Best nootropics for depression-2022

Best Nootropics for Major Depressive Disorder

David Tomen
Author:
David Tomen
17 minute read

Nootropic forums and blogs often describe depression as a neurotransmitter imbalance in the brain. And then offer suggestions on various nootropics for major depressive disorder or drugs to help lift your mood and reduce depression.

But this simplistic view of depression misses the complexity of this disease.

Recent research has shown that depression can have many possible causes. Including out of whack mood regulation by your brain, genetic problems, stressful events or living conditions, prescription medications or other medical problems causing cognitive impairments.

It’s true that neurotransmitters are involved in the process that contributes to depression. But it’s usually not a matter of one neurotransmitter being too low or another too high.

Here’s the thing. You have several neurotransmitter systems, amino acids, hormones and other neurochemicals working both inside and outside neurons.

The interaction of these neurochemical reactions make up a highly dynamic system that contributes to your mood. And how you perceive and experience life.

With this level of complexity, you may have similar symptoms of depression to the person next to you. But the issues in your brain and body may be completely different. So what works best for someone else experiencing your symptoms may not be best option for you.

And this is why we often say in the nootropic community that Your Mileage May Vary (YMMV) when describing a particular nootropic supplement. And how it feels.

In this article you’ll discover other possible causes contributing to your depression. How to recognize them. How to use nootropic supplements to test different possible causes so you can narrow down what may be causing your depression.

And I’ll share some nootropic supplement suggestions that may help relieve your depression symptoms for a better quality of life.

Depression and Neurogenesis

It turns out that brain cell signaling, neurogenesis and the function of neuronal circuits may play a more important role in depression than simply the levels of serotonin or dopamine.

For example, researchers in Munich studied 24 women who had a history of depression. And on average, their hippocampus was 9 – 13% smaller in the depressed women compared to healthy women. And the more bouts of depression a woman had, their hippocampus was even smaller compared to less depressed women in the study.[i]Best nootropics for mood enhancement

We know that stress can play a role in depression and on your central nervous system. And research has shown that stress can suppress neurogenesis. Which would account for the smaller hippocampus in these women.

We also know that Brain-Derived Neurotrophic Factor (BDNF), a naturally occurring protein in your brain, is critical for preventing apoptosis (brain cell death), is required for the growth of new neurons (neurogenesis) and the growth and maintenance of synapses.

Please check out my article on “13 Nootropics to Boost BDNF”. Increasing BDNF is one way to combat depression. Below I’ll share a list of nootropics for you to try some of which also help to increase levels of brain derived neurotrophic factor (BDNF) among other benefits for a healthy brain.

If you’ve ever tried antidepressants for alleviating depressive symptoms, you know that it often takes weeks to feel any benefit. Scientists have a theory that the value of some of these medications may be in generating new neurons (neurogenesis), strengthening neuron connections, and improving brain cell signaling. Which often takes time before you can feel the result.

So now researchers speculate that new medications could be developed to specifically promote neurogenesis. As it turns out, we already have this ability with several natural nootropic supplements.

Depression and Neurotransmitters

We know that neurotransmitter dysfunction is not the only cause of depression. But we can’t discount their importance either.

Neurons are designed to communicate with each other. When a neuron is activated, it passes an ‘action potential’, which is a tiny electrical signal, down its axon to the axon terminal (synapse).  Neurotransmitters are stored in synaptic vesicles.

The action potential (electrical signal) releases certain neurotransmitters into the synapse. Which then sends it over to a synapse on a dendrite connected to the receiving neuron. As the concentration of neurotransmitters rise in the synapse, they bind to receptors embedded in the membranes of the two neurons.

This release of a neurotransmitter from one neuron can activate or inhibit the second neuron. Once the first neuron has released a certain amount of neurotransmitter molecules, a feedback mechanism instructs the transmitting neuron to stop releasing neurotransmitter molecules and begin bringing them back into the 1st neuron. This process is called reuptake.

In those who are severely depressed or manic, this fine-tuned system of neuro-signaling can go out of whack. Either too much or too little of the neurotransmitter is released.

Or if the reuptake is overly efficient and mops up too many neurotransmitter molecules before they have a chance to bind to receptors. It can have a significant impact on mood.

The primary neurotransmitters that can play a role in depression include:

Each one of these neurotransmitters can be boosted, or their reuptake affected by nootropic supplements (listed below).

sulbutiamine-for-depression

Depressive Symptoms and Prescription Medication

Depression can result as a side effect of certain prescription drugs. These drugs can include antimicrobials, antibiotics, antifungals, antivirals, heart and blood pressure drugs, hormones, insomnia drugs, tranquilizers, antacids, narcotic pain drugs and more.

