Best nootropics for depression-2022

Best Nootropics for Major Depressive Disorder

David Tomen
Author:
David Tomen
17 minute read

Nootropic forums and blogs often describe depression as a neurotransmitter imbalance in the brain. And then offer suggestions on various nootropics for major depressive disorder or drugs to help lift your mood and reduce depression.

But this simplistic view of depression misses the complexity of this disease.

Recent research has shown that depression can have many possible causes. Including out of whack mood regulation by your brain, genetic problems, stressful events or living conditions, prescription medications or other medical problems causing cognitive impairments.

It’s true that neurotransmitters are involved in the process that contributes to depression. But it’s usually not a matter of one neurotransmitter being too low or another too high.

Here’s the thing. You have several neurotransmitter systems, amino acids, hormones and other neurochemicals working both inside and outside neurons.

The interaction of these neurochemical reactions make up a highly dynamic system that contributes to your mood. And how you perceive and experience life.

With this level of complexity, you may have similar symptoms of depression to the person next to you. But the issues in your brain and body may be completely different. So what works best for someone else experiencing your symptoms may not be best option for you.

And this is why we often say in the nootropic community that Your Mileage May Vary (YMMV) when describing a particular nootropic supplement. And how it feels.

In this article you’ll discover other possible causes contributing to your depression. How to recognize them. How to use nootropic supplements to test different possible causes so you can narrow down what may be causing your depression.

And I’ll share some nootropic supplement suggestions that may help relieve your depression symptoms for a better quality of life.

Depression and Neurogenesis

It turns out that brain cell signaling, neurogenesis and the function of neuronal circuits may play a more important role in depression than simply the levels of serotonin or dopamine.

For example, researchers in Munich studied 24 women who had a history of depression. And on average, their hippocampus was 9 – 13% smaller in the depressed women compared to healthy women. And the more bouts of depression a woman had, their hippocampus was even smaller compared to less depressed women in the study.[i]Best nootropics for mood enhancement

We know that stress can play a role in depression and on your central nervous system. And research has shown that stress can suppress neurogenesis. Which would account for the smaller hippocampus in these women.

We also know that Brain-Derived Neurotrophic Factor (BDNF), a naturally occurring protein in your brain, is critical for preventing apoptosis (brain cell death), is required for the growth of new neurons (neurogenesis) and the growth and maintenance of synapses.

Please check out my article on “13 Nootropics to Boost BDNF”. Increasing BDNF is one way to combat depression. Below I’ll share a list of nootropics for you to try some of which also help to increase levels of brain derived neurotrophic factor (BDNF) among other benefits for a healthy brain.

If you’ve ever tried antidepressants for alleviating depressive symptoms, you know that it often takes weeks to feel any benefit. Scientists have a theory that the value of some of these medications may be in generating new neurons (neurogenesis), strengthening neuron connections, and improving brain cell signaling. Which often takes time before you can feel the result.

So now researchers speculate that new medications could be developed to specifically promote neurogenesis. As it turns out, we already have this ability with several natural nootropic supplements.

Depression and Neurotransmitters

We know that neurotransmitter dysfunction is not the only cause of depression. But we can’t discount their importance either.

Neurons are designed to communicate with each other. When a neuron is activated, it passes an ‘action potential’, which is a tiny electrical signal, down its axon to the axon terminal (synapse).  Neurotransmitters are stored in synaptic vesicles.

The action potential (electrical signal) releases certain neurotransmitters into the synapse. Which then sends it over to a synapse on a dendrite connected to the receiving neuron. As the concentration of neurotransmitters rise in the synapse, they bind to receptors embedded in the membranes of the two neurons.

This release of a neurotransmitter from one neuron can activate or inhibit the second neuron. Once the first neuron has released a certain amount of neurotransmitter molecules, a feedback mechanism instructs the transmitting neuron to stop releasing neurotransmitter molecules and begin bringing them back into the 1st neuron. This process is called reuptake.

In those who are severely depressed or manic, this fine-tuned system of neuro-signaling can go out of whack. Either too much or too little of the neurotransmitter is released.

Or if the reuptake is overly efficient and mops up too many neurotransmitter molecules before they have a chance to bind to receptors. It can have a significant impact on mood.

