Noopept (n-phenylacetyl-l-prolylglycine ethyl ester or GVS-111) is an ampakine nootropic similar in action to the racetam-class of compounds. Noopept is up to 1000-times more potent than the original racetam, Piracetam.
Noopept was patented by Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals in 1996. Research shows Noopept has similar effects, but works differently than other nootropics in the racetam-family.
Noopept is not considered a true “racetam” because it doesn’t have a 2-oxo-pyrrolidine core.
Noopept does not appear in blood samples when taken as a supplement. Instead it elevates concentrations of cycloprolylglycine (CPG) in the brain.
CPG is a dipeptide consisting of proline and glycine which acts as a modulator of acetylcholine transmission and AMPA receptor function.[i]
Noopept is patented in both Russia and the USA. It is sold as a prescription drug in Russia, and other countries that were part of the Soviet Union. And as a supplement in the United States.
Neurohackers use Noopept to boost cognition, memory and learning. And to improve reflexes, perception, logical thinking and mood.
Noopept helps:
- Brain Optimization: Noopept increases Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). Critical for neuroplasticity and Long-Term Potentiation. Brain health gets a boost along with long-term memory.
- Neuroprotection: Noopept prevents the release of excess glutamate in your brain. Glutamate is the brain’s primary excitatory neurotransmitter. When there’s a lack of oxygen in the brain, neurons can’t receive glutamate. This leads to toxic levels of glutamate within brain cells. And can result in neuron damage and death. Diminishing this neurotoxic overload with Noopept is potent neuroprotection.[ii]
- Brain Waves: Noopept boosts Alpha and Beta brain wave activity. You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.
Table of Contents
Overview
Noopept (n-phenylacetyl-l-prolylglycine ethyl ester or GVS-111) is often included in the racetam-family of nootropic compounds. But is not a true “racetam” because it does not have a 2-oxo-pyrrolidine nucleus.
Noopept was developed in Russia where it is called Ноопепт or GVS-111. Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals synthesized Noopept in 1996 based off the endogenous neuropeptide cycloprolylglycine (CPG).
Researchers in Moscow found Noopept similar to Piracetam in not only it’s nootropic effect, but also anxiolytic activity.[iii]
Noopept is a water-soluble ampakine nootropic. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic) refers to one of three glutamate receptors in your brain.[iv]
Noopept could also be considered a Cholinergic compound because it affects acetylcholine levels in the brain.
One of the newer synthetic nootropic compounds, Noopept is known as a cognitive enhancer. And is known for its anxiolytic, or anti-anxiety effects.
Noopept is considered to be up to 1000-times more potent than Piracetam. As an ampakine nootropic, it helps increase attention span, alertness and boosts all three levels of memory. Memory formation, retention and recall.
Ampakines tend to have a stimulant effect. But do not produce the same stimulant side effects as Ritalin or coffee from prolonged use.
Noopept vs. Piracetam: What’s the Difference?
Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals developed Noopept in the late 1996 as a peptide analogue of the original nootropic Piracetam.[v]
Noopept and Piracetam are both water-soluble. And both Noopept and Piracetam are cognitive enhancers. Both have neuroprotective and anxiolytic (anti-anxiety) qualities.[vi] Both racetams are able to improve learning and memory. And both are able to repair brain damage.
But Noopept has additional benefits not shared with Piracetam. First, the effective dose of Noopept compared to Piracetam is 1,000-times lower. A typical dose of Noopept is 10 – 30 mg while Piracetam is often dosed up to 3 or 4,000 mg.
Second, Piracetam facilitates only the early stages of the memory process. On the other hand, Noopept influences memory consolidation AND retrieval steps as well.
So Noopept helps you develop the memory, retain the memory, and then recall what you have stored in memory.[vii]
Noopept also has additional selective anxiolytic (anti-anxiety) action. Researchers believe this is due in part to Noopept’s antioxidant effect, anti-inflammatory action, and the ability to prevent the neurotoxic effect of too much calcium and glutamate.
How does Noopept work in the Brain?
Noopept boosts brain health and function in several ways. But two in particular stand out.
