L-tyrosine dosage child


David Tomen
David Tomen
15 minute read
Tyrosine enhances working memory, executive function, creative flow states, stress reduction, better mood, anti-anxiety and lessens symptoms of ADHD  

Key Takeaways

  1. Tyrosine boosts working memory, executive function, and creativity.
  2. It aids in stress reduction, mood improvement, and anxiety alleviation.
  3. Tyrosine lessens symptoms of ADHD.
  4. L-Tyrosine is a crucial precursor for catecholamine neurotransmitters​​.

L-Tyrosine is the master precursor required to form all catecholamine neurotransmitters.

Your brain uses the enzyme tyrosine hydroxylase to convert L-Tyrosine into L-DOPA. Decarboxylation of L-DOPA results in synthesis of the neurotransmitter dopamine.[i]

Once converted into dopamine, the enzyme dopamine-beta-hydroxylase converts L-DOPA into norepinephrine (noradrenaline).

And Phenylethanolamine n-methyltransferase converts norepinephrine into epinephrine (adrenaline).

This triad of neurotransmitters are collectively known as “catecholamines”.

Tyrosine can be a highly effective nootropic for boosting cognitive function. And is particularly helpful in maintaining cognitive performance when you’re under practically any kind of stress. Including music played above 90 dB’s.

L-Tyrosine works in synergy with stimulants like methylphenidate (i.e. Ritalin).[ii] Drugs like Ritalin work by blocking the reuptake of the neurotransmitters dopamine, and norepinephrine. And if there’s not enough dopamine available to do the job, Ritalin doesn’t work very well. L-Tyrosine potentiates increases in extracellular dopamine.

L-Tyrosine also stimulates the production of thyroid hormones T3 (triiodothyronine) and T4 (thyroxine) which are crucial in maintaining both overall physical and cognitive health.

L-Tyrosine can boost libido, memoryfocusconcentration, mood, offers anti-depressant effects, and improves executive function in those with ADHD.

Tyrosine helps:

  • Cognitive Stress. L-Tyrosine produces the catecholamine-triad of neurotransmitters dopaminenorepinephrine, and epinephrine. Sleep deprivation and extreme stressors like heat and cold can deplete catecholamine levels. L-Tyrosine restores them to preserve optimal cognition.[iii]
  • Neurotransmitters. L-Tyrosine is a required precursor for dopamine, norepinephrine, and epinephrine. As your dopamine levels increase, you’re better able to concentrate, organize your thoughts, and stay productive.
  • Attention Deficit Disorder (ADHD). L-Tyrosine can be an effective treatment for ADHD symptoms. It works in synergy with pharmaceutical drugs like Ritalin and Adderall by boosting extracellular levels of dopamine. Helping these drugs be more effective. And mitigating side effects like crashes when the drug wears off.


Your brain converts L-Tyrosine to L-DOPA which then produces the neurotransmitter dopamine. The unused dopamine is then further converted into the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). This triad of neurotransmitters are collectively referred to as “catecholamines”.

l-tyrosine reviews“Tyrosine” is derived from the Greek word tyros, meaning cheese.  It was first discovered by German chemist Justus von Liebig in 1846 in the protein casein from cheese.

Tyrosine is considered a non-essential amino acid because it can be synthesized in your body from phenylalanine. Which is found in many high-protein foods such as poultry, fish, dairy, nuts, soy products, lima beans, avocados and bananas.

L-Tyrosine amino acid supplementation enhances working memory and executive function in the prefrontal cortex. It helps with creative flow states, is fuel for inspirationcognitive flexibility, and the kind of “convergent thinking” you do in multiple choice exams.

L-Tyrosine assists in the production of thyroid hormones T3 (triiodothyronine) and T4 (thyroxine) which are crucial in maintaining both overall physical and cognitive health.

L-Tyrosine vs N-Acetyl L-Tyrosine (NALT): What’s the Difference?

N-Acetyl L-Tyrosine (NALT) is the amino acid L-Tyrosine with an acetyl group added. When you take NALT as a supplement, it breaks down in your kidneys back into L-Tyrosine. So in theory, the two supplements offer the same benefits.

There is some debate in the nootropics community on which is more effective. NALT or plain L-Tyrosine. NALT is a more soluble form of L-Tyrosine so it should be more bioavailable to your body.