The primary neurotransmitters that can play a role in depression include:

Each one of these neurotransmitters can be boosted, or their reuptake affected by nootropic supplements (listed below).

sulbutiamine-for-depression

Depressive Symptoms and Prescription Medication

Depression can result as a side effect of certain prescription drugs. These drugs can include antimicrobials, antibiotics, antifungals, antivirals, heart and blood pressure drugs, hormones, insomnia drugs, tranquilizers, antacids, narcotic pain drugs and more.

We know from experience that many of these prescription drugs may be replaced by safer, natural nootropic supplements.

But I am NOT encouraging you to stop using whatever meds you’re currently on. Without consulting with your doctor first. I am encouraging you to learn about and possibly try safer alternatives that often do the job just as well and will enhance your brain health.

CAUTION: many nootropic supplements are contraindicated with prescription SSRIs, MAOIs, tricyclics, and others that work on the same neurotransmitter system. Combining any of these ‘natural’ nootropic supplements with the wrong drug can do serious harm. Including ending your life. Please, please read the Side Effects section of each nootropic review here on Nootropics Expert®. And if in doubt please ask me and consult with your doctor before trying a nootropic if you are using any of these prescription meds.

Depression and Stress

Nearly all of us experience stressful events. And while not every one of us who faces stress develops depressive disorders or other mental disorders. Stress however often does play an important role in depression.

Depending on how sensitive you are to stress, along with messed up neurochemistry and even genetics. A perfect storm of any or all of these influencing factors can lead to depression.

So, please read my extended article on “Best Nootropics for Anxiety” which includes several nootropic supplements that may help you deal with and conquer stress and even boosts your mental performance.

noopept-for-depression

Recommended Nootropics for Depression and Enhance Cognitive Performance

If you are currently being treated for depression. Or suspect you may be dealing with undiagnosed depression. And are looking for a more natural, safer way to treat your symptoms. Nootropics may be the answer.

You’re not alone looking for a natural alternative to drugs that often often associated with a host of side effects. Research in the United States and other countries show that significant numbers of people use ‘alternative medicine’ to treat their depression.

Researchers conducted a survey of more than 3,000 women in the USA to find out how many turned to alternative medicine for depression. Of the 220 women who said they had been officially diagnosed with depression, 54% said they used alternative medicine to treat their symptoms.[ii]

We have found that the following list of nootropics work well for different types and causes of depression.

As I mentioned before, your mileage may vary. What works for me may not work for you. Wise and careful experimentation is critical to finding a safer alternative for treating your depression.

    1. Aniracetam – A member of the racetam-family of nootropics, Aniracetam works with dopamine D2 and D3 receptors in your brain. And desensitizes AMPA (glutamate) receptors which can help control glutamate toxicity.Aniracetam is one of the most effective antidepressants I’ve even tried. And its effects on dopamine in your brain can have a profound effect on anxiety symptoms as well.

 

    1. Bacopa Monnieri – One of the most powerful herbs in Ayurvedic medicine. Bacopa Monnieri has been used for millennia to relieve anxiety, fatigue, restore energy and boost concentration.This adaptogen has been shown in clinical studies to work as well for depression as benzodiazepines and tricyclic antidepressants.[iii]

 

    1. Coenzyme Q10 (CoQ10)CoQ10 contributes to your cell’s natural source of energy. Producing ATP in your mitochondria by taking fat and converting it into usable energy. CoQ10 preserves brain function, helps fight mental illness and migraines.Major depression, bipolar disorder and schizophrenia are now being recognized as having mitochondrial dysfunction in common. With higher oxidative stress levels.[iv] Studies show that 1,200 mg per day of CoQ10 in bipolar adults experienced a significant reduction in depression.[v]

 

    1. 5-HTPI do NOT recommend using 5-HTP for treating depression. But only include it here since it is marketed as a “natural antidepressant”.This amino acid is naturally produced in your body. And synthesized from the amino acid tryptophan which you get from food. 5-HTP is the precursor needed to produce the ‘feel-good’ neurotransmitter serotonin. But a summary published in the Alternative Medicine Review noted a lack of evidence for ‘loading’ precursors to treat depression.[vi] Combining 5-HTP with SSRI’s, Tricyclics or MAOI’s will cause Serotonin Syndrome which can be deadly.

