Table of Contents
I often get emails from Nootropics Expert® readers asking me what my favorite nootropic stack is. And what I use every day. This post is a detailed response to that question.
NOTE: This review has been updated to reflect the changes to the Mind Lab Pro® formula which was refreshed in early 2017.
Mind Lab Pro® is by far the best nootropic stack I’ve ever used. And I’ve tried a lot of them over the last 12 years. Including ready-made stacks from the local vitamin shop to many of the well-known stacks found online.
14 years ago, I was diagnosed with Adult ADD and my doctor put me on Ritalin. It was like the lights suddenly came on in my brain. And for the first time in my life I could concentrate and focus.
Up to then, I took my brain for granted. And hadn’t considered that the health of my brain affected every single aspect of my life.
That point was also the beginning of a journey into how my brain worked. What was wrong, and an earnest search on how to fix it. I’ve read thousands of threads on Reddit, Longecity and nootropic blogs in this search for the ultimate nootropic stack.
My Nootropic Stack Criteria
As this deep dive into neuroscience took shape, I started to develop a map of sorts on what my options were. Areas that I could fix on my own. And other areas that could be boosted and tweaked to get the most out of this amazingly complex organ in my head.
This is the list of cognitive improvements I eventually came up with:
- increase memory and recall
- eliminate brain fog
- support the stimulant I am using for Adult ADD
- ramp up motivation
- boost personal confidence
- help with concentration
- magnify my ability to learn and retain
- focus easily
- maintain a better mood – tone down depression
- improve vocabulary – words come easily
- reduce stress levels
- have better coordination
- improve sleep
It soon became clear that no prescription drug on earth could help achieve the results I was looking for. A completely optimized brain firing on all cylinders.
So I turned to natural supplements and started experimenting. Through trial and error things started to come together. My memory and recall got better. Confidence levels improved and I was in a better mood. Stress levels went down. And a better night’s sleep was finally within reach.
Anyone who has been down this path of brain optimization knows the expense and work involved. I’ve spent thousands upon thousands of dollars on supplements. Trial and error with different compounds. Buying ready-made stacks that promised a lot. But always fell short in some way.
Eventually I started buying nootropic supplements in bulk powder form and began making my own capsules. Still a costly way to boost my brain power but entirely worth the effort and expense. Both in my career and relationships with those I love.
Discovering Mind Lab Pro
But I was always on the lookout for the ideal nootropic stack that could help replace some of the many supplements I was taking. And in late 2015 I finally found it in Mind Lab Pro®.
I’ve been using Mind Lab Pro every day since then. And haven’t found another premade nootropic stack that comes anywhere close to what this stack can do.
Who Makes Mind Lab Pro?
Mind Lab Pro is a premium nootropic stack developed in the U.K. The company promotes Mind Lab Pro as “the first Universal Nootropic” stack that boosts all aspects of cognition in all types of people.
This nootropic stack can be used by students, athletes, competitors in sports and games, working professionals and even those over 55.
So how can one stack promise so much in just two capsules per day? Let’s dig into the ingredients to see what they do in the brain, and how they work.
(Note that every ingredient in Mind Lab Pro listed here links through to a full review of each nootropic on Nootropics Expert. You’ll get more detail on the history, clinical studies, dosage recommendations, side effects and forms available).
Mind Lab Pro Ingredients
This is the formula that the team at Mind Lab Pro created that works so well for me. And thousands of other neurohackers around the world.
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- Bacopa Monnieri 150 mg standardized to 45% bacosides with 9 bioactives cuts back learning time, and improves memory including recall.[i]
The active bacosides in Bacopa protects brain cells from free radicals which prevents cell damage and death. Bacopa also boosts acetylcholine, GABA and serotonin – all tied to focus, clear memory and better mood. Bacopa even helps boost cerebral circulation.
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- Citicoline as Cognizin® 250 mg enhances attention, concentration, memory, logical reasoning, learning and focus.[ii]
Citicoline helps synthesize phosphatidylcholine (PC), a major phospholipid found in brain cell membranes. And supports the neurotransmitter acetylcholine while providing antioxidant activity.
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- Phosphatidylserine (PS) as Sharp PS® Green 100 mg improves memory and attention, increases cognitive processing speed, and accuracy.[iii]PS is a phospholipid making up 15% of brain cell membranes. Maintaining cellular fluidity, optimizing neuroreceptors and promoting acetylcholine and dopamine.