However, some studies report that in some cases, a sizeable percentage of supplemental NALT is excreted in urine before it’s converted into L-Tyrosine.[iv]

On a personal note, I haven’t had any issues using NALT as a source of L-Tyrosine. It gives me a dopamine and adrenal boost you’d expect from supplementing with a dopamine precursor.

But when I haven’t any NALT around I successfully switch to L-Tyrosine although at a slightly higher dose.

When dealing with ADHD/ADD, L-Tyrosine is particularly effective when stacked with ALCAR (Acetyl-L-Carnitine). ALCAR easily crosses the blood-brain barrier for boosting acetylcholine levels. And seems to positively influence serotonin levels. And Tyrosine provides my brain with the dopamine it needs to mitigate symptoms of ADHD/ADD.

I find that L-Tyrosine stacked with 20 mg of Ritalin twice a day works particularly well. Clearly, this brain doesn’t have the capacity to produce enough dopamine on its own. And needs the boost that comes from supplementing with Tyrosine.

So like all nootropics, YMMV. Always take into account how each nootropic works synergistically with others in your stack. And how they work with any meds you need to take.

This is as much art as it is science. And experimentation is key for optimal cognition.

L-tyrosine dosage

How does L-Tyrosine work in the Brain?

L-Tyrosine boosts brain health and function in several ways. But two in particular stand out.

  1. L-Tyrosine improves memory and cognition under acute stress. Acute stress is defined as short-term stressors that can affect cognition. Examples are extreme heat or cold. Things like cold showers, extreme sports, car accidents, relationship problems, intense movies, business deals gone awry, exams and war zones.

In one study done at the University of Bedfordshire in the UK, the effect of L-Tyrosine on cognitive performance was measured before an exercise task.

Researchers recruited 8 soccer players. And had them complete a 90-minute soccer simulation performance test in an environmental chamber set at 77 degrees Fahrenheit.

The soccer players were given either L-Tyrosine before exercise or a placebo. Cognitive performance was measured before the exercise task. Then again at “half-time”, following half time, and following the entire simulation.

The cognitive performance task assessed dual-task and vigilance. The outcome revealed that cognitive vigilance and reaction time among soccer players significantly improved following administration of L-Tyrosine.

Results showed that in warm-weather conditions, L-Tyrosine could enhance cognitive function and prevent cognitive impairment during exposure to exercise-heat stress.[v]

  1. L-Tyrosine boosts neurotransmitters. L-Tyrosine taken as a supplement converts into the neurotransmitter dopamine. Dopamine helps control movement in your body, is fundamental to memory, attention and problem solving.

The unused dopamine can then convert into the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

Norepinephrine is important for attentiveness, emotions, sleeping, dreaming and learning.

Epinephrine drives your ‘flight-or-flight’ response. It’s what prompts your reaction to dangerous circumstances, emergency situations, or in stressful situations or environments.

In one study done in the Netherlands, researchers determined if L-Tyrosine would boost cognitive resources associated with cognitive control. They performed tests designed to measure “working memory” using the N-Back Test.

Study participants were assigned to engage in a “1-back” condition of easy difficulty and then a 2-back condition of tougher difficulty. Those that used L-Tyrosine demonstrated superior performance in the 2-back test, but not the 1-back test.

The study authors suggested that L-Tyrosine provides greater cognitive enhancement when cognitive demand increases. The bottom-line; supplementation of L-Tyrosine may help you increase your IQ score due to maximizing catecholamine reserves.[vi]

How things go bad

As we get older, our brain and body chemistry and energy metabolism changes.

L-tyrosine side effects↓ Dopaminergic neurons are damaged or die

↓ Neurotransmitter levels decline

↓ Thyroid hormones decline

↑ Stress levels increase

↓ Working memory and mood decline

All of these changes are often attributed to aging. But could be a result of dietary and lifestyle choices.

Unchecked, they could lead to neurodegenerative diseases like Parkinson’s, a drop-in quality of life and depression.

L-Tyrosine benefits

L-Tyrosine can boost levels of the neurotransmitters dopamine, norepinephrine, and epinephrine. And contributes to the production of thyroid hormones T4 and T3.

Tyrosine can help boost cognition especially in stressful situations. It helps improve decision making, ‘flow state’ and creativity, cognitive flexibility, and working memory.