 

    1. Ginkgo Biloba – This tree native to China has been used for thousands of years to boost mental alertness, improve cerebral circulation and for better overall brain function. Many have found Ginkgo Biloba to be very effective for reducing anxiety and stress. And for boosting mood.1,570 men and women in England participated in a study using 120 mg of Ginkgo Biloba extract daily for 4, 6, and 10 months. Those who used Gingko Biloba the longest experienced the most improvement improvements for anxiety, depression, energy, drowsiness, sadness and happiness.[vii]

 

    1. Iodine – Did you know that iodine deficient populations are up to 13.5 IQ points less than those with optimal iodine levels in their system?[viii] Since iodine has largely been removed from table salt in some countries, it has been suggested that iodine deficiency is epidemic. Particularly in countries like the United States.Iodine is essential to thyroid health and the production of thyroid hormones. Nearly every tissue in your body relies on thyroid hormones for healthy function. Not enough iodine can result in hypothyroidism. Negatively affecting acetylcholine synthesis in your brain. Affecting cognition, learning and memory, recall and mood.

 

    1. Kava Kava is native to the South Pacific. And the islanders use kava for its sedative effects. Kava can help reduce anxiety and depression. Unlike benzodiazepines, Kava does not impair cognitive function. In fact, studies show that not only will Kava improve mood. It may also boost cognitive function as well.[ix]

 

    1. Lion’s Mane Mushroom – Also called the “smart mushroom”, Lion’s Mane boosts brain nerve growth factor which increases neurogenesis. Lion’s Mane can help improve focus and attention, boost thinking and processing speed, repair brain cells, and help relieve anxiety and depression.Women in Japan received Lion’s Mane-laced cookies for 4 weeks during a clinical trial. The researchers found that Lion’s Mane reduced anxiety and depression in these women during the trial.[x]

 

    1. Magnesium – Lack of adequate magnesium can result in brain fog, anxiety and depression. Plasticity of neuron synapses is affected by having enough magnesium in brain cells.A study was conducted with 5,708 people in Norway. The aim of the study was to examine the association between magnesium intake and depression and anxiety. The researchers found that low magnesium intake is related to depression.[xi]

 

    1. Mucuna Pruriens (L-DOPA)L-DOPA is synthesized from the amino acid tyrosine in your body. And is a precursor to the formation of dopamine, epinephrine and norepinephrine in your brain.Mucuna Pruriens has been used in Ayurveda medicine since 1500 B.C. For treating things like snakebite, intestinal problems, sexual issues and melancholy mood. Research shows that supplementing with L-DOPA extracted from Mucuna Pruriens can be a great natural antidepressant if you are low in dopamine.[xii]

 

    1. N-Acetyl L-Cysteine (NAC)NAC is an amino acid that regulates the amount of glutamate and dopamine in your brain. It helps restore dysfunctional dopamine receptors. And is a precursor to Glutathione which is your master antioxidant needed to reduce free radicals and oxidative stressA study with 75 subjects with bipolar disorder were given 1 gram of NAC twice daily for 24 weeks. Treatment with NAC resulted in a significant improvement with depression in these patients.[xiii]

 

    1. N-Acetyl L-Tyrosine (NALT) – NALT is a highly bioavailable form of the amino acid L-Tyrosine. Your brain uses tyrosine to produce dopamine and norepinephrine. Dopamine is involved in libido, memory, focus, goal-oriented concentration, is a mood elevator and antidepressant.If you are ADHD, or have other issues with low dopamine, supplementing with NALT or L-Tyrosine may help improve your memory, boost your IQ, and relieve depression. I highly recommend NALT or L-Tyrosine for anyone using stimulants like Adderall or Ritalin for treating ADHD.

 

    1. Nefiracetam – One of the newer members of the racetam-family of nootropics, Nefiracetam is used clinically to treat and prevent seizures, severe depression and has shown neuroprotective qualities.The structure of Nefiracetam is similar to the other great racetam antidepressant Aniracetam. Researchers at the University of Iowa did a trial with 159 stroke patients with major depression. The study concluded that Nefiracetam produced a significant improvement in the most severely depressed patients.[xiv]

 

    1. Noopept – This peptide-derived nootropic related to the racetam-family is much more potent than Piracetam. But its mechanism of action in your brain is similar to other racetams.Noopept stimulates dopamine, nicotinic and serotonin receptors. It boosts cognition, memory, logical thinking, reflexes and mood.[xv] Noopept increases Alpha brain waves and Beta brain waves. Increasing relaxation. Alpha brain waves increase relaxation and the Beta brain waves assist with your state of alertness and mental clarity. Both of these combined can move you into super-learning, flow states and joy.