- Noopept modulates AMPA and NMDA receptors and acetylcholine (ACh) transmission. Noopept boosts the level of cycloprolylglycine (CPG) in the brain. CPG is a dipeptide consisting of proline and glycine which acts as a modulator of acetylcholine transmission, and AMPA and NMDA receptors.
When brain cells are starved of oxygen, glutamate which is your brain’s primary excitatory neurotransmitter, does not work efficiently with neuroreceptors. The result can be a toxic buildup of glutamate within brain cells. Causing neuron damage and ultimately, neuron death.
Noopept modulates neuroreceptor function keeping glutamate transmission at normal levels. Protecting neurons and other brain cells from glutamate damage.
Noopept has also been shown to modulate acetylcholine flow in your brain. Restoring the harmony of glutamate and acetylcholine function not only protects your brain from damage. It can boost cognition, memory, learning, recall, mood and relieve anxiety.
- Noopept increases Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and mRNA. NGF and BDNF are directly related to neuroplasticity. This ability to repair and even grow new brain cells can have profound implications. Particularly with someone with neurodegenerative brain damage like Parkinson’s or Alzheimer’s. And even affecting Long-Term Potentiation needed for long-term memory development.
mRNA affects the expression of genes and intracellular communication in brain cells. This ongoing brain signaling and gene expression within brain cells is required for healthy cognition.
One study conducted in Moscow showed long-term use of Noopept boosted NGF, BDNF and mRNA. The animal subjects in this study showed no sign of tolerance. And long-term use of Noopept even potentiated the neurotrophic effect.[viii]
How things go bad
Glutamate is an excitatory relative of GABA. While GABA has a calming effect, glutamate stimulates. Glutamate is the most common neurotransmitter in the central nervous system.
But glutamate can be toxic to neurons. And too much of it in your brain can kill brain cells. Lou Gehrig’s Disease for example, is caused by excess glutamate.
But glutamate is a pivotal neurotransmitter in the brain. It links the brain circuits involved in memory, learning and perception.
↑ Too much glutamate can kill neurons
↓ Too little glutamate can cause problems with memory, learning and perception
↓ Acetylcholine levels decline
↓ Nerve Growth Factor declines
↓ Brain-Derived Neurotrophic Factor declines
All of these changes can happen at any age. And are a product of the food we eat, what we drink, lifestyle habits, the air we breathe and more.
So Noopept can help for age-related cognitive decline, as well as a student looking to do better in school. By boosting NGF, BDNF and acetylcholine, and controlling glutamate in the brain.
Noopept benefits
Noopept modulates AMPA and NMDA receptors. AMPA receptors are associated with how glutamate and calcium is used in your brain. With Noopept, it’s more of a neuroprotective role.
Similar to the AMPA receptor, the NMDA receptor is also associated with glutamate and calcium use in your brain. They work together to modulate how neurons use glutamate.
Noopept modulates levels of glutamate within and between neurons. It prevents glutamate toxicity, and influences Long-Term Potentiation (LTP). LTP is associated with neuroplasticity that allows long-term memories to form.
There is clinical evidence that Noopept boosts communication and neuron signaling. By boosting Alpha and Beta brain wave activity. You become calmer and more creative. It’s easier to go into a flow state. And you are prone to making innovative and resourceful decisions.
Noopept produces an anxiolytic (anti-anxiety) effect. It stimulates dopamine receptors (D2 and D3) and acetylcholine nicotinic receptors. And Noopept also seems to modulate some serotonin receptors. All contributing to a better mood and less anxiety.
Noopept has been shown in the lab to boost Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). NGF and BDNF are both involved in neuroplasticity, and the repair and replacement of damaged brain cells. Resulting in overall better brain health, memory and cognition.[ix]
Noopept is water-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.
How does Noopept feel?
Nootropics users report:
- Noopept as a study aid. On its own, Noopept increases focus and attention for many neurohackers. Mental arithmetic and grasping difficult concepts is easier.
- Increased verbal fluidity. Your conversation skills could increase with Noopept. Vocabulary comes easier. Being able to focus contributes to a more balanced dialogue. Neurohackers report being more outgoing, friendly and less self-conscious.
- Improved mood. With Noopept you may find yourself better able to deal with stressful situations and work issues that normally get you down. Once you get past the first few weeks of unpleasant memories related to PTSD you may find overwhelming emotions will subside. You could feel detached in a pleasant way from painful memories.