L-Tyrosine converts into L-DOPA to produce dopamine. L-DOPA is also used to make melanin in your body. This conversion process helps in the removal of neurotoxic quinones. And chelates heavy metals like mercury and lead which can accumulate in and damage neurons.

The dopamine that is not used by your brain is available to produce norepinephrine (noradrenaline) which is important for attentiveness, emotions, sleeping, dreaming, and learning.

L-Tyrosine can be an effective nootropic when stacked with ADHD/ADD meds like Ritalin or Adderall. It helps supply extracellular dopamine needed to improve the effectiveness of stimulants used to boost the uptake of dopamine in your brain.

How does L-Tyrosine as a nootropic feel?

Keep in mind that L-Tyrosine is a precursor to catecholamines. So if you’re not ‘low’ on dopamine, norepinephrine or epinephrine – you may not ‘feel’ anything.

L-tyrosine adhdMany neurohackers report a lift in mood, better focus, concentration, increased energy, and an overall sense of well-being. L-Tyrosine can help readjust your motivation levels. It can help lower anxiety levels, especially social anxiety.

Supplementing with L-Tyrosine can help bring your blood pressure down if its elevated from a stressful situation or environment. Take it before the stressful event if you can.

L-Tyrosine helps buffer the effects of stimulants like caffeine or amphetamines. It helps potentiate and prolong the effects of Ritalin or Adderall, and reduces the crash.

If you’re into athletics or do manual work, you’ll find that supplementing with L-Tyrosine before a workout or construction job will leave you feeling great afterwards. It helps mitigate many of the effects of acute stress caused by short-term stressors.

And L-Tyrosine helps your body to produce melanin, so you may find it easier to get a tan while at the beach.

l-tyrosine benefits

L-Tyrosine Research

L-Tyrosine to treat ADHD

Several studies have investigated using L-Tyrosine for the treatment of attention deficit hyperactivity disorder (ADHD). One informal study published in the 1980’s determined that L-Tyrosine resulted in short-term relief from ADHD symptoms. But subjects eventually reached tolerance and a diminished effect.

This is important for neurohackers to keep in mind. It seems that L-Tyrosine on its own can benefit some more than others. Regardless if you’re treating ADHD, or are perfectly cognitively healthy.

I’ve seen more than one report of nootropic users experiencing tolerance after just a week of supplementing with L-Tyrosine. But most peer-reviewed, published studies show positive results.

One study published in Neuropsychiatric Disease and Treatment in 2011 looked at using amino acid precursors for the treatment of deficit hyperactivity disorder (ADHD). Including L-Tyrosine for dopamine, and 5-HTP for serotonin.

The study used 85 young people aged 4 – 18 years old, all with a clinical diagnosis of ADHD. They were treated for an initial period of 8 – 10 weeks.

Urinary samples to determine serotonin and dopamine levels were collected within the first 4 weeks. If they didn’t reach adequate levels, subjects were moved to higher dosing levels 2 and then 3 until they got relief from symptoms.

Researchers found that the dopamine and serotonin precursors yielded similar results to Strattera and Ritalin. And “the amino acid protocol may be equal in efficacy to potent, pharmaceutical ADHD medications”.[vii]

L-Tyrosine reduces blood pressure under stress

This study is particularly interesting for its nootropic application. It’s commonly understood that blood pressure rises when we’re under stress. The source of stress doesn’t really matter. Stress up = blood pressure up.

A study in Amsterdam showed that L-Tyrosine administration decreased blood pressure about 15 minutes after ingestion. This study involved assessing task performance following acute stress.

Acute stress is usually short-term and can be caused by driving, fighting, athletics, martial arts training, war, combat training, CrossFit, cold showers, loud music, intense movies, loud noises, business deals, relationships, school, exams and more.

The point is, this study is applicable to every one of us. The study found that L-Tyrosine reduced diastolic blood pressure within 15 minutes of taking the supplement. And blood pressure normalized within 1 hour.

This study tells us that L-Tyrosine may promote a decrease in blood pressure caused by stress. And could be used to mitigate the effects of stressful situations if taken prior to the stressful event.[viii]

L-Tyrosine promotes cognitive flexibility

Cognitive flexibility applies to those who can adjust their thinking quickly to adapt to novel situations and stimuli. A high degree of cognitive flexibility is associated with increased fluid intelligence, superior reading and comprehension, and a healthier brain.