 

    1. Phenylalanine – This amino acid is a precursor to tyrosine in your brain. Tyrosine helps in the synthesis of dopamine, epinephrine, and norepinephrine.One study was done with 23 patients diagnosed with depression who had not responded to standard antidepressants. They were given 50 or 100 mg of Phenylalanine daily for 15 days. The researchers found that Phenylalanine completely improved mood in 17 of the patients. Within 13 days of the 15-day trial.[xvi]

 

    1. Rhodiola RoseaRhodiola Rosea activates AMPA receptors in your brain. Which can decrease depression and stress-related mood swings, reduces fatigue, stimulates energy and alertness, boosts cognition, and motivation.A clinical trial with 57 patients diagnosed with depression were given Rhodiola Rosea extract, sertraline (Zoloft®), or a placebo for 12 weeks. The study found that Rhodiola Rosea was slightly less effective than sertraline for depression. But produced far fewer side effects and was better tolerated.[xvii]

 

    1. SAM-eSAM-e is the naturally occurring amino acid methionine bound to an ATP molecule. It helps in the process of cell division and repair, and the generation of the neurotransmitters dopamine, serotonin, norepinephrine and melatonin. Which is why it’s considered a potent nootropic.SAM-e is used to boost mood, relieve depression, improve energy levels and reduce symptoms of fibromyalgia. 20 healthy volunteers took part in a study receiving infusions of 800 mg of SAM-e or a placebo for 7 days. EEG mapping during the study identified SAM-e as an antidepressant. Targeting brain regions crucial in the therapeutic efficacy of antidepressants.[xviii]

 

    1. St. John’s wort – This herb has traditionally been used for mood disorders and wound healing. Today it’s used mostly as a treatment for anxiety, depression and stress.St. John’s wort works like prescription SSRI’s by preventing the reuptake of serotonin in your brain. But please read the precautions for using this nootropic in the extended article. Before trying it as a nootropic supplement to treat your depression.

 

    1. Sulbutiamine – Sulbutiamine is a synthesized version of Vitamin B1 (thiamine) which easily crosses the blood-brain barrier. As a nootropic, it’s used to boost mood, memory and motivation.A study at the University of Wales Swansea in the UK worked with 120 young adult females. Study participants took either a placebo or 50 mg thiamine for 2 months. Mood, memory and reaction times were monitored before and after taking the tablets. 2 months after supplementing with thiamine, participants were more clearheaded, felt more composed and energetic, reaction times improved, and mood was better.[xix]

 

    1. Tryptophan – This essential amino acid is a precursor to serotonin, melatonin and niacin (Vitamin B3) in your body. Adding tryptophan to your stack can help boost your serotonin levels. And should help with anxiety, ADHD, depression, insomnia, memory loss, pain and eating disorders.

 

    1. TurmericTurmeric is one of the main spices in curries. In parts of India where curries are eaten most often, Alzheimer’s disease is extremely rare. This spice (and its extract called curcumin) has a unique ability to reduce inflammation common to Parkinson’s, Alzheimer’s and brain tumors.A study conducted in India looked at the efficacy and safety of using curcumin, the main active ingredient found in turmeric, for treating major depression.60 depressed patients took either 20 mg of Prozac®, 1000 mg of curcumin, or a combination of both daily for 6 weeks. The best response during the trial was with patients using the combination. And the researchers concluded that curcumin could be used as an effective and safe treatment for patients with major depression.

 

    1. Uridine Monophosphate – This precursor to Ribonucleic Acid (RNA) provides instructions from your DNA to help create memory by facilitating connections between brain neurons (synapses).Uridine supplementation as a nootropic uplifts and stabilizes mood, is anti-stress, helps Obsessive Compulsive Disorder (OCD), is anti-anxiety and helps modulate and normalize dopamine release.[xx]

 

    1. Vitamin B6Vitamin B6 helps your brain make serotonin, norepinephrine and melatonin. The activated form of Vitamin B6 called P-5-P is particularly effective in boosting serotonin and GABA in your brain.For depression, look for a P-5-P supplement or a B-Complex formula that uses P-5-P.

 

    1. Vitamin B12 – This B-vitamin plays a key role in the efficient conversion of carbohydrates to glucose which contributes to cellular fuel production (ATP). It helps your body convert fatty acids into energy.Supplementing with Vitamin B12 can help lower anxiety, and elevate alertness, cognition, energy, vision, elevate mood and relieve insomnia. No more mood swings!

