Key Takeaways

1. Qualia Senolytic is a monthly supplement regimen designed to eliminate senescent “zombie” cells that accumulate with aging
2. Qualia Senolytic contains 9 research-backed ingredients including Fisetin, Quercetin, Curcumin, Luteolin, and Piperlongumine taken for 2 consecutive days per month
3. Clinical studies show improved joint comfort, better cellular health markers, and cognition in users aged 35-79
4. Costs $79 per month with subscription discounts available from Qualia Life Sciences
5. Generally well-tolerated with minimal side effects reported by users and in clinical trials

 

Qualia Senolytic Review: Is This the Key to Fighting Cellular Aging?

The cells in your brain and body are a fundamental part of life. But gradual shifts in how these cells function change as you get older.

You start with healthy cells that function as designed. But as you get older, cells that no longer work the way they’re supposed to are naturally pruned and removed from your body and brain.

These non-functional cells are referred to as “senescent cells“ or “zombie cells“.

For example, your muscle tissue creates senescent cells after an intense workout as part of natural recovery. The removal of these cells is at the center of how you feel post-workout.

Senolytics are a class of nootropic supplements specifically designed to target and eliminate these senescent cells from your body.[i]

Your immune system was designed to find and remove these non-functional cells. But as you get older our immune system is not as efficient and can’t keep up. As a result, these senescent cells take the place of healthy cells.

Scientists call this natural shift one of the “Hallmarks of Aging“. But if you want to avoid this part of the “natural” aging process, Qualia say they have a solution.

In this Qualia Senolytic Review you will discover how Qualia promises to eliminate these problem cells using a unique monthly protocol with research-backed nootropic ingredients. And help you feel younger as a result.

You’ll also learn if this premium anti-aging supplement actually delivers results worth its $79 monthly price tag.

This comprehensive Qualia Senolytic review examines the science behind the formula, what customers say about using the product, and if this senolytic supplement can truly support healthy aging at the cellular level.

Who is Qualia Life Sciences?

Qualia Life Sciences is a neurohacking company founded in California by Daniel Schmachtenberger in 2015. The company’s focus is on premium nootropics and longevity supplements.

The company say they use a research-first approach. And collaborate with neuroscientists and longevity researchers to develop science-based formulations.

Qualia claims their research methodology involves reviewing hundreds of clinical studies before selecting ingredients and dosages when formulating a supplement.

Each ingredient is third-party tested for purity and potency. Qualia has built a reputation in the nootropics community for creating premium nootropic supplements. Their formulas often command higher prices compared to most of their competitors.

Other products in their lineup include Qualia Mind for cognitive enhancement, Qualia Focus for attention support, and Qualia Night for better sleep.

The company consistently emphasizes transparency by publishing ingredient amounts and providing detailed explanations for their formulations.

Qualia also ensures that the information presented to customers is clear, accurate, and transparent.

What is Qualia Senolytic?

Qualia Senolytic belongs to a new class called senolytic supplements designed to target cellular senescence.

Cellular senescence occurs when cells stop dividing but remain metabolically active. These inflammatory compounds damage surrounding healthy tissue.[ii]

Senescent cells are often called “zombie cells” because they resist normal programmed cell death which causes problems. Research shows senescent cells accumulate with age. Which often contributes to conditions like arthritis, cardiovascular disease, and cognitive decline.

Senolytic supplements are being researched for their potential to treat these and other age-related diseases by targeting the underlying cellular mechanisms.

In the past, anti-aging nootropics focused on antioxidants and general cellular support. Qualia Senolytic takes a different approach by specifically targeting these zombie cells for elimination.

The supplement uses nootropic ingredients shown to encourage senescent cells to undergo apoptosis (programmed cell death) while leaving healthy cells unharmed.

The unique intermittent dosing protocol involves taking six capsules per day for two consecutive days, then waiting four weeks before using the supplement again.