Recent research (2015) supports the idea that L-Tyrosine promotes cognitive flexibility. In this trial, researchers recruited 22 adults. And setup a double-blind, placebo-controlled study.

All subjects were assigned a task switching procedure to measure their flexibility. The results showed that receiving L-Tyrosine supplementation increased cognitive flexibility compared to the placebo group.

The researchers determined that “L-Tyrosine can facilitate cognitive flexibility by repleting cognitive resources”.[ix]

The team observed that increased cognitive flexibility was likely due to a boost in dopamine concentrations. They noted that L-Tyrosine enhanced usage of various cognitive resources. And one way to increase your cognitive flexibility would be to start supplementing with L-Tyrosine.

It stands to reason that people who are close-minded, set it their ways, are resistant to change and can’t cope with unexpected stimuli or situations have “cognitive rigidity”. And it’s likely due to suboptimal dopamine levels.

l tyrosine dosage child

L-Tyrosine Dosage

L-Tyrosine suggested dosage for cognitive benefit is 500 mg – 2 grams per day.

You may find your body responds to smaller doses. Or even more if you’re stacking it with stimulants like ADHD meds. Listen to your body and see how you react.

If you find you do not experience the full benefit from L-Tyrosine,  then try using it an hour before or two hours after a meal. Because L-Tyrosine taken as a supplement may compete with other amino acids in food for transport into your system.

I personally stack L-Tyrosine with my Ritalin dose twice per day. And a final dose of L-Tyrosine late afternoon to prevent a stimulant crash.

NOTE: long-term use of L-Tyrosine can suppress serotonin. Symptoms include depression, fatigue or severe anxiety feeling much like a panic attack. You can easily counter this by supporting serotonin with a 250 – 500 mg L-Tryptophan about 60 mins. before bed.

L-Tyrosine Side Effects

L-Tyrosine is considered non-toxic and very safe. Most neurohackers and healthy human adults don’t have any negative side effects from using amino acid tyrosine as a nootropic supplement.

At higher doses there are reports of stomach issues and migraines. Migraine problems usually happen to those who already suffer from migraines. This may be an indication that your neurotransmitter levels are already optimal, and you don’t need to supplement with L-Tyrosine.

L-Tyrosine can increase your thyroid hormones. So if you’re hyperthyroid you should use caution when supplementing with L-Tyrosine because it may change the way your thyroid meds work.

And if you’re taking MAO inhibitors (MAOI’s) like selegiline, Azilect, Marplan or Nardil you should not use L-Tyrosine.

Monoamine oxidase inhibitors (MAOIs) work in your brain by blocking the enzyme monoamine oxidase. This enzyme normally blocks excess dopamine. But when you block the enzyme, more dopamine is released.

So using L-Tyrosine in combination with MAOI’s could raise dopamine levels too high. Resulting in a rapid rise in blood pressure (hypertensive crisis). Causing severe headache, nausea and sweating, severe anxiety, rapid heartbeat, chest pain, vision changes, shortness of breath and confusion.

A severe increase in blood pressure from this combo can lead to hemorrhagic stroke or a heart attack.

Where to buy L-Tyrosine

L-Tyrosine is available to buy in powder, capsule and tablet form. Capsules and tablets are usually 300 – 500 mg.

Some pre-made nootropic stacks and workout stacks also include L-Tyrosine as part of their formula.

N-Acetyl L-Tyrosine (NALT) is an alternative to plain L-Tyrosine. NALT has an acetyl group added to L-Tyrosine in an attempt to make it more bioavailable.

For example, Mind Lab Pro® 4.0 contains 11 brain enhancing nootropic compounds including N-Acetyl L-Tyrosine.

I recommend Mind Lab Pro because it addresses all aspects of anxiety resistance, memory and cognitive enhancement, stabilizes mood, brain repair, and maintenance.

This premium nootropic stack is designed to affect neurotransmitters, cognitive energy, brain waves, neuroprotection, and regeneration. See my Mind Lab Pro review for a detailed report.

Ensure you read labels carefully and stick with manufacturers who follow Good Manufacturing Practices (GMP). And are GMP-Certified. And do your best to avoid toxic “other ingredients” which are usually listed at the bottom of “Supplement Facts” labels.

Nootropics Expert Recommendation

Nootropics Expert Tested and ApprovedL-Tyrosine 500 mg – 2 grams per day

I recommend using L-Tyrosine as a nootropic supplement.