 

Depressed No More

Nootropics can be a strong alternative to many antidepressant medications currently prescribed by doctors. And promoted by the Big Pharmaceutical companies.dopaminergic nootropics

But a very strong word of caution – if you are currently using any prescription antidepressant medications. Or any medication for that matter. Research each nootropic including side effects and prescription drug interactions before using them.

To finally beat depression, you must figure out the root cause of it. It is pointless to try otherwise without doing your research. Experiment with various nootropic supplements until you find what works for you.

Good luck in your search. There is hope. I know because I’ve conquered my own depression. And came out the other side better than before.

As an Amazon Associate I earn from qualifying purchases. This post may also contain other affiliate links and I will be compensated if you make a purchase after clicking on my links.

[i] Frodl T. et. Al. “Reduced hippocampal volume correlates with executive dysfunctioning in major depression” Journal of Psychiatry and Neuroscience 2006 Sep; 31(5): 316–325. (source)

[ii] “Alternative medicine for depression” Harvard Medical School July 1, 2007 (source)

[iii] Bhattacharya S.K., Bhattacharya A., Sairam K., “Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.” Phytomedicine 2000 Dec;7(6):463-9. (source)

[iv] Maes M., Galecki P., Chang Y.S., Berk M. “ A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness.” Progress in Neuropsychopharmacology and Biological Psychiatry. 2011 Apr 29;35(3):676-92. (source)

[v] Forester B.P., Zuo C.S., Ravichandran C., Harper D.G., Du F., Kim S., Cohen B.M., Renshaw P.F. “Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.” Journal of Geriatric Psychiatry and Neurology. 2012 Mar;25(1):43-50. (source)

[vi] Meyers S. “Use of neurotransmitter precursors for treatment of depression.” Alternative Medicine Revue. 2000 Feb;5(1):64-71. (source)

[vii] Trick L., Boyle J., Hindmarch I. “The effects of Ginkgo biloba extract (LI 1370) supplementation and discontinuation on activities of daily living and mood in free living older volunteers.” Phytotherapy Research. 2004 Jul;18(7):531-7. (source)

[viii] Qian M., Wang D., Watkins W.E., Gebski V., Yan Y.Q., Li M., Chen Z.P. “The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China.” Asia Pacific Journal of Clinical Nutrition 2005;14(1):32-42. (source)

[ix] Thompson R., Ruch W., Hasenöhrl R.U. “Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava). Human Psychopharmacology. 2004 Jun;19(4):243-50. (source)

[x] Nagano M., Shimizu K., Kondo R., Hayashi C., Sato D., Kitagawa K., Ohnuki K. “Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.” Biomedical Research. 2010 Aug;31(4):231-7. (source)

[xi] Jacka F.N. et. Al. “ Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study” Australian and New Zealand Journal of Psychiatry Volume 43, Issue 1, 2009 (source)

[xii] Rana D.G., Galani V.J. “Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression.” Ayu. 2014 Jan;35(1):90-7. (source)

[xiii] Berk M., Copolov D.L., Dean O., Lu K., Jeavons S, Schapkaitz I., Anderson-Hunt M., Bush A.I. “N-acetyl cysteine for depressive symptoms in bipolar disorder–a double-blind randomized placebo-controlled trial.” Biological Psychiatry. 2008 Sep 15;64(6):468-75 (source)

[xiv] Robinson R.G., Jorge R.E., Clarence-Smith K. “Double-blind randomized treatment of poststroke depression using nefiracetam.” Journal of Neuropsychiatry and Clinical Neurosciences. 2008 Spring;20(2):178-84. (source)

[xv] Gudasheva T.A., Konstantinopol’skii M.A., Ostrovskaya R.U., Seredenin S.B. “Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.” Bulletin of Experimental Biology and Medicine. 2001 May;131(5):464-6. (source)

[xvi] Fischer E., Heller B., Nachon M., Spatz H. “Therapy of depression by phenylalanine. Preliminary note.” Arzneimittelforschung. 1975 Jan;25(1):132. (source)

[xvii] Mao J.J., Xie S.X., Zee J., Soeller I., Li QS., Rockwell K., Amsterdam J.D. “Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.” Phytomedicine. 2015 Mar 15;22(3):394-9. (source)

[xviii] Saletu B., Anderer P., Di Padova C., Assandri A., Saletu-Zyhlarz G.M. “Electrophysiological neuroimaging of the central effects of S-adenosyl-L-methionine by mapping of electroencephalograms and event-related potentials and low-resolution brain electromagnetic tomography.” American Journal of Clinical Nutrition. 2002 Nov;76(5):1162S-71S (source)

