve Growth Factor declines

↓ Brain-Derived Neurotrophic Factor declines

All of these changes can happen at any age. And are a product of the food we eat, what we drink, lifestyle habits, the air we breathe and more.

So Noopept can help for age-related cognitive decline, as well as a student looking to do better in school. By boosting NGF, BDNF and acetylcholine, and controlling glutamate in the brain.

Noopept benefits

Noopept modulates AMPA and NMDA receptors. AMPA receptors are associated with how glutamate and calcium is used in your brain. As a neuroprotective agent Noopept, it’s more of a neuroprotective role.Noopept boosts Alpha and Beta brain wave activity. You become calmer and more creative. And it’s easier to go into a flow state.

Similar to the AMPA receptor, the NMDA receptor is also associated with glutamate and calcium use in your brain.  They work together to modulate how neurons use glutamate.

Noopept modulates levels of glutamate within and between neurons. It prevents glutamate toxicity, and influences Long-Term Potentiation (LTP). LTP is associated with neuroplasticity that allows long-term memories to form.

There is clinical evidence that Noopept boosts communication and neuron signaling. By boosting Alpha and Beta brain wave activity. You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.

Noopept produces an anxiolytic (anti-anxiety) effect. It stimulates dopamine receptors (D2 and D3) and acetylcholine nicotinic receptors. And Noopept also seems to modulate some serotonin receptors. All contributing to a better mood and less anxiety.

Noopept has been shown in the lab to boost Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). NGF and BDNF are both involved in neuroplasticity, and the repair and replacement of damaged brain cells. Resulting in overall better brain health, memory and cognition.[ix]

Noopept is water-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.

How does Noopept feel?

Nootropics users report:

  • Noopept as a study aid. On its own, Noopept increases focus and attention for many neurohackers. Mental arithmetic and grasping difficult concepts is easier.
  • Increased verbal fluidity. Your conversation skills could increase with Noopept. Vocabulary comes easier. Being able to focus contributes to a more balanced dialogue. Neurohackers report being more outgoing, friendly and less self-conscious.
  • Improved mood. With Noopept you may find yourself better able to deal with stressful situations and work issues that normally get you down. Once you get past the first few weeks of unpleasant memories related to PTSD you may find overwhelming emotions will subside. You could feel detached in a pleasant way from painful memories.
  • Music appreciation. Many users report increased pleasure when listening to music while using Noopept. For some it takes music to a different plane. Distinguishing between instruments in sound tracks is easier. As a whole, music sounds better.
  • Long-term memory. Noopept affects NGF and BDNF which affects long-term potentiation. Some neurohackers report memories long forgotten suddenly spring up. Which could be good or bad I suppose depending on the memory. But reports say memories are clear. And if they’re unpleasant there is an emotional detachment shielding from unpleasant feelings.

You should be able to experience the effects of Noopept soon after you take it. It’s water-soluble and enters your cells quickly especially if you take it sublingually.

A word of caution however; don’t go over the recommended 10 – 30 mg per day dose! You will not experience any added benefit, and could bring on unwanted side effects.

There is some debate on the water-solubility of Noopept. It’s not truly fat-soluble but it certainly doesn’t hurt to use a quality “good fat” when taking your Noopept dose.

Clinical studies show Noopept may help prevent the development of Alzheimer’s disease in patients with mild cognitive impairment.

Noopept Clinical Research

Noopept increases Nerve Growth Factor & BDNF

A study published by the Russian Academy of Medical Sciences in Moscow shows that Noopept stimulates Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).

In this study, researchers studied the effect of single and long-term treatment (28 days) of Noopept. They found that one-time treatment boosted mRNA in the cerebral cortex of rats. mRNA is a molecule in brain cells that carries codes from DNA where they specify the amino acid sequence of proteins.

And long-term treatment of Noopept increased Brain-Derived Neurotrophic Factor (BDNF).  The researchers speculated that this sequence of events in the brain plays a role in the restoration of neurons.

Improving neurotrophic synthesis in the hippocampus boosts cognitive function. Particularly consolidation and delayed memory retrieval.

The research team concluded that Noopeptholds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment”.[x]

Noopept boosts Brain Waves

Researchers in Moscow studied the effects of injecting Noopept in rats to see how it would affect brain waves.

The team found that Noopept increased Alpha and Beta brain wave activity throughout the brain.

You experience Alpha waves as you become more relaxed. Alpha waves are associated with super-learning, flow state and joy. Beta waves are associated with concentration, alertness and cognition.