PS even increases nerve growth factor to help neurogenesis, cell maintenance and repair.
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- Lion’s Mane Mushroom (full-spectrum) 500 mg is effective in improving memory, neuron repair,[iv] liver detox, and regulating blood sugar and cholesterol levels.
Lion’s Mane is the only mushroom that supports brain health. The active hericenones and erinacines stimulates Nerve Growth Factor which helps neurogenesis, and myelin axon sheath synthesis. Improving neuroplasticity which is involved in memory formation, and keeping cell membranes healthy.
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- Rhodiola Rosea 50 mg standardized to 3% rosavins and 1% salidrosides improves mental performance under stress, and enhances mood.[v]
Rhodiola boosts mood by influencing norepinephrine, serotonin and the feel-good opioids like beta-endorphins levels in your brain. It helps neurogenesis, activates the synthesis of ATP, and reduces the inflammatory C-reactive protein in your brain.
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- L-Theanine 100 mg as Suntheanine® improves focus[vi], sleep, immune system strength, and blood pressure control. L-Theanine increases alpha brain waves which are associated with relaxation and enhanced creativity.
It settles excitatory neurotransmitters while promoting calming neurotransmitters like serotonin and GABA. Sharpening attention, alertness and focus that help creative problem solving, learning and studying.
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- N-Acetyl L-Tyrosine (NALT) 175 mg is an amino acid critical for the synthesis of catecholamine neurotransmitters dopamine, epinephrine and norepinephrine in your brain. Boosting these catecholamines helps improve cognition, mood, and memory.
NALT has been shown to promote working memory when multitasking.[vii] And NALT helps optimize mental performance under high stress, fatigue and sleep deprivation.
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- Maritime Pine Bark Extract 75 mg standardized for a minimum of 95% proanthocyanidins. This extract helps increase levels of nitric oxide which helps dilate blood vessels. Delivering more oxygen and glucose to brain cells for more energy, better learning and memory, enhanced focus and elevated mood.
Pine Bark Extract is one the most potent antioxidants ever discovered. Scavenging free radicals to protect neurons from oxidative damage.
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- Vitamin B6 2.5 mg supplied in the bio-identical form of NutriGenesis® vitamins which is critical for the synthesis of the major neurotransmitters dopamine, GABA, norepinephrine and serotonin. Which influence mood, melatonin, and helps regulate your body clock.[x]
B6 also helps protect your brain from excess homocysteine that can damage blood vessel linings. And B6 helps form myelin which is the protective sheath that surrounds axons in your brain and body.
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- Vitamin B9 100 mcg in the bio-identical form of NutriGenesis® vitamins. This vitamin participates in one-carbon transfers for the synthesis of DNA and RNA. And works with the other two B-Vitamins in this stack help regulate homocysteine levels.
Folate is also involved in gene expression, amino acid synthesis, and myelin synthesis and repair.
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- Vitamin B12 7.5 mcg in the bio-identical form of NutriGenesis® vitamins which is required to regulate homocysteine levels in your brain and body.
B12 is also a cofactor in the synthesis of the major neurotransmitters dopamine, GABA, norepinephrine and serotonin. Low levels of Vitamin B12 has been linked to poor mood and cognition leading to cognitive decline at any age.[xi]
One of the things that stands out in this nootropic stack is the company chooses to use their proprietary NutriGenesis® form of vitamins. Which are nature-identical to ensure these B-Vitamins are completely absorbed and used by your body and brain.
Mind Lab Pro Dosage
The amount of each ingredient listed is for Mind Lab Pro’s recommended 2-capsules per day. You can safely increase your dose to 4-capsules per day. 2 in the morning and 2 early afternoon.
Like every nootropic, it’s always better to start low and see how your body and brain react before increasing your dosage.
Synergy of Nootropic Ingredients is Key
The key to making this nootropic stack work is two-fold:
- the exact amount required for optimal performance from each ingredient
- synergy or how they work together and complement each other for maximum results.
This idea of “synergy” is a big deal when putting together a nootropic stack. While each nootropic on its own could call for a higher dosage, when combined they work together better in the brain at smaller doses. But more on these doses in a minute.