- Music appreciation. Many users report increased pleasure when listening to music while using Noopept. For some it takes music to a different plane. Distinguishing between instruments in sound tracks is easier. As a whole, music sounds better.
- Long-term memory. Noopept affects NGF and BDNF which affects long-term potentiation. Some neurohackers report memories long forgotten suddenly spring up. Which could be good or bad I suppose depending on the memory. But reports say memories are clear. And if they’re unpleasant there is an emotional detachment shielding from unpleasant feelings.
You should be able to experience the effects of Noopept soon after you take it. It’s water-soluble and enters your cells quickly especially if you take it sublingually.
A word of caution however; don’t go over the recommended 10 – 30 mg per day dose! You will not experience any added benefit, and could bring on unwanted side effects.
There is some debate on the water-solubility of Noopept. It’s not truly fat-soluble but it certainly doesn’t hurt to use a quality “good fat” when taking your Noopept dose.
Noopept Clinical Research
Noopept increases Nerve Growth Factor & BDNF
A study published by the Russian Academy of Medical Sciences in Moscow shows that Noopept stimulates Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).
In this study, researchers studied the effect of single and long-term treatment (28 days) of Noopept. They found that one-time treatment boosted mRNA in the cerebral cortex of rats. mRNA is a molecule in brain cells that carries codes from DNA where they specify the amino acid sequence of proteins.
And long-term treatment of Noopept increased Brain-Derived Neurotrophic Factor (BDNF). The researchers speculated that this sequence of events in the brain plays a role in the restoration of neurons.
Improving neurotrophin synthesis in the hippocampus boosts cognitive function. Particularly consolidation and delayed memory retrieval.
The research team concluded that Noopept “holds much promise to prevent the development of Alzheimer’s disease in patients with mild cognitive impairment”.[x]
Noopept boosts Brain Waves
Researchers in Moscow studied the effects of injecting Noopept in rats to see how it would affect brain waves.
The team found that Noopept increased Alpha and Beta brain wave activity throughout the brain.
You experience Alpha waves as you become more relaxed. Alpha waves are associated with super-learning, flow state and joy. Beta waves are associated with concentration, alertness and cognition.
The researchers observed that NMDA receptors were involved with a single injection of Noopept. While AMPA receptors were activated after longer-term use of Noopept.[xi]
NMDA receptors are associated with Long-Term Potentiation (long-term memory) and neuroplasticity. AMPA receptors are associated with increased brain signaling activity. Boosting cognition and memory.
Noopept improves memory
Noopept is known within the nootropic community for enhancing memory. And dozens of studies support this claim of better memory when using Noopept.
One study done at the Russian Academy of Medical Sciences in Moscow experimented with Noopept on rats. The animals were trained in passive avoidance response.
The animal’s ability to both form a memory and retain a memory was impaired. But once the rats received a dose of Noopept, they were able to retain a memory and retrieve that memory later.
In other words, Noopept normalized learning capacity in animals with damage done to their cerebral cortex. And promoted training ability in rats with a hereditary learning deficit.
The researchers noted that “Noopept improves all three stages of memory”. And was most pronounced in those with impaired memory function.[xii]
Another study, again done with rats noted that Noopept stimulated learning after just a single administration. And repeated administration actually increased the number of successful learners among the animals who failed the initial training.[xiii]
Noopept Dosage
Recommended Noopept dosage is 10 – 30 mg per day.
Noopept is very bioavailable and easily crosses the blood-brain barrier.[xiv]
Noopept is sold in tablet, capsule and powder form. Tablets and capsules are usually 10 mg each.
Noopept is primarily water-soluble nootropic, but won’t easily dissolve in water or juice. So it may help if you take it with a meal containing healthy fats. Or with a tablespoon of extra virgin, expeller cold-pressed coconut or olive oil. Or other similar healthy fat to ensure quick absorption.
For even quicker absorption you can use Noopept sublingually. Let the tablet or powder dissolve under your tongue so it can go straight into your bloodstream, and into your brain. Bypassing your digestive system completely.
Noopept Side Effects
Noopept is a synthetic nootropic and consider non-toxic. So is considered well-tolerated and safe. As long as you stay within the recommended dosage.