The company claims that this approach helps your body clear away damaged cells without continuously disrupting normal cellular processes.

Qualia Senolytic Ingredients

The Qualia Senolytic formula contains nine ingredients selected for their ability to support cellular cleanup and allowing younger cells to thrive.

Each ingredient has been evaluated in clinical study models including human clinical trials shown to support senolytic activity. These ingredients have also been studied in humans to assess their senolytic activity and potential health benefits.

Fisetin (100mg)

Fisetin is considered the most potent senolytic compound available according to The Scripps Research Institute and Mayo Clinic.[iii] This natural flavonoid found in strawberries and apples has a remarkable ability to eliminate senescent cells while benefiting longevity.

The mechanism of action involves inhibiting anti-apoptotic pathways that allow senescent cells to survive.

Fisetin specifically targets the BCL-2 family proteins that prevent senescent cells from dying naturally. When this protective mechanism is disrupted, damaged cells naturally undergo programmed cell death.[iv]

One study demonstrated that Fisetin reduced senescent cells by up to 25% in mice. The research showed improved tissue health, enhanced cognitive function, and extended health span in treated animals compared to controls.[v]

Another animal study published in 2018 showed that Fisetin effectively removes senescent cells. In older mice, Fisetin helped increase their lifespan by 10 percent.

Fisetin easily crosses the blood-brain barrier and appears to promote cell communication in the hippocampus.[vi] A part of your brain is associated with long-term memory.

One clinical trial with older adults showed improved memory and reduced inflammation after 48 weeks of supplementing Fisetin. These results were observed in studies evaluating Fisetin’s effects on cognitive function and biomarkers of aging.

For more detailed information about how Fisetin works in your brain, see my detailed Fisetin Review.

Quercefit^® Quercetin Phytosome (250mg)

Quercetin Phytosome provides enhanced bioavailability compared to standard Quercetin. The Quercefit^® technology binds Quercetin to sunflower lecithin, which increases absorption by up to 20-times.

Quercetin works synergistically with Fisetin to enhance senolytic activity. While Fisetin targets specific anti-apoptotic pathways, Quercetin provides broader cellular protection and supports the cleanup process.

Research shows Quercetin can selectively eliminate senescent endothelial cells that contribute to vascular (blood vessel) aging. Resulting in better brain blood flow.

One placebo-controlled, double-blind clinical trial was conducted with 26 badminton players for eight weeks. Those who supplemented with Quercetin experienced significant differences in testosterone levels. And improvements in endurance exercise performance.[vii]

See my full Quercetin Review here.

Piperlongumine (50mg)

Piperlongumine is a natural compound extracted from the long pepper plant (Piper longum) that shows selective toxicity against stressed senescent cells.

University of Arkansas researchers found that this compound can uniquely distinguish between healthy cells and damaged zombie cells.

The mechanism works by targeting elevated stress pathways found in senescent cells. While normal cells can handle the mild oxidative stress Piperlongumine creates senescent cells with already compromised antioxidant systems cannot survive contact with this compound.

Studies show that supplementing Piperlongumine resulted in 40-60% reduction in senescent cells without affecting normal cells.[viii]

The compound appears to work through multiple pathways including disrupting mitochondrial function but only in damaged cells.

Animal studies show Piperlongumine is safe at doses used in this supplement. And its selective targeting mechanism does not harm healthy cells while using it.[ix]

Luteolin (150 mg)

Luteolin (Sophora japonica L) is a flavonoid compound found in plants and provides potent anti-inflammatory and neuroprotective benefits. Luteolin supports the senolytic process by reducing inflammation and supports cellular cleanup.[x]

Research shows Luteolin easily crosses the blood-brain barrier to support cognitive function. It inhibits inflammatory pathways that contribute to brain aging and neurodegeneration.

Clinical studies show better memory and cognitive performance in older adults supplementing with Luteolin.[xi]

The anti-inflammatory benefits of Luteolin help create an environment more conducive to healthy cellular turnover. By reducing chronic inflammation, Luteolin supports the body’s natural ability to clear damaged cells and regenerate tissue health.