We know from experience that many of these prescription drugs may be replaced by safer, natural nootropic supplements.

But I am NOT encouraging you to stop using whatever meds you’re currently on. Without consulting with your doctor first. I am encouraging you to learn about and possibly try safer alternatives that often do the job just as well and will enhance your brain health.

CAUTION: many nootropic supplements are contraindicated with prescription SSRIs, MAOIs, tricyclics, and others that work on the same neurotransmitter system. Combining any of these ‘natural’ nootropic supplements with the wrong drug can do serious harm. Including ending your life. Please, please read the Side Effects section of each nootropic review here on Nootropics Expert®. And if in doubt please ask me and consult with your doctor before trying a nootropic if you are using any of these prescription meds.

Depression and Stress

Nearly all of us experience stressful events. And while not every one of us who faces stress develops depressive disorders or other mental disorders. Stress however often does play an important role in depression.

Depending on how sensitive you are to stress, along with messed up neurochemistry and even genetics. A perfect storm of any or all of these influencing factors can lead to depression.

So, please read my extended article on “Best Nootropics for Anxiety” which includes several nootropic supplements that may help you deal with and conquer stress and even boosts your mental performance.

noopept-for-depression

Recommended Nootropics for Depression and Enhance Cognitive Performance

If you are currently being treated for depression. Or suspect you may be dealing with undiagnosed depression. And are looking for a more natural, safer way to treat your symptoms. Nootropics may be the answer.

You’re not alone looking for a natural alternative to drugs that often often associated with a host of side effects. Research in the United States and other countries show that significant numbers of people use ‘alternative medicine’ to treat their depression.

Researchers conducted a survey of more than 3,000 women in the USA to find out how many turned to alternative medicine for depression. Of the 220 women who said they had been officially diagnosed with depression, 54% said they used alternative medicine to treat their symptoms.[ii]

We have found that the following list of nootropics work well for different types and causes of depression.

As I mentioned before, your mileage may vary. What works for me may not work for you. Wise and careful experimentation is critical to finding a safer alternative for treating your depression.

    1. Aniracetam – A member of the racetam-family of nootropics, Aniracetam works with dopamine D2 and D3 receptors in your brain. And desensitizes AMPA (glutamate) receptors which can help control glutamate toxicity.Aniracetam is one of the most effective antidepressants I’ve even tried. And its effects on dopamine in your brain can have a profound effect on anxiety symptoms as well.

 

    1. Bacopa Monnieri – One of the most powerful herbs in Ayurvedic medicine. Bacopa Monnieri has been used for millennia to relieve anxiety, fatigue, restore energy and boost concentration.This adaptogen has been shown in clinical studies to work as well for depression as benzodiazepines and tricyclic antidepressants.[iii]

 

    1. Coenzyme Q10 (CoQ10)CoQ10 contributes to your cell’s natural source of energy. Producing ATP in your mitochondria by taking fat and converting it into usable energy. CoQ10 preserves brain function, helps fight mental illness and migraines.Major depression, bipolar disorder and schizophrenia are now being recognized as having mitochondrial dysfunction in common. With higher oxidative stress levels.[iv] Studies show that 1,200 mg per day of CoQ10 in bipolar adults experienced a significant reduction in depression.[v]

 

    1. 5-HTPI do NOT recommend using 5-HTP for treating depression. But only include it here since it is marketed as a “natural antidepressant”.This amino acid is naturally produced in your body. And synthesized from the amino acid tryptophan which you get from food. 5-HTP is the precursor needed to produce the ‘feel-good’ neurotransmitter serotonin. But a summary published in the Alternative Medicine Review noted a lack of evidence for ‘loading’ precursors to treat depression.[vi] Combining 5-HTP with SSRI’s, Tricyclics or MAOI’s will cause Serotonin Syndrome which can be deadly.