[xix] Benton D., Griffiths R., Haller J. “Thiamine supplementation mood and cognitive functioning.” Psychopharmacology 1997 Jan;129(1):66-71. (source)

[xx] Powell A. “Rx for depression: ‘Mangia, mangia!’ Harvard Gazette Archives new.harvard.edu March 03, 2005 Retrieved August 9, 2016 (source)

Subscribe to the Nootropics Expert newsletter

Keep up to date with the latest developments in the nootropics space.

Head First 2nd Editon

The Award Winning Guide to Healing & Optimizing Your Brain with Nootropic Supplements.

Head First 2nd Edition

NEW! Eliminate Brain Fog, Low Energy, Moodiness, Difficulty Sleeping, Memory Loss or Anxiety. Available on Amazon, Barnes & Noble, Apple Books, Walmart and more...



Where to Buy Nootropics

Wondering where to buy the best nootropic supplements? Well, you’re in the right place. Because here you will find the nootropic supplements that I personally use and recommend. Each supplement has a link to the company store and product that I use. I also include a link to my full review for each supplement here […]

The Definitive Guide to Nootropics

Nootropics can help increase your memory, boost learning ability, improve your mood and assist overall brain function. If you’re new to nootropics, or wonder about the difference between a nootropic and a smart drug, then this page is for you. Here you’ll find the definition of a nootropic, how to pronounce the word “nootropic”, the […]

The Most Comprehensive Nootropics List

This is our big list of the most popular Nootropics in use today. Here you’ll learn what each nootropic is, what it does and suggested dosages. What is this List of Nootropics About? Nootropic supplements are cognitive enhancers aiming to improve brain function. Whether you are looking to treat mild cognitive impairment, improve mental focus, or biohack […]



Free Secrets of the Brain 3rd Edition

Get “Secrets of the Optimized Brain,” 92 nootropics to help you plan your Nootropic Stack when you sign up for my newsletter:

Join The Discussion - 322 comments

Michael Panighetti
September 19, 2018

Hello David!

I’m new to the world of nootropics and I’m trying to treat depression and bipolar disorder without prescription medications.

I’m trying to achieve a more balanced and consistent life in regards to mood. For me, it is extreme ups and downs. The seesaw from one end to the other changes fast.

I strongly related to the following about serotonin:
When you have adequate serotonin levels in your brain and it’s working properly, you’ll be confident, easy-going, flexible, happy, and positive. (I admit, I’m the opposite of all of these things when I am “down” and boardline arrogant when I’m “up”. I wish I realized all of this about myself sooner, but I always blamed a current situation and am now seeing the long term pattern.)

Serotonin deficiency can result in you becoming depressed, irritable, obsessive, negative and worried.

This list is extensive and has a lot of great effects for each nootropic. I wish I could take them all because they all seem to help brain function in one way or another, but I doubt that would be sensible or even affordable for me, so how do I break these 12 down into a stack that I should take?

– Which ones work best when combined?
– Which one(s) should I start with?
– How do I figure out which ones would work best for my symptoms?

    John
    September 19, 2018

    Definitely try magnesium, lithium, selenium, and vitamin D, plus whatever else David might suggest.

    David Tomen
    September 19, 2018

    Michael, it’s a great question but also highlights why it is so difficult to recommend a nootropic stack for something like depression. Because it often takes a lot of experimenting until you hit the sweet spot for you.

    I’d suggest starting with the basics including the vitamins and minerals mentioned in this post. At the dosage recommendations in the original review for each of these. Not on this list but often works well for mood disorders is Lithium Orotate: https://nootropicsexpert.com/lithium-orotate/

    Then add something to boost serotonin, dopamine and acetylcholine. That could include L-Tryptophan (serotonin), L-Tyrosine (dopamine) and CDP-Choline (acetylcholine).

    For now, you don’t know exactly what’s going on in your brain. But with this stack, if you start to see improvements then you’ll know you’re on the right track. If you find some symptoms are less but you’re more irritable for example, then you may have too much norepinephrine. So you’d cut back on the L-Tyrosine. In other words, listen to your body for the subtle differences. Instead of using a broad stroke like “depression”.

    I’d also consider adding an adaptogen which works to help balance things out in your brain. Bacopa may be a good one to try.