Just Say “No” to Proprietary Formulas
One thing that irks me is the way many nootropic manufactures ‘hide’ the exact amount of each ingredient in their stack. They call it their “proprietary formula”.
But Mind Lab Pro chooses to disclose exact amounts on their packaging. So I know exactly what I’m taking. For me, this shows respect for me as a customer. Then I have the option of upping doses of certain nootropics that are unique to my condition and state of health.
For example, I’m Adult ADD and continue to use 20 mg of Ritalin twice a day. Ritalin works by blocking the reuptake and degradation of dopamine in my brain. Making more dopamine available to help my focus and concentration.
The problem for me, and for many with ADD and ADHD as we get older is there’s not enough dopamine in my brain to start with.
Mind Lab Pro addresses this lack of dopamine with NALT. But in my case, the dose of NALT is too low. So I add 800 mg of NALT and 1,000 mg of ALCAR each time I take my Ritalin dose.
The result has been greater efficacy of Ritalin. I’ve never had to increase my dose of Ritalin due to tolerance. And at the end of my day, I don’t experience a stimulant ‘crash’ which is common when using these types of stimulants.
Do I consider this a ‘con’ for Mind Lab Pro? Absolutely not. Because while I need extra dopamine and acetylcholine in my brain, you may not. Unless you’re dealing with something like ADHD.
And I know exactly how much NALT and ALCAR to add to this stack because Mind Lab Pro tells me how much they are supplying in their stack. There is no guessing.
How Mind Lab Pro Works in Real Life
I love this nootropic stack. Two capsules in the morning with a tablespoon of organic unrefined coconut oil. And it launches my day. In my case with ADD and being hypothyroid, I take another two capsules at noon with coconut oil.
I also use 1,000 mg of DHA in the morning. Along with Aniracetam and Sulbutiamine. Since starting Mind Lab Pro my productivity has increased. My mood is better. Focusing on several projects is not a problem. Work seems to go faster. And I get more done in less time.
Everything just seems better. And life flows.
Mind Lab Pro is Impressive value
One of the things I’ve learned over the years of working with nootropics is it’s not cheap. In fact, taking each nootropic on its own in my case, can add up to a few hundred dollars per month.
But using Mind Lab Pro has dramatically reduced my nootropic budget. Here’s a breakdown of how much each of these nootropics would cost if purchased individually.
Note: These prices are from Amazon.com here in the USA at the time I write this. They’re usually competitive with other retailers online, and brick & mortar stores. Prices could be different in your part of the world, or when you read this.
Bacopa Monnieri (45% bacosides) 250 mg – 90 capsules $14.99
Citicoline (Cognizin®) 250 mg – 60 capsules $20.38
Phosphatidylserine (PS) (Sharp PS® Green) 100 mg – 120 capsules $48.97
Lion’s Mane Mushroom (full-spectrum) 500 mg – 60 capsules $8.99
Rhodiola Rosea (3% rosavins, 1% salidrosides) 250 mg – 60 capsules $7.86
L-Theanine (Suntheanine®) 100 mg – 60 capsules $11.49
N-Acetyl-L-Tyrosine (NALT) 350 mg – 120 capsules $12.29
Pine Bark Extract (95% proanthocyanidins ) 100 mg – 300 capsules $18.52
Vitamin B6 (P-5-P) 25 mg – 100 capsules $17.95
Vitamin B9 (folate) 400 mcg – 90 capsules $7.21
Vitamin B12 (Methylcobalamin) 1 mg – 60 capsules $18.95
The total of each of these evidence-backed nootropics when purchased individually comes out to $187.60.
Now I realize that the dosages in this comparison are often higher when used individually. The quantities per bottle are often higher than a monthly supply. And I’ve included supplements packed in vegetarian capsules which are often priced a little higher than regular capsules.
Sure, I could re-calculate each of the comparison prices by counting capsules per bottle to figure out the exact monthly dose.
Adjusting the price per capsule accordingly.
But my point here is the cost of buying each of these nootropics individually will be higher. Much higher than what the company charges for Mind Lab Pro.
Mind Lab Pro for a 30-day supply if you take the recommended 2 capsules per day is only $69.00 (+ shipping & handling).
You can also choose a 3-month supply (3 boxes) of Mind Lab Pro for $207.00 and get one box free (including free international shipping & handling). That works out to $51.75 per box.