 

    1. Ginkgo Biloba – This tree native to China has been used for thousands of years to boost mental alertness, improve cerebral circulation and for better overall brain function. Many have found Ginkgo Biloba to be very effective for reducing anxiety and stress. And for boosting mood.1,570 men and women in England participated in a study using 120 mg of Ginkgo Biloba extract daily for 4, 6, and 10 months. Those who used Gingko Biloba the longest experienced the most improvement improvements for anxiety, depression, energy, drowsiness, sadness and happiness.[vii]

 

    1. Iodine – Did you know that iodine deficient populations are up to 13.5 IQ points less than those with optimal iodine levels in their system?[viii] Since iodine has largely been removed from table salt in some countries, it has been suggested that iodine deficiency is epidemic. Particularly in countries like the United States.Iodine is essential to thyroid health and the production of thyroid hormones. Nearly every tissue in your body relies on thyroid hormones for healthy function. Not enough iodine can result in hypothyroidism. Negatively affecting acetylcholine synthesis in your brain. Affecting cognition, learning and memory, recall and mood.

 

    1. Kava Kava is native to the South Pacific. And the islanders use kava for its sedative effects. Kava can help reduce anxiety and depression. Unlike benzodiazepines, Kava does not impair cognitive function. In fact, studies show that not only will Kava improve mood. It may also boost cognitive function as well.[ix]

 

    1. Lion’s Mane Mushroom – Also called the “smart mushroom”, Lion’s Mane boosts brain nerve growth factor which increases neurogenesis. Lion’s Mane can help improve focus and attention, boost thinking and processing speed, repair brain cells, and help relieve anxiety and depression.Women in Japan received Lion’s Mane-laced cookies for 4 weeks during a clinical trial. The researchers found that Lion’s Mane reduced anxiety and depression in these women during the trial.[x]

 

    1. Magnesium – Lack of adequate magnesium can result in brain fog, anxiety and depression. Plasticity of neuron synapses is affected by having enough magnesium in brain cells.A study was conducted with 5,708 people in Norway. The aim of the study was to examine the association between magnesium intake and depression and anxiety. The researchers found that low magnesium intake is related to depression.[xi]

 

    1. Mucuna Pruriens (L-DOPA)L-DOPA is synthesized from the amino acid tyrosine in your body. And is a precursor to the formation of dopamine, epinephrine and norepinephrine in your brain.Mucuna Pruriens has been used in Ayurveda medicine since 1500 B.C. For treating things like snakebite, intestinal problems, sexual issues and melancholy mood. Research shows that supplementing with L-DOPA extracted from Mucuna Pruriens can be a great natural antidepressant if you are low in dopamine.[xii]

 

    1. N-Acetyl L-Cysteine (NAC)NAC is an amino acid that regulates the amount of glutamate and dopamine in your brain. It helps restore dysfunctional dopamine receptors. And is a precursor to Glutathione which is your master antioxidant needed to reduce free radicals and oxidative stressA study with 75 subjects with bipolar disorder were given 1 gram of NAC twice daily for 24 weeks. Treatment with NAC resulted in a significant improvement with depression in these patients.[xiii]

 

    1. N-Acetyl L-Tyrosine (NALT) – NALT is a highly bioavailable form of the amino acid L-Tyrosine. Your brain uses tyrosine to produce dopamine and norepinephrine. Dopamine is involved in libido, memory, focus, goal-oriented concentration, is a mood elevator and antidepressant.If you are ADHD, or have other issues with low dopamine, supplementing with NALT or L-Tyrosine may help improve your memory, boost your IQ, and relieve depression. I highly recommend NALT or L-Tyrosine for anyone using stimulants like Adderall or Ritalin for treating ADHD.

 

    1. Nefiracetam – One of the newer members of the racetam-family of nootropics, Nefiracetam is used clinically to treat and prevent seizures, severe depression and has shown neuroprotective qualities.The structure of Nefiracetam is similar to the other great racetam antidepressant Aniracetam. Researchers at the University of Iowa did a trial with 159 stroke patients with major depression. The study concluded that Nefiracetam produced a significant improvement in the most severely depressed patients.[xiv]

 

    1. Noopept – This peptide-derived nootropic related to the racetam-family is much more potent than Piracetam. But its mechanism of action in your brain is similar to other racetams.Noopept stimulates dopamine, nicotinic and serotonin receptors. It boosts cognition, memory, logical thinking, reflexes and mood.[xv] Noopept increases Alpha brain waves and Beta brain waves. Increasing relaxation. Alpha brain waves increase relaxation and the Beta brain waves assist with your state of alertness and mental clarity. Both of these combined can move you into super-learning, flow states and joy.