      Michael
      September 19, 2018

      Thank you so much for getting back to me!

      You are honestly awesome for being here to answer questions like mine. Thank you so much for taking the time out of your day to do this.

      I will let you know how things work out!

      Michael
      October 7, 2018

      After a while of taking my stack, I’ve been doing great in terms of mood balance and depression management. So thank you! This stuff really does work. I’m taking:

      – L-Tyrosine
      – L-Tryptophan
      – CDP-Choline
      – Bacopa
      – Magnesium L-Threonate
      – Fish Oil
      – Taurine
      – Vit D
      – B-Complex
      – Occasional L-theanine and Caffeine

      However, I’m having a problem 2-5pm with sluggishness. My mind is alert and energized, but my body and muscles ache and feel tired. I haven’t found a way to prevent this yet. I take my stack in the morning, and some of again them before bed.

      I’m thinking of taking something in the afternoon to prevent a crash, but I’m unsure what I should use. Acetyl L-Carnitine perhaps?

        David Tomen
        October 8, 2018

        Michael, I’d split your dose of the entire stack so you take half in the morning and half again at noon. But make sure your dosages are high enough and based on the recommended dosage in each nootropic review here on Nootropic Expert.

        Then at noon I’d add ALCAR, L-Tyrosine (or NALT) and try your L-Theanine+caffeine stack either at noon or mid-afternoon.

        Magnesium however should be taken about 90 mins. before bed.

        Robert Long
        September 22, 2019

        How do you split doses with powder gel capsules?

        David Tomen
        September 22, 2019

        Robert, not sure I understand your question. But if you mean half of a 500 mg capsule and you need 250 mg then you open the capsule and dump half of it out. Or onto a plate or something for use next time.

John
August 30, 2018

You should probably include selenium as a nootropic. I noticed decreased thoughts of suicide when I was taking it, and they came back when I stopped taking it. Thanks.

    David Tomen
    August 31, 2018

    John, selenium is on my list of supplements to review. So thanks.

Jonathon Siemens
August 29, 2018

Hi
I have bipolar and OCD.
I’ve been in a depressive state for some time now.
Tianeptine has worked wonders.
You have this long list above.
I have used some in the past.

Can you tell me the best ones on the list? The most sought after?
The strongest?

I know you may say that every person is different therefore I can’t tell you.

But please, what is the strongest and best besides Tianeptine which I love.
Tianeptine is just not doing enough right now.
There must be some that are especially good.
I am sort of desparate

What do you take, or what is the most common one, or most
common stack?
Phenibut does not work for me. Aniracetam not either.

Thank You for now.

Jon

    David Tomen
    August 30, 2018

    Jon, if Tianeptine has worked for you the I suggest first learning everything you can about how it works in your brain. You can use this: https://en.wikipedia.org/wiki/Tianeptine. See the “Pharmacology” section.

    Next, find nootropics that work on each of what Tianeptine does in your brain. Including boosting serotonin, BDNF, action on NMDA and AMPA receptors and boosting dopamine. I’m not aware of any nootropic that works directly on μ-opioid receptors.

    This will take some work but you’ll end up with a nootropic stack that’s safer and you can use long-term without tolerance. This is not a “one pill” solution.

Jason
August 27, 2018

Hello David
I’m in a desperate way.. I came off psy drugs cold turkey 3 months ago after 20 years on them (drs did it as nothing helped anymore & I became intolerant), but I’m suffering massive suicidal depressive fluctuations, anxiety, confusion, panic attacks, mood swings, headaches, some times manic type stuff, blurred vision, sometimes anger.. I also have the sensation that the entire frontal lobe of my brain has gone numb/swollen/stopped functioning.. all this is accompanied with atrocious physical pains, constant cramps, nausea, chest pains & so much more.

I have no idea how much of all of this is protracted withdrawal symptoms which could take a year or a brain disfunction or something else.. all I know is I feel like I’m dying.. I’ve bought & tried so many supplements & products that it’s ridiculous.. but without guidance I don’t know what I’m doing, & may even be either worsening the problem, worsening withdrawal symptoms or even potentially putting my life into danger..

I even attempted taking an experimental drug called NSI-189 for 3 days but I think it made me worse & stopping it made me much much worse.. I’ve contacted drs, people, companies that sell me products, hospitals, er.. everyone.. I get different advice from different people..