Side effects are rare but can include fatigue, headaches, insomnia or stomach upset. Side effects are often a result of unusually high doses of the nootropic.
Headaches from using Noopept typically happen when you forget to combine it with a good choline supplement. Headaches are often a symptom of a choline deficit in your brain.
Where to buy Noopept
Noopept is sold in tablet, capsule and powder form. Tablets and capsules are usually 10 mg each.
In the USA, the best place to buy Noopept is Cosmic Nootropic – Noopept
In Russia and some other Eastern European countries, Noopept is a prescription drug.
Nootropics Expert Recommendation
Noopept 10 – 30 mg per day
I recommend using Noopept as a nootropic supplement.
Your body does not make Noopept on its own. So to get its benefits you must take it as a supplement.
Noopept is especially helpful for those looking to boost cognition, memory and recall. This nootropic helps boost the activity of acetylcholine in your brain. It modulates glutamate receptors which normalizes optimal neurotransmitter function. And increases Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) which helps the neuroplasticity needed for Long-Term Potentiation.
Noopept is also particularly useful to students and executives who want to boost cognition, learning and memory. My experience using Noopept shows it helps boost study scores, workflow, learning and memory.
Noopept also helps improve verbal fluidity and sociability. Words seem to come easily, and vocabulary you didn’t know you had access to come into play.
Music sounds richer and fuller, and your listening experience enters a new level of music appreciation.
You should stack Noopept with a good choline supplement like Alpha GPC or CDP-Choline. It helps boost neural acetylcholine, so demands the presence of more choline in your brain.
You should not exceed Noopept doses of more than 30 mg per day. Start with 10 mg and see how you respond.
In the USA, the best place to buy Noopept is Cosmic Nootropic – Noopept
[i] Gudasheva T.A. et. Al. “The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine.” European Journal of Drug Metabolism and Pharmacokinetics. 1997 Jul-Sep;22(3):245-52. (source)
[ii] Us K.S., Klodt P.M., Kudrin A., Sapronova Ya., Ostrovskaya R.U., Ugryumov M.V., Rayevsky K.S. “The effect of the synthetic neuroprotective dipeptide noopept on glutamate release from rat brain cortex slices” Neurochemical Journal June 2007, Volume 1, Issue 2, pp 138-142 (source)
[iii] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)
[iv] Purves D., Augustine G.J., Fitzpatrick D., et al., editors. “Glutamate Receptors” Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. (source)
[v] Ostrovskaya R.U., Mirsoev T.K., Romanova G.A., Gudasheva T.A., Kravchenko E.V., Trofimov C.C., Voronina T.A., Seredenin S.B. “Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.” Bulletin of Experimental Biology and Medicine. 2001 Oct;132(4):959-62. (source)
[vi] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)
[vii] Ostrovskaia R.U., Gudasheva T.A., Voronina T.A., Seredenin S.B. “[The original novel nootropic and neuroprotective agent noopept].” in Russian Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. (source)
[viii] Ostrovskaya R.U., Gudasheva T.A., Zaplina A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., Seredenin S.B. “Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bulletin of Experimental Biology and Medicine. 2008 Sep;146(3):334-7. (source)
[ix] Ostrovskaia R.U., Vakhitova Iu.V., Salimgareeva M.Kh., Iamidanov R.S., Sadovnikov S.V., Kapitsa I.G., Seredenin S.B. “[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].” in Russian Eksp Klin Farmakol. 2010 Dec;73(12):2-5. (source)
[x] Ostrovskaya R.U., Gudasheva T.A., Zaplina A.P., Vahitova J.V., Salimgareeva M.H., Jamidanov R.S., Seredenin S.B. “Noopept stimulates the expression of NGF and BDNF in rat hippocampus.”Bulletin of Experimental Biology and Medicine. 2008 Sep;146(3):334-7. (source)
[xi] Vorobyov V., Kaptsov V., Kovalev G., Sengpiel F. “Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors.” Brain Research Bulletin. 2011 May 30;85(3-4):123-32. (source)
[xii] Romanova G.A., Shakova F.M., Gudasheva T.A., Ostrovskaya R.U. “Impairment of learning and memory after photothrombosis of the prefrontal cortex in rat brain: effects of Noopept.” Bulletin of Experimental Biology and Medicine. 2002 Dec;134(6):528-30. (source)
[xiii] Ostrovskaya R.U., Mirsoev T.K., Romanova G.A., Gudasheva T.A., Kravchenko E.V., Trofimov C.C., Voronina T.A., Seredenin S.B. “Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.” Bulletin of Experimental Biology and Medicine. 2001 Oct;132(4):959-62. (source)
[xiv] Boiko S.S., Ostrovskaya R.U., Zherdev V.P., Korotkov S.A., Gudasheva T.A., Voronina T.A., Seredenin S.B. “Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration.” Bulletin of Experimental Biology and Medicine. 2000 Apr;129(4):359-61. (source)
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David,
Are you aware of any research using NAD+ (IV) and powder Noopept?