 

    1. Phenylalanine – This amino acid is a precursor to tyrosine in your brain. Tyrosine helps in the synthesis of dopamine, epinephrine, and norepinephrine.One study was done with 23 patients diagnosed with depression who had not responded to standard antidepressants. They were given 50 or 100 mg of Phenylalanine daily for 15 days. The researchers found that Phenylalanine completely improved mood in 17 of the patients. Within 13 days of the 15-day trial.[xvi]

 

    1. Rhodiola RoseaRhodiola Rosea activates AMPA receptors in your brain. Which can decrease depression and stress-related mood swings, reduces fatigue, stimulates energy and alertness, boosts cognition, and motivation.A clinical trial with 57 patients diagnosed with depression were given Rhodiola Rosea extract, sertraline (Zoloft®), or a placebo for 12 weeks. The study found that Rhodiola Rosea was slightly less effective than sertraline for depression. But produced far fewer side effects and was better tolerated.[xvii]

 

    1. SAM-eSAM-e is the naturally occurring amino acid methionine bound to an ATP molecule. It helps in the process of cell division and repair, and the generation of the neurotransmitters dopamine, serotonin, norepinephrine and melatonin. Which is why it’s considered a potent nootropic.SAM-e is used to boost mood, relieve depression, improve energy levels and reduce symptoms of fibromyalgia. 20 healthy volunteers took part in a study receiving infusions of 800 mg of SAM-e or a placebo for 7 days. EEG mapping during the study identified SAM-e as an antidepressant. Targeting brain regions crucial in the therapeutic efficacy of antidepressants.[xviii]

 

    1. St. John’s wort – This herb has traditionally been used for mood disorders and wound healing. Today it’s used mostly as a treatment for anxiety, depression and stress.St. John’s wort works like prescription SSRI’s by preventing the reuptake of serotonin in your brain. But please read the precautions for using this nootropic in the extended article. Before trying it as a nootropic supplement to treat your depression.

 

    1. Sulbutiamine – Sulbutiamine is a synthesized version of Vitamin B1 (thiamine) which easily crosses the blood-brain barrier. As a nootropic, it’s used to boost mood, memory and motivation.A study at the University of Wales Swansea in the UK worked with 120 young adult females. Study participants took either a placebo or 50 mg thiamine for 2 months. Mood, memory and reaction times were monitored before and after taking the tablets. 2 months after supplementing with thiamine, participants were more clearheaded, felt more composed and energetic, reaction times improved, and mood was better.[xix]

 

    1. Tryptophan – This essential amino acid is a precursor to serotonin, melatonin and niacin (Vitamin B3) in your body. Adding tryptophan to your stack can help boost your serotonin levels. And should help with anxiety, ADHD, depression, insomnia, memory loss, pain and eating disorders.

 

    1. TurmericTurmeric is one of the main spices in curries. In parts of India where curries are eaten most often, Alzheimer’s disease is extremely rare. This spice (and its extract called curcumin) has a unique ability to reduce inflammation common to Parkinson’s, Alzheimer’s and brain tumors.A study conducted in India looked at the efficacy and safety of using curcumin, the main active ingredient found in turmeric, for treating major depression.60 depressed patients took either 20 mg of Prozac®, 1000 mg of curcumin, or a combination of both daily for 6 weeks. The best response during the trial was with patients using the combination. And the researchers concluded that curcumin could be used as an effective and safe treatment for patients with major depression.

 

    1. Uridine Monophosphate – This precursor to Ribonucleic Acid (RNA) provides instructions from your DNA to help create memory by facilitating connections between brain neurons (synapses).Uridine supplementation as a nootropic uplifts and stabilizes mood, is anti-stress, helps Obsessive Compulsive Disorder (OCD), is anti-anxiety and helps modulate and normalize dopamine release.[xx]

 

    1. Vitamin B6Vitamin B6 helps your brain make serotonin, norepinephrine and melatonin. The activated form of Vitamin B6 called P-5-P is particularly effective in boosting serotonin and GABA in your brain.For depression, look for a P-5-P supplement or a B-Complex formula that uses P-5-P.

 

    1. Vitamin B12 – This B-vitamin plays a key role in the efficient conversion of carbohydrates to glucose which contributes to cellular fuel production (ATP). It helps your body convert fatty acids into energy.Supplementing with Vitamin B12 can help lower anxiety, and elevate alertness, cognition, energy, vision, elevate mood and relieve insomnia. No more mood swings!

 

Depressed No More

Nootropics can be a strong alternative to many antidepressant medications currently prescribed by doctors. And promoted by the Big Pharmaceutical companies.dopaminergic nootropics

But a very strong word of caution – if you are currently using any prescription antidepressant medications. Or any medication for that matter. Research each nootropic including side effects and prescription drug interactions before using them.