Pros & Cons of Mind Lab Pro
Mind Lab Pro has taken an extra step to include NutriCaps® instead of regular vegetarian capsules in their stack. These vegan caps are made from tapioca.
Most competitors (including the nootropics listed above) use HPMC vegetarian capsules which are made from a semi-synthetic polymer.
Now, let’s look at what I think are the pros and cons of this premium nootropic stack.
Pros
- Full disclosure on the amount of each ingredient
- High quality branded ingredients (i.e. Cognizin®, Sharp PS®, NutriGenesis® vitamins, Suntheanine®)
- Vegan natural NutriCaps®
- Highly bioavailable B-Vitamins (P-5-P and methylcobalamin)
- No additives
- Organic when available, and always free of toxic heavy metals and other contaminates
- Tested prior to encapsulation for allergens, GMOs, microbes, pesticides and herbicides
- Batches are re-tested to confirm potency, purity and activity after encapsulation
- Ships in recyclable cardboard security boxes filled with biodegradable packing peanuts
- Competitively priced
Cons
- Only available on their website (more on this in a minute)
- Citicoline dose is too low if you’re using racetams
In all, I think the dosages included in Mind Lab Pro are perfect for this stack. In these dosage ranges side effects are minimized, or non-existent.
And because they fully disclose how much is in each 2-capsule dose, I have a better idea on what I need to add to this stack for my unique issues.
Nootropics Expert Recommendation
I recommend Mind Lab Pro as a nootropic stack for total brain optimization.
Pricing of Mind Lab Pro is very competitive for what you get. Some on reddit.com and other blogs have commented that the company only sells this stack from their site. And don’t offer a free trial.
I’ve been in internet marketing for many years and completely understand the hazards of offering a free trial. Especially when you’re selling a high-quality product at the best price you can to stay competitive. It doesn’t make sense to offer free trials when you back it up with a risk-free, “empty bottle”, money-back guarantee.
The company has also decided not to offer Mind Lab Pro on Amazon.com because they don’t want this stack to appear alongside low-quality junk products. I get that. Amazon can also be a place where reviews are easily manipulated by jealous competitors.
And for anyone looking to understand the methodology that went into developing this stack, Amazon.com is not the place for extensive product descriptions.
So if you’ve been experimenting with nootropics for a while, or even considering getting into neurohacking – I recommend giving Mind Lab Pro a try.
This is the best pre-made nootropic stack I’ve ever tried. And this after nearly 10 years of trying dozens of nootropics. Both individual ingredients, and various stacks by different manufacturers.
It’s certainly not the cheapest nootropic stack on the market. But it’s not unreasonably priced either at only $69 for a month supply. You can’t put this stack together individually for less than twice or even three times what Opti Nutra charges.
And for me, Mind Lab Pro went the extra mile by going top notch with everything in this stack. Product and packaging quality, brand name ingredients, testing and more testing, organic when they can. Right down to using and NutriGenesis® and NutriCaps®. Touches the average person wouldn’t even notice. Now that’s cool.
If you’d like to try Mind Lab Pro, or learn more about this premium stack, please go to their website for more:
Join The Discussion - 227 comments
Bernardo
June 19, 2018
Hello, David. Thanks for the great review and all the great content on your website.
I will start taking Min Lab Pro (M.L.P.) soon and this will be my first ever nootropic (if we are not considering theanine and caffeine as nootropics…also took panax ginseng for about a month or two, years ago)
My intention for M.L.P was to take it only on intense classes days, like the MBA classes I take on some weekends/month which last all day long (Sat. and Sun.), and maybe some other days that I needed that extra push on brain performance. I do have brain fog and other brain issues that I´m already adressing with diet and some other things that are yet to be improved.
However, I noticed Mind Lab Pro (M.L.P) is not the best choice when you want a sort of an instant push on brain performance, like you may would get by taking True Brain, for instance. I was actually deciding amongst those 2 premaid Nootropics, and ended up deciding for M.L.P. as it is all natural and concidering this will be my 1st time so I didn´t want to start with racetams (like in TrueBrain).
That said, do you think I´ll benefit from M.L.P, like, if I take it next saturday/sunday which are classes days? Or it is only worth it if I take it continuously? If so, I´m considering taking like 3 days on/1 day off or so, because I always want to be extra cautious to avoid any sort of tolerance (although I do take a fair amount of caffeine thru black coffee every day).