THanks in advance…..John
John, I am not aware of any clinical research combining those two which is not surprising because who wants to spend multi-millions to conduct a study on natural supplements?
Where shall I buy noopept in Africa… Kenya in particular…?
Joseph, you will need to search within country for someone who sells or imports Noopept. Maybe someone in Kenya will read this and have a suggestion.
As of today David, and thank you for in my opinion for being the primary spokesperson for nootropics, and supplements in general.
You use layman’s terms that folks like myself who are fairly deep into nootropics and supplements, can certainly understand.
*** Now to my point, as of today, Pure Nootropics has Noopept in stock / 3 different forms as well.
In case you weren’t already aware. Run Run lol probably not a good idea after back surgery and considering I believe you live in South Florida 😉
Thanks again sir for all you do. Quite extraordinary
Deron, thanks for the update. I’ll hunt down my link for Nootropics Depot and update the where to buy section. Much appreciated.
Hi,
I am a recovering addict and would like to try noopept for my semester ahead.
I have 6 years of sobriety and I am now afraid that noopept causes a relapse.
I would like to have your opinion
Thanks
Best
David
David, I do not see how Noopept would lead to a relapse.
In fact, if you add some L-Tyrosine to increase dopamine and CDP-Choline to increase acetylcholine it will help Noopept work better. Because Noopept increases the density of dopamine receptors. There should be even less of a chance of falling off the wagon because your system is getting the stuff it was trying to get by using. That craving should no longer be there.
Hi David,
Thanks for your deep study and sharing your knowledge so generously. I was wondering if you’re aware of any contraindications for Noopept with epilepsy or anticonvulsant drugs.
Thanks,
Ryan
Ryan, scroll up and read the Side Effects section of this review. I did not come across any contraindications when researching this compound. You can try Googling “Noopept contraindications” and see if anything turns up.
Hi David,
I have taken a stack I am used to:
L-Theanine 300mg
PS – 100mg
ALCAR -300mg
CDP Choline – 250mg
Caffieine from coffee – 300mg
L-tyrosine – 450mg
Methylene Blue – 9 drops (approx 5mg Total dose)
Today i added 10mg of Noopept
I am definitely feeling “heady” if that explains it, especially after the MB which was taken about an hour after the stack above.
Should I be worried? Are there any contraindications in this stack?
Also, should I eliminate or add anything?
I promise I will have a consultation with you soon 🙂 I already referred a patient to you and she was thoroughly impressed with the time, and the long report.
Thanks for your guidance.
Mark, if you are doing 300 mg of caffeine in one dose that’s a little high. The maximum adult dosage is 400 mg per day.
The rest of your stack looks OK. Have you tried each supplement on its own to see how you react?
Can I use this with Alpha GPC 300mg? Or does it have to be CDP-Choline 300mg? Can it be CDP-Choline 250mg? What exactly will the benefits be in adding Noopept in my stack? What does not go with noopept and lessen their ability to get the full effect?
My stack
PhosphatidylSerine
Bacopa Monnieri
Alpha GPC
Ashwaghanda
Rhodiola Rosea
Multivitamins
Natasha, “What exactly will the benefits be in adding Noopept in my stack?” The entire article above explains the benefits of Noopept. I suggest you read it.
You can use Alpha GPC or CDP-Choline to increase the acetylcholine that Noopept uses to provide many of its benefits.