To finally beat depression, you must figure out the root cause of it. It is pointless to try otherwise without doing your research. Experiment with various nootropic supplements until you find what works for you.

Good luck in your search. There is hope. I know because I’ve conquered my own depression. And came out the other side better than before.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Frodl T. et. Al. “Reduced hippocampal volume correlates with executive dysfunctioning in major depression” Journal of Psychiatry and Neuroscience 2006 Sep; 31(5): 316–325. (source)

[ii] “Alternative medicine for depression” Harvard Medical School July 1, 2007 (source)

[iii] Bhattacharya S.K., Bhattacharya A., Sairam K., “Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.” Phytomedicine 2000 Dec;7(6):463-9. (source)

[iv] Maes M., Galecki P., Chang Y.S., Berk M. “ A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness.” Progress in Neuropsychopharmacology and Biological Psychiatry. 2011 Apr 29;35(3):676-92. (source)

[v] Forester B.P., Zuo C.S., Ravichandran C., Harper D.G., Du F., Kim S., Cohen B.M., Renshaw P.F. “Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.” Journal of Geriatric Psychiatry and Neurology. 2012 Mar;25(1):43-50. (source)

[vi] Meyers S. “Use of neurotransmitter precursors for treatment of depression.” Alternative Medicine Revue. 2000 Feb;5(1):64-71. (source)

[vii] Trick L., Boyle J., Hindmarch I. “The effects of Ginkgo biloba extract (LI 1370) supplementation and discontinuation on activities of daily living and mood in free living older volunteers.” Phytotherapy Research. 2004 Jul;18(7):531-7. (source)

[viii] Qian M., Wang D., Watkins W.E., Gebski V., Yan Y.Q., Li M., Chen Z.P. “The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China.” Asia Pacific Journal of Clinical Nutrition 2005;14(1):32-42. (source)

[ix] Thompson R., Ruch W., Hasenöhrl R.U. “Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava). Human Psychopharmacology. 2004 Jun;19(4):243-50. (source)

[x] Nagano M., Shimizu K., Kondo R., Hayashi C., Sato D., Kitagawa K., Ohnuki K. “Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.” Biomedical Research. 2010 Aug;31(4):231-7. (source)

[xi] Jacka F.N. et. Al. “ Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study” Australian and New Zealand Journal of Psychiatry Volume 43, Issue 1, 2009 (source)

[xii] Rana D.G., Galani V.J. “Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression.” Ayu. 2014 Jan;35(1):90-7. (source)

[xiii] Berk M., Copolov D.L., Dean O., Lu K., Jeavons S, Schapkaitz I., Anderson-Hunt M., Bush A.I. “N-acetyl cysteine for depressive symptoms in bipolar disorder–a double-blind randomized placebo-controlled trial.” Biological Psychiatry. 2008 Sep 15;64(6):468-75 (source)

[xiv] Robinson R.G., Jorge R.E., Clarence-Smith K. “Double-blind randomized treatment of poststroke depression using nefiracetam.” Journal of Neuropsychiatry and Clinical Neurosciences. 2008 Spring;20(2):178-84. (source)

[xv] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)

[xvi] Fischer E., Heller B., Nachon M., Spatz H. “Therapy of depression by phenylalanine. Preliminary note.” Arzneimittelforschung. 1975 Jan;25(1):132. (source)

[xvii] Mao J.J., Xie S.X., Zee J., Soeller I., Li QS., Rockwell K., Amsterdam J.D. “Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.” Phytomedicine. 2015 Mar 15;22(3):394-9. (source)

[xviii] Saletu B., Anderer P., Di Padova C., Assandri A., Saletu-Zyhlarz G.M. “Electrophysiological neuroimaging of the central effects of S-adenosyl-L-methionine by mapping of electroencephalograms and event-related potentials and low-resolution brain electromagnetic tomography.” American Journal of Clinical Nutrition. 2002 Nov;76(5):1162S-71S (source)

[xix] Benton D., Griffiths R., Haller J. “Thiamine supplementation mood and cognitive functioning.” Psychopharmacology 1997 Jan;129(1):66-71. (source)

[xx] Powell A. “Rx for depression: ‘Mangia, mangia!’ Harvard Gazette Archives new.harvard.edu March 03, 2005 Retrieved August 9, 2016 (source)

Subscribe to the Nootropics Expert newsletter

Keep up to date with the latest developments in the nootropics space.

Head First 2nd Editon

The Award Winning Guide to Healing & Optimizing Your Brain with Nootropic Supplements.