The researchers observed that NMDA receptors were involved with a single injection of Noopept. While AMPA receptors were activated after longer-term use of Noopept.[xi]

NMDA receptors are associated with Long-Term Potentiation (long-term memory) and neuroplasticity. AMPA receptors are associated with increased brain signaling activity. Boosting cognition and memory.

Noopept improves memory

Noopept is known within the nootropic community to enhance cognitive function and memory. And dozens of studies support this claim of better memory when using Noopept.

One study done at the Russian Academy of Medical Sciences in Moscow conducted animal studies, experimenting with Noopept on rats. The animals were trained in passive avoidance response.

The animal’s ability to both form a memory and retain a memory was impaired. But once the rats received a dose of Noopept, they were able to retain a memory and retrieve that memory later.

In other words, their cognitive functions improved. Noopept normalized learning capacity in animals that had damage done to their cerebral cortex. And promoted training ability in rats who started with a hereditary learning deficit.

The researchers noted that “Noopept improves all three stages of memory”. And was most pronounced in those with impaired memory function.[xii]

Another study, again done with rats noted that Noopept stimulated learning after just a single administration. And repeated administration actually increased the number of successful learners among the animals who failed the initial training.[xiii]

Noopept Dosage

Recommended Noopept dosage is 10 – 30 mg per day.

Noopept is very bioavailable and easily crosses the blood-brain barrier.[xiv]Noopept dosage for better learning and memory.

Noopept is sold in tablet, capsule and powder form. Tablets and capsules are usually 10 mg each.

Noopept is primarily water-soluble nootropic, but won’t easily dissolve in water or juice. So it may help if you take it with a meal containing healthy fats. Or with a tablespoon of extra virgin, expeller cold-pressed coconut or olive oil. Or other similar healthy fat to ensure quick absorption.

For even quicker absorption you can use Noopept sublingually. Let the tablet or powder dissolve under your tongue so it can go straight into your bloodstream, and into your brain. Bypassing your digestive system completely.

Noopept Side Effects

Is Noopept safe to use? Noopept is a synthetic nootropic and consider non-toxic. So is considered well-tolerated and safe. As long as you stay within the recommended dosage.

Side effects are rare but can include fatigue, headaches, insomnia or stomach upset. Side effects are often a result of unusually high doses of the nootropic.

Recent research has found that Noopept promotes the level of the Hypoxia-inducible factor 1 (HIF1α) protein. This action helps increase oxygen supply to areas where oxygen levels are low. But it also means that increasing the oxygen supply to tumor cells helps those tumors to proliferate. So, if you have cancer of any kind you should not use Noopept.

Headaches from using Noopept typically happen when you forget to combine it with a good choline supplement. Headaches are often a symptom of a choline deficit in your brain.

Where to buy Noopept

Noopept is sold in tablet, capsule and powder form. Tablets and capsules are usually 10 mg each.

In the USA, you can buy Noopept from Cosmic Nootropic – Noopept

And you can also get Noopept powder or liquid from Science.bio, who have just opened their store again. Science.bio-Noopept Powder or Science.bio-Noopept Solution who sell Noopept as a “research” compound. It is sold to be used in an academic laboratory research setting. They go on to state “nothing we sell is intended for nor is it manufactured for diagnostic or therapeutic purposes in humans.”

In Russia and some other Eastern European countries, Noopept is a prescription drug.

Frequently Asked Questions

Students who use Noopept as a study aid say it helps them with focus and attention. Mental arithmetic and grasping difficult concepts is easier. Many say Noopept helps with verbal fluidity. They report being more outgoing, friendly and less self-conscious.

With Noopept you may find yourself better able to deal with stressful situations and work issues that normally get you down. Many users report increased pleasure when listening to music while using Noopept.  And Noopept seems to help reconnect brain circuits so it is easier to remember long-lost memories. And I personally find that when I use Noopept, I’m more productive.

Noopept really does work. See the section above on How does Noopept feel? And see what real users say about their experience with Noopept for studying, listening to music, improving verbal fluidity, and putting them in a better mood.

Noopept has not been approved by the FDA in the USA as a dietary supplement. So supplement bottles will often say the contains contain a “research compound”. It is NOT illegal to buy or own Noopept in America.

Noopept is not a banned substance in America. Neither has it been approved by the FDA as a dietary supplement. Noopept has not been “scheduled” in Australia, is available OTC in Brazil, but Noopept may be held up in customs in Canada, and so on. For other countries around the world, see my article Are Nootropics Legal in My Country? 