Thank you and sorry for the long question.
David Tomen
June 20, 2018
Bernardo, many consider L-Theanine, caffeine, and ginseng as nootropics because they directly influence brain function. So you already have some experience with nootropics.
To get the full benefit of Mind Lab Pro, you should be using it every day. Because while the benefits are immediate, the full effect of MLP comes from using it consistently. In a month or two you may find you will not need a “boost” on your heavy study days. But until then I suggest you use Mind Lab Pro every day. And something like TruBrain that contains the racetams on your heavy study days.
Colleen
June 12, 2018
Hi David,
Just received my first batch of Mind Lab Pro!
I was just wondering, should I stack this with a full B-vitamin complex or only with B1 given that vitamins B6/9/12 are already in the product? I’ve been taking a B Complex vitamin for some time but I don’t know if continued use of this would be ‘overdosing’ on B vitamins.
Also plan to stack with fish oil and magnesium as per your recommendations…I may want to try additional nootropics that are meant to help with anxiety but I’ll see how I get on with MLP first!
Thanks in advance.
David Tomen
June 12, 2018
Colleen, the B-Vitamin dosages in Mind Lab Pro are low enough that you can safely use a quality B-Complex without overdoing it. I do and it works great for me. Just keep an eye on the total dosages.
Huge
April 11, 2018
Hi David,
I am taking MLP for 2 weeks and I do not feel anything different than before. Do you recommend to combine it with others nootropics, vitamins, supplements, etc? to enhance MLP. In this case, which supplements do you think can help enhance MLP?
Thank you very much and congratulations for your blog, it is really helpful.
David Tomen
April 11, 2018
Hugo, I do recommend using additional vitamins and minerals when using Mind Lab Pro. Most of us do not get sufficient nutrients from the food we eat every day. And our body and brain require these vitamins and minerals to make things like neurotransmitters.
You could be low in any one of magnesium, iodine, selenium, any of the B-Vitamins, Vitamin A, etc. If only one or two of these critical nutrients are low there is no nootropic on earth that will help.
On the other hand, if you are in perfect health and your body is getting everything it needs everyday it’s possible that Mind Lab Pro is not the right nootropic stack for you.
Nsika
March 22, 2018
Hi David
Thanks for the post I have been looking for something like this for a long time. I would say I consider myself very sound in terms of health (I am also vegetarian). However, I run 3 businesses and for a long time my only tool has been ultra marathons, Vitamin B and unhealthy doses of caffeine. I want to start using Mind Lab Pro but i notice it doesn’t have some of the nootropics in your 2018 list What are the essential add-ons to the Mind Lab Pro stack?
David Tomen
March 22, 2018
Nsika, great question and thanks for asking. Mind Lab Pro is a great pre-made nootropic stack to use as a base. And for the “average” person who isn’t pursuing a high-octane lifestyle like you or I.
But depending on what you are trying to achieve you may need other nootropics in addition to Mind Lab Pro. But I stress it depends on what you are working on to help cognition, memory and mood.
In my case, I’m Adult ADD and require more dopamine and acetylcholine than what Mind Lab Pro offers. So I use the stack described in my ADHD post: https://nootropicsexpert.com/best-nootropics-for-adhd-add/.
In your case I highly recommend making sure your B-Complex is all bioavailable. Using methylcobalamin and folate instead of cyanocobalamin and folic acid.
Aniracetam is at the top of many a high-achievers list of nootropics. But it needs to be stacked with Alpha GPC or CDP-Choline to get the full benefit.
Don’t beat yourself up over caffeine consumption. Please see my recent review on caffeine here > https://nootropicsexpert.com/caffeine/
DHA in a high quality Omega-3 is a must. As is a raw-food or whole-food multivitamin/mineral supplement. I’ve been using a multivitamin for years but didn’t realize until I wrote the last couple of posts how important this addition was for my body and brain.
You are even more challenged as a vegetarian. Please use the search box top right for the keyword “vegetarian” and see what turns up. There are certain nutrients you are almost certainly lacking by following this diet. Learn what you are missing in your diet and how to fix it with the right nootropic supplements.
Final word is using a high quality coconut or MCT oil 2 or 3 times per day. Your brain needs this fat and I cannot stress strongly enough what a difference this single thing can do for your cognitive health.