Head First 2nd Edition

NEW! Eliminate Brain Fog, Low Energy, Moodiness, Difficulty Sleeping, Memory Loss or Anxiety. Available on Amazon, Barnes & Noble, Apple Books, Walmart and more...



Where to Buy Nootropics

Wondering where to buy the best nootropic supplements? Well, you’re in the right place. Because here you will find the nootropic supplements that I personally use and recommend. Each supplement has a link to the company store and product that I use. I also include a link to my full review for each supplement here […]

The Definitive Guide to Nootropics

Nootropics can help increase your memory, boost learning ability, improve your mood and assist overall brain function. If you’re new to nootropics, or wonder about the difference between a nootropic and a smart drug, then this page is for you. Here you’ll find the definition of a nootropic, how to pronounce the word “nootropic”, the […]

The Most Comprehensive Nootropics List

This is our big list of the most popular Nootropics in use today. Here you’ll learn what each nootropic is, what it does and suggested dosages. What is this List of Nootropics About? Nootropic supplements are cognitive enhancers aiming to improve brain function. Whether you are looking to treat mild cognitive impairment, improve mental focus, or biohack […]



Free Secrets of the Brain 3rd Edition

Get “Secrets of the Optimized Brain,” 92 nootropics to help you plan your Nootropic Stack when you sign up for my newsletter:

Join The Discussion - 326 comments

DLM
March 1, 2018

Hi David – Researching the best nootropics for what I need has proven to be confusing and exhausting as I continually read conflicting information on blogs and ‘authoritative’ sources.

I’m wondering about hordenine and if there is a reason it wasn’t included on your above list? It apparently acts as an MAO inhibitor. I have been taking SSRI’s for many years with some benefit in mood but I have seen the most helpful affects from meds that increase dopamine (for motivation) so I’m looking for nootropics that help with either increasing production or inhibiting breakdown, of dopamine – I’m not sure which action is best at this point.

Thank you for any help.

    David Tomen
    March 1, 2018

    Hordenine is on my list and haven’t gotten to it yet. If you are looking for monoamine oxidase inhibitors, please see the individual review for Methylene Blue, Rhodiola Rosea, Ginkgo Biloba, Berberine, Oat Straw and Turmeric (curcumin) which are, or act as MAOI’s.

    You can also boost dopamine by using NALT or Mucuna Pruriens.

    Each of us responds differently to the nootropics I’ve listed here. The key is experimenting one by one until you find the one, two or three that work best for you. The best approach is usually building a small nootropic stack for something like catecholamine-based depression.

    Last suggestion is click on the “Blog” link above in the menu and scan down the list of posts. Most of them either have a recommended stack or several suggestions on what to try.

Becky
January 22, 2018

I take it that for treating depression St John’s Wort shouldn’t be used with NooCube?

Each NooCube capsule contains:
Alpha GPC
Cat’s Claw
Oat Straw
Huperzine A
Bacopa Monnieri
L-Theanine
L-Tyrosine

    David Tomen
    January 22, 2018

    Becky, the biggest concern with St. John’s wort is Serotonin Syndrome. Please see this section of my St. John’s wort review here > https://nootropicsexpert.com/st-johns-wort/#st-johns-wort-and-serotonin-syndrome

    If you are not using any other prescription medication, St. John’s wort ‘may’ be safe with NooCube. I say “may be safe” because I do not know how much of each nootropic is used in the NooCube formula. I could not find the exact dosage of each ingredient. So there is no way to tell if the nootropics in their formula that boost serotonin increase it to unsafe levels when combined with St. John’s wort.

Brandon
December 22, 2017

hi,
I am 24 dealing with major depression and addiction. I am currently on 200 mg of Wellbutrin and deplin. I just starting reading about nootropics and I am thinking about purchasing Aniracetam. Does anyone have any ideas? I cannot get out of bed, see my friends, or do anything. I feel like a loser and committing suicide every day. Anything would help. Thank you

    David Tomen
    December 22, 2017

    Brandon, Aniracetam may help but it may not be the best place for you to start with nootropic supplements. Please carefully read the full review for each of these and consider trying them:

    https://nootropicsexpert.com/vitamin-d/

    https://nootropicsexpert.com/lithium-orotate/

    https://nootropicsexpert.com/dha/

    I realize that DHA, Vitamin D and Lithium Orotate are not ‘sexy’ and seem tame by comparison to potent prescription antidepressants and some of the racetams. But you may be pleasantly surprised. Because sometimes we can correct major health issues simply by correcting imbalances in our body and brain.