Nootropics Expert Recommendation

Noopept 10 – 30 mg per day

Nootropics Expert has Tested and Approved the use of Noopept as a nootropic supplement.I recommend using Noopept as a nootropic supplement.

Your body does not make Noopept on its own. So to get its benefits you must take it as a supplement.

Noopept is especially helpful for those looking to boost cognition, memory and recall. This nootropic helps boost the activity of acetylcholine in your brain. It modulates glutamate receptors which normalizes optimal neurotransmitter function. And increases Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) which helps the neuroplasticity needed for Long-Term Potentiation.

Noopept is also particularly useful to students and executives who want to boost cognition, learning and memory. My experience using Noopept shows it helps boost study scores, workflow, learning and memory.

Noopept also helps improve verbal fluidity and sociability. Words seem to come easily, and vocabulary you didn’t know you had access to come into play.

Music sounds richer and fuller, and your listening experience enters a new level of music appreciation.

You should stack Noopept with a good choline supplement like Alpha GPC or CDP-Choline. It helps boost neural acetylcholine, so demands the presence of more choline in your brain.

You should not exceed Noopept doses of more than 30 mg per day. This nootropic supplement is highly bioavailable and passes through the blood-brain barrier quite easily. Start with 10 mg and see how you respond.

In the USA, you can buy Noopept from Cosmic Nootropic – Noopept

And you can also get Noopept powder or liquid from Science.bio, who have just opened their store again. Science.bio-Noopept Powder or Science.bio-Noopept Solution

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Gudasheva T.A. et. Al. “The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine.” European Journal of Drug Metabolism and Pharmacokinetics. 1997 Jul-Sep;22(3):245-52. (source)

[ii] Us K.S., Klodt P.M., Kudrin A., Sapronova Ya., Ostrovskaya R.U., Ugryumov M.V., Rayevsky K.S. “The effect of the synthetic neuroprotective dipeptide noopept on glutamate release from rat brain cortex slices” Neurochemical Journal June 2007, Volume 1, Issue 2, pp 138-142 (source)

[iii] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)

[iv] Purves D., Augustine G.J., Fitzpatrick D., et al., editors. “Glutamate Receptors” Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. (source)

[v] Ostrovskaya R.U., Mirsoev T.K., Romanova G.A., Gudasheva T.A., Kravchenko E.V., Trofimov C.C., Voronina T.A., Seredenin S.B. “Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.” Bulletin of Experimental Biology and Medicine. 2001 Oct;132(4):959-62. (source)

[vi] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)

[vii] Ostrovskaia R.U., Gudasheva T.A., Voronina T.A., Seredenin S.B. “[The original novel nootropic and neuroprotective agent noopept].” in Russian Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. (source)

[viii] Ostrovskaya R.U., Gudasheva T.A., Zaplina A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., Seredenin S.B. “Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bulletin of Experimental Biology and Medicine. 2008 Sep;146(3):334-7. (source)

[ix] Ostrovskaia R.U., Vakhitova Iu.V., Salimgareeva M.Kh., Iamidanov R.S., Sadovnikov S.V., Kapitsa I.G., Seredenin S.B. “[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].” in Russian Eksp Klin Farmakol. 2010 Dec;73(12):2-5. (source)

[x] Ostrovskaya R.U., Gudasheva T.A., Zaplina A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., Seredenin S.B. “Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bulletin of Experimental Biology and Medicine. 2008 Sep;146(3):334-7. (source)

[xi] Vorobyov V., Kaptsov V., Kovalev G., Sengpiel F. “Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors.” Brain Research Bulletin. 2011 May 30;85(3-4):123-32. (source)

[xii] Romanova G.A., Shakova F.M., Gudasheva T.A., Ostrovskaya R.U. “Impairment of learning and memory after photothrombosis of the prefrontal cortex in rat brain: effects of Noopept.” Bulletin of Experimental Biology and Medicine. 2002 Dec;134(6):528-30. (source)

[xiii] Ostrovskaya R.U., Mirsoev T.K., Romanova G.A., Gudasheva T.A., Kravchenko E.V., Trofimov C.C., Voronina T.A., Seredenin S.B. “Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.” Bulletin of Experimental Biology and Medicine. 2001 Oct;132(4):959-62. (source)

[xiv] Boiko S.S., Ostrovskaya R.U., Zherdev V.P., Korotkov S.A., Gudasheva T.A., Voronina T.A., Seredenin S.B. “Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration.” Bulletin of Experimental Biology and Medicine. 2000 Apr;129(4):359-61. (source)

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Join The Discussion - 188 comments

Louis
April 5, 2018

Hi david love your site very informative. Just a question really iv been using buprenorphine for 3 years now and iv been on a taper schedule i was on 20mg and now down to 1.2 so almost there. Iv been taking l methionine, tyrosine, dlpa, l leucine, and glycine. I use 5 htp to help with sleep and theanine. Would it be ok to start using noopept and possibly phenibut as i get to 0.8mcg?
Many thanks
Louis

    David Tomen
    April 5, 2018

    Louis, buprenorphine is a opioid receptor agonist so should not interact with Noopept. But please follow the dosage instructions in this post carefully. Start with the lowest dose and see how your body reacts.