Hi David,
I’m new to nootropics and after few researches I would like to start with a simple stack like noopept + alpha gpc and/or choline cdp (in small dosages and I will increase until I will find the sweet spot) from nootropics depot, then I would like to add lion’s mane 8:1.
I don’t have big problems, but usually I’m not in the mood, I have low energy from time to time and sometimes I forget simple things (I repeat, I have quite normal functions, but sometimes those things happens).
Usually I take a complex of multivitamins and mineral, tribulus terrestris, fish oil, hmb and a pre-workout for the gym activity.
So what do you think about my stack?
Cheers!
Eduard, Noopept + Alpha GPC will work for a depressed mood and low energy only if you are low in acetylcholine. If that is the case it’ll help your mood more than energy.
Your energy levels during the day are a result of ATP production in your mitochondria. See this article for more: https://nootropicsexpert.com/best-energy-supplements-to-buy/
And for depression see this article: https://nootropicsexpert.com/best-nootropics-for-depression/
My personal stack are Noopept 20 mg, Alpha-GPC 300 mg and Adrafinil 600 mg, I take them 5 times per week and Phenibut 600 mg 3 times per week. I take them in one sitting. To improve my memory, productivity, energy and calm. Could you please advise me or warn on the mixup?
Faqehi, if it works for you and you are not experiencing any problems then you are OK.
I was diagnosed with Hashimoto’s Thyroiditis probably 7 years ago and have made lifestyle changes and am believing to get to a point of it being reversed. Even though my last labs looked the best the have in years and my TSH finally went down, I’ve been experiencing fatigue even though I’m getting 7 hours of sleep, diet is clean. I’m thinking my estrogen must be off even though I haven’t gone through menopause (I’m over 50).
Because concentration and focus has been challenging for me, I’ve tried 30mg of Noopept a couple times. I notice that it wakes me up a bit, like a cup of coffee, but honestly it doesn’t make me feel motivated or focused. What does it mean if Noopept doesn’t work for someone? Does that indicate they’d do better from taking a racetam like piracetam for focus and motivation? I’m wanting something that I can take daily because I run two businesses.
Bethany, Noopept works better if you use it with CDP-Choline 300 mg each time you use Noopept.
But TSH is useless in measuring thyroid health. You need to know what your Free T4 and Free T3 are. This website was my ‘bible’ when I was first diagnosed hypothyroid: https://stopthethyroidmadness.com/recommended-labwork/. I suggest you study as many pages on that site as you can and learn how to get your thyroid hormones where they need to be.
Fatigue is a classic symptom of low Free T4 and/or Free T3. Along with adrenal fatigue.
Hello David,
I just got my first bottle of noopept. I am wondering if there is anything that I should NOT take along with it. I am already taking a considerable number of supplements:
bacopa, rhodiola, lions mane, ginseng, ashwaganda,
taurine, ALCAR, phenylalanine, theanine,
PS and PC, magnesium, iodine (lugols), omega 3 fish oil.
I have decided after 2 years to thin out my stack considerably, if only for the expense, as well as the efficacy. I am not going to re-order some of these when they run out.
Any advice about which ones I can cut out?
Thanks.
Noopept is not contraindicated with anything in your stack. But you may want to eliminate the Phosphatidylcholine (PC) and replace it with CDP-Choline if you are going to use Noopept.
Hello I am on 150 Wellbutrin and I was thinking about adding noopept and possibly nac. Is there any contradictions ? I have adhd depression and my memory is very bad.
Kristi, if you are dealing with ADHD and using Wellbutrin NAC is a good addition because it helps repair dysfunctional dopamine receptors.
But rather than using Noopept, I suggest using my ADHD protocol instead. Because it is designed to support the use of prescription stimulants.
https://nootropicsexpert.com/best-nootropics-for-adhd-add/
Hello David,
I’m taking Sertraline (Zoloft) which is a SSRI anti depressant.
Does Noopept interact with this class of medication, considering it impacts serotonin receptors. Does it elevate serotonin in the brain?
My main concern is related to Serotonin Syndrome risk.
Thank you in advance for letting me know your thoughts on the topic.