    When fundamentals including certain vitamins, minerals and phospholipids get out of whack it can seem like our world is coming to an end. And truth be told, if left unchecked, it will come to an end. For proof of this all you need to do is read some of the studies done over the last 100 years for lithium.

    Did you know that “Deplin” is just an expensive pharmaceutical version of Vitamin B9 (folate)? Doctors prescribe it to boost folate in your body when regular antidepressants are not working as designed. What that tells me is the B-Complex vitamins are essential for normal mood and memory. And absolutely required to synthesize all the major neurotransmitters including acetylcholine, dopamine, norepinephrine, epinephrine, serotonin, and melatonin.

Robert Smith
November 2, 2017

Sounds good.
Yeah, Cymbalta is a especially difficult to get off of. There are many sites devoted to it. Ive cut 30% so far at 1% per day. Its a long process but better safe then sorry.
I decided to go with Alpha GPC (Choline) 99% pure from healingtreeoflife and Aniracetam powder from nootropicsdepot.
If im taking 750mg Aniracetam twice a day with a spoonful of coconut oil how much Choline do i take with each dose… 500mg?

    David Tomen
    November 2, 2017

    Try 500 mg of Alpha GPC (or whatever the capsule size is) each time you dose Aniracetam. And see how you feel. If you start feeling fatigued you know you’re getting too much choline. Cut the dose in half if that happens. It’s good to know the Alpha GPC is “99% pure” because many manufacturers cut it by 50% with a filler to prevent it from liquefying.

      Marchelle
      April 18, 2018

      Hi Robert,

      I also had a big problem weaning off of Cymbalta – the first time, experiencing a month-long headache even after getting down to 5 “balls” of the medication (from inside the capsule) per day before stopping.

      By the next time I had to wean off Cymbalta, I’d learned about 5-HTP. Although Dave is correct that it’s best to be cautious, I got back down to the “5 balls” per day and then one day, just stopped all Cymbalta and started taking 50mg 5-HTP (once daily) instead. Worked wonders! No headache or other withdrawal, and similar anti-depressant effects. Since it’s a precursor to melatonin AS WELL AS serotonin, best to try this for the first time on a weekend or some other time when you are sure you don’t have to operate heavy machinery, take a test, etc. as some people are made quite sleepy by it if they are melatonin-deficient. I realize this is an old post, but just wanted to share in case you’re still searching (or for others).

Robert Smith
October 31, 2017

Ouch… looks like Choline, Ginseng & Rhodiola Rosea all affect Serotonin levels. Looks like im stuck until ive completely weaned off the cymbalta… unless i can safely get started with something once im down to a very low dose?

    David Tomen
    November 1, 2017

    Robert, you shouldn’t have any problem with the various choline supplements and Cymbalta. But I would stay away from Ginseng and Rhodiola. Because either of those could influence serotonin enough to possibly cause Serotonin Syndrome.

    Once you’re down to a very low dose of Cymbalta, I’d still use caution because who knows who long this stuff stays in your system to cause problems. Just not worth messing around with. SSRI’s and MAOI’s are very potent pharmaceuticals. And SSRI’s are especially difficult to quit because of the withdrawal symptoms. I strongly advise finding an osteopath or naturopathic doctor who has the knowledge to walk your through this.

Robert Smith
October 29, 2017

David,

Very informative site. I took Lexapro for 10 years for social anxiety and depression and then Cymbalta for 2 when the Lexapro stopped working. I am currently weaning off Cymbalta at 1% a day. I’ve done a fair bit of research on beneficial supplements and added them to my diet. Recently I’ve been reading about microdosing mushrooms for treating depression and I’m starting to learn about nootropics. Can you recommend a nootropic stack?

Thanks,

Rob

    David Tomen
    October 29, 2017

    Robert, recent research shows that depression is likely caused by inflammation. And that is one of the reasons Cymbalta works. By creating a decrease in proinflammatory cytokine activity and an increase in anti-inflammatory cytokines. So look for nootropics to replace Cymbalta with something natural that affects neurotransmitters and reduces inflammatory cytokines.

    Ginseng provides these benefits. You can read the whole story here > https://nootropicsexpert.com/ginseng/. But play special attention to the right type of Ginseng and getting a quality supplement that will actually work.

    You also need a high quality, bio-available B-Complex formula. Using folate (NOT folic acid) and methylcobalamin (NOT cyanocobalamin). You also require Vitamin D and Magnesium to make the neurotransmitters you need. See the review for each here on Nootropics Expert so you understand how they work.