    I don’t know why you’ve been using buprenorphine but if it has anything to do with addiction then please stay away from Phenibut. You have plenty of other anxiolytics available that can provide similar benefits to Phenibut.

Chris
March 27, 2018

Hi. I was considering stack Noopept with CBD oil. I have poor memory but also problems with anxiety. Any thoughts ?

    David Tomen
    March 27, 2018

    Chris, I would be very careful about stacking Noopept with CBD Oil. I understand what you are trying to achieve but I am not aware of any research on how these two would react or interact.

    Please see my post on learning and memory here > https://nootropicsexpert.com/best-nootropics-for-learning-and-memory/

    And my post of dealing with anxiety here > https://nootropicsexpert.com/best-nootropics-for-social-anxiety/

    All the nootropics in each of those posts have been extensively researched including interactions and side effects. But throwing CBD Oil in the mix is a wild card. You may be better off trying some other nootropics to get anxiety under control. And save CBD Oil for later when you have more experience.

      Ronald
      October 17, 2019

      Hallo David
      I am also using CBD Oil, but for joint pain because I am having an autoimmune condition called psoriasis arthritis and it is helping with the pain. I do also have cognitive issues like brain fatigue, memory…..partly caused by the psoriasis condition. What do you recommend in such circumstances?

Mickey Cordero
February 3, 2018

Hey David,

Great site buddy, I’d just like to ask if you have any tips on how I could improve my experience with Noopept. I’ve been taking it for several days now, in different routes of administration(oral & sublingual) and dosage (10-30mg), but sadly I don’t feel anything at all. I’m planning to stack it with piracetam and alpha CPG soon. Do you think that would help? Thanks and

    David Tomen
    February 3, 2018

    Mickey, Noopept is likely fat-soluble and affects acetylcholine levels in your brain. Which means the only way to experience any benefit with Noopept is to take is with a a healthy fat like a tablespoon of unrefined coconut oil, MCT oil or virgin olive oil. And take it with either Alpha GPC or CDP-Choline because your brain is demanding extra choline while using Noopept.

Francisco Silva
January 2, 2018

Hi David,
I know noopept with CDP Choline/ Alpha GPC is great, but can i add to this stack L-tyrosine? I have read that l-tyrosine stacks well with noopept.
And modafinil/noopept what you think?
Tnahk you very much,
Best Regards

    David Tomen
    January 2, 2018

    Francisco, L-Tyrosine stacks well with Noopept and either CDP-Choline or Alpha GPC. I personally have used NALT instead of L-Tyrosine because it works more effectively for me.

    I do not have any experience with modafinil so cannot offer an opinion on stacking it with Noopept. I’ve used Noopept with Ritalin and it worked well.

Samantha
July 28, 2017

Hi David,
I appreciate finding this website, as it is very informative and helping me understand nootropics better 🙂
I’m quite new to nootropics, and just received my first bottle of aniracetam. The stack I started taking is 1/2 a capsule of aniracetam (about 375mg) with CDP choline, l-tyrosine (thinking of trying alcar once I finish the tyrosine) and l- theanine with caffeine.. In the morning and afternoon. Oh, and I also take 1TB coconut oil and 1TB nutritional yeast (for the b vitamins)
I really enjoy how this stack makes me feel!!

I’m curious and want to try and add noopept to this stack and occasionally sulbutiamine. What are your thoughts on a stack like this?
Can I take noopept with aniracetam? I’m concerned if this stack would cause excess glutamate … I want to be careful and not kill my neurons or have any other negative effects.

    David Tomen
    July 28, 2017

    Samantha, if your stack feels good then you’re definitely on the right track! I use Aniracetam with Noopept and love it. Noopept is an amazing nootropic and I’m surprised more don’t know about it. But your mileage may vary because everyone’s body and brain is unique. Try it and see if it works for you.

      Samantha
      July 28, 2017

      Thank you so much for your reply! I will certainly give it a try and see how it works for me.