Eli, Noopept seems to ‘modulate’ certain serotonin receptors but it does not increase physical levels of serotonin. I have not seen any published reports of contraindications with SRRIs or reports of problems with the two in forums.
That’s not to say you will not have problems. I’m just not aware of any potential issues.
hi david I am suffering from TBI a year since the injury and am looking to take one of the racetams. i have read up on all your reviews and am still having a hard time selecting the right one as they all sound fairly similar. is it a matter of trial and error? should i start with the basic piracetam first or go for something more potent? please recommend one for me.
ilva, here is a summary of all the main racetams: https://nootropicsexpert.com/the-top-7-racetams-which-one-is-best/
I suggest you click through to the full review for each one and read the section called “How does ______ feel?” And see what others have to say about the benefits of each.
Hi David,
I see Nootropics Depot has Noopept too, in powder and capsules. The capsules are 30mg though so that could be a problem and I would have to figure out how to measure the powder, but it might be worth it to avoid problems with Pure Nootropics. Super Smart has it in 10 mg tablets.
Bye again
Christine
Thank you Christine for the tip.
I was told most racetams are directly neurotoxic due to increased levels of glutamate, is this the case for Noopept? Im having trouble finding any literature on this specific subject.
Rob, the reason why you are having trouble finding literature on this subject is because it is not true. Not for Noopept or for any of the racetams.
“Once you get past the first few weeks of unpleasant memories related to PTSD you may find overwhelming emotions will subside.”
Hello dear David, does Noopept only trigger Trauma related issues or is it also involved in a healing process. Im also asking cause you didnt mention Noopept in your article about nootropics and PTSD.
https://nootropicsexpert.com/treating-post-hurricane-ptsd-with-nootropic-supplements/
Thanks for your support!
Chris
Chris, Noopept helps prevent the neurotoxic effect of too much calcium and glutamate which is released during a traumatic event or TBI. So, I suppose you could say Noopept is involved in the healing process by providing an environment where the brain can heal itself. Which is impossible if you are experiencing the toxic release of excess calcium and glutamate.
I did not mention is in my PTSD article because Noopept is difficult to find lately. Most vendors in the US have stopped selling Noopept.
David,
I purchased some in powder form last year from a pharmaceutical firm in Russia. I have been having good results with it.
Do you know why the US vendors have stopped selling it?
Curt, because a few major vendors received letters from the FDA threatening them for making “health claims”. According to the laws in this country and part of the Dietary Supplement Health and Education Act of 1994 dietary supplement companies can not make specific health claims. That is reserved for the major pharmaceutical companies. Because they fund the FDA and have more lobbyists in Washington than we do.
The sentence in the act is this “A statement under this subparagraph may not claim to diagnose, mitigate, treat, cure, or prevent a specific disease or class of diseases.”
Hi David! I want to take 30mg of Noopept daily in three doses.
1. Morning 10mg + Alpha GPC 300mg
2. Noon 10mg + 250mg Cognizin
3. Afternoon 10mg
Can I take it like that? Or should I also add third dose of choline?
And my second question:
– If I take my noopept under tongue should I consume choline source about 30 minutes before? I assume Noopept sublingualy will arrive to my brain faster than choline from my stomach. Thanks!
Sandra, the half-life of Cognizin is long enough so you many not need a 3rd dose with your 3rd Noopept dose. For the first two doses if you were using it sublingually you would need to use the choline supplement in advance. But if you use Cognizin at noon you should not need to worry about taking another choline dose at all.
Hi David, I searched for Noopept on HR Supplements website and there were no results for Noopept. Do you have any other suggestions on where I could purchase Noopept please?
Thank you kindly.
Try Nootropics Depot
Thank you!
Dear David!
What do you think about stacking Aniracetam with Noopept for someone with very low Acetylcholine and Dopamine. “I’ve done dr. braveman test” (everyday I try to take methyl b complex and 2000g of choline bitartrate to make some ground for racetam use)
Would it work? :))
Thanks for sharing your knowledge!
Borys, choline bitartrate is not a good way to try and increase acetylcholine because you need to take so much of it. Your best option is Alpha GPC or CDP-Choline if you are using Aniracetam and/or Noopept.
And if you are low in dopamine you should be using L-Tyrosine to increase it.