    That will get you started. I’d also investigate Rhodiola Rosea here > https://nootropicsexpert.com/rhodiola-rosea/. And possibly Aniracetam which I’ve found to be one of the best antidepressants I’ve ever used. But keep in mind that what works for me may not work for you. It’ll take some trial and error on your part. And patience.

    One last thing … as long as you are using Cymbalta, pay special attention to nootropics that ‘directly increase serotonin’. And DO NOT USE THEM! You must avoid Serotonin Syndrome or you could get into a load of trouble.

      Robert Smith
      October 30, 2017

      Thanks for the info…

      Good news is I already take Methyl Folate, methylcobalamin, vitamin D and magnesium. I’ll definitely look into the rest.

      I’ve read about serotonin syndrome. As I mentioned I’m weaning off Cymbalta by 1% day. Would you recommend waiting until completely off before starting something like Aniracetam or do you think it would be safe once I’m down to a very low dose?

        David Tomen
        October 30, 2017

        Aniracetam shouldn’t be a problem. I’ve flagged all the nootropics that could cause Serotonin Syndrome in each of the reviews. Look for it in either dosage notes or side effects for each.

CHUCK
August 26, 2017

8/26/17
David …
Just happen 2 find your ‘great’ nootropicsexpert website …
Very impressed with your fully detailed product summaries …
Am currently reviewing ‘depression’ summary …
Adding niacin powder to ‘Emergen-C’ electrolyte drink @ 4-5 a.m. wakeup really wonders on my brain …
Begin to feel incredible ‘effect’ in my scalp/brain area starting within 2 minutes after entering bloodstream …
Then drift off into sleep without realizing that I in fact did …
Will probably follow up with future emails for your professional advice …
Keep up the good work!!!
CWHEIL
Minnesota

    David Tomen
    August 28, 2017

    Chuck, you touched on a very good point and one that is often missed in the biohackers and nootropics community. And that point is that most of us are literally starved for the vitamins our body and brains need to function. We do not get them from our food supply. No matter how healthy we try to eat. The nutrients are just not there in factory-farmed food today. And the amount of toxins we’re exposed to everyday is crazy. Further depleting what vitamin stores we managed to accumulate along the way. Thanks for the compliment and enjoy Nootropics Expert!

Mark
August 7, 2017

David,

I’m a 53 year old male w 25 years diagnosed w severe clinical depression w/anxiety and now ADHD this year.

Issues with executive functioning skills. Tested low.

Hate Aderall. What in your opinion should I research as the best stack for me to help my brain & its many disorders. Including memory loss due to repeated concussions.

Thank you,
Mark

    David Tomen
    August 7, 2017

    Mark, it would be helpful to know why you hate Adderall. I do as well and use Ritalin instead. These two stimulants work differently in the brain. And I found Ritalin works better for me. I did an experiment last year for personal reasons and discontinued use of Ritalin altogether (for an entire year). I used the stack you’ll find near the top of this page > https://nootropicsexpert.com/best-nootropics-for-adhd-add/. It’s right under the sub-title “Adult ADD Nootropic Stack”. Mind Lab Pro was key to making that stack work. But it worked very well.

    I did go back on (a lower dose) of Ritalin because I too have big issues with Executive Function. The stimulant works to help executive function. But it needs the support of the rest of that same stack to work efficiently. And eliminate side effects.

    The combination of Aniracetam and Sulbutiamine works great for the depression I deal with. It’s not severe depression but it may be worth a try for you.

    For anxiety, please see this post > https://nootropicsexpert.com/best-nootropics-for-social-anxiety/. One of the things I’ve learned is anxiety is often caused by excess norepinephrine. One of the best ways to counter that is with this > https://nootropicsexpert.com/lithium-orotate/. Lithium has a bad rap because it’s been used for decades to treat bipolar disorder and mania. I’ve found in my case it works beautifully to tame spikes in aggression and rage type feelings. They don’t happen often for me but micro-dosing lithium stops it within 15 minutes.

    It’ll take some trial and error because each of use is unique. Those posts should get you started. Along the way you may find like I did that you need more dopamine. Especially at your age. So I use Mucuna Pruriens (L_DOPA). But have to amp up my serotonin. So I use small doses (25 mg) of 5-HTP which is a direct precursor to serotonin.

    And for traumatic brain injury, that’ll be my next article. So please make sure you’re subscribed to the list so you’ll get an email when it’s published. Should be in the next week or so. Please report back on how you’re doing.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.