For more information about how Luteolin works in your brain and its cognitive benefits, see my full review here: Artichoke Extract (Luteolin).

Longvida^® Optimized Curcumin (750 mg)

Longvida^® is a patented form of curcumin that the company claims is 67-285 times more bioavailable than standard 95% curcumin.

Curcumin supports senolytic activity through multiple biological mechanisms including as an anti-inflammatory and reducing cellular stress. The compound helps eliminate damaged cells while protecting healthy aging.[xii]

One study demonstrated significant improvements in joint comfort and mobility in older adults after 8 weeks of supplementing with Curcumin.[xiii]

Research shows Longvida^® can support cognitive function and protect against age-related cognitive decline.

See my full Curcumin Review for more on how Curcumin works in your brain.

Olive Leaf Extract (250 mg)

Olive leaf extract (standardized for 40% oleuropein) is a potent antioxidant and anti-inflammatory that supports cellular health and longevity.

The primary active compound, oleuropein, has been studied for its ability to protect cells from oxidative damage which in turn supports healthy aging.

A 2020 study showed that oleuropein supported the management of senescent chondrocytes. Chondrocytes are the cells that create cartilage, so using Olive Leaf extract supports healthy joints.[xiv]

Oleuropein has also been shown to inhibit senescence-associated secretory phenotype (SASP) which is how zombie cells influence and harm adjacent healthy cells.[xv]

Soybean Seed Extract (200 mg)

Soybean seed extract provides isoflavones and other bioactive compounds that support hormonal balance and cellular health during aging.

Research shows soy isoflavones can provide protective effects against age-related diseases by modulating estrogen levels and providing antioxidant protection at the cellular level.

Clinical studies indicate soybean extract supplementation may help maintain bone density and support cardiovascular health in postmenopausal women and older adults.[xvi]

Milk Thistle Seed Extract (125 mg)

The active compound in Milk Thistle seed extract is silymarin which has long been used to support liver health. Your liver plays a critical role in clearing senescent cells and their inflammatory byproducts from your body.

Research shows Milk Thistle can improve liver function and support your body’s natural detoxification system. This enhanced clearance capacity helps remove cellular debris and inflammatory compounds released while using a senolytic supplement.[xvii]

Senescent cells seems to rely on complex cellular pathways (called SCAPs). Research shows that if you restore SCAPs to healthy function they can then prune senescent cells and prevent them from causing damage.

The silymarin in Milk Thistle Extract helps restore SCAPs to a healthy state.[xviii]

Senactiv^® (Panax notoginseng & Rosa roxburghii) (50 mg)

Senactiv^® is a patented blend of Panax notoginseng and Rosa roxburghii extracts designed to support cellular renewal and energy production. Research shows this combination can help clear senescent cells while promoting regeneration of younger, healthier cells.

Studies show supplementing Senactiv^® can improve exercise capacity and reduce fatigue in older adults.

The compound appears to support mitochondrial function and cellular energy production while promoting healthy cellular turnover.[xix]

See my full Ginseng review here.

Other Ingredients

Qualia Senolytic uses Hypromellose capsules (made from wood pulp), L-Leucine (supports muscle growth), Silica (Silicon Dioxide) used as a flow agent), and rice flour (as an anti-caking agent).

Manufacturers use flow agents and anti-caking agents to prevent powders from clogging encapsulation machinery. And to prevent powders from clumping up during encapsulation.

The rice hulls are not a problem and safe to use in supplements.

However, the other so-called inactive ingredient (Silica) does nothing for purity. And while it does not interfere with the active compounds used in this supplement, I do my best to avoid Silicon Dioxide in any nootropic supplement I use.

Qualia Senolytic Recommended Dosage

The recommended Qualia Senolytic dosage is 6 capsules daily for 2 consecutive days, then waiting 4 weeks before the next course.