Your body does synthesize some L-Tyrosine from phenylalanine which comes from high-protein foods like chicken, fish, almonds, avocados and bananas.

But most of us don’t get enough L-Tyrosine from our diet. So supplementation will help.

L-Tyrosine is helpful for most neurohackers to combat stress and sleep deprivation. It’ll boost dopamine, norepinephrine and epinephrine levels.

It’s particularly helpful if you take L-Tyrosine prior to a stressful situation, workout or physically demanding job.

L-Tyrosine is especially helpful to those dealing with ADHD/ADD. It’s a great compliment to stack with stimulant meds like Ritalin or Adderall. L-Tyrosine will provide the dopamine your brain needs. It will help smooth out and prolong the effects of stimulant meds. And help prevent the associated crash when they wear off.

A good stack for ADHD is using your usual med dose with L-Tyrosine 500 mg, Alpha GPC 300 mg, and ALCAR 500 mg. Which is should particularly effective if you are dealing with any phenylalanine abnormalities.

You can buy individual L-Tyrosine supplements. Or you could try my favorite pre-formulated nootropic stack Mind Lab Pro® 4.0 which includes N-Acetyl L-Tyrosine (NALT).

Mind Lab Pro contains a synergistic blend of 11 brain enhancing nootropics covering all aspects of cognition and brain health. See my full Mind Lab Pro review for more.

You can safely use up to 2,000 mg per day when stacking with ADHD meds. But in smaller divided doses throughout your day.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Slominski A., Zmijewski M., Pawelek J. “L-tyrosine and L-DOPA as hormone-like regulators of melanocytes functions” Pigment Cell Melanoma Research. 2012 Jan; 25(1): 14–27. (source)

[ii] Woods S.K., Meyer J.S. “Exogenous tyrosine potentiates the methylphenidate-induced increase in extracellular dopamine in the nucleus accumbens: a microdialysis study.” Brain Research. 1991 Sep 27;560(1-2):97-105. (source)

[iii] Hase A., Jung S.E., aan het Rot M. “Behavioral and cognitive effects of tyrosine intake in healthy human adults.” Pharmacology, Biochemistry and Behavior. 2015 Jun;133:1-6. (source)

[iv] Magnusson I., Ekman L., Wångdahl M., Wahren J. “N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans.” Metabolism. 1989 Oct;38(10):957-61. (source)

[v] Coull N.A., Watkins S.L., Aldous J.W., Warren L.K., Chrismas B.C., Dascombe B., Mauger A.R., Abt G., Taylor L. “Effect of tyrosine ingestion on cognitive and physical performance utilising an intermittent soccer performance test (iSPT) in a warm environment.” European Journal of Applied Physiology. 2015 Feb;115(2):373-86. (source)

[vi] Colzato L.S., Jongkees B.J., Sellaro R., Hommel B. “Working memory reloaded: tyrosine repletes updating in the N-back task.” Frontiers in Behavioral Neuroscience. 2013 Dec 16;7:200. (source)

[vii] Hinz M., Stein A., Neff R., Weinberg R., Uncini T. “Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation” Neuropsychiatric Disease and Treatment. 2011; 7: 31–38. (source)

[viii] Deijen J.B., Orlebeke J.F. “Effect of tyrosine on cognitive function and blood pressure under stress.” Brain Research Bulletin. 1994;33(3):319-23. (source)

[ix] Steenbergen L., Sellaro R., Hommel B., Colzato L.S. “Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance.” Neuropsychologia. 2015 Mar;69:50-5 (source)

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Join The Discussion - 384 comments

March 3, 2019

Hi! thank you so much for building that great website.

Can I stack 500mg L-Tyorsine with 1g of Taurine in the morning? do they both work well together?

or even with ALCAR and L-Theanine? or is it too much?

thanks a lot

    David Tomen
    March 3, 2019

    Karim, all four of those nootropics should work well together. But if it’s your first time I’d recommend starting with the lower recommended dosage for each and see how it affects you.

      April 11, 2019

      thanks a lot!!!

February 22, 2019

Can Tyrosine cause tolerance to phenylalanine or vice versa since they are closely related? Basically, I’m asking if doing a cycle with tyrosine followed by a cycle with phenylalanine would be effective or would one limit the effectiveness of the other?