      This website is amazing! I absolutely love it. Thanks again David!

Vince
May 17, 2017

Hi, i m trying noopept (10mgx2 sublingually) , i started 2 weeks ago and i feel more focus and a memory improvement.
But I m so scared about the possibility of irreversible sides effects…it s a stupid scared?

I would like to continue with noopept but I m scared as I said, I have not noticed any sides effects right now (maybe a little irritability).
What do you think about?
Thank you very much

    David Tomen
    May 17, 2017

    Vince, I’ve been using Noopept for years. And have experienced no side effects. Referring to the Side Effects section of this article, “Side effects are rare but can include fatigue, headaches, insomnia or stomach upset. Side effects are often a result of unusually high doses of the nootropic.”

    Everyone’s body chemistry and genetics are different. So only you can tell if Noopept does not agree with you. I’m not going to tell you that your fears are unfounded. Listen to your body. And make sure you’re giving your brain the choline it needs by using something like Alpha GPC or CDP-Choline every time you use Noopept.

    The “placebo effect” applies just as much to side effect symptoms as it does to the efficacy of anything you put in your body. So your fears could be causing the “irritability”. Or it could be because you don’t have adequate choline available to synthesize acetylcholine.

      Vince
      May 17, 2017

      Thank you David.
      Do you think is useful cycling noopept like 1 month on and 1 week off or 2 months on and 1/2 week off?

      However, I mean, I m not scared about little side effect like dizziness, I m scared about irreversible damage, maybe is a stupid fear, but somewhere I red also this.

        David Tomen
        May 17, 2017

        Vince, as long as your older than 18 years I’m not aware of any mechanism of action with Noopept that would cause any type of brain damage. And the way Noopept works in the brain, there’s no reason to cycle it. It certainly wouldn’t hurt the cycle it. I simply don’t see any benefit.

Jhonny
April 15, 2017

hello, i would like to try noopept. i was thinking about start with 10mg of powder sublingually (after meal??) with 300 mg of choline. i need a little help in order to study with a little more focus. Do you think is a good idea?
i have tried piracetam for 1 months with no results,i’m a little bit scared about using new nootropics but i red that noopept is extremly safe so i’m interested to try it.
thank you very much for your answer. Have a nice day.

    David Tomen
    April 15, 2017

    Sounds like a good idea. And certainly worth trying. 10 mg is a good starting point. It’s high enough of a dose that if it’s going to work for you, you should know with 10 mg of Noopept. And the dose is low enough that you shouldn’t experience any side effects. What type of choline are you using?

    One more thing… there is some debate whether Noopept is water or fat-soluble. So you may want to take a tablespoon of coconut or olive oil when you take your stack. Just in case…

Daniel
October 25, 2016

Hello,
I am planning on taking noopept in combination with centrophenoxine. Should centrophenoxine be enough as a choline source for noopept?

    David Tomen
    October 25, 2016

    Some neurohackers use Centrophenoxine as their choline source when stacking with a racetam. Including Noopept. And others insist it’s not a reliable choline source and use Alpha GPC or CDP-Choline as well. Everyone’s body and brain are different which is the reason we always say “Your Mileage May Vary”.

    Try 500 mg of Centrophenoxine on its own with Noopept and see how you react. If you don’t get the benefits of Noopept or you get a ‘racetam headache’ you can either boost your dose of Centrophenoxine to 1 gram. Or you’ll know you need to add an additional choline source.

    It would be helpful if you reported back on your experience Daniel. And let us know if Centrophenoxine was enough or you had to add another choline source. Experimentation is key to get the most out of your nootropic stack.

    John Gough
    May 8, 2019

    Today is my First day using noopept. I’m finding 30 mg noopept combined with ashwaghanda and 2 mg nicotine lozenges seem to provide necessary acetylcholine for body and mind. What are your thoughts on this stack? I also supplement with many other b vitamins and vitamin type nootropics including: Nac, milk thistle, SAM-e, vit-c, vit-e, green tea, bacopa, green tea, thyroid complex, l theanine, coq-10, vit d3, and turmeric to name plenty. These are taken with my first meal. When the Folate arrives in the mail I am considering make sam-e part of my morning fast with coffee. Another nootropic I took for the first time today was adrafinil. I do not intend to take this again tomorrow. Upon reading a few articles at least 2 articles advised cycling adrafinil 3 times weekly with a 1-2 week break in between weeks. Also its not to be taken for more than 5 months at a time. Have you heard of adrafinil? Do you consider reviewing it as a nootropic?
    Thanks,
    John

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