This intermittent approach allows sufficient time for cellular cleanup while preventing potential side effects from continuous senolytic activity.

Take the capsules with food to improve absorption and reduce the chance of stomach upset. The large capsule size may be challenging for some people.

But splitting the dose between morning and evening can help. Avoid taking alcohol or other medications that might interfere with liver function.

If you are taking any medication, consult a healthcare professional before starting Qualia Senolytic to avoid potential interactions.

The monthly cycling approach is based on research showing that continuous senolytic treatment may not be necessary or optimal.[xx]

Senescent cells accumulate slowly, so periodic elimination appears more effective than daily dosing. This protocol also reduces the risk of eliminating beneficial senescent cells that play roles in wound healing and immune function.

Most users suggest marking calendar dates for your monthly Senolytic regimen to maintain consistency.

The manufacturer recommends continuing their supplement for at least 3-6 months to feel its full effectiveness, though many users report benefits within the first few supplement cycles.

Qualia Senolytic Review – Are Customers Happy?

Verified customer reviews are generally positive from users who have used Qualia Senolytic for several months.

Amazon customer feedback shows an average rating of 4.4 out of 5 stars based on over 480 reviews, with most customers reporting less brain fog, more energy and better overall feelings of well-being.

Common benefits reported by users include increased energy levels within 2-3 weeks of starting the supplement. Some report less join pain and better mobility, better sleep quality, and enhanced mental clarity.

The time to experience results varies among users. But most report feeling better within 4-6 weeks. Some customers describe feeling “reset” or refreshed after completing their monthly Qualia Senolytic regimen.

Users over 50 tend to report more dramatic improvements compared to younger adults.

Negative feedback primarily focuses on the high cost of this supplement. Some customers report mild digestive upset during the first use of this supplement, though this typically is not a problem with subsequent use.

Healthcare professionals who recommend the product note that patient compliance is generally good because of the infrequent dosing schedule.

Qualia Senolytic Pros & Cons

Pros

Clinically tested formula with published research – Each ingredient has been backed with clinical studies, and many have human clinical trials supporting their effectiveness for cellular health and healthy aging.

Qualia has also conducted their own double-blind, placebo-controlled clinical trial with 36 adults aged 35 to 79 years old. The study showed a 68% reduction in joint discomfort and improved physical function.

Convenient monthly dosing schedule – The 2-day monthly protocol is more manageable than daily supplements for some users. And this schedule seems to align with the scientific understanding of senolytic mechanisms.

High-quality, bioavailable ingredients – The formula uses premium and patented forms like Quercefit^® quercetin Phytosome and Longvida^® curcumin that provide enhanced absorption compared to standard ingredients.

Endorsed by longevity researchers and physicians – Multiple anti-aging specialists and researchers have recommended the product based on its evidence-based formula and ingredient selection.

Vegan, non-GMO, gluten-free formulation – The product meets various dietary restrictions and uses clean ingredients without artificial additives or common allergens.

Transparency. The quantity of each active ingredient is clearly listed on the supplement facts label to ensure transparency and proper dosing.

Cons

Large capsule size and 6-pill daily dose during treatment days – The capsules are larger than average and the six-capsule dose may be a problem for people who have difficulty swallowing pills.

Premium price compared to individual senolytic supplements – At up to $79 per month, the cost is significantly higher compared to purchasing individual ingredients like Fisetin and Quercetin separately.

Results may take several months of use to become noticeable – Many users need at least 2-3 monthly use cycles before experiencing significant improvements, requiring patience and consistent use.

Qualia Senolytic Side Effects

Clinical trial safety data from a 36-person study showed the supplement was generally well-tolerated with minimal adverse effects. Safety assessments included monitoring vital signs such as blood pressure and heart rate throughout the study.[xxi]

The most common side effects reported were mild digestive upset at first, which typically resolved with continued use.