Right now I stopped everything except omega 3 high does epa/dha content but it’s not helping much.. please, can I give you a list of everything I have by pm.. I’d really appreciate your advice as to what I should take, or not take & for how long.. It seems to much stimulants make me hyper/aggressive, notably to much seratonine..

to much of certain other neurotransmitters also worsen my anxiety & products that boost dopamine short term (for a few hours) have crash effects & thus make me more depressed & aggressive after a few hours.. in fact anything that has a short term effect makes me fluctuate worse..

Please help, I’m desperate & don’t know where to turn. Please contact me by email if this post is too long to be posted.. thank you.

    David Tomen
    August 27, 2018

    Jason, first and I hate to tell you something you likely already know. You can’t quit taking antidepressant meds ‘cold turkey’ after prolonged use. Likely the best advice I can give you right now is contact Dr. Kelly Brogan (https://kellybroganmd.com/). She helps people titrate safely off of antidepressant and antianxiety meds. Abruptly quitting these types of medications is very dangerous.

    I’m not a doctor and don’t even play one on TV. So please work with someone like Dr. Brogan and get at least somewhat stable again. And then we can start experimenting with nootropic supplements. And find the right stack for you.

Robert
July 12, 2018

Have you looked into kratom? do you have any experience or opinion on this plant?

    David Tomen
    July 13, 2018

    Robert, I’ve several years of experience with Kratom and use it daily for pain. My wife uses it for mood and sleep. Different strains work for different things and it takes a lot of trial and error to find what works.

    Quality is also critical and finding the right vendor takes some doing. I just hope the American Kratom Association can convince the regulators to keep it legal in this country.

Gabriella
May 5, 2018

Hi, I really appreciate the list of nootropics, but how do I get them all and in what dosages? Is the one pill that has them all (in the right dosage)? I would like to try them and go the natural way an=bout depression but nothing sofar has worked or not consistently.
What do you suggest?

Thanks, Gabriella

    David Tomen
    May 6, 2018

    Gabriella, unlike what the big pharmaceuticals would like us to believe, there is no “one pill” solution. And it’s not possible to create an effective nootropic stack for depression because there are so many potential causes.

    I recommend reading this post again and see if anything resonates with you. Is your depression caused by problems with dopamine, or serotonin, or inflammation? I realize there is no way to tell for sure. So to get started you’ll have to experiment with various nootropic supplements until you find the ones that work for you.

    Each nootropic mentioned in this post has a live link through to a complete review of that supplement. Including recommended dosages, side effects, prescription drug interactions and more.

    Start with the basics like magnesium and the B-Vitamins. And try one or two supplements like Bacopa Monnieri, Mucuna Pruriens or Kava. Other than the basic vitamins and minerals, try only one or two at a time. Because if you find something that makes you feel better, you’ll want to know what is providing that effect. Which is difficult to do when you are using too many supplements at once.

Ted
April 4, 2018

Hi sir,
It’s 3 years that I suffer from IBS and 2 years I’m suffering from severe depression and generalized anxiety. I’ve tried SSRI’s but i’ve immediately stopped because they worsen my IBS symptoms. So i am very interested in using nootropics like ashwagandha,ginseng,bacopa,rhodiola ecc.. Could you please tell me what would be the best combination and does exist any supplement whith good organic combination of these adaptogens?? Thank you

    David Tomen
    April 5, 2018

    Ted, I’m not aware of a combination of these herbs specifically for depression. And even it there was I wouldn’t trust it until you find out what works for you. You know your body better than anyone. So I suggest you carefully read each review and see if anything resonates with you. Find a trusted brand and try them one at a time. That is the only way to isolate and find out what works for you without side effects.

    Once you read through each review, find that supplement on a site like Amazon that has a lot of reviews and read through them. You’ll be amazed what may turn up with someone dealing with issues similar to yours sharing how it worked for them.

    I realize this will take time and effort. But you need to put the time and investment in if you want to get better. It took me 3 years of experimenting until I felt better. So know what you are going through to a certain extent.

      Ted
      April 7, 2018

      thank you sir

Japneet
March 9, 2018

Hi Sir

Can i use tianeptine with St john’s wort. As tianeptine is not a an SSRI and is not a classical TCA antidepressant

    David Tomen
    March 9, 2018

    Japneet, I highly recommend that you NOT combine St. John’s wort with tianeptine. The potential is irregular heart beat or heart attack. With the possibility of convulsions, hyperthermia and death.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.