Thank you,


    David Tomen
    February 22, 2019

    Nicholas, it would help if you understood the dopamine pathway a little better. It goes like this: Phenylalanine > Tyrosine > L-DOPA > Dopamine > Norepinephrine > Epinephrine. The first is needed for the synthesis of the next, and the next, and the next, etc.

    Some people respond better to phenylalanine or tyrosine while others respond better to N-Acetyl L-Tyrosine or Mucuna Pruriends (L-DOPA). So it’s not a matter of cycling anything. It’s about getting the dosage and daily timing right and using the nootropic that works best for you.

      February 22, 2019

      Great, thank you so much. I have been having great result using phenylalanine lately and I was concerned about building up a tolerance to it.

February 17, 2019

Hi David,

I’ve been using Tyrosine 500mg daily for a couple of months as part of a natural approach to treating anxiety/depression. I find that I feel a bit spaced out and sleepy after taking it. Would this indicate that I don’t need it and that my symptoms are more serotonin related?

    David Tomen
    February 17, 2019

    Kenneth, anxiety and depression can be caused by any number of things and not just problems with dopamine or serotonin. And excess dopamine will deplete serotonin and vice versa.

    Here’s a post I wrote about depression which may give you some other ideas to try: https://nootropicsexpert.com/best-nootropics-for-depression/

      February 18, 2019

      Thanks David,

      I’m currently taking:
      St John’s Wort; 600mg of 0.3% Hypericin and 600mg of Perika
      Ashwagandha 400mg
      Niacin 1.5g-2g
      Tyrosine 500mg
      Tryptophan 500mg at night
      5-Htp 50mg
      B complex
      Magnesium and Zinc
      Vit C 2g
      Gingko Biloba

      This is helping a lot with mood, however tinnitus is a problem. It developed while I was taking Mirtazapine for 5 months. Any nootropic that you can recommend for tinnitus?

        David Tomen
        February 18, 2019

        Kenneth, read the reviews for Vitamin B6, Taurine, Iodine and Picamilon for tinnitus. I personally haven’t found anything so far that completely eliminates tinnitus. But it’s not as bad as it once was.

        February 21, 2019

        Hi David,

        On a different note, I was on lorazepam for a short period, i.e. three weeks. Is it better to avoid using GABA for the time being?


        David Tomen
        February 21, 2019

        Kenneth, find out the exact mechanism of action for lorazepam. It affects more than just GABAa receptors. Ion channels and gene expression is also involved. Not sure how long those effects last after quitting this drug. While not life threatening as far as I can tell, you may want to give it a week before trying GABA.

Jen W
February 8, 2019

Hi David,
I have used L-Tyrosine in the past with a stack of 5-htp. However, when I have done this in the past I did suffer from some migraines that stopped after discontinuing the tyrosine. I too and adult ADD and it really helped with my mood, energy, and motivation so I’m pretty bummed out that it gave me migraines. I am looking to start a stack again to help with the ADD but especially the energy, motivation and overall mood. Is there anything else I can take that has the same effects as the Tyrosine but doesnt cause headaches and if so do you need to stack it with a serotonin supplement as well?
I have one other question about all nootropics, I had someone tell me that you need to take breaks from these supplements to keep your brain producing these chemicals on their own, so I used to take these supplements for about 4 months then I’d take 4 months off. Do you agree with this assessment and does it apply across the board?

I really appreciate any insight from your own experience/research!


    David Tomen
    February 8, 2019

    Jen, a couple of things could be going on here. First, L-Tyrosine converts to L-DOPA which helps chelate heavy metals. Which could cause side effects like headaches. Second, one of the side effects of too much L-Tyrosine is migraines. Which happens could happen if you have a history of migraines. Or it could mean that your dopamine levels are already optimal.

    Adult ADD is not solely due to dopamine and dopamine signaling. Dr. Amen has made a career of studying ADD and ADHD and has identified different types affecting different areas of the brain. I suggest checking out the information he has published over the years and see if you can find some answers.

    The dopamine pathway is basically phenylalanine > tyrosine > L-DOPA > dopamine. So you could try phenylalanine or Mucuna Pruriens (L-DOPA) but not sure it would make much of a difference. Or you could try using less Tyrosine per dose and/or less often.

    As you likely know, dopamine and serotonin levels need to stay in balance. I keep mine in balance by using very low doses of 5-HTP for serotonin. But it’s a delicate kind of thing and unique to each person. You could also use L-Tryptophan which would be safer and easier to manage I think.