Roman
March 4, 2018
Hello,
Have you ever heard of Qualia? They also offer rather a complete pre-made stack, but there are a lot of ingredients. Could you maybe do a review in the future?
Kind regards
David Tomen
March 4, 2018
Roman, I plan to begin doing pre-formulated stack reviews sometime in the next couple of months. And Qualia is on my list to review.
Mohinder
February 14, 2018
Hi! i Have been using mind lab pro for 2 and 1/2 weeks but i haven’t noticing any difference! now i know it takes time to see a difference but i have a question about the dosages! Its actually to little for each nootropic! so for instance, l theanine is 100 mg if i take it every day but don’t feel anything but in the long term will I see the benefits from it or must i take a higher dose?
David Tomen
February 14, 2018
Mohinder, the dosages in Mind Lab Pro are high enough for a relatively healthy brain. The formula was designed so the nootropic supplements included in this stack work in synergy. To provide the kind of effect you would get if you were using much higher doses of individual nootropics.
I find that I get the best results with Mind Lab Pro when I take it with a tablespoon of unrefined coconut oil, supplemental DHA, a B-Complex vitamin and magnesium. That stack would likely help anyone using MLP. Because most of us are low in Omega-3’s, the B-Vitamin, and magnesium. Coconut oil helps with better absorption of the fat-soluble nootropics in Mind Lab Pro.
Everyone’s brain and body is different and will react differently to any nootropic stack. Including MLP. I find the changes are subtle. But have been getting more profound the longer I use it. Different forms of memory are better, I feel better, think faster, and am in a better mood. But I only notice these differences when I’m truly aware of what is going on with me and my environment.
You can double your dose of MLP every day. Two capsules in the morning and two at noon.
Laura
January 27, 2018
David, I would like to order your book and am wondering if I will receive the hard copy as well as the digital. I am also needing to know if someone is on methadone is it safe to take these nootropics. Is there info regarding this in your book.
Thanks for the wealth of information you provide.
David Tomen
January 27, 2018
Laura, Head First is available as a digital download with a choice of .pdf, .mobi, or .epub depending on the reading device you prefer. I’m hoping to release a hard copy of Head First as well. But it is taking awhile to put together the logistics. So for now it is digital only.
Your question about Methadone and interactions with natural nootropic supplements is important. But there is no simple answer. The best resource I’ve found so far for checking drug interactions is here: https://www.drugs.com/drug-interactions/methadone-index.html. One example I found doing a quick search is you should not use Ginkgo Biloba with Methadone: https://www.drugs.com/drug-interactions/ginkgo-biloba-with-methadone-1174-10621-1578-0.html.
I’m sure there are several others as well. Most nootropics will be safe with Methadone. But some will not. So it’s important to check every supplement you are considering by using a resource like drugs.com before you take it.
Safety is of course our highest priority here at Nootropics Expert. So my advice is get the book Head First and use the interactions list on drugs.com before trying anything.
James
December 8, 2017
David,
Almost 3 weeks into taking MindLabPro, 5 days a week, off sat & sun. Only taking one capsule in morning, One at noon with food. Stomach upset was no problem splitting the dose, but the effect of drowsiness, dizziness, actual loss of clear thinking or short term memory has me baffled. I thought this formula would be to my benefit. I have yet to find one nootropic that works! I am extremely frustrated. My Mother has dementia, so I am afraid I will go the same route as her.
David Tomen
December 8, 2017
James, that’s why we say “your mileage may vary” when it comes to nootropics. Or any dietary supplement. You’re the first person I’ve heard from who has reported a negative experience with Mind Lab Pro. Which is saying something for that stack.
Fortunately, we have a ton of research on nootropic supplements for helping dementia and Alzheimer’s. My suggestion is do a search here on Nootropics Expert for “dementia” and another search for “Alzheimer’s”. And see what turns up. You’ll be surprised at your choices. It’ll take some research on your part and the willingness to experiment. Even on yourself first. And find something that works.
It’s easier with individual supplements vs a pre-made stack because you’ll know almost immediately if something may cause a bad reaction. One thing to note is even though you are directly related, you won’t share ALL exactly the same genetic makeup. So something that doesn’t work well for one person may work well for the next. Even someone in the same blood line. Just keep that in mind please.