Potential side effects from Fisetin may include nausea or headaches if you are sensitive to supplements. But the 100 mg dose used in this formula is well below the levels that typically cause problems according to clinical studies.

Quercetin can interact with blood thinners. The compound can affect drug metabolism in your liver, so if you are taking medications you should consult a licensed health care professional before using Qualia Senolytic. It also inhibits aromatase so if you’re being treated for breast cancer – talk to your doctor before using this supplement.

If you are pregnant or breastfeeding, use caution because safety data is insufficient in this case. If you have serious health issues or are taking medicine you should speak with your doctor before starting Qualia Senolytic.

Qualia Senolytic may also affect blood glucose levels, so if you are diabetic then you should monitor your blood sugar more closely when beginning use.

Is Qualia Senolytic Right for You?

Qualia Senolytic is for adults over 30 if you are experiencing signs of aging such as decreased energy, joint stiffness, or not recovering as quickly from exercise.

And Qualia Senolytic is right for you if you are interested in proactive aging support instead of waiting for age-related diseases to manifest. You could benefit most from using a senolytic supplement.

Those seeking cellular health and longevity support who want to address aging at the fundamental cellular level rather than just managing symptoms then you may find this supplement is right for you.

This senolytic approach targets the root causes of aging rather than just providing antioxidant protection or amino acid support.

People interested in cutting-edge anti-aging solutions who stay current with longevity research. And those who want access to the latest scientific developments may appreciate this evidence-based formula and pro-active approach to longevity.

Who should avoid this supplement includes pregnant and nursing women due to insufficient safety data.

Qualia Senolytic may also interact with blood thinners and other medications, so if you have a significant medical history you may want to consult with your doctor first.

People who prefer daily supplements or have difficulty remembering monthly protocols may find the 2-day dosing schedule per month a challenge. And if you hate large capsules or are unable to take six capsules at once then you should likely avoid this supplement.

How Much Does Qualia Senolytic Cost?

One time purchase of Qualia Senolytic costs $79 for a month supply containing 12 capsules (enough for one treatment cycle of 6 capsules daily for 2 consecutive days). This pricing puts it in the premium supplement category compared to individual senolytic ingredients.

Subscription pricing reduces your cost to $69 per month which is a 15% discount and free shipping included. The subscription can be paused or cancelled at any time, making it a lower-risk option if you don’t know if you’re going to use the supplement long-term.

Bulk purchasing options include quarterly and annual packages with additional savings for customers committed to long-term use. You may find buying multiple months at once more convenient than monthly deliveries.

The company offers a 100-day money-back guarantee policy that allows customers to try the supplement for multiple treatment cycles before deciding whether to continue. This extended return period acknowledges that senolytic benefits may take several months to become apparent.

When compared to purchasing individual ingredients separately, the cost may seem high. However, sourcing patented-grade Fisetin, Quercefit^® quercetin, and other premium ingredients individually will cost more. And you don’t have the convenience of a pre-formulated product.

Where to Buy Qualia Senolytic

The supplement is available directly from Qualia Life Sciences website, which ensures product authenticity and provides access to the full money-back guarantee. Purchasing from the official source also guarantees proper storage and handling of the product.

Select retail locations including some Whole Foods stores and independent health stores carry the product, though availability varies by location. Call ahead to confirm they have it in stock can save you time if shopping locally.

Amazon and other online retailers offer the supplement, sometimes with slightly different pricing or shipping options. However, purchasing from third-party sellers carries the potential risk of poor quality products or improper storage conditions.

My recommendation is to purchase directly from Qualia because you’re sure your getting authentic product and customer support. Qualia’s website also provides additional ingredient information, and customer service for questions about the product.

Cart add-ons and bundle deals are sometimes available directly from Qualia, so you can combine other Qualia products for even more savings.

Go to the Qualia store here:  Qualia Senolytic and get a 15% discount with code: NOOTROPICSX