    As for cycling, thing about it. If your brain requires dopamine and serotonin (along with a host of other neurotransmitters, proteins, fats, etc.) how would taking a break help? The idea is find the ideal balance and once you do, stay with whatever you found works. Taking a break would throw things out of whack all over again.

      September 30, 2019

      Hi David,

      Can I use L-Theanine instead of 5-htp? Thank you

        David Tomen
        September 30, 2019

        Carmen, these are two very different nootropic supplements. While L-Theanine does boost serotonin, 5-HTP does it directly because it is the direct precursor to serotonin. So it depends on what you are trying to do. What is your ultimate goal for using either of these supplements?

        September 30, 2019

        I am trying to manage my ADHD. I want to try L-Tyrosine, you have mentioned that it needs to be coupled with 5-htp or L-Tryptophan. Since I already take L-Theanine, I was wondering If I could just use L-Theanine for the same purpose.
        Thank you!

        David Tomen
        October 1, 2019

        Carmen, L-Tyrosine is used for the synthesis of dopamine which is the main neurotransmitter involved in ADHD. That and problems with brain cell signalling seem to be the main problems.

        When dopamine is raised too much it suppresses serotonin. So we use L-Tryptophan to increase serotonin and balance it with dopamine.

        L-Theanine has been shown to help boost serotonin but it does not directly synthesize it like it’s natural precursor L-Tryptophan does. So most of the time is not nearly as efficient in producing this neurotransmitter.

        5-HTP also helps make serotonin. But you must be very careful on how much you use. Because too much causes problems. L-Tryptophan does the job but it’s gentler and more forgiving when it comes to dosage.

February 6, 2019

Dear David, I take XanthoMax and Elevate Coffee “Smart Coffee” are there any peer-reviewed magazine articles or information regarding the contents and efficacy of these products? There are nootropics in the ingredients but I am trying to do some research specifically on these particular items. Thank you in advance for your assistance. Israel

January 8, 2019


Ecellelent breakdown as usual David!
Is it OK to stack L Phenylalanine with Tyrosine? They sound very similar.

I’ve used a product on the market that stacks these amino acids with TMG, and some b vitamins. I find that it works quite well for me.

Thanks again!

    David Tomen
    January 9, 2019

    Shibs, you can stack them together. The first one is a precursor to the second. And they need the B-vitamins to synthesize dopamine.

October 6, 2018

Hello David,
I’m wondering if you could give me advice or guide me.

I’m using successfully some of the nootropics you recommend here in your website!
Thanks so much!
I have an issue with my sexual life,
Whenever i masturbate after i finish, i feel really agresive and angry, i don’t understand why before i feel so free and i can think of what ever fantasy and it’s all good, but after all that, agression and anger comes to me and i can only get better after days, i was reading a little about dopamine and seretonin but it’s still not understandable for me because i don’t know if that is related at all or what is it that is related to what i feel.

Thank you so much!

    David Tomen
    October 6, 2018

    David, this is what happens when you orgasm and ejaculate: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896089/. I’ve found that quickly boosting serotonin levels and taming norepinephrine helps. Try either 500 mg L-Tryptophan or 50 mg 5-HTP + 1 or 2 Lithium Orotate tablets. And you should be good.

July 17, 2018

Hello David,
I have tried L-Tyrosine and each day I tried even just 500mg, I was hit with strong anxiety.
The only stimulant I take is one coffee in the morning.
Have you had any other reports of anxiety as a side effect of tyrosine?

    David Tomen
    July 17, 2018

    Yes, this is a classic problem of not enough serotonin caused by excess dopamine.

    You can counter it with a very low dose of 5-HTP or higher dose of L-Tryptophan. I typically dose 25 mg of sublingual 5-HTP 3-times per day and it works for me. But it really depends on individual brain chemistry and neurotransmitter balance. Trial and error is key.

      October 8, 2019

      Hi David,

      Instead of taking L-Tryptophan, can I take Essential Amino Acids which has L-Tryptophan? Apparently, that can help achieve a good amino acid balance?

      Thank you

        David Tomen
        October 9, 2019

        Carmen, you certainly can use an amino acid supplement. But it depends on what you are trying to do. Sometimes a more targeted approach is needed depending on your goals.

        October 9, 2019

        Thanks David!

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